Macular morphology and circumpapillary retinal nerve fiber layer thickness in Parkinson's disease evaluated by spectral-domain optical coherence tomography_Chinese Journal of Ocular Fundus Diseases

Authors：

HuangJiang , ZhangQin , XuGuoxu , MaoChengjie , LiuJing , ZhangYanlin , LiuChunfeng ,  LuoWeifeng

Department of Ophthalmology (Huang Jiang , Xu Guoxu), Department of Neurology (Zhang Qin, Mao Chengjie, Liu Jing, Zhang Yanlin, Liu Chunfeng, Luo Weifeng), The Second Affiliated Hospital of Soochow University, Suzhou 215004, China;

Corresponding author：

LuoWeifeng, Email: lwfwxx@126.com

Keywords：

Parkinson disease/diagnosis; Macula lutea/pathology; Nerve fibers/pathology; Retina/physiopathology; Tomography, optical coherence/utilization

DOI：

10.3760/cma.j.issn.1005-1015.2017.01.008

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the macular morphology and circumpapillary retinal nerve fiber layer thickness (RNFL) in Parkinson's disease (PD) evaluated by spectral-domain optical coherence tomography (SD-OCT). Methods A total of 37 patients (74 eyes) with PD were in the PD group, 32 age- and sex-matched healthy subjects (64 eyes) in the control group. All subjects underwent SD-OCT examination with 5 line scanning, macular cube 512×128 scanning and optic disc volume 200×200 scanning. The retinal thickness, central foveal thickness (CFT), macular volume and thickness of circumpapillary, superior, inferior, nasal, and temporal of RNFL between two groups were comparatively analyzed. The relationship between SD-OCT parameters and age, disease duration, scores of Hoehn-Yahr and unified PD rating scale (UPDRS) Ⅲ in PD patients was analyzed by Pearson correlation analysis. Results Both of the retinal thickness and macular volume in PD group were significantly reduced than those in control group (t= −2.546, −3.410;P=0.012, 0.001). There was no difference of CFT (t= −0.463,P=0.644) and the thickness of circumpapillary (t= −1.645,P=0.102), superior (t= −0.775,P=0.439), inferior (t=−1.844,P=0.067), nasal (t= −0.344,P=0.732) and temporal (t= −0.541,P=0.590) of RNFL between two groups. The retinal thickness, macular volume, CFT and the thickness of circumpapillary, superior, inferior, nasal, temporal of RNFL had no relationship with age, disease duration and scores of Hoehn-Yahr and UPDRS Ⅲ in PD patients (P＞0.05). Conclusions In PD patients, the retinal thickness and macular volume are decreased, however, the circumpapillary RNFL have no obvious alterations.

Citation： HuangJiang, ZhangQin, XuGuoxu, MaoChengjie, LiuJing, ZhangYanlin, LiuChunfeng, LuoWeifeng. Macular morphology and circumpapillary retinal nerve fiber layer thickness in Parkinson's disease evaluated by spectral-domain optical coherence tomography. Chinese Journal of Ocular Fundus Diseases, 2017, 33(1): 27-30. doi: 10.3760/cma.j.issn.1005-1015.2017.01.008 Copy

