Improve our understanding of ocular fundus diseases with ultra-wide-field fluorescein angiography_Chinese Journal of Ocular Fundus Diseases

Authors：

 ChenChangzheng , XuA'min

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, China;

Corresponding author：

ChenChangzheng, Email: whuchenchzh@163.com

Keywords：

Retinal diseases/diagnosis; Fluorescein angiography; Diagnostic techniques, ophthalmological; Editorial

DOI：

10.3760/cma.j.issn.1005-1015.2017.01.003

Video：

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Ultra-wide-field fluorescein angiography (UWFA) can obtain very wide retinal images (up to 200°), and is a very helpful tool to detect peripheral retinal lesions which cannot be found by other imaging methods. Analyzing the characteristics of the UWFA images may improve our understanding, treatment outcomes and management strategies of ocular fundus diseases. However this technology is still in its premature stage, there is still a lot of work to be done to improve its clinical application and study the characteristics and clinical meanings of these peripheral retinal lesions.

Citation： ChenChangzheng, XuA'min. Improve our understanding of ocular fundus diseases with ultra-wide-field fluorescein angiography. Chinese Journal of Ocular Fundus Diseases, 2017, 33(1): 7-9. doi: 10.3760/cma.j.issn.1005-1015.2017.01.003 Copy

1.	周金琼, 魏文斌. Optos 200Tx广角眼底血管造影及其临床应用[J]. 国际眼科纵览, 2015, 39(2): 103-106. DOI: 10.3760/cma. j.issn.1673-5803.2015.02.007.Zhou JQ, Wei WB. Optos 200Tx scanning laser ophthalmoscope for wide-field fluorescein angiography and its clinicalapplication[J]. Int Rev Ophthalmol, 2015, 39(2): 103-106. DOI: 10.3760/cma. j.issn.1673-5803.2015.02.007.
2.	Spaide RF. Peripheral areas of nonperfusion in treated central veinocclusion as imaged by wide-field fluoresceinangiography[J]. Retina, 2011, 31(5): 829-837. DOI: 10.1097/IAE.0b013e 31820c841e.
3.	Singer M, Sagong M, vanHemert J, et al. Ultra-widefield imaging of the peripheral retinal vasculature in normal subjects[J]. Ophthalmology, 2016, 123(5): 1053-1059. DOI: 10.1016/j.Ophtha. 2016.01.022.
4.	Sagong M, van Hemert J, Olmos de Koo LC, et al. Assessment of accuracy and precision of quantification of ultra-widefield images[J]. Ophthalmology, 2015, 122(4): 864-866. DOI: 10.1016/j.ophtha.2014.11.016.
5.	Shah AR, Abbey AM, Yonekawa Y, et al. Widefield fluorescein angiography in patients without peripheral disease: astudy ofnormal peripheralfindings[J]. Retina, 2016, 36(6): 1087-1092. DOI: 10.1097/IAE.0000000000000878.
6.	Wessel MM, Aaker GD, Parlitsis G, et al. Ultra-widefield fluorescein angiography improves the detection and classification of diabeticretinopathy[J]. Retina, 2012, 32(4): 785-791. DOI: 10.1097/IAE.0b013e3182278b64.
7.	Wessel MM, Nair N, Aaker GD, et al. Peripheral retinal ischaemia, as evaluated byultra-widefield fluorescein angiography, is associatedwith diabetic macular oedema[J]. Br J Ophthalmol, 2012, 96(5): 694-698. DOI: 10.1136/bjophthalmol-2011-300774.
8.	Karampelas M, Sim DA, Chu C, et al. Quantitative analysis of peripheral vasculitis, ischemia and vascular leakage in uveitisusing ultra widefield fluorescein angiography[J]. Am J Ophthalmol, 2015, 159(6): 1161-1168. DOI: 10.1016/j.ajo.2015.02.009.
