The thickness of the retina, choroid and sclera in different posterior sclera shape in high myopia_Chinese Journal of Ocular Fundus Diseases

Authors：

Liu LiLi ,  Liu Weifeng

The Eye Hospital of Nanchang University, Nanchang 330006, China (Liu Lili);;
Department of Ophthalmology, The Third Affiliated Hospital of Nanchang University, Nanchang 330006, China (Liu Weifeng);

Corresponding author：

Liu Weifeng, Email: 18970040725@163.com

Keywords：

Myopia, degenerative/complications; Scleral diseases; Tomography, optical coherence; Retinal thickness; Choroidal thickness

DOI：

10.3760/cma.j.issn.1005-1015.2017.06.010

Video：

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Objective To observe the thickness of the retina, retinal nerve fiber layer (RNFL), choroid and sclera among the difference posterior sclera shape (PSS) in high myopia (HM). Methods Sixty HM patients (96 eyes) were enrolled in this study. There were 18 males (25 eyes) and 42 females (71 eyes). The mean age was (51.32±10.06) years. The mean spherical equivalent was (-14.38±6.31) DS. The mean axial length was (29.49±2.44) mm. The eyes were evaluated from deep range imaging optical coherent tomography (DRI-OCT) Atlantis 3D model, and divided as four groups include PSS-Ⅰ (27 eyes), PSS-Ⅱ (46 eyes), PSS-Ⅲ (11 eyes) and PSS-Ⅸ (12 eyes) according to the Curtin classification method. The thickness of the retina, RNFL, choroid and sclera were measured in the EDTRS Grid area. Results There were statistically significant differences in the thickness of retina of the central, first circle, second circle in the EDTRS Grid area among PSS-Ⅰ, PSS-Ⅱ, PSS-Ⅲ and PSS-Ⅸ groups (F=4.48, 5.03, 4.98; P＜0.01). There was no statistically significant differences in the thickness of RNFL among four groups (F=0.13, P=0.93). There was no statistically significant differences in the central choroidal thickness (F=0.31, P=0.81). There were statistically significant differences in the first circle, second circle choroidal thickness among four groups (F=2.86, 2.96; P=0.04, 0.04). There was no statistically significant differences in the thickness of sclera under macular fovea among four groups (F=0.80, P=0.49). Conlusions There are changes of thickness of the retina, choroid present in the difference EDTRS Grid area among the difference PSS in HM, and changes in PSS-Ⅸ is most obvious.

Citation： Liu LiLi, Liu Weifeng. The thickness of the retina, choroid and sclera in different posterior sclera shape in high myopia. Chinese Journal of Ocular Fundus Diseases, 2017, 33(6): 597-600. doi: 10.3760/cma.j.issn.1005-1015.2017.06.010 Copy

