Applications of ultra-wide-field fluorescein angiography in the diagnosis and treatment of retinal diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

TianMeng ,  WangKang

Beijing Friendship Hospital Affiliated to the Capital Medical University, Beijing 100050, China;

Corresponding author：

WangKang, Email: bnbn2000@163.com

Keywords：

Retinal diseases/diagnosis; Fluorescein angiography; Diagnostic techniques, ophthalmological; Review

DOI：

10.3760/cma.j.issn.1005-1015.2017.01.029

Video：

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Ultra-wide-field fluorescein angiography (UWFA) is a novel breakthrough in ocular fundus imaging technology, which can capture a single, high-resolution, 200° wide image of the ocular fundus that traditional fluorescein angiography cannot reach. This technology has important impacts on the screening, diagnosis, staging, treatment and follow-up of vascular diseases involving peripheral retina (such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, uveitis and so on).

Citation： TianMeng, WangKang. Applications of ultra-wide-field fluorescein angiography in the diagnosis and treatment of retinal diseases. Chinese Journal of Ocular Fundus Diseases, 2017, 33(1): 90-92. doi: 10.3760/cma.j.issn.1005-1015.2017.01.029 Copy

1.	Aplskova M. Ultra-wide-field fluorescein angiography of the ocular fundus[J]. Am J Ophthalmol, 2005, 140(3): 525-527. DOI: 10.1016/j.ajo.2005.02.055.
2.	Friberg TR, Forrester JV. Ultra-wide angle (200°+) fluorescein angiography using a modified Optos Panoramic200TM imaging system[J/OL]. Invest Ophthalmol Vis Sci, 2004, 45(13): 3001 [2004-05-01]. http://iovs.arvojournals.org/article.aspx? articleid=2408542.
3.	Witmer MT, Parlitsis G, Patel S, et al. Comparison of ultra-widefield fluorescein angiography with the Heidelberg Spectralis^® noncontact ultra-widefield module versus the Optos^® Optomap^® [J]. Clin Ophthalmol, 2013, 7: 389-394. DOI: 10.2147/OPTH.S41731.
4.	Neubauer AS, Kernt M, Haritoglou C, et al. Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap)[J]. Graefe’s Arch Clin Exp Ophthalmol, 2008, 246(2): 229-235. DOI: 10.1007/s00417-007-0631-4.
5.	Prasad PS, Oliver SCN, Coffee RE, et al. Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion[J]. Ophthalmology, 2010, 117(4): 780-784. DOI: 10.1016/j.ophtha.2009.09.019.
6.	Spaide RF. Peripheral areas of nonperfusion in treated central retinal vein occlusion as imaged by wide-field fluorescein angiography[J]. Retina, 2011, 31(5): 829-837. DOI: 10.1097/IAE.0b013e 31820c841e.
7.	Patel RD, Messner LV, Teitelbaum B, et al. Characterization of ischemic index using ultra-widefield fluorescein angiography in patients with focal and diffuse recalcitrant diabetic macular edema[J]. Am J Ophthalmol, 2013, 155(6): 1038-1044. DOI: 10.1016/j.ajo.2013.01.007.
8.	Silva PS, Cavallerano JD, Haddad NM, et al. Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years[J]. Ophthalmology, 2015, 122(5): 949-956. DOI: 10.1016/j.ophtha.2015.01.008.
9.	Wessel MM, Aaker GD, Parlitsis G, et al. Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy[J]. Retina, 2012, 32(4): 785-791. DOI: 10.1097/IAE. 0b013e3182278b64.
