Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy_Chinese Journal of Ocular Fundus Diseases

Authors：

 Jiang Libin , Chen Lanlan , Qiu Xiujuan , Jiang Ran , Wang Yaxing , Xu Liang , Timothy Y. Y. Lai

Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China (Chen Lanlan, Jiang Libin, Qiu Xiujuan, Jiang Ran, Wang Yaxing, Xu Liang); Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong; Retina & Macula Centre, Kowloon, Hong Kong (Timothy Y.Y. Lai);

Corresponding author：

Jiang Libin, Email: jlbjlb@sina.com

Keywords：

Non-arteritic anterior ischemic optic neuropathy; Choroidal thickness; Optical coherence tomography

DOI：

10.3760/cma.j.issn.1005-1015.2017.05.006

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To observe the peripapillary choroidal thicknesses (pCT) and subfoveal choroidal thicknesses (SFCT) of nonarteritic anterior ischemic optic neuropathy (NAION). Methods Forty-four Chinese patients with unilateral NAION were recruited and compared with 60 eyes of 60 normal age and refractive-error matched control subjects. pCT and SFCT were measured by enhanced depth imaging optical coherence tomography. Choroidal thicknesses of eyes with NAION and unaffected fellow eyes were compared with normal controls. Choroidal thicknesses of NAION eyes with or without optic disc edema were also compared. The correlation between choroidal thickness and retinal nerve fiber layer (RNFL) thickness, logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), and the mean deviation (MD) of Humphrey static perimetry in NAION eyes were analyzed. Results The pCT at the nasal, nasal inferior and temporal inferior quadrants in NAION eyes with optic disc edema were significantly thicker than that of normal subjects (t=3.152, 3.166, 2.808; P＜0.05). There was no significant difference in the choroidal thicknesses between the unaffected fellow eyes of NAION patients and normal eyes of healthy controls; or between the NAION eyes with resolved optic disc edema and normal eyes (P＞0.05). No significant correlation between choroidal thickness (r=－0.220, －0.140, 0.110), SFCT (r=0.096, －0.148, －0.131) and logMAR BCVA, perimetry MD and RNFL was found in eyes affected by NAION (P＞0.05). Conclusions The peripapillary choroidal thicknesses increase in some quadrants in NAION eyes with optic disc edema. However, the choroidal thickness of NAION eyes is the same in age and refractive error-matched normal subjects.

Citation： Jiang Libin, Chen Lanlan, Qiu Xiujuan, Jiang Ran, Wang Yaxing, Xu Liang, Timothy Y. Y. Lai. Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy. Chinese Journal of Ocular Fundus Diseases, 2017, 33(5): 462-466. doi: 10.3760/cma.j.issn.1005-1015.2017.05.006 Copy

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10.	Wang W, Zhou M, Huang W, et al. Does acute primary angle-closure cause an increased choroidal thickness[J]. Invest Ophthalmol Vis Sci, 2013, 54(5): 3538-3545. DOI: 10.1167/iovs.13-11728.
11.	Ehrlich JR, Peterson J, Parlitsis G, et al. Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography[J]. Exp Eye Res, 2011, 92(3): 189-194. DOI: 10.1016/j.exer.2011.01.002.
12.	Yang L, Jonas JB, Wei W. Choroidal vessel diameter in central serous chorioretinopathy[J]. Acta Ophthalmol, 2013, 91(5): 358-362. DOI: 10.1111/aos.12059.
13.	Hirooka K, Tenkumo K, Fujiwara A, et al. Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma[J]. BMC Ophthalmol, 2012, 12: 29. DOI: 10.1186/1471-2415-12-29.
14.	Katz B, Spencer WH. Hyperopia as a risk factor for nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 1993, 116(6): 754-758.
15.	Philips B, Dralands L, Missotten L. Non-arteritic anterior ischemic optic neuropathy and refraction[J]. Bull Soc Belge Ophtalmol, 1995, 259: 183-187.
16.	Zhao L, Wang Y, Chen CX, et al. Retinal nerve fibre layer thickness measured by spectralis spectral-domain optical coherence tomography: the Beijing eye study[J]. Acta Ophthalmol, 2014, 92(1): 35-41.
17.	Suh W, Cho HK, Kee C. Evaluation of peripapillary choroidal thickness in unilateral normal-tension glaucoma[J]. Jpn J Ophthalmol, 2014, 58(1): 62-67. DOI: 10.1007/s10384-013-0290-4.
18.	Shao L, Xu L, Wei WB, et al. Visual acuity and subfoveal choroidal thickness: the Beijing eye study[J]. Am J Ophthalmol, 2014, 158(4): 702-709. DOI: 10.1016/j.ajo.2014.05.023.
19.	Wei WB, Xu L, Jonas JB, et al. Subfoveal choriodal thickness: the Beijing eye study[J]. Ophthalmology, 2013, 120(1): 175-180. DOI: 10.1016/j.ophtha.2012.07.048.

