The characteristics of multifocal microperimetry and its relationship with visual acuity and multifocal ganglion cell complex in nonarteritic anterior ischemic optic neuropathy_Chinese Journal of Ocular Fundus Diseases

Authors：

 Gong Hongxia , Wang Lanhui

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin 300020, China;

Corresponding author：

Gong Hongxia, Email: ghx35@163.com

Keywords：

Optic neuropathy, ischemic; Visual fields; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2018.01.009

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the characteristics of multifocal microperimetry and its relationship with visual acuity and multifocal ganglion cell complex (GCC) in nonarteritic anterior ischemic optic neuropathy (NAION). Methods A retrospective case study. A total of 38 patients (54 eyes) with NAION were enrolled in this study. 25 NAION eyes (25 patients) and 29 contralateral health eyes (29 patients) were randomly selected into case group and control group respectively. All eyes underwent best corrected visual acuity (BCVA), slit lamp microscope, indirect ophthalmoscope, color fundus photography, optical coherence tomography (OCT), visual field and multifocal microperimetry. Logarithm of the minimum angle of resolution (logMAR) was used to calculate BCVA. There were no significantly differences on age (t=−0.647), gender, dominant eyes ( χ²=0.128, 0.099), intraocular pressure (t=0.376) between two groups (P>0.05). Macular GCC thickness, superior and inferior GCC thickness were measured by OCT, focal loss volume (FLV) and global loss volume (GLV) were obtained at the same time. Microperimetry were measured by macular integrity assessment instrument (MAIA microperimetry), and mean retinal sensitivities (MS) in macular area 10° and fixation rate in the macular central 2° and 4° were determined. The relationship between MS, macular GCC and BCVA were analyzed by Spearman correlation analysis. Results The mean logMAR BCVA of case group and control group were 0.68±0.79 and 0.07±0.06, respectively. There was significantly statistical difference in MS between two groups (t=−2.507, P=0.037). There were no significantly statistical difference in mean GCC (t=−1.245, P=0.259), superior and inferior GCC (t=−1.336, −1.024; P=0.230, 0.346), FLV (t=1.058, P=0.331) and GLV (P=0.182) between two groups. The correlation between BCVA and MS (r=−0.809, P=−0.005) was observed. However, there were no correlation between BCVA and GCC, superior and inferior GCC, FLV, GLV (r=−0.98, −0.466, −0.061, 0.442, 0.442; P=0.817, −0.244, 0.885, 0.273, 0.273). And also, there were no correlation between MS and GCC, superior and inferior GCC, FLV, GLV (r=0.238, 0.524, 0.286, 0.643, −0.619; P=0.570, 0.183, 0.493, 0.086, 0.102). Conclusions MS reduced in early stage NAION eyes, which did not correlate with macular GCC.

Citation： Gong Hongxia, Wang Lanhui. The characteristics of multifocal microperimetry and its relationship with visual acuity and multifocal ganglion cell complex in nonarteritic anterior ischemic optic neuropathy. Chinese Journal of Ocular Fundus Diseases, 2018, 34(1): 34-37. doi: 10.3760/cma.j.issn.1005-1015.2018.01.009 Copy