9.	Silva PS, Cavallerano JD, Sun JK, et al. Peripheral lesions identified by mydriaticultrawide field imaging: distribution and potential impact ondiabetic retinopathyseverity[J]. Ophthalmology, 2013, 120(12): 2587-2595. DOI: 10.1016/j.ophtha.2013.05.004.
10.	Silva PS, Cavallerano JD, Haddad NM, et al. Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years[J]. Ophthalmology, 2015, 122(5): 949-956. DOI: 10.1016/j.ophtha.2015.01.008.
11.	Oliver SC, Schwartz SD.Peripheralvesselleakage(PVL): a new angiographic finding in diabetic retinopathy identified with ultrawide-field fluorescein angiography[J]. Semin Ophthalmol, 2010, 25(1-2): 27-33. DOI: 10.3109/08820538.2010.481239.
12.	Kook D, Wolf A, Kreutzer T, et al. Long-term effect of intravitreal bevacizumab (avastin) in patients with chronic diffuse diabetic macular edema[J]. Retina, 2008, 28(8): 1053-1060. DOI: 10.1097/IAE.0b013e318176de48.
13.	Arevalo JF, Sanchez JG, Fromow-Guerra J, et al. Comparison of two doses of primary intravitreal bevacizumab (Avastin) for diffuse diabetic macular edema: results from the Pan-American Collaborative Retina Study Group (PACORES) at 12-month follow-up[J]. Graefe′s Arch Clin Exp Ophthalmol, 2009, 247(6): 735-743. DOI: 10.1007/s00417-008-1034-x.
14.	Michaelides M, Kaines A, Hamilton RD, et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2[J]. Ophthalmology, 2010, 117(6): 1078-1086. DOI: 10.1016/j.ophtha.2010.03.045.
15.	Muqit MM, Marcellino GR, Henson DB, et al. Optos-guided pattern scan laser (Pascal)-targeted retinal photocoagulation in proliferative diabetic retinopathy[J]. Acta Ophthalmol, 2013, 91(3): 251-258. DOI: 10.1111/j.1755-3768.2011.02307.x.
16.	Prasad PS, Oliver SC, Coffee RE, et al. Ultrawide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion[J]. Ophthalmology, 2010, 117(4): 780-784. DOI: 10.1016/ j.ophtha.2009.09.019.
17.	Tsui I, Kaines A, Havunjian MA, et al. Ischemic index and neovascularization in central retinal vein occlusion[J]. Retina, 2011, 31(1): 105-110. DOI: 10.1097/IAE.0b013e3181e36c6d.
18.	马景学, 安建斌. 充分发挥广角眼底影像检查诊断新技术的临床应用价值, 不断提升眼底病诊断治疗水平[J]. 中华眼底病杂志, 2016, 32(3): 232-236. DOI: 10.3760/cma.j.issn.1005-1015. 2016.03.002.Ma JX, An JB.Applying wide-angle fundus imaging modalities to improve the diagnosis and treatment of ocular fundus diseases[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 232-236. DOI: 10.3760/ cma.J.issn.1005-1015.2016. 03.002.
19.	Kaines A, Tsui I, Sarraf D, et al. The use of ultra wide field fluoreseein angiography in evaluation and management of uveitis[J]. Semin Ophthalmol, 2009, 24(1): 19-24. DOI: 10.1080/08820 530802520095.
20.	Aggarwal K, Mulkutkar S, Mahajan S, et al. Role ofultra-widefield imaging in the management of tubercular posterior uveitis[J]. Ocul Immunol Inflamm, 2016, 24(6): 631-636. DOI: 10.3109/0927 3948.2015.1099681.
21.	Canny CL, Oliver GL. Fluorescein angiographic findings in familial exudative vitreo retinopathy[J]. Arch Ophthalmol, 1976, 94(7): 1114-1120.
22.	Kang KB, Wessel MM, Tong J, et al. Ultra-widefield imaging for the management of pediatric retinal diseases[J]. J Pediatr Ophthalmol Strabismus, 2013, 50(5): 282-288. DOI: 10.3928/ 01913913-20130528-04.
23.	Lu J, Mai G, Luo Y, et al. Appearance of far peripheral retina in normal eyes by ultra-widefield fluorescein angiography[J]. Am J Ophthalmol, 2017, 173: 84-90. DOI: 10.1016/j.ajo.2016.09.024.

