Quantitative analysis of biochemical components in the suprachoroidal space fluid of choriodal detachment associated with rhegmatogenous retinal detachment_Chinese Journal of Ocular Fundus Diseases

Authors：

Han Linfeng ,  Ke Genjie , Wang Lin , Gu Yonghao , Gu Qihong , Dong Kai , Liu Jiajia

Department of Ophthalmology, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China (Han Linfeng, postgraduate, now working at the Wuhu Eye Hospital);

Corresponding author：

Ke Genjie, Email: kegenjie@163.com

Keywords：

Retinal detachment/etiology; Choroid diseases/etiology; Retinal perforations/complications; Exudates and transudates

DOI：

10.3760/cma.j.issn.1005-1015.2017.05.011

Video：

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Objective To investigate the nature of the suprachoroidal fluid by detecting the concentration of total protein (TP), lactate dehydrogenase (LDH), albumin (ALB), total cholesterol (CHOL), total bilirubin (TBIL) in suprachoroidal liquid of patients who have rhegmatogenous retinal detachment with choroid detachment (RRDCD). Methods Eighteen RRDCD patients (18 eyes) who underwent vitrectomy were enrolled in this study. There were 10 males (10 eyes) and 8 females (8 eyes), 8 right eyes and 10 left eyes. There were 8 patients with age of ≤55 years, 10 patients with age of ＞55 years. There were 7 patients with duration of ≤30 days, 11 patients with duration of ＞30 days. There were 7 eyes with diopters of ≥−6.0 D, 11 eyes with diopters of ＜−6.0 D. There were 11 eyes with class C proliferative vitreoretinopathy (PVR), 7 eyes with class D PVR. Suprachoroidal fluid samples were collected from all the patients, and took preoperative serum samples as RRDCD group. Ten serum samples of normal people were set as control group. The concentration of TP, LDH, ALB, CHOL, TBIL in all the subjects were measured. The properties of the suprachoroidal fluid were identified by Light standard and concentration standard of ALB, CHOL, TBIL. Results There was no difference on the concentration of TP, LDH, ALB, CHOL, TBIL from suprachoroidal fluid samples in the patients with different age, sex, eyes, diopter, PVR grade (P＞0.05). There was no difference on the concentration of TP, LDH, ALB, CHOL, TBIL from preoperative serum samples in the patients between RRDCD group and control group (P＞0.05). There was no difference on the concentration of ALB and CHOL from suprachoroidal fluid samples and preoperative serum samples in the RRDCD patients (P＞0.05), but there were significant differences on the concentration of TP, LDH, TBIL (P＜0.05). According to the Light standard, there were 17 cases of exudates and 1 case of transudate. According to the concentration standard of ALB, CHOL and TBIL, there were 14, 18, and 16 cases of exudates, and 4, 0, and 2 cases of transudate, respectively. There was no difference on the identification result of Light standard and concentration standard of ALB, CHOL, TBIL (χ²=2.090, 1.029, 0.364; P＞0.05). Conclusion The suprachoroidal fluid of RRDCD patients composed of TP, LDH, CHOL and TBIL. The suprachoroidal fluid is more likely to be exudate.

Citation： Han Linfeng, Ke Genjie, Wang Lin, Gu Yonghao, Gu Qihong, Dong Kai, Liu Jiajia. Quantitative analysis of biochemical components in the suprachoroidal space fluid of choriodal detachment associated with rhegmatogenous retinal detachment. Chinese Journal of Ocular Fundus Diseases, 2017, 33(5): 485-489. doi: 10.3760/cma.j.issn.1005-1015.2017.05.011 Copy

