The status and advances in the application of optical coherence tomography and optical coherence tomography angiography in non-arteritic ischemic optic neuropathy_Chinese Journal of Ocular Fundus Diseases

Authors：

 Gong Hongxia , Wang Lanxui

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin 300020, China;

Corresponding author：

Gong Hongxia, Email: ghx35@163.com

Keywords：

Optic neuropathy ischemic/diagnosis; Tomography, optical coherence; Optic disk; Nerve fibers; Choroid; Regional blood flow; Review

DOI：

10.3760/cma.j.issn.1005-1015.2018.01.024

Video：

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Abstract Full text Figures/Tables Video References Cited by

Non-arteritic ischemic optic neuropathy (NAION) is a neurological disease due to poor perfusion in optic disk. It causes severe visual function impairment, characterized by loss of vision and visual field defect. Optical coherence tomography (OCT) is vital for detecting anterior laminar depth, peripapillary nerve fiber layer thickness, ganglion cell complex thickness and peripapillary choroid thickness change in eyes with NAION at different course of the disease. In addition, OCT features are in accordance with visual function impairment. OCT angiography (OCTA) reveals retinal and choroidal vasculature networks in optic and macular area. OCTA revealed vasculature perfusion decline in eyes with NAION, even if their visual sensitivity and visual evoked potential were normal. Studying OCT and OCTA features is vital for exploring the pathogenesis and prognosis of NAION.

Citation： Gong Hongxia, Wang Lanxui. The status and advances in the application of optical coherence tomography and optical coherence tomography angiography in non-arteritic ischemic optic neuropathy. Chinese Journal of Ocular Fundus Diseases, 2018, 34(1): 80-82. doi: 10.3760/cma.j.issn.1005-1015.2018.01.024 Copy