1.	Cordeiro MF, Guo L, Luong V, et al. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration[J]. Proc Natl Acad Sci USA, 2004, 101(36): 13352-13356. DOI: 10.1073/pnas. 0405479101.
2.	Tatton WG, Chalmers-Redman R, Brown D, et al. Apoptosis in Parkinson's disease: signals for neuronal degradation[J]. Ann Neurol, 2003, 53 Suppl 3:S61-72. DOI: 10.1002/ana.10489.
3.	Lee HJ, Kim MS, Jo YJ, et al. Ganglion cell-inner plexiform layer thickness in retinal diseases: repeatability study of spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2015, 160(2): 283-289. DOI: 10.1016/j.ajo.2015.05.015.
4.	魏文斌. 重视眼底相干光断层成像技术的临床应用与图像解读[J]. 中华眼科杂志, 2012, 48(2): 97-99. DOI:10.3760/cma. j.issn.0412-4081.2012.02.001.Wei WB. Focus on clinical application of optical coherence tomography and image analysis[J]. Chin J Ophthalmol, 2012,48(2):97-99. DOI:10.3760/cma.j.issn.0412-4081.2012.02.001.
5.	Maldonado RS, Mettu P, El-Dairi M, et al. The application of optical coherence tomography in neurologic diseases[J]. Neurol (Clin Pract), 2015, 5(5): 460-469. DOI: 10.1212/CPJ.0000000000000187.
6.	黄江, 易全勇, 季晓燕, 等. 急性中心性浆液性脉络膜视网膜病变激光治疗前后渗漏灶视网膜色素上皮形态变化观察[J]. 中华眼底病杂志, 2016, 32(3): 266-269. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.009.Huang J, Yi QY, Ji XY, et al. Morphologic features of retina pigment epithelial around fluorescein leakage sites in acute central serous chorioretinopathy before and after laser coagulation[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 266-269. DOI:10.3760/ cma.j.issn.1005-1015.2016.03.009.
7.	庞燕华, 谭志, 周舟, 等. 视网膜色素变性患眼环视盘神经纤维层厚度及视盘参数改变观察[J]. 中华眼底病杂志, 2016, 32(1): 44-46. DOI: 10.3760/cma.j.issn.1005-1015.2016.01.011.Pang YH, Tan Z, Zhou Z, et al. The circumpapillary retinal nerve fiber layer thickness and optic disc parameters in retinitis pigmentosa eyes[J]. Chin J Ocul Fundus Dis, 2016, 32(1): 44-46. DOI: 10.3760/cma.j.issn.1005-1015.2016.01.011.
8.	Sari ES, Koc R, Yazici A, et al. Ganglion cell–inner plexiform layer thickness in patients with Parkinson disease and association with disease severity and duration[J]. J Neuro-Ophthalmol, 2015, 35(2): 117-121. DOI: 10.1097/WNO.0000000000000203.
9.	Schneider M, Müller HP, Lauda F, et al. Retinal single-layer analysis in Parkinsonian syndromes: an optical coherence tomography study[J]. J Neural Transm (Vienna), 2014, 121(1): 41-47. DOI: 10.1007/s00702-013-1072-3.
10.	Lee JY, Kim JM, Ahn J, et al. Retinal nerve fiber layer thickness and visual hallucinations in Parkinson's disease[J]. Mov Disord, 2014, 29(1): 61-67. DOI: 10.1002/mds.25543.
11.	Aaker GD, Myung JS, Ehrlich JR, et al. Detection of retinal changes in Parkinson’s disease with spectral-domain optical coherence tomography[J]. Clin Ophthalmol, 2010, 4: 1427-1432. DOI: 10.2147/OPTH.S15136.
12.	赵颖, 戴惟葭. 早期帕金森病患者视网膜神经纤维层厚度变化与视野平均缺损的关系[J]. 中华眼底病杂志, 2010, 26(4): 339-342. DOI:10.3760/cma.j.issn.1005-1015.2010.04.10.Zhao Y, Dai WJ. Changes of retinal nerve fiber layer thickness and its correlation with visual field mean defects in early Parkinson's disease[J].Chin J Ocul Fundus Dis, 2010, 26(4): 339-342. DOI:10.3760/cma.j.issn.1005-1015.2010.04.10.
13.	李玲, 季晓燕, 毛成洁, 等. 早期帕金森病患者视网膜及视野改变的临床研究[J]. 中华内科杂志, 2015, 54(6): 521-524. DOI: 10.3760/cma.j.issn.0578-1426.2015.06.010.Li L, Ji XY, Mao CJ, et al. A clinical study of changes in retina and visual field in patients with early Parkinson's disease[J]. Chin J Intern Med, 2015, 54(6): 521-524. DOI: 10.3760/cma.j.issn.0578-1426.2015.06.010.
14.	中华医学会神经病学分会运动障碍及帕金森病学组. 帕金森病的诊断[J]. 中华神经科杂志, 2006, 39(6): 408-409. DOI: 10.3760/j.issn:1006-7876.2006.06.024.Movement Disorder and Parkinson's Disease Group, Neurology Association, Chinese Medical Association. The diagnosis of Parkinson's disease[J]. Chin J Neurol, 2006, 39(6): 408-409. DOI: 10.3760/j.issn:1006-7876.2006.06.024.
15.	Tsironi EE, Dastiridou A, Katsanos A, et al. Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease[J]. BMC Ophthalmol, 2012, 12: 54. DOI: 10.1186/1471-2415-12-54.
16.	Thenganatt MA, Louis ED. Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations[J]. Expert Rev Neurother, 2012, 12(6): 687-696. DOI: 10.1586/ern.12.49.
17.	Braak H, Ghebremedhin E, Rüb U, et al. Stages in the development of Parkinson’s disease-related pathology[J]. Cell Tissue Res, 2004, 318(1): 121-134. DOI: 10.1007/s00441-004-0956-9.
18.	Bayer AU, Keller ON, Ferrari F, et al. Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer’s disease and Parkinson’s disease[J]. Am J Ophthalmol, 2002, 133(1): 135-137. DOI: 10.1016/S0002-9394(01)01196-5.
19.	Forno LS. Neuropathology of Parkinson's disease[J]. J Neuropathol Exp Neurol, 1996, 55(3): 259-272.

