Comparison of central foveal thickness and subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia_Chinese Journal of Ocular Fundus Diseases

Authors：

Hong Tingting , Ma Zicheng , Fu Xiuwen ,  Wang Jun

Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;

Corresponding author：

Wang Jun, Email: wangjun6670@126.com

Keywords：

Pre-eclampsia; Pregnant women; Retina/physiopathology; Choroid/physiopathology; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2017.06.007

Video：

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Objective To compare the central foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) in healthy pregnant women and patients with pre-eclampsia. Methods A prospective control study. Twenty normal subjects, 20 healthy pregnant women and 20 patients with pre-eclampsia were included. The difference of gestational weeks between healthy pregnant women and patients with pre-eclampsia was not significant (χ²=0.012, P=0.913). The differences of age and spherical equivalent among normal subjects, healthy pregnant women and patients with pre-eclampsia were not significant (χ²=1.760, 0.087; P=0.413, 0.957). All eyes underwent optical coherence tomography examination to measure the CFT and SFCT. Results The mean CFT of normal subjects, healthy pregnant women and patients with pre-eclampsia were (194.40±16.17), (201.2±17.33), (199.00±15.46) μm, there was no significant difference among the three groups (χ²=0.888, P=0.641). The mean SFCT of normal subjects, healthy pregnant women and patients with pre-eclampsia were (263.45±69.66), (330.00±49.20), (373.40±52.00) μm, there was significant difference among the three groups (χ²=22.818, P=0.000). The mean SFCT of healthy pregnant women was increased than that of normal subjects (Z=−2.991, P=0.002). The mean SFCT of patients with pre-eclampsia was increased than that of healthy pregnant women (Z=−2.638, P=0.007). Conclusion The mean SFCT of patients with pre-eclampsia is increased than healthy pregnant women.

Citation： Hong Tingting, Ma Zicheng, Fu Xiuwen, Wang Jun. Comparison of central foveal thickness and subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia. Chinese Journal of Ocular Fundus Diseases, 2017, 33(6): 584-586. doi: 10.3760/cma.j.issn.1005-1015.2017.06.007 Copy