10.	Oliver SC, Schwartz SD.Peripheral vessel leakage (PVL): a new angiographic finding in diabetic retinopathy identified with ultra wide-field fluorescein angiography[J]. Semin Ophthalmol, 2010, 25(1-2): 27-33. DOI: 10.3109/08820538.2010.481239.
11.	The Diabetic Retinopathy Study Research Group.Photocoagulation treatment of proliferative diabetic retinopathy.Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS report number 8[J]. Ophthalmology, 1981, 88(7): 583-600.
12.	Reddy S, Hu A, Schwartz SD. Ultra wide field fluorescein angiography guided targeted retinal photocoagulation (TRP)[J]. Semin Ophthalmol, 2009, 24(1): 9-14. DOI: 10.1080/08820 530802519899.
13.	Silva PS, Cavallerano JD, Sun JK, et al. Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy[J]. Am J Ophthalmol, 2012, 154(3): 549-559. DOI: 10.1016/j.ajo.2012.03.019.
14.	Nomura Y, Takahashi H, Tan X, et al. Widespread choroidal thickening and abnormal midperipheral fundus autofluorescence characterize exudative age-related macular degeneration with choroidal vascular hyperpermeability[J]. Clin Ophthalmol, 2015, 9: 297-304. DOI: 10.2147/OPTH.S78210.
15.	Klufas MA, Yannuzzi NA, Pang CE, et al. Feasibility and clinical utility of ultra-widefield indocyanine green angiography[J]. Retina, 2015, 35(3): 508-520. DOI: 10.1097/IAE.0000000000000318.
16.	Tsui I, Kaines A, Havunjian MA, et al. Ischemic index and neovascularization in central retinal vein occlusion[J]. Retina, 2011, 31(1): 105-110. DOI: 10.1097/IAE.0b013e3181e36c6d.
17.	Singer M, Tan CS, Bell D, et al. Area of peripheral retinal nonperfusion and treatment response in branch and central retinal vein occlusion[J]. Retina, 2014, 34(9): 1736-1742. DOI: 10.1097/ IAE.0000000000000148.
18.	Tsui I, Francocardenas V, Hubschman JP, et al. Ultra wide field fluorescein angiography can detect macular pathology in central retinal vein occlusion[J]. Ophthalmic Surg Lasers Imaging, 2012, 43(3): 257-262. DOI: 10.3928/15428877-20120424-01.
19.	Tsui I, Kaines A, Schwartz S. Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography[J]. Semin Ophthalmol, 2009, 24(1): 29-33. DOI: 10.1080/08820530802520186.
20.	Kaines A, Tsui I, Sarraf D, et al. The use of ultra wide field fluorescein angiography in evaluation and management of uveitis[J]. Semin Ophthalmol, 2009, 24(1): 19-24. DOI: 10.1080/08820 530802520095.
21.	Campbell JP, Leder HA, Sepah YJ, et al. Wide-field retinal imaging in the management of noninfectious posterior uveitis[J]. Am J Ophthalmol, 2012, 154(5): 908-911. DOI: 10.1016/j.ajo.2012. 05.019.
22.	Leder HA, Campbell JP, Sepah YJ, et al. Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis[J]. Optom Vis Sci, 2013, 90(5): 430-438. DOI: 10.1097/OPX. 0b013e31828f4dfe.
23.	Heussen FM, Vasconcelossantos DV, Pappuru RR, et al. Ultra-wide-field green-light (532-nm) autofluorescence imaging in chronic Vogt-Koyanagi-Harada disease[J]. Ophthalmic Surg Lasers Imaging, 2011, 42(4): 272-277. DOI: 10.3928/15428877-20110505-01.
24.	Patel M, Kiss S. Ultra-wide-field fluorescein angiography in retinal disease[J]. Curr Opin Ophthalmol, 2014, 25(3): 213-220. DOI: 10.1097/ICU.0000000000000042.