1.	Hayreh SS. Ischemic optic neuropathy[J]. Prog Retin Eye Res, 2009, 28(1): 34-62. DOI: 10.1016/j.preteyeres.2008.11.002.
2.	Hirsch T, Remky A, Plange N, et al. Quantification of fluorescein angiography in patients with non-arteritic anterior ischemic optic neuropathy[J]. Ophthalmologe, 2011, 108(8): 728-732. DOI: 10.1007/s00347-011-2387-9.
3.	Arnold AC, Hepler RS. Fluorescein angiography in acute nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 1994, 117(2): 222-230.
4.	Kaup M, Plange N, Arend KO, et al. Retrobulbar haemodynamics in non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2006, 90(11): 1350-1353.
5.	Leiba H, Rachmiel R, Harris A, et al. Optic nerve head blood flow measurements in non-arteritic anterior ischaemic optic neuropathy[J]. Eye (Lond), 2000, 14(Pt 6): 828-833. DOI: 10.1038/eye.2000.231.
6.	Wang Y, Fawzi AA, Varma R, et al. Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases[J]. Invest Ophthalmol Vis Sci, 2011, 52(2): 840-845. DOI: 10.1167/iovs.10-5985.
7.	Moghimi S, Afzali M, Akbari M, et al. Crowded optic nerve head evaluation with optical coherence tomography in anterior ischemic optic neuropathy[J]. Eye (Lond), 2017, 31(8): 1191-1198. DOI: 10.1038/eye.2017.56.
8.	Han M, Zhao C, Han QH, et al. Change of retinal nerve optic neuropathy revesled by fourier anterior ischemic optic neuropathy revealed by fourier domain optical coherence tomography[J].Curr Eye Res, 2016, 41(8): 1076-1081. DOI: 10.3109/02713683.2015.1084640.
9.	Alasil T, Tan O, Lu AT, et al. Correlation of fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy[J]. Ophthalmic Surg Lasers Imaging, 2008, 39(4 Suppl): S71-79.
10.	Aggarwal D, Tan O, Huang D, et al. Patterns of ganglion cell complex and nerve fiber layer loss in nonarteritic ischemic optic neuropathy by fourier-domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(8): 4539-4545. DOI: 10.1167/iovs.11-9300.
11.	Oya D, Gamze K, Aylin Y, et al. Macular evaluation wıth spectral domain type optic coherence tomography in eyes with acute nonarteritic ischemic optic neuropathy at the presentation visit[J]. Open Ophthalmol J, 2017, 11: 17-23.DOI: 10.2174/1874364101711010017.
12.	Hedges TR, Vuong LN, Gonzalez-Garcia AO, et al.Subretinal fluid from anterior ischemic optic neuropathy demonstrated by optical coherence tomography[J].Arch Ophthalmol, 2008, 126(6): 812-815. DOI: 10.1001/archopht.126.6.812.
13.	Papchenko T, Grainger BT, Savino P, et al. Macular thickness predictive of visual field sensitivity in ischaemic optic neuropathy[J]. Acta Ophthalmol, 2012, 90(6): 463-469. DOI: 10.1111/j.1755-3768.2012.02467.x.
14.	Sun MH, Liao YJ. Structure-function analysis of nonarteritic anterior ischemic optic neuropathy and age-related differences in outcome[J].J Neuroophthalmol, 2017, 37(3): 258-264. DOI: 10.1097/WNO.0000000000000521.
15.	巩鸿霞, 庞雅菊, 王兰惠. 非动脉炎性前部缺血性视神经病变多焦视网膜电图特征及其与视力和黄斑中心区视网膜厚度的关系[J].中华眼底病杂志, 2015, 31(6): 532-535. DOI:10.3760/cma.j.issn.1005-1015.2015.06.005.Gong HX, Pang YJ, Wang LH. Characteristics of multifocal eletrotetinogram in nonarteritic anterior ischemic optic neuropathy and its relationship with visual acuity and macular central retinal thickness[J]. Chin J Ocul Fundus Dis, 2015, 31(6): 532-535. DOI:10.3760/cma.j.issn.1005-1015.2015.06.005.
16.	Lina N, Carrie H, John J, et al. Peripapillary pachychoroid in nonarteritic anterior ischemic optic neuropathy[J].Invest Ophthalmol Vis Sci, 2016, 57(11): 4679-4685. DOI: 10.1167/iovs.16-19315.
17.	Fard MA, Abdi P, Kasaei A, et al. Perpapillary choroidal thickness in nonarteritic anterior ischemic optic neuropathy[J].Invest Ophthalmol Vis Sci, 2015, 5(6): 3027-3033. DOI: 10.1167/iovs.14-15661.
18.	Pérez-Sarriegui A, Muñoz-Negrete FJ, Noval S, et al. Automated evaluation of choroidal thickness and minimum rim width thickness in nonarteritic anterior ischemic optic neuropathy[J/OL].J Neuroophthalmol, 2017, 2017:E1[2017-09-06]. http://insights.ovid.com/pubmed?pmid=28885450. DOI: 10.1097/WNO.0000000000000571. [publishedonline ahead of print].
19.	Saban G, Sansal G, Bengu EK, et al. Evaluation of choroidal thickness in non-arteritic anterior ischaemic optic neuropathy at the acute and chronic stages[J].Neuroophthalmology, 2016, 40(4): 181-187. DOI: 10.1080/01658107.2016.1198918.
20.	Jiang L, Chen L, Qiu X, et al. Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy[J]. BMC Ophthalmol, 2016, 16(1): 153. DOI: 10.1186/s12886-016-0313-2.
21.	Dias-Santos AF, Ferreira J, Pinto L, et al. Choroidal thickness in nonarteritic anterior ischaemic optic neuropathy: a study with optical coherence tomography[J]. Neuro-Ophthalmology, 2014, 38: 173-179.
22.	Schuster AK, Steinmetz P, Forster TM, et al.Choroidal thickness in nonarteritic anterior ischemic optic neuropathy[J].Am J Ophthalmol, 2014, 158(6): 1342-1347. DOI:10.1016/j.ajo.2014.09.008.
23.	姜利斌, 陈兰兰, 仇秀娟, 等.非动脉炎性前部缺血性视神经病变患眼脉络膜厚度研究[J]. 中华眼底病杂志, 2017, 33(5): 462-466. DOI:10.3760/cma.j.issn.1005-1015.2017.05.006.Jiang LB, Chen LL, Qiu XJ, et al. Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 462-466. DOI:10.3760/cma.j.issn.1005-1015.2017.05.006.
24.	Saeedi O, Pillar A, Jefferys J, et al.Change in choroidal thickness and axial length with change in intraocular pressure after trabeculectomy[J].Br J Ophthalmol, 2014, 98(7): 976-979. DOI:DOI:10.1136/bjophthalmol-2013-304433.
25.	Balducci N, Morara M, Veronese C, et al. Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy[J]. Graefe’s Arch Clin Exp Ophthalmol, 2017, 255(11): 2255-2261. DOI: 10.1007/s00417-017-3774-y.
26.	Sharma S, Ang M, Najjar RP, et al. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2017, 101(8): 1045-1051. DOI: 10.1136/bjophthalmol-2016-309245.
27.	杨沫, 王伟, 魏世辉, 等. 非动脉炎性前部缺血性视神经病变光相干断层扫描血管成像特征及其与视野的相关性分析[J].中华眼底病杂志, 2017, 33(5): 453-457. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.004.Yang M, Wang W, Wei SH, et al. The characteristics of optical coherence tomography angiography and its relationship with visual field defect in nonarteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 453-457. DOI:10.3760/cma.j.issn.1005-1015.2017.05.004.
28.	Rougier MB, Delyfer MN, Korobelnik JF. OCT angiography of acute non-arteritic anterior ischemic optic neuropathy[J].J Fr Ophtalmol, 2017, 40(2): 102-109. DOI: 10.1016/j.jfo.2016.09.020.
29.	Liu CH, Kao LY, Sun MH, et al. Retinal vessel density in optical coherence tomography angiography in optic atrophy after nonarteritic anterior ischemic optic neuropathy[J/OL].J Ophthalmol, 2017, 2017:9632647[2017-02-19]. https://dx.doi.org/10.1155/2017/9632647. DOI: 10.1155/2017/9632647.