1.	杨孜. 多因素、多通路、多机制致病解子痫前期综合征制胜真实世界临床实践[J]. 中国实用妇科与产科杂志, 2017, 33(1): 45-51. DOI: 10.19538/j.fk2017010111.Yang Z. Multiple factor, multiple pass and multiple pathogenesis to realize pre-eclampsia syndrome [J]. Chin J Prac Gynecol Obstetr, 2017, 33(1): 45-51. DOI: 10.19538/j.fk2017010111.
2.	Schultz KL, Birnbaum AD, Goldstein DA. Ocular disease in pregnancy[J]. Curr Opin Ophthalmol, 2005, 16(5): 308-314.
3.	王文玲, 关艳玲, 户秀慧.中心性浆液性脉络膜视网膜病变患者脉络膜毛细血管扩张和中心凹下脉络膜厚度关系的研究[J]. 眼科新进展, 2017, 37(5): 466-468. DOI: 10.13389/j.cnki.rao.2017.0118.Wang WL, Guan YL, Hu XH.Relationship between choroidal telangiectasia and subfoveal choroidal thickness in patients with central serous chorioretinopathy[J]. Rec Adv Ophthalmol, 2017, 37(5): 466-468. DOI: 10.13389/j.cnki.rao.2017.0118.
4.	Chung YR, Kim JW, Choi SY, et al. Subfoveal choroidal thickness and vascular diameter in active and resolved central serous chorioretinopathy[J/OL]. Retina, 2017, 2017: E1[2017-01-18]. http://insights.ovid.com/pubmed?pmid=28106708. DOI: 10.1097/IAE.0000000000001502. [published online ahead of print].
5.	Duru N, Ulusoy DM, Ozkose A, et al. Choroidal changes in pre-eclampsia during pregnancy and the postpartum period: comparison with healthy pregnancy[J]. Arq Bras Oftalmol, 2016, 79(3): 143-146. DOI: 10.5935/0004-2749.20160044.
6.	Kim JW, Park MH, Kim YJ, et al. Comparison of subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia[J]. Eye (Lond), 2016, 30(3): 349-354. DOI: 10.1038/eye.2015.215.
7.	Garg A, Wapner RJ, Ananth CV, et al. Choroidal and retinal thickening in severe preeclampsia[J]. Invest Ophthalmol Vis Sci, 2014, 55(9): 5723-5729. DOI: 10.1167/iovs.14-14143.
8.	苟文丽. 妊娠期高血压疾病[M]//乐杰. 妇产科学. 北京: 人民卫生出版社, 2008: 97-106.Gou WL. Hypertensive disorder complicating pregnancy [M]//Le J. Gynecotokology. Beijing: People's Medical Publishing House, 2008: 97-106.
9.	Li Z, Zeng J, Jin W, et al. Time-course of changes in choroidal thickness after complete mydriasis induced by compound tropicamide in children[J/OL]. PLoS One, 2016, 11(9): 0162468[2016-09-13]. http://dx.plos.org/10.1371/journal.pone.0162468. DOI: 10.1371/journal.pone.0162468.
10.	Lupton SJ, Chiu CL, Hodgson LA, et al. Temporal changes in retinal microvascular caliber and blood pressure during pregnancy[J]. Hypertension, 2013, 61(4): 880-885. DOI: 10.1161/HYPERTENSIONAHA.111.00698.
11.	Lupton SJ, Chiu CL, Hodgson LA, et al. Changes in retinal microvascular caliber precede the clinical onset of preeclampsia[J]. Hypertension, 2013, 62(5): 899-904. DOI: 10.1161/HYPERTENSIONAHA.113.01890.
12.	Sato T, Sugawara J, Aizawa N, et al. Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy[J/OL]. PLoS One, 2017, 12(3): 0173127[2017-03-03]. http://dx.plos.org/10.1371/journal.pone.0173127. DOI: 10.1371/journal.pone.0173127.
13.	Iwase T, Yamamoto K, Ra E, et al. Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow[J]. Medicine (Baltimore), 2015, 94(6): 519. DOI: 10.1097/MD.0000000000000519.
14.	董海英, 刘诗芳, 崔明花, 等. 子痫前期及子痫孕妇血清C-反应蛋白水平分析[J]. 中国妇幼保健, 2017, 32(9): 1861-1863. DOI: 10.7620/zgfybj.j.issn.1001-4411.2017.09.12.Dong HY, Liu SF, Cui MH, et al. Analysis on serum C-reactive protein levels in pregnant women with preeclampsia and eclampsia[J]. Maternal and Child Health Care of China, 2017, 32(9): 1861-1863. DOI: 10.7620/zgfybj.j.issn.1001-4411.2017.09.12.