1.	Hayreh SS.Ischemic optic neuropathy[J]. Prog Retin Eye Res, 2009, 28(1): 34-62. DOI: 10.1016/j.preteyeres.2008.11.002.
2.	Han M, Zhao C, Han QH, et al. Change of retinal nerve optic neuropathy revesled by Fourier anterior ischemic optic neuropathy revealed by Fourier domain optical coherence tomography[J]. Curr Eye Res, 2016, 41(8): 1076-1081. DOI: 10.3109/02713683.2015.1084640.
3.	Hayreh SS, Zimmerman MB.Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(7): 1029-1046. DOI: 10.1007/s00417-008-0805-8.
4.	Hayreh SS.Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy[J]. Surv Ophthalmol, 2010, 55(4): 399-400. DOI: 10.1016/j.survophthal.2010.03.003.
5.	Hayeh SS.Role of steroid therapy in nonarteritic anterior ischemic optic neuropathy[J]. J Neuroophthalmol, 2010, 30(4): 388-389. DOI: 10.1097/WNO.0b013e3181fab01b.
6.	Alasil T, Tan O, Lu AT, et al. Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy[J]. Ophthalmic Surg Lasers Imag, 2008, 39(4 Suppl): S71-79. DOI: 10.3109/01658107.2015.1136654.
7.	Papchenko T, Grainger BT, Savino PJ, et al. Macular thickness predictive of visual field sensitivity in ischaemic optic neuropathy[J]. Acta Ophthalmol, 2012, 90(6): 463-469. DOI: 10.1111/j.1755-3768.2012.02467.x.
8.	Goto K, Miki A, Araki S, et al. Time course of macular and peripapillary inner retinal thickness in non-arteritic anterior ischaemic optic neuropathy using spectral-domain optical coherence tomography[J]. Neuroophthalmology, 2016, 40(2): 74-85. DOI: 10.3109/01658107.2015.1136654.
9.	Contreras I, Noval S, Rebolleda G, et al. Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography[J]. Ophthalmology, 2007, 114: 2338-2344. DOI: 10.1016/j.ophtha.2007.05.042.
10.	Kim, DY, Yang HS, Kook YJ, et al. Association between microperimetric parameters and optical coherent tomographic fingdings in various macular diseases[J]. Korean J Ophthalmol, 2015, 29(2): 92-101. DOI: 10.3341/KJO.2015.29.2.92.
11.	Fujii GY, de Juan E Jr, Humayun MS, et al. Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration[J]. Am J Ophthalmol, 2003, 136(6): 1067-1078.
12.	Fletcher DC, Schuchard RA.Preferred retinal loci relationship to macular scotomas in a low-vision population[J]. Ophthalmology, 1997, 104(4): 632-638.
13.	Kerr NM, Chew SS, Danesh-Meyer HV.Non-arteritic anterior ischaemic optic neuropathy: review and update[J]. Clin Neurosci, 2009, 16: 994-1000. DOI: 10.1016/j.jocn.2009.04.002.
14.	Schulze-Bonsel K, Feltgen N, Burau H, et al. Visual acuities "hand motion" and "counting fingers" can be quantified with the freiburg visual acuity test[J]. Invest Ophthalmol Vis Sci, 2006, 47(3): 1236-1240. DOI: 10.1167/iovs.05-0981.
15.	Miller NR, Arnold AC.Current concepts in the diagnosis pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy[J]. Eye(Lond), 2015, 29(1): 65-67. DOI: 10.1038/eye.2014.144.
16.	Hedges TR 3rd, Vuong LN, Gonzalez-Garcia AO, et al. Subretinal fluid from anterior ischemic optic neuropathy demonstrated by optical coherence tomography[J]. Arch Ophthalmol, 2008, 126(6): 812-815. DOI: 10.1001/archopht.126.6.812.
17.	中华医学会眼科学分会神经眼科学组.我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J]. 中华眼科杂志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-ophthalmology Group, Ophthalmology Branch of Chinese Medical Association. Diagnosis and treatment guideline of nonarteritic anterior ischemic optic neuropathy in China[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
18.	巩鸿霞, 庞雅菊, 王兰惠.非动脉炎性前部缺血性视神经病变多焦视网膜电图特征及其与视力和黄斑中心区视网膜厚度的关系[J]. 中华眼底病杂志, 2015, 31(6): 532-535. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.005.Gong HX, Pang YJ, Wang LH. Characteristics of multifocal eletrotetinogram in nonarteritic anterior ischemic optic neuropathy and its relationship with visual acuity and macular central retinal thickness[J]. Chin J Ocul Fundus Dis, 2015, 31(6): 532-535. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.005.
19.	Guo Y, Mehrabian Z, Bernstein SL.The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)[J/OL]. J Vis Exp, 2016(117): 54504[2016-11-20]. https://www.jove.com/video/54504/the-rodent-model-nonarteritic-anterior-ischemic-optic-neuropathy. DOI: 10.3791/54504.
20.	Johnson MA, Miller NR, Nolan T, et al. Peripapillary retinal nerve fiber layer swelling predicts peripapillary atrophy in a primate model of nonarteritic anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2016, 57(2): 527-532. DOI: 10.1167/iovs.15-17880.
21.	Choi J, Kwon J, Shin JW, et al. Quantitative optical coherence tomography angiography of macular vascular structure and foveal avascular zone in glaucoma[J/OL]. PLoS One, 2017, 12(9): 0184948[2017-09-21]. https://doi.org/10.1371/journal.pone.0184948. DOI: 10.1371/journal.pone.0184948.
22.	毛羽, 周海英, 高丽琴, 等.抗血管内皮生长因子药物玻璃体腔注射以及联合光动力疗法治疗渗出型老年性黄斑变性疗效观察[J]. 中华眼底病杂志, 2011, 27(6): 520-524. DOI: 10.3760/cma.j.issn.1005-1015.201.06.05.Mao Y, Zhou HY, Gao LQ, et al. Combination treatments of photodynamic therapy and intravitreal anti-vascular endothelial growth factor drugs for exudative age-related macular degeneration[J]. Chin J Ocul Fundus Dis, 2011, 27(6): 520-524. DOI: 10.3760/cma.j.issn.1005-1015.201.06.05.