1. 周金琼, 魏文斌. Optos 200Tx广角眼底血管造影及其临床应用[J]. 国际眼科纵览, 2015, 39(2): 103-106. DOI: 10.3760/cma. j.issn.1673-5803.2015.02.007.Zhou JQ, Wei WB. Optos 200Tx scanning laser ophthalmoscope for wide-field fluorescein angiography and its clinicalapplication[J]. Int Rev Ophthalmol, 2015, 39(2): 103-106. DOI: 10.3760/cma. j.issn.1673-5803.2015.02.007.
2. Spaide RF. Peripheral areas of nonperfusion in treated central veinocclusion as imaged by wide-field fluoresceinangiography[J]. Retina, 2011, 31(5): 829-837. DOI: 10.1097/IAE.0b013e 31820c841e.
3. Singer M, Sagong M, vanHemert J, et al. Ultra-widefield imaging of the peripheral retinal vasculature in normal subjects[J]. Ophthalmology, 2016, 123(5): 1053-1059. DOI: 10.1016/j.Ophtha. 2016.01.022.
4. Sagong M, van Hemert J, Olmos de Koo LC, et al. Assessment of accuracy and precision of quantification of ultra-widefield images[J]. Ophthalmology, 2015, 122(4): 864-866. DOI: 10.1016/j.ophtha.2014.11.016.
5. Shah AR, Abbey AM, Yonekawa Y, et al. Widefield fluorescein angiography in patients without peripheral disease: astudy ofnormal peripheralfindings[J]. Retina, 2016, 36(6): 1087-1092. DOI: 10.1097/IAE.0000000000000878.
6. Wessel MM, Aaker GD, Parlitsis G, et al. Ultra-widefield fluorescein angiography improves the detection and classification of diabeticretinopathy[J]. Retina, 2012, 32(4): 785-791. DOI: 10.1097/IAE.0b013e3182278b64.
7. Wessel MM, Nair N, Aaker GD, et al. Peripheral retinal ischaemia, as evaluated byultra-widefield fluorescein angiography, is associatedwith diabetic macular oedema[J]. Br J Ophthalmol, 2012, 96(5): 694-698. DOI: 10.1136/bjophthalmol-2011-300774.
8. Karampelas M, Sim DA, Chu C, et al. Quantitative analysis of peripheral vasculitis, ischemia and vascular leakage in uveitisusing ultra widefield fluorescein angiography[J]. Am J Ophthalmol, 2015, 159(6): 1161-1168. DOI: 10.1016/j.ajo.2015.02.009.
9. Silva PS, Cavallerano JD, Sun JK, et al. Peripheral lesions identified by mydriaticultrawide field imaging: distribution and potential impact ondiabetic retinopathyseverity[J]. Ophthalmology, 2013, 120(12): 2587-2595. DOI: 10.1016/j.ophtha.2013.05.004.
10. Silva PS, Cavallerano JD, Haddad NM, et al. Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years[J]. Ophthalmology, 2015, 122(5): 949-956. DOI: 10.1016/j.ophtha.2015.01.008.
11. Oliver SC, Schwartz SD.Peripheralvesselleakage(PVL): a new angiographic finding in diabetic retinopathy identified with ultrawide-field fluorescein angiography[J]. Semin Ophthalmol, 2010, 25(1-2): 27-33. DOI: 10.3109/08820538.2010.481239.
12. Kook D, Wolf A, Kreutzer T, et al. Long-term effect of intravitreal bevacizumab (avastin) in patients with chronic diffuse diabetic macular edema[J]. Retina, 2008, 28(8): 1053-1060. DOI: 10.1097/IAE.0b013e318176de48.
13. Arevalo JF, Sanchez JG, Fromow-Guerra J, et al. Comparison of two doses of primary intravitreal bevacizumab (Avastin) for diffuse diabetic macular edema: results from the Pan-American Collaborative Retina Study Group (PACORES) at 12-month follow-up[J]. Graefe′s Arch Clin Exp Ophthalmol, 2009, 247(6): 735-743. DOI: 10.1007/s00417-008-1034-x.
14. Michaelides M, Kaines A, Hamilton RD, et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2[J]. Ophthalmology, 2010, 117(6): 1078-1086. DOI: 10.1016/j.ophtha.2010.03.045.
15. Muqit MM, Marcellino GR, Henson DB, et al. Optos-guided pattern scan laser (Pascal)-targeted retinal photocoagulation in proliferative diabetic retinopathy[J]. Acta Ophthalmol, 2013, 91(3): 251-258. DOI: 10.1111/j.1755-3768.2011.02307.x.
16. Prasad PS, Oliver SC, Coffee RE, et al. Ultrawide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion[J]. Ophthalmology, 2010, 117(4): 780-784. DOI: 10.1016/ j.ophtha.2009.09.019.
17. Tsui I, Kaines A, Havunjian MA, et al. Ischemic index and neovascularization in central retinal vein occlusion[J]. Retina, 2011, 31(1): 105-110. DOI: 10.1097/IAE.0b013e3181e36c6d.
18. 马景学, 安建斌. 充分发挥广角眼底影像检查诊断新技术的临床应用价值, 不断提升眼底病诊断治疗水平[J]. 中华眼底病杂志, 2016, 32(3): 232-236. DOI: 10.3760/cma.j.issn.1005-1015. 2016.03.002.Ma JX, An JB.Applying wide-angle fundus imaging modalities to improve the diagnosis and treatment of ocular fundus diseases[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 232-236. DOI: 10.3760/ cma.J.issn.1005-1015.2016. 03.002.
19. Kaines A, Tsui I, Sarraf D, et al. The use of ultra wide field fluoreseein angiography in evaluation and management of uveitis[J]. Semin Ophthalmol, 2009, 24(1): 19-24. DOI: 10.1080/08820 530802520095.
20. Aggarwal K, Mulkutkar S, Mahajan S, et al. Role ofultra-widefield imaging in the management of tubercular posterior uveitis[J]. Ocul Immunol Inflamm, 2016, 24(6): 631-636. DOI: 10.3109/0927 3948.2015.1099681.
21. Canny CL, Oliver GL. Fluorescein angiographic findings in familial exudative vitreo retinopathy[J]. Arch Ophthalmol, 1976, 94(7): 1114-1120.
22. Kang KB, Wessel MM, Tong J, et al. Ultra-widefield imaging for the management of pediatric retinal diseases[J]. J Pediatr Ophthalmol Strabismus, 2013, 50(5): 282-288. DOI: 10.3928/ 01913913-20130528-04.
23. Lu J, Mai G, Luo Y, et al. Appearance of far peripheral retina in normal eyes by ultra-widefield fluorescein angiography[J]. Am J Ophthalmol, 2017, 173: 84-90. DOI: 10.1016/j.ajo.2016.09.024.

Chinese Journal of Ocular Fundus Diseases

Improve our understanding of ocular fundus diseases with ultra-wide-field fluorescein angiography

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