Inverted internal limiting membrane flap technique for macular hole retinal detachment of high myopia_Chinese Journal of Ocular Fundus Diseases

Authors：

Liu Haiyun ,  Sun Xiaodong

Department of Ophthalmology, Shanghai General Hospital of Shanghai Jiao Tong University, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China;

Corresponding author：

Sun Xiaodong, Email: xdsun@sjtu.edu.cn

Keywords：

Myopia, degenerative/complications; Retinal perforations/surgery; Retinal detachment/surgery; Vitreoretinal surgery; Epiretinal membrane; Editorial

DOI：

10.3760/cma.j.issn.1005-1015.2018.02.001

Video：

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The reattachment rate, macular hole (MH) closure rate, visual acuity improvement and re-detachment rate of MH retinal detachment (MHRD) of high myopia are not satisfactory owing to long axis oculi, posterior scleral staphyloma and macular atrophy. At present, minimally invasive vitrectomy surgery combined with the internal limiting membrane flap technique has become popular in the treatment of MHRD, as it can promote MH closure, and significantly improve the outcome of MHRD. However if this method can improve the postoperative visual function is still controversial. The advantage of this technique is that the loosened internal limiting membrane is applied to cover the MH surface to form a scaffold structure similar to the basement membrane. It can stimulate Müller cell gliosis more effectively, and promote tissue filling in the MH which results in MH closure. It can also promote retinal reattachment and reduce the likelihood of retinal re-detachment. This technique is expected to be a standard surgical method for the treatment of MHRD of high myopia in the future. The inserted internal limiting membrane flap technique is relatively easy to perform, induces stable flaps by simple procedures, and can be an essential complement procedure of the inverted internal limiting membrane flap technique. In order to reduce the recurrence rate in the future, it is necessary to further define the indications of different surgical methods and the predictive effects of MH healing mode on the success rate and visual function recovery.

Citation： Liu Haiyun, Sun Xiaodong. Inverted internal limiting membrane flap technique for macular hole retinal detachment of high myopia. Chinese Journal of Ocular Fundus Diseases, 2018, 34(2): 107-110. doi: 10.3760/cma.j.issn.1005-1015.2018.02.001 Copy

