Comparative analysis of microperimetry in acute and chronic central serous chorioretinopathy_Chinese Journal of Ocular Fundus Diseases

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State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China;

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Keywords：

Central serous chorioretinopathy/diagnosis; Visual fields

DOI：

10.3760/cma.j.issn.1005-1015.2016.06.014

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Objective To investigate the difference in microperimetry between acute and chronic central serous chorioretinopathy (CSC). Methods Cross-sectional cases study. A consecutive series of 208 patients (221 eyes) with CSC diagnosed by fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) were enrolled in the study. The patients were divided into acute group (136 patients, 143 eyes) and chronic group (72 patients, 78 eyes) according to the duration and FFA. There were no statistical difference in sex (χ²=0.012, P=0.912) and mean age (t=-1.492, P=0.137) between two groups. All eyes received the examination of microperimetry and minimum resolution angle in logarithmic (logMAR) best corrected visual acuity (BCVA). The mean retinal sensitivities (MS) and fixation rate in the central 2°(P1) and 4° (P2) were determined. Results The mean value of logMAR BCVA in acute group and chronic group were 0.32±0.23 and 0.48±0.33, there was significant difference (Z=-3.353, P=0.001). In acute group and chronic group, the MS were (21.25±5.06) and (15.82±7.23) dB, P1 were (76.36±25.78)% and (55.01±32.34)%, P2 were (92.21±13.06)% and (79.83±23.11)%. There were statistical differences in MS (Z=-5.456, P < 0.001), P1 (Z=-4.629, P < 0.001) and P2 (Z=-4.265, P < 0.001) between two groups. In acute group, fixation was stable in 98 eyes (68.5%), relative unstable in 30 eyes (21.0%), unstable in 15 eyes (10.5%). In chronic group, fixation was stable in 30 eyes (38.5%), relative unstable in 22 eyes (28.2%), unstable in 26 eyes (33.3%). The difference of fixation between two groups was statistically significant (χ²=23.196, P < 0.001). Conclusion MS, fixation rate and fixation stability in chronic CSC eyes were all decreased compared with acute CSC eyes.

Citation： ZhouLijun, HuangChuangxin, LaiKunbei, XuFabao, ZhongXiaojing, YuShanshan, MaLi, ChenGuandi, HuJun, LyuLin, JinChenjin. Comparative analysis of microperimetry in acute and chronic central serous chorioretinopathy. Chinese Journal of Ocular Fundus Diseases, 2016, 32(6): 624-627. doi: 10.3760/cma.j.issn.1005-1015.2016.06.014 Copy