1. Hayreh SS. Ischemic optic neuropathy[J]. Prog Retin Eye Res, 2009, 28(1): 34-62. DOI: 10.1016/j.preteyeres.2008.11.002.
2. Hirsch T, Remky A, Plange N, et al. Quantification of fluorescein angiography in patients with non-arteritic anterior ischemic optic neuropathy[J]. Ophthalmologe, 2011, 108(8): 728-732. DOI: 10.1007/s00347-011-2387-9.
3. Arnold AC, Hepler RS. Fluorescein angiography in acute nonarteritic anterior ischemic optic neuropathy[J]. Am J Ophthalmol, 1994, 117(2): 222-230.
4. Kaup M, Plange N, Arend KO, et al. Retrobulbar haemodynamics in non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2006, 90(11): 1350-1353.
5. Leiba H, Rachmiel R, Harris A, et al. Optic nerve head blood flow measurements in non-arteritic anterior ischaemic optic neuropathy[J]. Eye (Lond), 2000, 14(Pt 6): 828-833. DOI: 10.1038/eye.2000.231.
6. Wang Y, Fawzi AA, Varma R, et al. Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases[J]. Invest Ophthalmol Vis Sci, 2011, 52(2): 840-845. DOI: 10.1167/iovs.10-5985.
7. Moghimi S, Afzali M, Akbari M, et al. Crowded optic nerve head evaluation with optical coherence tomography in anterior ischemic optic neuropathy[J]. Eye (Lond), 2017, 31(8): 1191-1198. DOI: 10.1038/eye.2017.56.
8. Han M, Zhao C, Han QH, et al. Change of retinal nerve optic neuropathy revesled by fourier anterior ischemic optic neuropathy revealed by fourier domain optical coherence tomography[J].Curr Eye Res, 2016, 41(8): 1076-1081. DOI: 10.3109/02713683.2015.1084640.
9. Alasil T, Tan O, Lu AT, et al. Correlation of fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy[J]. Ophthalmic Surg Lasers Imaging, 2008, 39(4 Suppl): S71-79.
10. Aggarwal D, Tan O, Huang D, et al. Patterns of ganglion cell complex and nerve fiber layer loss in nonarteritic ischemic optic neuropathy by fourier-domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(8): 4539-4545. DOI: 10.1167/iovs.11-9300.
11. Oya D, Gamze K, Aylin Y, et al. Macular evaluation wıth spectral domain type optic coherence tomography in eyes with acute nonarteritic ischemic optic neuropathy at the presentation visit[J]. Open Ophthalmol J, 2017, 11: 17-23.DOI: 10.2174/1874364101711010017.
12. Hedges TR, Vuong LN, Gonzalez-Garcia AO, et al.Subretinal fluid from anterior ischemic optic neuropathy demonstrated by optical coherence tomography[J].Arch Ophthalmol, 2008, 126(6): 812-815. DOI: 10.1001/archopht.126.6.812.
13. Papchenko T, Grainger BT, Savino P, et al. Macular thickness predictive of visual field sensitivity in ischaemic optic neuropathy[J]. Acta Ophthalmol, 2012, 90(6): 463-469. DOI: 10.1111/j.1755-3768.2012.02467.x.
14. Sun MH, Liao YJ. Structure-function analysis of nonarteritic anterior ischemic optic neuropathy and age-related differences in outcome[J].J Neuroophthalmol, 2017, 37(3): 258-264. DOI: 10.1097/WNO.0000000000000521.
15. 巩鸿霞, 庞雅菊, 王兰惠. 非动脉炎性前部缺血性视神经病变多焦视网膜电图特征及其与视力和黄斑中心区视网膜厚度的关系[J].中华眼底病杂志, 2015, 31(6): 532-535. DOI:10.3760/cma.j.issn.1005-1015.2015.06.005.Gong HX, Pang YJ, Wang LH. Characteristics of multifocal eletrotetinogram in nonarteritic anterior ischemic optic neuropathy and its relationship with visual acuity and macular central retinal thickness[J]. Chin J Ocul Fundus Dis, 2015, 31(6): 532-535. DOI:10.3760/cma.j.issn.1005-1015.2015.06.005.
16. Lina N, Carrie H, John J, et al. Peripapillary pachychoroid in nonarteritic anterior ischemic optic neuropathy[J].Invest Ophthalmol Vis Sci, 2016, 57(11): 4679-4685. DOI: 10.1167/iovs.16-19315.