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1. Romero-Candeira S, Hernandez L, Romero-Brufao S, et al. Is it meaningful to use biochemical parameters to discriminate between transudative and exudative pleural effusions?[J]. Chest, 2002, 122(5): 1524-1529.
2. 李海英, 李月川. 胸腔积液胆固醇对胸腔积液性质的判定价值[J]. 天津医药, 2012, 40(8): 823-825.Li HY, Li YC. The value of cholesterol in pleural effusion in the determination of pleural effusion [J]. Tianjin Med J, 2012, 40(8): 823-825. DOI: 10.3969/j.issn.0253-9896.2012.08.024.
3. Zoia A, Slater LA, Heller J, et al. A new approach to pleural effusion in cats: markers for distinguishing transudates from exudates[J]. J Feline Med Surg, 2009, 11(10): 847-855. DOI: 10.1016/j.jfms.2009.04.005.
4. Okino AM, Burger C, Cardoso JR, et al. The acute-phase proteins serum amyloid A and C reactive protein in transudates and exudates[J/OL]. Mediators Inflamm, 2006, 2006(1): 47297. http://dx.doi.org/10.1155/MI/2006/47297. DOI: 10.1155/MI/2006/47297.
5. Light RW. The Light criteria: the beginning and why they are useful 40 years later[J]. Clin Chest Med, 2013, 34(1): 21-26. DOI: 10.1016/j.ccm.2012.11.006.
6. 高岩冰, 齐春英, 杨智, 等. 二维及彩色多普勒超声对视网膜脉络膜脱离的诊断价值[J]. 中国现代医学杂志, 2010, 20(19): 3017-3019. DOI: 10.3969/j.issn.1005-8982.2010.19.039.Gao YB, Qi CY, Yang Z, et al. Value of two-dimensional and color Doppler ultrasound in diagnosis of retinal detachment and choroid detachment[J]. China Journal of Modern Medicine, 2010, 20(19): 3017-3019. DOI: 10.3969/j.issn.1005-8982.2010.19.039.
7. 刘琳琳, 郑运马, 刁慧杰.彩色多普勒诊断脉络膜脱离的临床应用[J]. 牡丹江医学院学报, 2010, 31(3): 73-74. DOI: 10.3969/j.issn.1001-7550.2010.03.040.Liu LL, Zheng YM, Diao HJ. Clinical application of color Doppler imaging in the diagnosis of choroidal detachment [J]. Journal Of Mudanjiang Medical University, 2010, 31(3): 73-74. DOI: 10.3969/j.issn.1001-7550.2010.03.040.
8. 潘红飙, 顾永昊, 鲍建, 等. 20 MHz B超联合UBM在脉络膜脱离型视网膜脱离诊断中应用[J]. 中国实用眼科杂志, 2014, 32(12): 1449-1453. DOI: 10.3760/cma.j.issn.1006-4443.2014.012.013.Pan HB, Gu YH, Bao Jian, et al. The application of 20 MHz B-scan and ultrasound biomicroscopy in the diagnosis of retinal detachment associated with choroidal detachment[J]. Chin J Pract Ophthalmol, 2014, 32(12): 1449-1453. DOI: 10.3760/cma.j.issn.1006-4443.2014.012.013.
9. 陈娟, 陈忠平, 王启常, 等.孔源性视网膜脱离玻切术前超声生物显微镜检查结果分析[J]. 国际眼科杂志, 2015(5): 900-903. DOI: 10.3980/j.issn.1672-5123.2015.5.44.Chen J, Chen ZP, Wang QC, et al. Analysis of the results detected by ultrasound biomicroscopy before patients with rhegmatogenous retinal detachment perform pars plana vitrectomy[J]. Int Eye Sci, 2015, 15(5): 900-903. DOI: 10.3980/j.issn.1672-5123.2015.5.44.
10. 林红, 牛鹰筠, 康菊.视网膜脱离合并脉络膜脱离的超声诊断[J]. 中华眼底病杂志, 2000, 16(1): 59-60.Lin H, Niu YJ, Kang J. Ultrasonographic diagnosis of retinal detachment associated with choroidal detachment [J]. Chin J Ocul Fundus Dis, 2000, 16(1): 59-60.
11. Mancino R, Aiello F, Ciuffoletti E, et al. Inferior retinotomy and silicone oil tamponade for recurrent inferior retinal detachment and grade C PVR in eyes previously treated with pars plana vitrectomy or scleral buckle[J]. BMC Ophthalmol, 2015, 15: 173. DOI: 10.1186/s12886-015-0167-z.
12. Shalaby KA. Relaxing retinotomies and retinectomies in the management of retinal detachment with severe proliferative vitreoretinopathy (PVR)[J]. Clin Ophthalmol, 2010, 4: 1107-1114. DOI: 10.2147/OPTH.S4934.
13. Gagliano C, Toro MD, Avitabile T, et al. Intravitreal steroids for the prevention of PVR after surgery for retinal detachment[J]. Curr Pharm Des, 2015, 21(32): 4698-4702. DOI: 10.2174/1381612821666150909100212.