1. Hayreh SS.Ischemic optic neuropathy[J]. Prog Retin Eye Res, 2009, 28(1): 34-62. DOI: 10.1016/j.preteyeres.2008.11.002.
2. Han M, Zhao C, Han QH, et al. Change of retinal nerve optic neuropathy revesled by Fourier anterior ischemic optic neuropathy revealed by Fourier domain optical coherence tomography[J]. Curr Eye Res, 2016, 41(8): 1076-1081. DOI: 10.3109/02713683.2015.1084640.
3. Hayreh SS, Zimmerman MB.Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(7): 1029-1046. DOI: 10.1007/s00417-008-0805-8.
4. Hayreh SS.Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy[J]. Surv Ophthalmol, 2010, 55(4): 399-400. DOI: 10.1016/j.survophthal.2010.03.003.
5. Hayeh SS.Role of steroid therapy in nonarteritic anterior ischemic optic neuropathy[J]. J Neuroophthalmol, 2010, 30(4): 388-389. DOI: 10.1097/WNO.0b013e3181fab01b.
6. Alasil T, Tan O, Lu AT, et al. Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy[J]. Ophthalmic Surg Lasers Imag, 2008, 39(4 Suppl): S71-79. DOI: 10.3109/01658107.2015.1136654.
7. Papchenko T, Grainger BT, Savino PJ, et al. Macular thickness predictive of visual field sensitivity in ischaemic optic neuropathy[J]. Acta Ophthalmol, 2012, 90(6): 463-469. DOI: 10.1111/j.1755-3768.2012.02467.x.
8. Goto K, Miki A, Araki S, et al. Time course of macular and peripapillary inner retinal thickness in non-arteritic anterior ischaemic optic neuropathy using spectral-domain optical coherence tomography[J]. Neuroophthalmology, 2016, 40(2): 74-85. DOI: 10.3109/01658107.2015.1136654.
9. Contreras I, Noval S, Rebolleda G, et al. Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography[J]. Ophthalmology, 2007, 114: 2338-2344. DOI: 10.1016/j.ophtha.2007.05.042.
10. Kim, DY, Yang HS, Kook YJ, et al. Association between microperimetric parameters and optical coherent tomographic fingdings in various macular diseases[J]. Korean J Ophthalmol, 2015, 29(2): 92-101. DOI: 10.3341/KJO.2015.29.2.92.
11. Fujii GY, de Juan E Jr, Humayun MS, et al. Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration[J]. Am J Ophthalmol, 2003, 136(6): 1067-1078.
12. Fletcher DC, Schuchard RA.Preferred retinal loci relationship to macular scotomas in a low-vision population[J]. Ophthalmology, 1997, 104(4): 632-638.
13. Kerr NM, Chew SS, Danesh-Meyer HV.Non-arteritic anterior ischaemic optic neuropathy: review and update[J]. Clin Neurosci, 2009, 16: 994-1000. DOI: 10.1016/j.jocn.2009.04.002.
14. Schulze-Bonsel K, Feltgen N, Burau H, et al. Visual acuities "hand motion" and "counting fingers" can be quantified with the freiburg visual acuity test[J]. Invest Ophthalmol Vis Sci, 2006, 47(3): 1236-1240. DOI: 10.1167/iovs.05-0981.