17. Fard MA, Abdi P, Kasaei A, et al. Perpapillary choroidal thickness in nonarteritic anterior ischemic optic neuropathy[J].Invest Ophthalmol Vis Sci, 2015, 5(6): 3027-3033. DOI: 10.1167/iovs.14-15661.
18. Pérez-Sarriegui A, Muñoz-Negrete FJ, Noval S, et al. Automated evaluation of choroidal thickness and minimum rim width thickness in nonarteritic anterior ischemic optic neuropathy[J/OL].J Neuroophthalmol, 2017, 2017:E1[2017-09-06]. http://insights.ovid.com/pubmed?pmid=28885450. DOI: 10.1097/WNO.0000000000000571. [publishedonline ahead of print].
19. Saban G, Sansal G, Bengu EK, et al. Evaluation of choroidal thickness in non-arteritic anterior ischaemic optic neuropathy at the acute and chronic stages[J].Neuroophthalmology, 2016, 40(4): 181-187. DOI: 10.1080/01658107.2016.1198918.
20. Jiang L, Chen L, Qiu X, et al. Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy[J]. BMC Ophthalmol, 2016, 16(1): 153. DOI: 10.1186/s12886-016-0313-2.
21. Dias-Santos AF, Ferreira J, Pinto L, et al. Choroidal thickness in nonarteritic anterior ischaemic optic neuropathy: a study with optical coherence tomography[J]. Neuro-Ophthalmology, 2014, 38: 173-179.
22. Schuster AK, Steinmetz P, Forster TM, et al.Choroidal thickness in nonarteritic anterior ischemic optic neuropathy[J].Am J Ophthalmol, 2014, 158(6): 1342-1347. DOI:10.1016/j.ajo.2014.09.008.
23. 姜利斌, 陈兰兰, 仇秀娟, 等.非动脉炎性前部缺血性视神经病变患眼脉络膜厚度研究[J]. 中华眼底病杂志, 2017, 33(5): 462-466. DOI:10.3760/cma.j.issn.1005-1015.2017.05.006.Jiang LB, Chen LL, Qiu XJ, et al. Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 462-466. DOI:10.3760/cma.j.issn.1005-1015.2017.05.006.
24. Saeedi O, Pillar A, Jefferys J, et al.Change in choroidal thickness and axial length with change in intraocular pressure after trabeculectomy[J].Br J Ophthalmol, 2014, 98(7): 976-979. DOI:DOI:10.1136/bjophthalmol-2013-304433.
25. Balducci N, Morara M, Veronese C, et al. Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy[J]. Graefe’s Arch Clin Exp Ophthalmol, 2017, 255(11): 2255-2261. DOI: 10.1007/s00417-017-3774-y.
26. Sharma S, Ang M, Najjar RP, et al. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy[J]. Br J Ophthalmol, 2017, 101(8): 1045-1051. DOI: 10.1136/bjophthalmol-2016-309245.
27. 杨沫, 王伟, 魏世辉, 等. 非动脉炎性前部缺血性视神经病变光相干断层扫描血管成像特征及其与视野的相关性分析[J].中华眼底病杂志, 2017, 33(5): 453-457. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.004.Yang M, Wang W, Wei SH, et al. The characteristics of optical coherence tomography angiography and its relationship with visual field defect in nonarteritic anterior ischemic optic neuropathy[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 453-457. DOI:10.3760/cma.j.issn.1005-1015.2017.05.004.
28. Rougier MB, Delyfer MN, Korobelnik JF. OCT angiography of acute non-arteritic anterior ischemic optic neuropathy[J].J Fr Ophtalmol, 2017, 40(2): 102-109. DOI: 10.1016/j.jfo.2016.09.020.
29. Liu CH, Kao LY, Sun MH, et al. Retinal vessel density in optical coherence tomography angiography in optic atrophy after nonarteritic anterior ischemic optic neuropathy[J/OL].J Ophthalmol, 2017, 2017:9632647[2017-02-19]. https://dx.doi.org/10.1155/2017/9632647. DOI: 10.1155/2017/9632647.

Chinese Journal of Ocular Fundus Diseases

The status and advances in the application of optical coherence tomography and optical coherence tomography angiography in non-arteritic ischemic optic neuropathy

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