1. Aplskova M. Ultra-wide-field fluorescein angiography of the ocular fundus[J]. Am J Ophthalmol, 2005, 140(3): 525-527. DOI: 10.1016/j.ajo.2005.02.055.
2. Friberg TR, Forrester JV. Ultra-wide angle (200°+) fluorescein angiography using a modified Optos Panoramic200TM imaging system[J/OL]. Invest Ophthalmol Vis Sci, 2004, 45(13): 3001 [2004-05-01]. http://iovs.arvojournals.org/article.aspx? articleid=2408542.
3. Witmer MT, Parlitsis G, Patel S, et al. Comparison of ultra-widefield fluorescein angiography with the Heidelberg Spectralis^® noncontact ultra-widefield module versus the Optos^® Optomap^® [J]. Clin Ophthalmol, 2013, 7: 389-394. DOI: 10.2147/OPTH.S41731.
4. Neubauer AS, Kernt M, Haritoglou C, et al. Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap)[J]. Graefe’s Arch Clin Exp Ophthalmol, 2008, 246(2): 229-235. DOI: 10.1007/s00417-007-0631-4.
5. Prasad PS, Oliver SCN, Coffee RE, et al. Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion[J]. Ophthalmology, 2010, 117(4): 780-784. DOI: 10.1016/j.ophtha.2009.09.019.
6. Spaide RF. Peripheral areas of nonperfusion in treated central retinal vein occlusion as imaged by wide-field fluorescein angiography[J]. Retina, 2011, 31(5): 829-837. DOI: 10.1097/IAE.0b013e 31820c841e.
7. Patel RD, Messner LV, Teitelbaum B, et al. Characterization of ischemic index using ultra-widefield fluorescein angiography in patients with focal and diffuse recalcitrant diabetic macular edema[J]. Am J Ophthalmol, 2013, 155(6): 1038-1044. DOI: 10.1016/j.ajo.2013.01.007.
8. Silva PS, Cavallerano JD, Haddad NM, et al. Peripheral lesions identified on ultrawide field imaging predict increased risk of diabetic retinopathy progression over 4 years[J]. Ophthalmology, 2015, 122(5): 949-956. DOI: 10.1016/j.ophtha.2015.01.008.
9. Wessel MM, Aaker GD, Parlitsis G, et al. Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy[J]. Retina, 2012, 32(4): 785-791. DOI: 10.1097/IAE. 0b013e3182278b64.
10. Oliver SC, Schwartz SD.Peripheral vessel leakage (PVL): a new angiographic finding in diabetic retinopathy identified with ultra wide-field fluorescein angiography[J]. Semin Ophthalmol, 2010, 25(1-2): 27-33. DOI: 10.3109/08820538.2010.481239.
11. The Diabetic Retinopathy Study Research Group.Photocoagulation treatment of proliferative diabetic retinopathy.Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS report number 8[J]. Ophthalmology, 1981, 88(7): 583-600.
12. Reddy S, Hu A, Schwartz SD. Ultra wide field fluorescein angiography guided targeted retinal photocoagulation (TRP)[J]. Semin Ophthalmol, 2009, 24(1): 9-14. DOI: 10.1080/08820 530802519899.
13. Silva PS, Cavallerano JD, Sun JK, et al. Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy[J]. Am J Ophthalmol, 2012, 154(3): 549-559. DOI: 10.1016/j.ajo.2012.03.019.
14. Nomura Y, Takahashi H, Tan X, et al. Widespread choroidal thickening and abnormal midperipheral fundus autofluorescence characterize exudative age-related macular degeneration with choroidal vascular hyperpermeability[J]. Clin Ophthalmol, 2015, 9: 297-304. DOI: 10.2147/OPTH.S78210.
15. Klufas MA, Yannuzzi NA, Pang CE, et al. Feasibility and clinical utility of ultra-widefield indocyanine green angiography[J]. Retina, 2015, 35(3): 508-520. DOI: 10.1097/IAE.0000000000000318.
16. Tsui I, Kaines A, Havunjian MA, et al. Ischemic index and neovascularization in central retinal vein occlusion[J]. Retina, 2011, 31(1): 105-110. DOI: 10.1097/IAE.0b013e3181e36c6d.
17. Singer M, Tan CS, Bell D, et al. Area of peripheral retinal nonperfusion and treatment response in branch and central retinal vein occlusion[J]. Retina, 2014, 34(9): 1736-1742. DOI: 10.1097/ IAE.0000000000000148.
18. Tsui I, Francocardenas V, Hubschman JP, et al. Ultra wide field fluorescein angiography can detect macular pathology in central retinal vein occlusion[J]. Ophthalmic Surg Lasers Imaging, 2012, 43(3): 257-262. DOI: 10.3928/15428877-20120424-01.
19. Tsui I, Kaines A, Schwartz S. Patterns of periphlebitis in intermediate uveitis using ultra wide field fluorescein angiography[J]. Semin Ophthalmol, 2009, 24(1): 29-33. DOI: 10.1080/08820530802520186.
20. Kaines A, Tsui I, Sarraf D, et al. The use of ultra wide field fluorescein angiography in evaluation and management of uveitis[J]. Semin Ophthalmol, 2009, 24(1): 19-24. DOI: 10.1080/08820 530802520095.
21. Campbell JP, Leder HA, Sepah YJ, et al. Wide-field retinal imaging in the management of noninfectious posterior uveitis[J]. Am J Ophthalmol, 2012, 154(5): 908-911. DOI: 10.1016/j.ajo.2012. 05.019.
22. Leder HA, Campbell JP, Sepah YJ, et al. Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis[J]. Optom Vis Sci, 2013, 90(5): 430-438. DOI: 10.1097/OPX. 0b013e31828f4dfe.
23. Heussen FM, Vasconcelossantos DV, Pappuru RR, et al. Ultra-wide-field green-light (532-nm) autofluorescence imaging in chronic Vogt-Koyanagi-Harada disease[J]. Ophthalmic Surg Lasers Imaging, 2011, 42(4): 272-277. DOI: 10.3928/15428877-20110505-01.
24. Patel M, Kiss S. Ultra-wide-field fluorescein angiography in retinal disease[J]. Curr Opin Ophthalmol, 2014, 25(3): 213-220. DOI: 10.1097/ICU.0000000000000042.

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