14. Mondal BC, Shim J, Evans CJ, et al. Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors[J/OL]. Elife, 2014, 2014: E03626[2014-09-08]. DOI: 10.7554/eLife.03626. DOI: 10.7554/eLife.03626. [published online ahead of print].
15. 蒋瑜, 张晓峰.孔源性视网膜脱离视网膜下液S100蛋白的初步研究[J]. 中华疾病控制杂志, 2011, 15(5): 428-430.Jiang Y, Zhang XF.Preliminary research of S100 protein concentration in the subretinal fluid of rhegmatogenous retinal detachment[J]. Chin J Dis Control Perv, 2011, 15(5): 428-430.
16. 魏勇, 王润生, 王睿, 等. 玻璃体切割联合球周及眼内注射曲安奈德治疗脉络膜脱离型视网膜脱离[J]. 中华眼底病杂志, 2014, 30(4): 404-406. DOI: 10.3760/cma.j.issn.1005-1015.2014.04.017.Wei Y, Wang RS, Wang R, et al. Vitrectomy combined with retrobulbar and intraocular injection of triamcinolone acetonide for the treatment of choroidal detachment associated with retinal detachment [J]. Chin J Ocul Fundus Dis, 2014, 30(4): 404-406. DOI: 10.3760/cma.j.issn.1005-1015. 2014.04.017.
17. 贺严, 刘存宁, 张亚林. 前房成形联合脉络膜上腔放液术治疗青光眼滤过性手术后睫状体脉络膜脱离[J]. 国际眼科杂志, 2014(3): 542-544. DOI: 10.3980/j.jssn.1672-5123.2014.03.46.He Y, Liu CN, Zhang YL.Clinical observation of anterior chamber forming with draining out suprachoroidal fluid on ciliochoroidal detachment after filtering operation[J]. Int Eye Sci, 2014, 14(3): 542-544.
18. 刘文, 张少波, 柯治生, 等. 微创玻璃体切割手术治疗脉络膜脱离型视网膜脱离临床疗效观察[J]. 中华眼底病杂志, 2012, 28(6): 593-597. DOI: 10.3760/cma.j.issn.1005-1015.2012.06.012.Liu W, Zhang SB, Ke ZS, et al. The efficacy of micro-invasive vitrectomy for retinal detachment associated with choroidal detachment[J]. Chin J Ocul Fundus Dis, 2012, 28(6): 593-597. DOI: 10.3760/cma.j.issn.1005-1015.2012.06.012.
19. 曾洁, 汪静, 张传宝, 等.15种血清总蛋白检测方法测定结果准确性和可比性研究[J]. 中华检验医学杂志, 2015(5): 292-295. DOI: 10.3760/cma.j.issn.1009-9158.2015.05.002.Zeng J, Wang J, Zhang CB, et al. Method comparison and accuracy of 15 commercial serum total protein assays[J]. Chin J Lab Med, 2015(5): 292-295. DOI: 10.3760/cma.j.issn.1009-9158.2015.05.002.
20. 张群.血清前清蛋白在肝病检测中的临床意义[J]. 检验医学与临床, 2012, 9(1): 53-55. DOI: 10.3969/j.issn.1672-9455.2012.01.029.Zhang Q. The clinical significance of serum prealbumin in detection of hepatitis[J]. Lab Med Clin, 2012, 9(1): 53-55. DOI: 10.3969/j.issn.1672-9455.2012.01.02.
21. 贾雄飞, 吴乐斌, 王惠萱, 等.血清胆固醇自主研发生化诊断试剂的临床研究[J]. 检验医学与临床, 2011, 8(6): 644-646. DOI: 10.3969/j.issn.1672-9455.2011.06.002.Jia XF, Wu LB, Wang HX, et al. Cliniacl research of serum cholesterin biochemistry diagnostic reagent by independent research and development[J]. Lab Med Clin, 2011, 8(6): 644-646. DOI: 10.3969/j.issn.1672-9455.2011.06.002.
22. 邬建民, 张晓丽.酶法测定直接胆红素的评价[J]. 检验医学, 2011, 26(4): 274-276. DOI: 10.3969/j.issn.1673-8640.2011.04.020.Wu JM, Zhang XL. Evaluation of enzymatic determination of direct bilirubin[J]. Laboratory Medicine, 2011, 26(4): 274-276. DOI: 10.3969/j.issn.1673-8640.2011.04.020.
23. Jarrett WN. Rhematogenous retinal detachment complicated by severe intraocular inflammation, hypotony, and choroidal detachment[J]. Trans Am Ophthalmol Soc, 1981, 79: 664-683.
24. 王昀, 柯根杰, 顾永昊, 等. 高度近视合并脉络膜脱离型视网膜脱离的疗效观察[J]. 安徽医科大学学报, 2013, 48(4): 413-415.Wang Y, Ke GJ, Gu YH.Observation on the treatment of high myopia combined with choroidal and retinal detachment[J]. Acta Universitatis Medicinalis Anhui, 2013, 48(4): 413-415.
25. 段安丽, 王宁利, 王景昭. 脉络膜脱离型视网膜脱离的临床研究[J]. 眼科研究, 2007, 25(3): 222-225.Duan AL, Wang NL, Wang JZ.Clinical study on retinal detachment associated with choroidal detachment[J]. Chin Ophthal Res, 2007, 25 (3): 222-225.
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Chinese Journal of Ocular Fundus Diseases

Quantitative analysis of biochemical components in the suprachoroidal space fluid of choriodal detachment associated with rhegmatogenous retinal detachment

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