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2.	Saw SM, Tong L, Chua WH, et al. Incidence and progression of myopia in Singaporean school children[J]. Invest Ophthalmol Vis Sci, 2005, 46(1): 51-57.DOI:10.1167/iovs.04-0565.
3.	Yun SH, Bouma BE. Wavelength swept lasers[M]//Drexler W, Fujimoto JG. Optical coherence tomography: technology and applications. New York: Springer, 2008: 359-377.
4.	Hirata M, Tsujikawa A, Matsumoto A, et al. Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52(8): 4971-4978.DOI: 10.1167/iovs.11-7729.
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6.	Fledelius HC, Goldschmidt E. Eye shape and peripheral visual field recording in high myopia at approximately 54 years of age, as based on ultrasonography and Goldmann kinetic perimetry[J]. Acta Ophthalmol, 2010, 88(5): 521-526.DOI:10.1111/j.1755-3768.2009.01550.x.
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9.	Ohno-Matsui K. Proposed classification of posterior staphylomas based on analyses of eye shape by three-dimensional magnetic resonance imaging and wide-field fundus imaging[J]. Ophthalmology, 2014, 121(9): 1798-1809.DOI:10.1016/j.ophtha. 2014.03.035.
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11.	Chang L, Pan CW, Ohno-Matsui K, et al. Myopia-related fundus changes in Singapore adults with high myopia[J]. Am J Ophthalmol, 2013, 155(6): 991-999.DOI:10.1016/j.ajo.2013.01.016.
12.	Vongphanit J, Mitchell P, Wang JJ. Prevalence and progression of myopic retinopathy in an older population[J]. Ophthalmology, 2002, 109(4): 704-711.
13.	Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spectral- domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2009, 50(8): 3876-3880. DOI:10.1167/iovs.08-3325.
14.	Manjunath V, Taha M, Fujimoto JG, et al. Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography[J]. Am J Ophthalmol, 2010, 150(3): 325-329. DOI:10.1016/j.ajo.2010.04.018.
15.	Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes[J]. Am J Ophthalmol, 2009, 147(5): 811-815. DOI: 10.1016/j.ajo.2008.12.008.
16.	Takahashi A, Ito Y, Iguchi Y, et al. Axial length increases and related changesin highly myopic normal eyes with myopic complications in fellow eyes[J]. Retina, 2012, 32(1): 127-133. DOI: 10.1097/IAE.0b013e318214d094.
17.	Wang NK, Lai CC, Chu HY, et al. Classification of early drytype myopic maculopathy with macular choroidal thickness[J]. Am J Ophthalmol, 2012, 153(4): 669-677. DOI:10.1016/j.ajo. 2011. 08.039.
18.	Flores-Moreno I, Lugo F, Duker JS, et al. The relationship between axial length and choroidal thickness in eyes with high myopia[J]. Am J Ophthalmol, 2013, 155(2): 314-319. DOI:10.1016/j.ajo.2012.07.015.
19.	Ohno-Matsui K, Akiba M, Modegi T, et al. Association between shape of sclera and myopic retinochoroidal lesions in patients with pathologic myopia[J]. Invest Ophthalmol Vis Sci, 2012, 53 (10): 6046-6061. DOI:10.1167/iovs.12-10161.
20.	Hayashi M, Ito Y, Takahashi A, et al. Scleral thickness in highly myopic eyes measured byenhanced depth imaging optical coherence tomography[J]. Eye (Lond), 2013, 27(3): 410-417. DOI:10.1038/eye.2012.289.
21.	Ohno-Matsui K, Akiba M, Moriyama M, et al. Imaging the retrobulbar subarachnoid space around the optic nerve by swept source optical coherence tomography in eyes with pathologic myopia[J]. Invest Ophthalmol Vis Sci, 2011, 52(13): 9644-9650. DOI:10.1167/iovs.11-8597.