1. Hayreh SS.Ischemic optic neuropathy[J]. Prog Retin Eye Res, 2009, 28(1): 34-62. DOI: 10.1016/j.preteyeres.2008.11.002.
2. Jirarattanasopa P, Ooto S, Nakata I, et al. Choroidal thickness, vascular hyperpermeability, and complement factor H in age-related macular degeneration and polypoidal choroidal vasculopathy[J]. Invest Ophthalmol Vis Sci, 2012, 53(7): 3663-3672. DOI: 10.1167/iovs.12-9619.
3. Roberts KF, Artes PH, O'Leary N, et al. Peripapillary choroidal thickness in healthy controls and patients with focal, diffuse, and sclerotic glaucomatous optic disc damage[J]. Arch Ophthalmol, 2012, 130(8): 980-986. DOI: 10.1001/archophthalmol.2012.371.
4. Yang L, Jonas JB, Wei W. Optical coherence tomography-assisted enhanced depth imaging of central serous chorioretinopathy[J]. Invest Ophthalmol Vis Sci, 2013, 54(7): 4659-4665. DOI: 10.1167/iovs.12-10991.
5. Fujiwara T, Imamura Y, Margolis R, et al. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes[J]. Am J Ophthalmol, 2009, 148(3): 445-450. DOI: 10.1016/j.ajo.2009.04.029.
6. Zhou M, Wang W, Ding X, et al. Choroidal thickness in fellow eyes of patients with acute primary angle-closure measured by enhanced depth imaging spectral-domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2013, 54(3): 1971-1978. DOI: 10.1167/iovs.12-11090.
7. Schuster AK, Steinmetz P, Forster TM, et al. Choroidal thickness in Non-arteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 2014, 158(6): 1342-1347. DOI: 10.1016/j.ajo.2014.09.008.
8. Fard MA, Abdi P, Kasaei A, et al. Peripapillary choroidal thickness in nonarteritic anterior ischemic optic neuropathy[J/OL]. Invest Ophthalmol Vis Sci, 2015, 2515: E1[2015-05-26]. http://iovs.arvojournals.org/article.aspx?articleid=2319138. DOI: 10.1167/iovs.14-15661.[published online ahead of print].
9. Hayreh SS, Zimmerman MB. Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome[J]. Ophthalmology, 2008, 115(2): 298-305. DOI: 10.1016/j.ophtha.2007.05.027.
10. Wang W, Zhou M, Huang W, et al. Does acute primary angle-closure cause an increased choroidal thickness[J]. Invest Ophthalmol Vis Sci, 2013, 54(5): 3538-3545. DOI: 10.1167/iovs.13-11728.
11. Ehrlich JR, Peterson J, Parlitsis G, et al. Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography[J]. Exp Eye Res, 2011, 92(3): 189-194. DOI: 10.1016/j.exer.2011.01.002.
12. Yang L, Jonas JB, Wei W. Choroidal vessel diameter in central serous chorioretinopathy[J]. Acta Ophthalmol, 2013, 91(5): 358-362. DOI: 10.1111/aos.12059.
13. Hirooka K, Tenkumo K, Fujiwara A, et al. Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma[J]. BMC Ophthalmol, 2012, 12: 29. DOI: 10.1186/1471-2415-12-29.
14. Katz B, Spencer WH. Hyperopia as a risk factor for nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 1993, 116(6): 754-758.
15. Philips B, Dralands L, Missotten L. Non-arteritic anterior ischemic optic neuropathy and refraction[J]. Bull Soc Belge Ophtalmol, 1995, 259: 183-187.
16. Zhao L, Wang Y, Chen CX, et al. Retinal nerve fibre layer thickness measured by spectralis spectral-domain optical coherence tomography: the Beijing eye study[J]. Acta Ophthalmol, 2014, 92(1): 35-41.
17. Suh W, Cho HK, Kee C. Evaluation of peripapillary choroidal thickness in unilateral normal-tension glaucoma[J]. Jpn J Ophthalmol, 2014, 58(1): 62-67. DOI: 10.1007/s10384-013-0290-4.
18. Shao L, Xu L, Wei WB, et al. Visual acuity and subfoveal choroidal thickness: the Beijing eye study[J]. Am J Ophthalmol, 2014, 158(4): 702-709. DOI: 10.1016/j.ajo.2014.05.023.
19. Wei WB, Xu L, Jonas JB, et al. Subfoveal choriodal thickness: the Beijing eye study[J]. Ophthalmology, 2013, 120(1): 175-180. DOI: 10.1016/j.ophtha.2012.07.048.

Chinese Journal of Ocular Fundus Diseases

Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy

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