1.	Yadav NK, Jayadev C, Mohan A, et al. Subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy:safety profile and treatment outcome[J]. Eye (Lond), 2015, 29(2):258-264. DOI:10.1038/eye.2014.315.
2.	张桐梅, 韩梅, 谢世勇.慢性中心性浆液性脉络膜视网膜病变患者光动力疗法治疗后黄斑区内层和外层视网膜厚度变化观察[J].中华眼底病杂志, 2015, 31(3):235-239. DOI:10.3760/cma.j.issn.1005-1015.2015.03.006.Zhang TM, Han M, Xie SY.Analysis of inner and outer retinal thickness after photodynamic therapy in chronic central serous chorioretinopathy[J].Chin J Ocul Fundus Dis, 2015, 31(3):235-239. DOI:10.3760/cma.j.issn.1005-1015.2015.03.006.
3.	Vujosevic S, Pilotto E, Bottega E, et al. Retinal fixation impairment in diabetic macular edema[J]. Retina, 2008, 28(10):1443-1450.DOI:10.1097/IAE.0b013e318183571e.
4.	Rohrschneider K, Bultmann S, Springer C. Use of fundus perimetry (microperimetry) to quantify macular sensitivity[J]. Prog Retin Eye Res, 2008, 27(5):536-548. DOI:10.1016/j.preteyeres.2008.07.003.
5.	丁怡, 陈晓.特发性黄斑裂孔手术前后视功能的MP-1微视野检查[J].中华眼底病杂志, 2012, 28(4):407-408. DOI:10.3760/cma.j.issn.1005-1015.2012.04.024.Ding Y, Chen X.Microperimetry for visual function before and after surgery in idiopathic macular hole patients[J].Chin J Ocul Fundus Dis, 2012, 28(4):407-408. DOI:10.3760/cma.j.issn.1005-1015.2012.04.024.
6.	师燕芸, 梁忠英, 杨继红, 等.黄斑区脉络膜新生血管患眼光动力疗法治疗前后黄斑结构和功能的光相干断层扫描联合微视野检查[J].中华眼底病杂志, 2012, 28(4):404-406. DOI:10.3760/cma.j.issn.1005-1015.2012.04.023.Shi YY, Liang ZY, Yang JH, et al.Optic coherence tomography and microperimetry for macular structure and function before and after photodynamic therapy in macular choroidal neovascularization eyes[J].Chin J Ocul Fundus Dis, 2012, 28(4):404-406. DOI:10.3760/cma.j.issn.1005-1015.2012.04.023.
7.	徐吉, 魏璐, 俞素勤, 等.病理性近视患者黄斑功能的微视野检查[J].中华眼底病杂志, 2011, 27(1):52-55.DOI:10.3760/cma.j.issn.1005-1015.2011.01.012.Xu J, Wei L, Yu SQ, et al.Macular function of pathologic myopic retina evaluated by microperimetry[J].Chin J Ocul Fundus Dis, 2011, 27(1):52-55.DOI:10.3760/cma. j.issn. 1005-1015.2011.01.012.
8.	Fujii GY, De Juan E Jr, Humayun MS, et al. Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration[J].Am J Ophthalmol, 2003, 136(6):1067-1078.
9.	Nicholson B, Noble J, Forooghian F, et al. Central serous chorioretinopathy:update on pathophysiology and treatment[J].Surv Ophthalmol, 2013, 58(2):103-126. DOI:10.1016/j.survophthal.2012.07.004.
10.	Springer C, Bultmann S, Volcker HE, et al. Fundus perimetry with the micro perimeter 1 in normal individuals:comparison with conventional threshold perimetry[J].Ophthalmology, 2005, 112(5):848-854. DOI:10.1016/j.ophtha.2004.11.051.
11.	Fujita K, Shinoda K, Matsumoto CS, et al. Microperimetric evaluation of chronic central serous chorioretinopathy after half-dose photodynamic therapy[J]. Clin Ophthalmol, 2012, 6:1681-1687. DOI:10.2147/OPTH.S35338.
12.	Roisman L, Ribeiro JC, Fechine FV, et al. Does microperimetry have a prognostic value in central serous chorioretinopathy?[J]. Retina, 2014, 34(4):713-718. DOI:10.1097/IAE.0b013e3182a323fe.
13.	Chan WM, Lai TY, Lai RY, et al. Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy:one-year results of a randomized controlled trial[J]. Ophthalmology, 2008, 115(10):1756-1765. DOI:10.1016/j.ophtha.2008.04. 014.
14.	曾苗, 宋艳萍.微脉冲激光治疗急性中心性浆液性脉络膜视网膜病变疗效观察[J].中华眼底病杂志, 2015, 31(3):230-234. DOI:10.3760/cma.j.issn.1005-1015.2015.03.005.Zeng M, Song YP.Micro-pulse laser therapy for acute central serous chorioretinopathy[J].Chin J Ocul Fundus Dis, 2015, 31(3):230-234. DOI:10.3760/cma.j.issn. 1005-10152015.03.005.
15.	Yannuzzi LA. Central serous chorioretinopathy:a personal perspective[J]. Am J Ophthalmol, 2010, 149(3):361-363. DOI:10.1016/j.ajo.2009.11.017.
16.	Ozkaya A, Alkin Z, Ozveren M, et al. The time of resolution and the rate of recurrence in acute central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy:a case-control study[J]. Eye (Lond), 2016, 30(7):1005-1010. DOI:10.1038/eye.2016.79.
17.	Gemenetzi M, De Salvo G, Lotery AJ. Central serous chorioretinopathy:an update on pathogenesis and treatment[J].Eye (Lond), 2010, 24(12):1743-1756. DOI:10.1038/eye.2010.130.
18.	Ozdemir H, Karacorlu SA, Senturk F, et al. Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy[J]. Eye (Lond), 2008, 22(2):204-208. DOI:10.1038/sj.eye.6702563.

