• Henan Eye Institute&Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou 450003, China;
Zhao Zhaoxia, Email: zhaozhaoxia61@126.com
Export PDF Favorites Scan Get Citation

Objective To evaluate ocular surface changes following minimal vitreoretinal surgery in postmenopausal women patients with proliferative diabetic retinopathy (PDR). Methods Sixty-one women PDR patients (61 eyes) underwent vitreous microsurgery were recruited in this prospective study, including 31 postmenopausal women (PMW group) and 30 non-postmenopausal women (non-PMW group). The contralateral eyes were considered as the control group. Corneal fluorescein (FL) staining, tear break-up time (TBUT), Schirmer I test (SIT), central corneal sensitivity and ocular surface disease index (OSDI) were estimated. All tests were carried out 1 day preoperatively and 1 day, 10 days, 1 month and 3 months postoperatively. The student’st test or Mann-WhitneyU and ANOVA for repeat measurements test were used. Results Preoperatively, TBUT of surgery and non-surgery eyes in PMW were shorter than non-PMW (t=−2.115, −2.035;P<0.05), but higher OSDI scores were found in PMW (t=2.482, 2.208;P<0.05). TBUT reduction rate (Z=−2.771, −1.993;P<0.05) and OSDI rising rate (Z=2.539, 2.157;P<0.05) of surgery eyes in PMW were higher than non-PMW 1 day and 10 days postoperatively. The lower SIT of surgery eyes in PMW were observed at 1 day and 10 days (t=−2.403, −2.029;P<0.05) after surgery. At 10 days after surgery, FL and OSDI scores of surgery eyes in non-PMW returned to preoperative level (Z=−0.447, −0.513;P>0.05), but in PMW, the recovery process experienced 1 month (Z=−1.500, −0.853;P>0.05). TBUT and SIT of surgery eyes in two groups both reached preoperative level at 1 month following surgery (Z=−0.715, −1.266, −1.531, −0.522;P>0.05). Conclusions PMW with PDR had ocular surface dysfunction, which resulted in aggravated dry eye after minimal vitreoretinal surgery.

Citation: Gao Shaohui, Li Zhanrong, Pei Han, Li Shiqing, Zhao Zhaoxia. Changes in ocular surface following minimal vitreoretinal surgery in postmenopausal women patients with proliferative diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2017, 33(3): 252-256. doi: 10.3760/cma.j.issn.1005-1015.2017.03.008 Copy

  • Previous Article

    The correlation between estrogen and diabetic retinopathy of the postmenopasual patients
  • Next Article

    The establishment and preliminary verification of a risk model for the prediction of diabetic retinopathy in patients with type 2 diabetes