Consistency analysis of optical coherence tomography angiography and fundus fluorescein angiography in the diagnosis of central retinal vein occlusion_Chinese Journal of Ocular Fundus Diseases

Authors：

 ZengMiao , ChenXiao , SongYanping , DingQin , ChenZhongshan

Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China;

Corresponding author：

ZengMiao, Email: zengmiao1982@163.com

Keywords：

Retinal vein occlusion/diagnosis; Tomography,optical coherence; Fluorescein angiography

DOI：

10.3760/cma.j.issn.1005-1015.2016.04.005

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To assess the consistency of diagnostic results using optical coherence tomography angiography (OCTA) and fundus fluorescein angiography (FFA) in the central retinal vein occlusion (CRVO). Methods This is a retrospective case series of 26 eyes of 26 patients with CRVO. There were 10 females (10 eyes) and 16 males (16 eyes). The mean age was (49.19±10.50) years. The mean course of the disease was (27.81±21.60) days. Simultaneous OCTA and FFA were performed in all patients using 7-standard field of Early Treatment Diabetic Retinopathy Study (ETDRS) to evaluate the microaneurysms, nonperfused areas, optical disc/retinal neovascularization and macular edema. The consistency was evaluated using weighted Kappa statistic values. Kappa≥0.75, consistency is excellent; 0.60≤Kappa < 0.75, consistency is good; 0.40≤Kappa < 0.60, consistency is general; Kappa < 0.40, consistency is poor. Results Based on OCTA, microaneurysms were found in 23 eyes, nonperfused areas in 16 eyes, optical disc/retinal neovascularization in 8 eyes and macular edema in 21 eyes. Based on FFA, 23 eyes were diagnosed to have microaneurysms, 14 eyes have nonperfused area, 8 eyes have optical disc/retinal neovascularization, 22 eyes have macular edema. The consistency was excellent for microaneurysms and optical disc/retinal neovascularization (Kappa=0.772, 0.766; P < 0.01), good for nonperfused areas and macular edema (Kappa=0.703, 0.600,P < 0v01). Conclusion There is high consistency between OCTA and FFA in the diagnosis of microaneurysms, macular edema, nonperfused areas and optical disc/retinal neovascularization in CRVO patients.

Citation： ZengMiao, ChenXiao, SongYanping, DingQin, ChenZhongshan. Consistency analysis of optical coherence tomography angiography and fundus fluorescein angiography in the diagnosis of central retinal vein occlusion. Chinese Journal of Ocular Fundus Diseases, 2016, 32(4): 362-366. doi: 10.3760/cma.j.issn.1005-1015.2016.04.005 Copy

1.	Kwiterovich KA, Maguire MG, Murphy RP, et al. Frequency of adverse systemic reactions after fluorescein angiography. Results of a prospective study[J]. Ophthalmology,1991, 98(7):1139-1142.
2.	Schwartz DM, Fingler J, Kim DY, et al. Phase-variance optical coherence tomography:a technique for noninvasive angiography[J]. Ophthalmology, 2014, 121(1):180-187.DOI:10.1016/j.ophtha.2013.09.002.
3.	Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4):4710-4725. DOI:10.1364/OE.20.004710.
4.	Fleiss JL, Leein B, Paik MC. Statistical methods for rates and proportions[M]. 3rd ed. Hoboken:John Wiley & Sons Inc., 2003:608-610.
5.	Novotny HR, Alvis DL. A method of photographing fluorescence in circulating blood in the human retina[J]. Circulation, 1961, 24(1):82-86.
6.	Laatikainen L.The fluorescein angiography revolution:a breakthrough with sustained impact[J].Acta Ophthalmol Scand, 2004,82(4):381-392.
7.	Ascaso FJ, Tiestos MT, Navales J, et al. Fatal acute myocardial infarction after intravenous flluorescein angiography[J]. Retina, 1993, 13(3):238-239.
8.	Weinhaus RS, Burke FC, Delori FC, et al. Comparison of fluorescein angiography with microvascular anatomy macoque retinas[J]. Exp Eye Res,1995,61(1):1-16.
9.	Teussink MM, Breukink MB, van Grinsven MJ, et al. OCT angiography compared to fluorescein and indocyanine green angiography in chronic central serous chorioretinopathy[J]. Invest Ophthalmol Vis Sci,2015,56(9):5229-5237.DOI:10.1167/iovs.15-17140.
10.	Palejwala NV, Jia Y, Gao SS, et al. Detection of nonexudative choroidal neovascularization in age-related macular degeneration with optical coherence tomography angiography[J]. Retina, 2015,35(11):2204-2211.DOI:10.1097/IAE.0000000000000867.
11.	Yu J, Jiang CH, Sun XH, et al. Macular perfusion in healthy Chinese:a optical coherence tomography angiogram study[J]. Invest Ophthalmol Vis Sci,2014,56(5):3212-3217.DOI:10.1167/iovs.14-16270.
12.	Moore J, Bagley S, Ireland G, et al. Three dimensional analysis of microaneurysms in the human diabetic retina[J]. J Anat,1999,194(1):89-100.
13.	Tan PE, Yu PK, Balaratnasingam C, et al. Quantitative confocal imaging of the retinal microvasculature in the human retina[J]. Invest Ophthalmol Vis Sci,2012,53(9):5502-5514.DOI:10.1167/iovs.12-10265.
14.	Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy:a prospective pilot study[J]. Am J Ophthalmol,2015,160(1):35-44.DOI:10.1016/j.ajo.2015.04.021.
15.	Imai A, Toriyama Y, Iesato Y, et al. En face swept-source optical coherence tomography detecting thinning of inner retinal layers as an indicator of capillary nonperfusion[J]. Eur J Ophthalmol,2015,25(2):153-158.DOI:10.5301/ejo.5000514.

