The fast blood flow density of intermediate choroid in endogenous Cushing syndrome: analysis of optical coherence tomography angiography_Chinese Journal of Ocular Fundus Diseases

Authors：

Wang Erqian , Xia Song , Yang Jingyuan , Du Hong , Li Donghui ,  Chen Youxin

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China;

Corresponding author：

Chen Youxin, Email: chenyouxinpumch@163.com

Keywords：

Cushing syndrome; Choroid; Regional blood flow; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2017.04.017

Video：

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ObjectiveTo compare the fast blood flow density (FBFD) of intermediate choroid between endogenous Cushing syndrome (ECS) patients and healthy control subjects.MethodsThirteen eyes of 7 eligible ECS patients (ECS group) and 13 eyes of 7 gender, age, axial length matched healthy volunteers (control group) were enrolled in this study. For each subject, macular radial scan with swept source optical coherence tomography (SS-OCT) was performed and subfoveal choroidal thickness (SCT) was measured. Then 3.0 mm×3.0 mm macular scan with SS-OCT angiography was performed, and selected blood flow image at intermediate choroid level or 1/2 SCT beneath Bruch membrane. The grayscale images were then binarized for the analysis of FBFD.ResultsThe SCT in ECS group was (394.7±77.7) μm, which was significantly thicker than (332.1±68.1) μm in control group (t=2.923, P=0.008). The FBFD of intermediate choroid in ECS group were (76.35±14.46)%, which were significantly greater than (63.57±13.42)% in control group (t=2.775, P=0.01).ConclusionECS patients had increased FBFD at intermediate choroid level compared with healthy controls.

Citation： Wang Erqian, Xia Song, Yang Jingyuan, Du Hong, Li Donghui, Chen Youxin. The fast blood flow density of intermediate choroid in endogenous Cushing syndrome: analysis of optical coherence tomography angiography. Chinese Journal of Ocular Fundus Diseases, 2017, 33(4): 400-403. doi: 10.3760/cma.j.issn.1005-1015.2017.04.017 Copy

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1. Raff H, Carroll T. Cushing’s syndrome: from physiological principles to diagnosis and clinical care[J]. J Physiol, 2015, 593(3): 493-506. DOI: 10.1113/jphysiol.2014.282871.
2. Karaca C, Karaca Z, Kahraman N, et al. Is there a role of acth in increased choroidal thickness in cushing syndrome?[J]. Retina, 2017, 37(3): 536-543. DOI: 10.1097/IAE.0000000000001198.
3. Carvalho-Recchia CA, Yannuzzi LA, Negrão S, et al. Corticosteroids and central serous chorioretinopathy[J]. Ophthalmology, 2002, 109(10): 1834-1837.
4. 李略, 李东辉, 杨治坤, 等, 中心性浆液性脉络膜视网膜病变眼底血管造影及脉络膜厚度分析[J].中华眼科杂志, 2012, 48 (10): 878-882. DOI: 10.3760/cma.j.issn.0412-4081.2012.10.005.Li L, Li DH, Yang ZK, et al. Analysis of fundus fluorescein angiography, indocyanine green angiography and choroidal thickness in central serous chorioretinopathy[J].Chin J Ophthalmol, 2012, 48(10): 878-882. DOI: 10.3760/cma.j.issn.0412-4081.2012.10.005.
5. Falavarjani KG, Sarraf D. Optical coherence tomography angiography of the retina and choroid; current applications and future directions[J]. J Curr Ophthalmol, 2017, 29(1): 1-4. DOI: 10.1016/j.joco.2017.02.005.
6. Chan SY, Wang Q, Wei WB, et al. Optical coherence tomographic angiography in central serous chorioretinopathy[J]. Retina, 2016, 36(11): 2051-2058. DOI: 10.1097/IAE.0000000000001064.
7. Shinojima A, Kawamura A, Mori R, et al. Findings of optical coherence tomographic angiography at the choriocapillaris level in central serous chorioretinopathy[J]. Ophthalmologica, 2016, 236(2): 108-113. DOI: 10.1159/000448436.
8. Costanzo E, Cohen SY, Miere A, et al. Optical coherence tomography angiography in central serous chorioretinopathy[J/OL].J Ophthalmol, 2015, 2015: 134783 [2015-11-08]. http://dx.doi.org/10.1155/2015/134783. DOI: 10.1155/2015/134783.
9. Nicolo M, Rosa R, Musetti D, et al. Choroidal vascular flow area in central serous chorioretinopathy using swept-source optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2017, 58(4): 2002-2010. DOI: 10.1167/iovs.17-21417.
10. Otsuka Y. Problems with spinal dysraphism as a disease related to spina bifida[J]. Jikken Dobutsu, 1979, 28(4): 601-603.
11. Lavinsky F, Lavinsky D. Novel perspectives on swept-source optical coherence tomography [J].Int J Retina Vitreous, 2016, 2: 25. DOI: 10.1186/s40942-016-0050-y.
12. Kuroda Y, Ooto S, Yamashiro K, et al. Increased choroidal vascularity in central serous chorioretinopathy quantified using swept-source optical coherence tomography[J]. Am J Ophthalmol, 2016, 169: 199-207. DOI: 10.1016/j.ajo.2016.06.043.
13. Chen FK, Viljoen RD, Bukowska DM. Classification of image artefacts in optical coherence tomography angiography of the choroid in macular diseases[J]. Clin Exp Ophthalmol, 2016, 44(5): 388-399. DOI: 10.1111/ceo.12683.
14. Abalem MF, Machado MC, Santos HN, et al. Choroidal and retinal abnormalities by optical coherence tomography in endogenous cushing’s syndrome[J]. Front Endocrinol (Lausanne), 2016, 7: 154. DOI: 10.3389/fendo.2016.00154.
15. Harb E, Hyman L, Gwiazda J, et al. Choroidal Thickness profiles in myopic eyes of young adults in the correction of myopia evaluation trial cohort[J]. Am J Ophthalmol, 2015, 160 (1): 62-71. DOI: 10.1016/j.ajo.2015.04.018.
16. Gupta P, Saw SM, Cheung CY, et al. Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore[J]. Acta Ophthalmol, 2015, 93(7): 585-592. DOI: 10.1111/aos.12631.

Chinese Journal of Ocular Fundus Diseases

The fast blood flow density of intermediate choroid in endogenous Cushing syndrome: analysis of optical coherence tomography angiography

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