1.	Gonvers M, Machemer R. A new approach to treating retinal detachment with macular hole[J]. Am J Ophthalmol, 1982, 94(4): 468-472.
2.	Li XI, Wang W, Tang S, et al. Gas injection versus vitrectomy with gas for treating retinal detachment owing to macular hole in high myopes[J]. Ophthalmology, 2009, 116(6): 1182-1187. DOI: 10.1016/j.ophtha.2009.01.003.
3.	Oshima Y, Ikuno Y, Motokura M, et al. Complete epiretinal membrane separation in highly myopic eyes with retinal detachment resulting from a macular hole[J].Am J Ophthalmol, 1998, 126(5): 669-676.
4.	Lam RF, Lai WW, Cheung BT, et al. Pars plana vitrectomy and perfluoropropane (C3F8) tamponade for retinal detachment due to myopic macular hole: a prognostic factor analysis[J]. Am J Ophthalmol, 2006, 142(6): 938-944.DOI: 10.1016/j.ajo.2006.07.056.
5.	Scholda C, Egger SF. Silicone oil tamponade in eyes with posterior staphyloma and retinal detachment caused by macular hole[J]. Acta Ophthalmol Scand, 1998, 76(6): 704-706.
6.	Mancino R, Ciuffoletti E, Martucci A, et al. Anatomical and functional results of macular hole retinal detachment surgery in patients with high myopia and posterior staphyloma treated with perfluoropropane gas or silicone oil[J]. Retina, 2013, 33(3): 586-592. DOI: 10.1097/IAE.0b013e3182670fd7.
7.	Nishimura A, Kimura M, Saito Y, et al. Efficacy of primary silicone oil tamponade for the treatment of retinal detachment caused by macular hole in high myopia[J]. Am J Ophthalmol, 2011, 151: 148-155.DOI: 10.1016/j.ajo.2010.07.023.
8.	Kadonosono K, Yazama F, Itoh N, et al. Treatment of retinal detachment resulting from myopic macular hole with internal limiting membrane removal[J]. Am J Ophthalmol, 2001, 131 (2): 203-207.
9.	Uemoto R, Yamamoto S, Tsukahara I, et al. Efficacy of internal limiting membrane removal for retinal detachments resulting from a myopic macular hole[J]. Retina, 2004, 24(4): 560-566.
10.	Ichibe M, Yoshizawa T, Murakami K, et al. Surgical management of retinal detachment associated with myopic macular hole: anatomic and functional status of the macula[J]. Am J Ophthalmol, 2003, 136(2): 277-284.
11.	Tornambe PE, Poliner LS, Cohen RG.Definition of macular hole surgery end points: elevated/open, flat/open, flat/closed[J].Retina. 1998;18(3): 286-287.
12.	Imai M, Iijima H, Gotoh T, et al.Optical coherence tomography of successfully repaired idiopathic macular holes[J].Am J Ophthalmol, 1999, 128(5): 621-627.
13.	Kuriyama S, Hayashi H, Jingami Y, et al.Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia[J]. Am J Ophthalmol, 2013, 156(1): 125-131.DOI: 10.1016/j.ajo.2013.02.014.
14.	Takahashi H, Inoue M, Koto T, et al.Inverted internal limiting membrane flap technique for treatment of macular hole retinal detachment in highly myopic eyes[J/OL]. Retina, 2017, 2017: E1 [2017-10-23]. https: //insights.ovid.com/pubmed?pmid=29065014. DOI: 10.1097/IAE.0000000000001898.[publishedonline ahead of print].
15.	Sasaki H, Shiono A, Kogo J, et al.Inverted internal limiting membrane flap technique as a useful procedure for macular holeassociated retinal detachment in highly myopic eyes[J]. Eye (Lond), 2017, 31(4): 545-550.DOI: 10.1038/eye.2016.263.
16.	Kinoshita T, Onoda Y, Maeno T. Long-term surgical outcomes of the inverted internal limiting membrane flap technique in highly myopic macular hole retinal detachment[J]. Graefe’s Arch Clin Exp Ophthalmol, 2017, 255(6): 1101-1106.DOI: 10.1007/s00417-017-3614-0.