1. Kwiterovich KA, Maguire MG, Murphy RP, et al. Frequency of adverse systemic reactions after fluorescein angiography. Results of a prospective study[J]. Ophthalmology,1991, 98(7):1139-1142.
2. Schwartz DM, Fingler J, Kim DY, et al. Phase-variance optical coherence tomography:a technique for noninvasive angiography[J]. Ophthalmology, 2014, 121(1):180-187.DOI:10.1016/j.ophtha.2013.09.002.
3. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography[J]. Opt Express, 2012, 20(4):4710-4725. DOI:10.1364/OE.20.004710.
4. Fleiss JL, Leein B, Paik MC. Statistical methods for rates and proportions[M]. 3rd ed. Hoboken:John Wiley & Sons Inc., 2003:608-610.
5. Novotny HR, Alvis DL. A method of photographing fluorescence in circulating blood in the human retina[J]. Circulation, 1961, 24(1):82-86.
6. Laatikainen L.The fluorescein angiography revolution:a breakthrough with sustained impact[J].Acta Ophthalmol Scand, 2004,82(4):381-392.
7. Ascaso FJ, Tiestos MT, Navales J, et al. Fatal acute myocardial infarction after intravenous flluorescein angiography[J]. Retina, 1993, 13(3):238-239.
8. Weinhaus RS, Burke FC, Delori FC, et al. Comparison of fluorescein angiography with microvascular anatomy macoque retinas[J]. Exp Eye Res,1995,61(1):1-16.
9. Teussink MM, Breukink MB, van Grinsven MJ, et al. OCT angiography compared to fluorescein and indocyanine green angiography in chronic central serous chorioretinopathy[J]. Invest Ophthalmol Vis Sci,2015,56(9):5229-5237.DOI:10.1167/iovs.15-17140.
10. Palejwala NV, Jia Y, Gao SS, et al. Detection of nonexudative choroidal neovascularization in age-related macular degeneration with optical coherence tomography angiography[J]. Retina, 2015,35(11):2204-2211.DOI:10.1097/IAE.0000000000000867.
11. Yu J, Jiang CH, Sun XH, et al. Macular perfusion in healthy Chinese:a optical coherence tomography angiogram study[J]. Invest Ophthalmol Vis Sci,2014,56(5):3212-3217.DOI:10.1167/iovs.14-16270.
12. Moore J, Bagley S, Ireland G, et al. Three dimensional analysis of microaneurysms in the human diabetic retina[J]. J Anat,1999,194(1):89-100.
13. Tan PE, Yu PK, Balaratnasingam C, et al. Quantitative confocal imaging of the retinal microvasculature in the human retina[J]. Invest Ophthalmol Vis Sci,2012,53(9):5502-5514.DOI:10.1167/iovs.12-10265.
14. Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy:a prospective pilot study[J]. Am J Ophthalmol,2015,160(1):35-44.DOI:10.1016/j.ajo.2015.04.021.
15. Imai A, Toriyama Y, Iesato Y, et al. En face swept-source optical coherence tomography detecting thinning of inner retinal layers as an indicator of capillary nonperfusion[J]. Eur J Ophthalmol,2015,25(2):153-158.DOI:10.5301/ejo.5000514.

Previous Article
Optical coherence tomography angiography in retinal vein occlusion
Next Article
Short-tern efficacy of conbercept versus ranibizumab for macular edema in central retinal vein occlusion

Chinese Journal of Ocular Fundus Diseases

Consistency analysis of optical coherence tomography angiography and fundus fluorescein angiography in the diagnosis of central retinal vein occlusion

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content