15. Miller NR, Arnold AC.Current concepts in the diagnosis pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy[J]. Eye(Lond), 2015, 29(1): 65-67. DOI: 10.1038/eye.2014.144.
16. Hedges TR 3rd, Vuong LN, Gonzalez-Garcia AO, et al. Subretinal fluid from anterior ischemic optic neuropathy demonstrated by optical coherence tomography[J]. Arch Ophthalmol, 2008, 126(6): 812-815. DOI: 10.1001/archopht.126.6.812.
17. 中华医学会眼科学分会神经眼科学组.我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J]. 中华眼科杂志, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.Neuro-ophthalmology Group, Ophthalmology Branch of Chinese Medical Association. Diagnosis and treatment guideline of nonarteritic anterior ischemic optic neuropathy in China[J]. Chin J Ophthalmol, 2015, 51(15): 323-326. DOI: 10.3760/cma.j.issn.0412-4081.2015.05.002.
18. 巩鸿霞, 庞雅菊, 王兰惠.非动脉炎性前部缺血性视神经病变多焦视网膜电图特征及其与视力和黄斑中心区视网膜厚度的关系[J]. 中华眼底病杂志, 2015, 31(6): 532-535. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.005.Gong HX, Pang YJ, Wang LH. Characteristics of multifocal eletrotetinogram in nonarteritic anterior ischemic optic neuropathy and its relationship with visual acuity and macular central retinal thickness[J]. Chin J Ocul Fundus Dis, 2015, 31(6): 532-535. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.005.
19. Guo Y, Mehrabian Z, Bernstein SL.The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)[J/OL]. J Vis Exp, 2016(117): 54504[2016-11-20]. https://www.jove.com/video/54504/the-rodent-model-nonarteritic-anterior-ischemic-optic-neuropathy. DOI: 10.3791/54504.
20. Johnson MA, Miller NR, Nolan T, et al. Peripapillary retinal nerve fiber layer swelling predicts peripapillary atrophy in a primate model of nonarteritic anterior ischemic optic neuropathy[J]. Invest Ophthalmol Vis Sci, 2016, 57(2): 527-532. DOI: 10.1167/iovs.15-17880.
21. Choi J, Kwon J, Shin JW, et al. Quantitative optical coherence tomography angiography of macular vascular structure and foveal avascular zone in glaucoma[J/OL]. PLoS One, 2017, 12(9): 0184948[2017-09-21]. https://doi.org/10.1371/journal.pone.0184948. DOI: 10.1371/journal.pone.0184948.
22. 毛羽, 周海英, 高丽琴, 等.抗血管内皮生长因子药物玻璃体腔注射以及联合光动力疗法治疗渗出型老年性黄斑变性疗效观察[J]. 中华眼底病杂志, 2011, 27(6): 520-524. DOI: 10.3760/cma.j.issn.1005-1015.201.06.05.Mao Y, Zhou HY, Gao LQ, et al. Combination treatments of photodynamic therapy and intravitreal anti-vascular endothelial growth factor drugs for exudative age-related macular degeneration[J]. Chin J Ocul Fundus Dis, 2011, 27(6): 520-524. DOI: 10.3760/cma.j.issn.1005-1015.201.06.05.

Chinese Journal of Ocular Fundus Diseases

The characteristics of multifocal microperimetry and its relationship with visual acuity and multifocal ganglion cell complex in nonarteritic anterior ischemic optic neuropathy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content