1. Yadav NK, Jayadev C, Mohan A, et al. Subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy:safety profile and treatment outcome[J]. Eye (Lond), 2015, 29(2):258-264. DOI:10.1038/eye.2014.315.
2. 张桐梅, 韩梅, 谢世勇.慢性中心性浆液性脉络膜视网膜病变患者光动力疗法治疗后黄斑区内层和外层视网膜厚度变化观察[J].中华眼底病杂志, 2015, 31(3):235-239. DOI:10.3760/cma.j.issn.1005-1015.2015.03.006.Zhang TM, Han M, Xie SY.Analysis of inner and outer retinal thickness after photodynamic therapy in chronic central serous chorioretinopathy[J].Chin J Ocul Fundus Dis, 2015, 31(3):235-239. DOI:10.3760/cma.j.issn.1005-1015.2015.03.006.
3. Vujosevic S, Pilotto E, Bottega E, et al. Retinal fixation impairment in diabetic macular edema[J]. Retina, 2008, 28(10):1443-1450.DOI:10.1097/IAE.0b013e318183571e.
4. Rohrschneider K, Bultmann S, Springer C. Use of fundus perimetry (microperimetry) to quantify macular sensitivity[J]. Prog Retin Eye Res, 2008, 27(5):536-548. DOI:10.1016/j.preteyeres.2008.07.003.
5. 丁怡, 陈晓.特发性黄斑裂孔手术前后视功能的MP-1微视野检查[J].中华眼底病杂志, 2012, 28(4):407-408. DOI:10.3760/cma.j.issn.1005-1015.2012.04.024.Ding Y, Chen X.Microperimetry for visual function before and after surgery in idiopathic macular hole patients[J].Chin J Ocul Fundus Dis, 2012, 28(4):407-408. DOI:10.3760/cma.j.issn.1005-1015.2012.04.024.
6. 师燕芸, 梁忠英, 杨继红, 等.黄斑区脉络膜新生血管患眼光动力疗法治疗前后黄斑结构和功能的光相干断层扫描联合微视野检查[J].中华眼底病杂志, 2012, 28(4):404-406. DOI:10.3760/cma.j.issn.1005-1015.2012.04.023.Shi YY, Liang ZY, Yang JH, et al.Optic coherence tomography and microperimetry for macular structure and function before and after photodynamic therapy in macular choroidal neovascularization eyes[J].Chin J Ocul Fundus Dis, 2012, 28(4):404-406. DOI:10.3760/cma.j.issn.1005-1015.2012.04.023.
7. 徐吉, 魏璐, 俞素勤, 等.病理性近视患者黄斑功能的微视野检查[J].中华眼底病杂志, 2011, 27(1):52-55.DOI:10.3760/cma.j.issn.1005-1015.2011.01.012.Xu J, Wei L, Yu SQ, et al.Macular function of pathologic myopic retina evaluated by microperimetry[J].Chin J Ocul Fundus Dis, 2011, 27(1):52-55.DOI:10.3760/cma. j.issn. 1005-1015.2011.01.012.
8. Fujii GY, De Juan E Jr, Humayun MS, et al. Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration[J].Am J Ophthalmol, 2003, 136(6):1067-1078.
9. Nicholson B, Noble J, Forooghian F, et al. Central serous chorioretinopathy:update on pathophysiology and treatment[J].Surv Ophthalmol, 2013, 58(2):103-126. DOI:10.1016/j.survophthal.2012.07.004.
10. Springer C, Bultmann S, Volcker HE, et al. Fundus perimetry with the micro perimeter 1 in normal individuals:comparison with conventional threshold perimetry[J].Ophthalmology, 2005, 112(5):848-854. DOI:10.1016/j.ophtha.2004.11.051.
11. Fujita K, Shinoda K, Matsumoto CS, et al. Microperimetric evaluation of chronic central serous chorioretinopathy after half-dose photodynamic therapy[J]. Clin Ophthalmol, 2012, 6:1681-1687. DOI:10.2147/OPTH.S35338.
12. Roisman L, Ribeiro JC, Fechine FV, et al. Does microperimetry have a prognostic value in central serous chorioretinopathy?[J]. Retina, 2014, 34(4):713-718. DOI:10.1097/IAE.0b013e3182a323fe.
13. Chan WM, Lai TY, Lai RY, et al. Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy:one-year results of a randomized controlled trial[J]. Ophthalmology, 2008, 115(10):1756-1765. DOI:10.1016/j.ophtha.2008.04. 014.
14. 曾苗, 宋艳萍.微脉冲激光治疗急性中心性浆液性脉络膜视网膜病变疗效观察[J].中华眼底病杂志, 2015, 31(3):230-234. DOI:10.3760/cma.j.issn.1005-1015.2015.03.005.Zeng M, Song YP.Micro-pulse laser therapy for acute central serous chorioretinopathy[J].Chin J Ocul Fundus Dis, 2015, 31(3):230-234. DOI:10.3760/cma.j.issn. 1005-10152015.03.005.
15. Yannuzzi LA. Central serous chorioretinopathy:a personal perspective[J]. Am J Ophthalmol, 2010, 149(3):361-363. DOI:10.1016/j.ajo.2009.11.017.
16. Ozkaya A, Alkin Z, Ozveren M, et al. The time of resolution and the rate of recurrence in acute central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy:a case-control study[J]. Eye (Lond), 2016, 30(7):1005-1010. DOI:10.1038/eye.2016.79.
17. Gemenetzi M, De Salvo G, Lotery AJ. Central serous chorioretinopathy:an update on pathogenesis and treatment[J].Eye (Lond), 2010, 24(12):1743-1756. DOI:10.1038/eye.2010.130.
18. Ozdemir H, Karacorlu SA, Senturk F, et al. Assessment of macular function by microperimetry in unilateral resolved central serous chorioretinopathy[J]. Eye (Lond), 2008, 22(2):204-208. DOI:10.1038/sj.eye.6702563.

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