1. Cordeiro MF, Guo L, Luong V, et al. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration[J]. Proc Natl Acad Sci USA, 2004, 101(36): 13352-13356. DOI: 10.1073/pnas. 0405479101.
2. Tatton WG, Chalmers-Redman R, Brown D, et al. Apoptosis in Parkinson's disease: signals for neuronal degradation[J]. Ann Neurol, 2003, 53 Suppl 3:S61-72. DOI: 10.1002/ana.10489.
3. Lee HJ, Kim MS, Jo YJ, et al. Ganglion cell-inner plexiform layer thickness in retinal diseases: repeatability study of spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2015, 160(2): 283-289. DOI: 10.1016/j.ajo.2015.05.015.
4. 魏文斌. 重视眼底相干光断层成像技术的临床应用与图像解读[J]. 中华眼科杂志, 2012, 48(2): 97-99. DOI:10.3760/cma. j.issn.0412-4081.2012.02.001.Wei WB. Focus on clinical application of optical coherence tomography and image analysis[J]. Chin J Ophthalmol, 2012,48(2):97-99. DOI:10.3760/cma.j.issn.0412-4081.2012.02.001.
5. Maldonado RS, Mettu P, El-Dairi M, et al. The application of optical coherence tomography in neurologic diseases[J]. Neurol (Clin Pract), 2015, 5(5): 460-469. DOI: 10.1212/CPJ.0000000000000187.
6. 黄江, 易全勇, 季晓燕, 等. 急性中心性浆液性脉络膜视网膜病变激光治疗前后渗漏灶视网膜色素上皮形态变化观察[J]. 中华眼底病杂志, 2016, 32(3): 266-269. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.009.Huang J, Yi QY, Ji XY, et al. Morphologic features of retina pigment epithelial around fluorescein leakage sites in acute central serous chorioretinopathy before and after laser coagulation[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 266-269. DOI:10.3760/ cma.j.issn.1005-1015.2016.03.009.
7. 庞燕华, 谭志, 周舟, 等. 视网膜色素变性患眼环视盘神经纤维层厚度及视盘参数改变观察[J]. 中华眼底病杂志, 2016, 32(1): 44-46. DOI: 10.3760/cma.j.issn.1005-1015.2016.01.011.Pang YH, Tan Z, Zhou Z, et al. The circumpapillary retinal nerve fiber layer thickness and optic disc parameters in retinitis pigmentosa eyes[J]. Chin J Ocul Fundus Dis, 2016, 32(1): 44-46. DOI: 10.3760/cma.j.issn.1005-1015.2016.01.011.
8. Sari ES, Koc R, Yazici A, et al. Ganglion cell–inner plexiform layer thickness in patients with Parkinson disease and association with disease severity and duration[J]. J Neuro-Ophthalmol, 2015, 35(2): 117-121. DOI: 10.1097/WNO.0000000000000203.
9. Schneider M, Müller HP, Lauda F, et al. Retinal single-layer analysis in Parkinsonian syndromes: an optical coherence tomography study[J]. J Neural Transm (Vienna), 2014, 121(1): 41-47. DOI: 10.1007/s00702-013-1072-3.
10. Lee JY, Kim JM, Ahn J, et al. Retinal nerve fiber layer thickness and visual hallucinations in Parkinson's disease[J]. Mov Disord, 2014, 29(1): 61-67. DOI: 10.1002/mds.25543.