1. 杨孜. 多因素、多通路、多机制致病解子痫前期综合征制胜真实世界临床实践[J]. 中国实用妇科与产科杂志, 2017, 33(1): 45-51. DOI: 10.19538/j.fk2017010111.Yang Z. Multiple factor, multiple pass and multiple pathogenesis to realize pre-eclampsia syndrome [J]. Chin J Prac Gynecol Obstetr, 2017, 33(1): 45-51. DOI: 10.19538/j.fk2017010111.
2. Schultz KL, Birnbaum AD, Goldstein DA. Ocular disease in pregnancy[J]. Curr Opin Ophthalmol, 2005, 16(5): 308-314.
3. 王文玲, 关艳玲, 户秀慧.中心性浆液性脉络膜视网膜病变患者脉络膜毛细血管扩张和中心凹下脉络膜厚度关系的研究[J]. 眼科新进展, 2017, 37(5): 466-468. DOI: 10.13389/j.cnki.rao.2017.0118.Wang WL, Guan YL, Hu XH.Relationship between choroidal telangiectasia and subfoveal choroidal thickness in patients with central serous chorioretinopathy[J]. Rec Adv Ophthalmol, 2017, 37(5): 466-468. DOI: 10.13389/j.cnki.rao.2017.0118.
4. Chung YR, Kim JW, Choi SY, et al. Subfoveal choroidal thickness and vascular diameter in active and resolved central serous chorioretinopathy[J/OL]. Retina, 2017, 2017: E1[2017-01-18]. http://insights.ovid.com/pubmed?pmid=28106708. DOI: 10.1097/IAE.0000000000001502. [published online ahead of print].
5. Duru N, Ulusoy DM, Ozkose A, et al. Choroidal changes in pre-eclampsia during pregnancy and the postpartum period: comparison with healthy pregnancy[J]. Arq Bras Oftalmol, 2016, 79(3): 143-146. DOI: 10.5935/0004-2749.20160044.
6. Kim JW, Park MH, Kim YJ, et al. Comparison of subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia[J]. Eye (Lond), 2016, 30(3): 349-354. DOI: 10.1038/eye.2015.215.
7. Garg A, Wapner RJ, Ananth CV, et al. Choroidal and retinal thickening in severe preeclampsia[J]. Invest Ophthalmol Vis Sci, 2014, 55(9): 5723-5729. DOI: 10.1167/iovs.14-14143.
8. 苟文丽. 妊娠期高血压疾病[M]//乐杰. 妇产科学. 北京: 人民卫生出版社, 2008: 97-106.Gou WL. Hypertensive disorder complicating pregnancy [M]//Le J. Gynecotokology. Beijing: People's Medical Publishing House, 2008: 97-106.
9. Li Z, Zeng J, Jin W, et al. Time-course of changes in choroidal thickness after complete mydriasis induced by compound tropicamide in children[J/OL]. PLoS One, 2016, 11(9): 0162468[2016-09-13]. http://dx.plos.org/10.1371/journal.pone.0162468. DOI: 10.1371/journal.pone.0162468.
10. Lupton SJ, Chiu CL, Hodgson LA, et al. Temporal changes in retinal microvascular caliber and blood pressure during pregnancy[J]. Hypertension, 2013, 61(4): 880-885. DOI: 10.1161/HYPERTENSIONAHA.111.00698.
11. Lupton SJ, Chiu CL, Hodgson LA, et al. Changes in retinal microvascular caliber precede the clinical onset of preeclampsia[J]. Hypertension, 2013, 62(5): 899-904. DOI: 10.1161/HYPERTENSIONAHA.113.01890.
12. Sato T, Sugawara J, Aizawa N, et al. Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy[J/OL]. PLoS One, 2017, 12(3): 0173127[2017-03-03]. http://dx.plos.org/10.1371/journal.pone.0173127. DOI: 10.1371/journal.pone.0173127.
13. Iwase T, Yamamoto K, Ra E, et al. Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow[J]. Medicine (Baltimore), 2015, 94(6): 519. DOI: 10.1097/MD.0000000000000519.
14. 董海英, 刘诗芳, 崔明花, 等. 子痫前期及子痫孕妇血清C-反应蛋白水平分析[J]. 中国妇幼保健, 2017, 32(9): 1861-1863. DOI: 10.7620/zgfybj.j.issn.1001-4411.2017.09.12.Dong HY, Liu SF, Cui MH, et al. Analysis on serum C-reactive protein levels in pregnant women with preeclampsia and eclampsia[J]. Maternal and Child Health Care of China, 2017, 32(9): 1861-1863. DOI: 10.7620/zgfybj.j.issn.1001-4411.2017.09.12.

Chinese Journal of Ocular Fundus Diseases

Comparison of central foveal thickness and subfoveal choroidal thickness in healthy pregnancy and pre-eclampsia

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