The status and progress of lamellar hole-associated epiretinal proliferation_Chinese Journal of Ocular Fundus Diseases

Authors：

LiXin , ZhangQi ,  ZhaoPeiquan

Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200092, China;

Corresponding author：

ZhaoPeiquan, Email: zhaopeiquan@126.com

Keywords：

Retinal perforations; Macula lutea; Membranes; Review

DOI：

10.3760/cma.j.issn.1005-1015.2016.05.027

Video：

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Recently, the new term "lamellar hole-associated epiretinal proliferation" was introduced to describe a specific epiretinal proliferation. Different from conventional epimacular retinal membrane, lamellar hole-associated epiretinal proliferation (LHEP) can be found around the edge of lamellar macular holes and part of full thickness macular holes. It is defined as a thick homogenous layer of yellowish material without any contractive properties on the epiretinal surface with medium reflectivity on optical coherence tomography images. Immunocytochemical analysis showed the presence of glial cells, fibroblasts, hyalocytes and collagen type Ⅱ. Electron microscopy revealed fibroblasts and hyalocytes as predominant cell types, densely packed in cell agglomerations. LHEP is a secondary event in lamellar macular hole formation and may represent a repair process after large and deep retinal defect. Further studies on its clinical features and clinical significance are still required.

Citation： LiXin, ZhangQi, ZhaoPeiquan. The status and progress of lamellar hole-associated epiretinal proliferation. Chinese Journal of Ocular Fundus Diseases, 2016, 32(5): 547-549. doi: 10.3760/cma.j.issn.1005-1015.2016.05.027 Copy

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4.	Lai TT, Chen SN, Yang CM, et al. Epiretinal proliferation in lamellar macular holes and full-thickness macular holes:clinical and surgical findings[J].Graefe's Arch Clin Exp Ophthalmol, 2016, 254(4):629-638. DOI:10.1007/s00417-015-3133-9.
5.	Pang CE, Spaide RF, Freund KB, et al. Comparing functional and morphologic characteristics of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation[J].Retina, 2015, 35(4):720-726. DOI:10.1097/IAE.0000000000000390.
6.	Compera D, Entchev E, Haritoglou C, et al. Lamellar hole-associated epiretinal proliferation in comparison to epiretinal membranes of macular pseudoholes[J].Am J Ophthalmol, 2015, 160(2):373-384. DOI:10.1016/j.ajo.2015.05.010.
7.	Compera D, Entchev E, Haritoglou C, et al. Correlative microscopy of lamellar hole-associated epiretinal proliferation[J/OL]. J Ophthalmol, 2015, 2015:450212[2015-09-03]. http://dx.doi.org/10.1155/2015/450212.DOI:10.1155/2015/450212.

1. Witkin AJ, Ko TH, Fujimoto JG, et al. Redefining lamellar holes and the vitreomacular interface:an ultrahigh-resolution optical coherence tomography study[J]. Ophthalmology, 2006, 113(3):388-397.DOI:10.1016/j.ophtha.2005.10.047.
2. Parolini B, Schumann RG, Cereda MG, et al. Lamellar macular hole:a clinicopathologic correlation of surgically excised epiretinal membranes[J]. Invest Ophthalmol Vis Sci, 2011, 52(12):9074-9083. DOI:10.1167/iovs.11-8227.
3. Pang CE, Spaide RF, Freund KB. Epiretinal proliferation seen in association with lamellar macular holes:a distinct clinical entity[J].Retina, 2014, 34(8):1513-1523. DOI:10.1097/IAE.0000000000000163.
4. Lai TT, Chen SN, Yang CM, et al. Epiretinal proliferation in lamellar macular holes and full-thickness macular holes:clinical and surgical findings[J].Graefe's Arch Clin Exp Ophthalmol, 2016, 254(4):629-638. DOI:10.1007/s00417-015-3133-9.
5. Pang CE, Spaide RF, Freund KB, et al. Comparing functional and morphologic characteristics of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation[J].Retina, 2015, 35(4):720-726. DOI:10.1097/IAE.0000000000000390.
6. Compera D, Entchev E, Haritoglou C, et al. Lamellar hole-associated epiretinal proliferation in comparison to epiretinal membranes of macular pseudoholes[J].Am J Ophthalmol, 2015, 160(2):373-384. DOI:10.1016/j.ajo.2015.05.010.
7. Compera D, Entchev E, Haritoglou C, et al. Correlative microscopy of lamellar hole-associated epiretinal proliferation[J/OL]. J Ophthalmol, 2015, 2015:450212[2015-09-03]. http://dx.doi.org/10.1155/2015/450212.DOI:10.1155/2015/450212.

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