11. Aaker GD, Myung JS, Ehrlich JR, et al. Detection of retinal changes in Parkinson’s disease with spectral-domain optical coherence tomography[J]. Clin Ophthalmol, 2010, 4: 1427-1432. DOI: 10.2147/OPTH.S15136.
12. 赵颖, 戴惟葭. 早期帕金森病患者视网膜神经纤维层厚度变化与视野平均缺损的关系[J]. 中华眼底病杂志, 2010, 26(4): 339-342. DOI:10.3760/cma.j.issn.1005-1015.2010.04.10.Zhao Y, Dai WJ. Changes of retinal nerve fiber layer thickness and its correlation with visual field mean defects in early Parkinson's disease[J].Chin J Ocul Fundus Dis, 2010, 26(4): 339-342. DOI:10.3760/cma.j.issn.1005-1015.2010.04.10.
13. 李玲, 季晓燕, 毛成洁, 等. 早期帕金森病患者视网膜及视野改变的临床研究[J]. 中华内科杂志, 2015, 54(6): 521-524. DOI: 10.3760/cma.j.issn.0578-1426.2015.06.010.Li L, Ji XY, Mao CJ, et al. A clinical study of changes in retina and visual field in patients with early Parkinson's disease[J]. Chin J Intern Med, 2015, 54(6): 521-524. DOI: 10.3760/cma.j.issn.0578-1426.2015.06.010.
14. 中华医学会神经病学分会运动障碍及帕金森病学组. 帕金森病的诊断[J]. 中华神经科杂志, 2006, 39(6): 408-409. DOI: 10.3760/j.issn:1006-7876.2006.06.024.Movement Disorder and Parkinson's Disease Group, Neurology Association, Chinese Medical Association. The diagnosis of Parkinson's disease[J]. Chin J Neurol, 2006, 39(6): 408-409. DOI: 10.3760/j.issn:1006-7876.2006.06.024.
15. Tsironi EE, Dastiridou A, Katsanos A, et al. Perimetric and retinal nerve fiber layer findings in patients with Parkinson’s disease[J]. BMC Ophthalmol, 2012, 12: 54. DOI: 10.1186/1471-2415-12-54.
16. Thenganatt MA, Louis ED. Distinguishing essential tremor from Parkinson's disease: bedside tests and laboratory evaluations[J]. Expert Rev Neurother, 2012, 12(6): 687-696. DOI: 10.1586/ern.12.49.
17. Braak H, Ghebremedhin E, Rüb U, et al. Stages in the development of Parkinson’s disease-related pathology[J]. Cell Tissue Res, 2004, 318(1): 121-134. DOI: 10.1007/s00441-004-0956-9.
18. Bayer AU, Keller ON, Ferrari F, et al. Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer’s disease and Parkinson’s disease[J]. Am J Ophthalmol, 2002, 133(1): 135-137. DOI: 10.1016/S0002-9394(01)01196-5.
19. Forno LS. Neuropathology of Parkinson's disease[J]. J Neuropathol Exp Neurol, 1996, 55(3): 259-272.

Chinese Journal of Ocular Fundus Diseases

Macular morphology and circumpapillary retinal nerve fiber layer thickness in Parkinson's disease evaluated by spectral-domain optical coherence tomography

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content