17.	Hayashi H, Kuriyama S. Foveal microstructure in macular holes surgically closed by inverted internal limiting membrane flap technique[J]. Retina, 2014, 34(12): 2444-2450. DOI: 10.1097/IAE.0000000000000252.
18.	Okuda T, Higashide T, Kobayashi K, et al.Macular hole closure over residual subretinal fluid by an inverted internal limiting membrane flap technique in patients with macular hole retinal detachment in high myopia[J]. Retin Cases Brief Rep, 2016, 10(2): 140-144. DOI: 10.1097/ICB.0000000000000205.
19.	Chen SN.Large semicircular inverted internal limiting membrane flap in the treatment of macular hole in high myopia[J].Graefe’s Arch Clin Exp Ophthalmol, 2017, 255(12): 2337-2345. DOI: 10.1007/s00417-017-3808-5.
20.	徐昶中, 吴建华, 何俊文, 等.单层内界膜翻转治疗高度近视眼黄斑裂孔视网膜脱离的临床观察[J].中华眼科杂志, 2017, 53 (5): 338-343.DOI: 10.3760/cma.j.issn.0412-4081.2017.05.005.Xu CZ, Wu JH, He JW, et al.Observation of single-layered inverted internal limiting membrane flap technique for macular hole with retinal detachment in high myopia[J].Chin J Ophthalmo, 2017, 53 (5): 338-343.DOI: 10.3760/cma.j.issn.0412-4081.2017.05.005.
21.	刘海芸, 高敏, 杨名, 等.玻璃体切割联合改良内界膜覆盖手术治疗复杂黄斑裂孔疗效观察[J].中华眼底病杂志, 2017, 33(4): 354-358.DOI: 10.3760/cma.j.issn.1005-1015.2017.04.007.Liu HY, Gao M, Yang M, et al.Clinical efficacy of vitrectomy combined with modified inverted internal limiting membrane flap covering technique for complicated macular hole[J].Chin J Ocul Fundus Dis, 2017, 33(4): 354-358.DOI: 10.3760/cma.j.issn.1005-1015.2017.04.007.
22.	Ho TC, Ho A, Chen MS. Vitrectomy with a modified temporal inverted limiting membrane flap to reconstruct the foveolar architecture for macular hole retinal detachment in highly myopic eyes[J]. Acta Ophthalmol, 2018, 96(1): 46-53.DOI: 10.1111/aos.13514.
23.	Michalewska Z, Michalewski J, Adelman RA, et al. Inverted internal limiting membrane flap technique for large macular holes[J]. Ophthalmology, 2010, 117(10): 2018-2025. DOI: 10.1016/j.ophtha.2010.02.011.
24.	Shin MK, Park KH, Park SW, et al.Perfluoro-n-octane-assisted single-layered inverted internal limiting membrane flap technique for macular hole surgery[J]. Retina, 2014, 34(9): 1905-1910. DOI: 10.1097/IAE.0000000000000339.
25.	Kuriyama S, Hayashi H, Jingami Y, et al.Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia[J]. Am J Ophthalmol, 2013, 156 (1): 125-131.DOI: 10.1016/j.ajo.2013.02.014.
26.	Michalewska Z, Michalewski J, Dulczewska-Cichecka K, et al.Inverted internal limiting membrane flap technique for surgical repair of myopic macular holes[J]. Retina, 2014, 34(4): 664-669.DOI: 10.1097/IAE.0000000000000042.
27.	Oleñik A, Rios J, Mateo C. Inverted internal limiting membrane flap technique for macular holes in high myopia with axial length≥30 mm[J]. Retina, 2016, 36(9): 1688-1693. DOI: 10.1097/IAE.0000000000001010.
28.	Chen SN, Yang CM. Inverted internal limiting membrane insertion for macular hole-associated retinal detachment in high myopia[J]. Am J Ophthalmol, 2016, 162: 99-106. DOI: 10.1016/j.ajo.2015.11.013.
29.	Baba R, Wakabayashi Y, Umazume K, et al. Efficacy of the inverted internal limiting membrane flap technique with vitrectomy for retinal detachment associated with myopic macular holes[J]. Retina, 2017, 37(3): 466-471.DOI: 10.1097/IAE.0000000000001211.
30.	Lai CC, Chen YP, Wang NK, et al. Vitrectomy with internal limiting membrane repositioning and autologous blood for macular hole retinal detachment in highly myopic eyes[J]. Ophthalmology, 2015, 122(9): 1889-1898.DOI: 10.1016/j.ophtha.2015.05.040.