1. Curtin BJ. The posterior Staphyloma of pathologicalmyopia[J]. Trans Am Ophthalmol Soc, 1977, 75: 67-86.
2. Saw SM, Tong L, Chua WH, et al. Incidence and progression of myopia in Singaporean school children[J]. Invest Ophthalmol Vis Sci, 2005, 46(1): 51-57.DOI:10.1167/iovs.04-0565.
3. Yun SH, Bouma BE. Wavelength swept lasers[M]//Drexler W, Fujimoto JG. Optical coherence tomography: technology and applications. New York: Springer, 2008: 359-377.
4. Hirata M, Tsujikawa A, Matsumoto A, et al. Macular choroidal thickness and volume in normal subjects measured by swept-source optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52(8): 4971-4978.DOI: 10.1167/iovs.11-7729.
5. Spaide RF, Akiba M, Ohno-Matsui K. Evaluation of peripapillary intrachoroidal cavitation with swept source and enhanced depth imaging optical coherence tomography [J]. Retina, 2012, 32(6): 1037-1044.DOI: 10.1097/IAE.0b013e318242b9c0.
6. Fledelius HC, Goldschmidt E. Eye shape and peripheral visual field recording in high myopia at approximately 54 years of age, as based on ultrasonography and Goldmann kinetic perimetry[J]. Acta Ophthalmol, 2010, 88(5): 521-526.DOI:10.1111/j.1755-3768.2009.01550.x.
7. Hsiang HW, Ohno-Matsui K, Shimada N, et al. Clinical characteristics of posterior staphyloma in eyes with pathologic myopia[J]. Am J Ophthalmol, 2008, 146(1): 102-110. DOI: 10.1016/j.ajo.2008.03.010.
8. Leung CK, Mohamed S, Leung KS, et al. Retinal nerve fiber layer measurements in myopia: an optical coherence tomography study[J]. Invest Ophthalmol Vis Sci 2006, 47(12): 5171-5176. DOI:10.1167/iovs.06-0545.
9. Ohno-Matsui K. Proposed classification of posterior staphylomas based on analyses of eye shape by three-dimensional magnetic resonance imaging and wide-field fundus imaging[J]. Ophthalmology, 2014, 121(9): 1798-1809.DOI:10.1016/j.ophtha. 2014.03.035.
10. Miyake M, Yamashiro K, Akagi-Kurashige Y, et al. Analysis of fundus shape in highly myopic eyes by using curvature maps constructed from optical coherence tomography [J/OL]. PLoS One, 2014, 9(9): 107923[2014-09-26]. https://doi.org/10.1371/journal.pone.0107923. DOI:10.1371/journal.pone.0107923.
11. Chang L, Pan CW, Ohno-Matsui K, et al. Myopia-related fundus changes in Singapore adults with high myopia[J]. Am J Ophthalmol, 2013, 155(6): 991-999.DOI:10.1016/j.ajo.2013.01.016.
12. Vongphanit J, Mitchell P, Wang JJ. Prevalence and progression of myopic retinopathy in an older population[J]. Ophthalmology, 2002, 109(4): 704-711.
13. Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spectral- domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2009, 50(8): 3876-3880. DOI:10.1167/iovs.08-3325.
14. Manjunath V, Taha M, Fujimoto JG, et al. Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography[J]. Am J Ophthalmol, 2010, 150(3): 325-329. DOI:10.1016/j.ajo.2010.04.018.
15. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes[J]. Am J Ophthalmol, 2009, 147(5): 811-815. DOI: 10.1016/j.ajo.2008.12.008.
16. Takahashi A, Ito Y, Iguchi Y, et al. Axial length increases and related changesin highly myopic normal eyes with myopic complications in fellow eyes[J]. Retina, 2012, 32(1): 127-133. DOI: 10.1097/IAE.0b013e318214d094.
17. Wang NK, Lai CC, Chu HY, et al. Classification of early drytype myopic maculopathy with macular choroidal thickness[J]. Am J Ophthalmol, 2012, 153(4): 669-677. DOI:10.1016/j.ajo. 2011. 08.039.
18. Flores-Moreno I, Lugo F, Duker JS, et al. The relationship between axial length and choroidal thickness in eyes with high myopia[J]. Am J Ophthalmol, 2013, 155(2): 314-319. DOI:10.1016/j.ajo.2012.07.015.
19. Ohno-Matsui K, Akiba M, Modegi T, et al. Association between shape of sclera and myopic retinochoroidal lesions in patients with pathologic myopia[J]. Invest Ophthalmol Vis Sci, 2012, 53 (10): 6046-6061. DOI:10.1167/iovs.12-10161.
20. Hayashi M, Ito Y, Takahashi A, et al. Scleral thickness in highly myopic eyes measured byenhanced depth imaging optical coherence tomography[J]. Eye (Lond), 2013, 27(3): 410-417. DOI:10.1038/eye.2012.289.
21. Ohno-Matsui K, Akiba M, Moriyama M, et al. Imaging the retrobulbar subarachnoid space around the optic nerve by swept source optical coherence tomography in eyes with pathologic myopia[J]. Invest Ophthalmol Vis Sci, 2011, 52(13): 9644-9650. DOI:10.1167/iovs.11-8597.

Chinese Journal of Ocular Fundus Diseases

The thickness of the retina, choroid and sclera in different posterior sclera shape in high myopia

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