1. Gonvers M, Machemer R. A new approach to treating retinal detachment with macular hole[J]. Am J Ophthalmol, 1982, 94(4): 468-472.
2. Li XI, Wang W, Tang S, et al. Gas injection versus vitrectomy with gas for treating retinal detachment owing to macular hole in high myopes[J]. Ophthalmology, 2009, 116(6): 1182-1187. DOI: 10.1016/j.ophtha.2009.01.003.
3. Oshima Y, Ikuno Y, Motokura M, et al. Complete epiretinal membrane separation in highly myopic eyes with retinal detachment resulting from a macular hole[J].Am J Ophthalmol, 1998, 126(5): 669-676.
4. Lam RF, Lai WW, Cheung BT, et al. Pars plana vitrectomy and perfluoropropane (C3F8) tamponade for retinal detachment due to myopic macular hole: a prognostic factor analysis[J]. Am J Ophthalmol, 2006, 142(6): 938-944.DOI: 10.1016/j.ajo.2006.07.056.
5. Scholda C, Egger SF. Silicone oil tamponade in eyes with posterior staphyloma and retinal detachment caused by macular hole[J]. Acta Ophthalmol Scand, 1998, 76(6): 704-706.
6. Mancino R, Ciuffoletti E, Martucci A, et al. Anatomical and functional results of macular hole retinal detachment surgery in patients with high myopia and posterior staphyloma treated with perfluoropropane gas or silicone oil[J]. Retina, 2013, 33(3): 586-592. DOI: 10.1097/IAE.0b013e3182670fd7.
7. Nishimura A, Kimura M, Saito Y, et al. Efficacy of primary silicone oil tamponade for the treatment of retinal detachment caused by macular hole in high myopia[J]. Am J Ophthalmol, 2011, 151: 148-155.DOI: 10.1016/j.ajo.2010.07.023.
8. Kadonosono K, Yazama F, Itoh N, et al. Treatment of retinal detachment resulting from myopic macular hole with internal limiting membrane removal[J]. Am J Ophthalmol, 2001, 131 (2): 203-207.
9. Uemoto R, Yamamoto S, Tsukahara I, et al. Efficacy of internal limiting membrane removal for retinal detachments resulting from a myopic macular hole[J]. Retina, 2004, 24(4): 560-566.
10. Ichibe M, Yoshizawa T, Murakami K, et al. Surgical management of retinal detachment associated with myopic macular hole: anatomic and functional status of the macula[J]. Am J Ophthalmol, 2003, 136(2): 277-284.
11. Tornambe PE, Poliner LS, Cohen RG.Definition of macular hole surgery end points: elevated/open, flat/open, flat/closed[J].Retina. 1998;18(3): 286-287.
12. Imai M, Iijima H, Gotoh T, et al.Optical coherence tomography of successfully repaired idiopathic macular holes[J].Am J Ophthalmol, 1999, 128(5): 621-627.
13. Kuriyama S, Hayashi H, Jingami Y, et al.Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia[J]. Am J Ophthalmol, 2013, 156(1): 125-131.DOI: 10.1016/j.ajo.2013.02.014.
14. Takahashi H, Inoue M, Koto T, et al.Inverted internal limiting membrane flap technique for treatment of macular hole retinal detachment in highly myopic eyes[J/OL]. Retina, 2017, 2017: E1 [2017-10-23]. https: //insights.ovid.com/pubmed?pmid=29065014. DOI: 10.1097/IAE.0000000000001898.[publishedonline ahead of print].
15. Sasaki H, Shiono A, Kogo J, et al.Inverted internal limiting membrane flap technique as a useful procedure for macular holeassociated retinal detachment in highly myopic eyes[J]. Eye (Lond), 2017, 31(4): 545-550.DOI: 10.1038/eye.2016.263.
16. Kinoshita T, Onoda Y, Maeno T. Long-term surgical outcomes of the inverted internal limiting membrane flap technique in highly myopic macular hole retinal detachment[J]. Graefe’s Arch Clin Exp Ophthalmol, 2017, 255(6): 1101-1106.DOI: 10.1007/s00417-017-3614-0.
17. Hayashi H, Kuriyama S. Foveal microstructure in macular holes surgically closed by inverted internal limiting membrane flap technique[J]. Retina, 2014, 34(12): 2444-2450. DOI: 10.1097/IAE.0000000000000252.
18. Okuda T, Higashide T, Kobayashi K, et al.Macular hole closure over residual subretinal fluid by an inverted internal limiting membrane flap technique in patients with macular hole retinal detachment in high myopia[J]. Retin Cases Brief Rep, 2016, 10(2): 140-144. DOI: 10.1097/ICB.0000000000000205.
19. Chen SN.Large semicircular inverted internal limiting membrane flap in the treatment of macular hole in high myopia[J].Graefe’s Arch Clin Exp Ophthalmol, 2017, 255(12): 2337-2345. DOI: 10.1007/s00417-017-3808-5.
20. 徐昶中, 吴建华, 何俊文, 等.单层内界膜翻转治疗高度近视眼黄斑裂孔视网膜脱离的临床观察[J].中华眼科杂志, 2017, 53 (5): 338-343.DOI: 10.3760/cma.j.issn.0412-4081.2017.05.005.Xu CZ, Wu JH, He JW, et al.Observation of single-layered inverted internal limiting membrane flap technique for macular hole with retinal detachment in high myopia[J].Chin J Ophthalmo, 2017, 53 (5): 338-343.DOI: 10.3760/cma.j.issn.0412-4081.2017.05.005.
21. 刘海芸, 高敏, 杨名, 等.玻璃体切割联合改良内界膜覆盖手术治疗复杂黄斑裂孔疗效观察[J].中华眼底病杂志, 2017, 33(4): 354-358.DOI: 10.3760/cma.j.issn.1005-1015.2017.04.007.Liu HY, Gao M, Yang M, et al.Clinical efficacy of vitrectomy combined with modified inverted internal limiting membrane flap covering technique for complicated macular hole[J].Chin J Ocul Fundus Dis, 2017, 33(4): 354-358.DOI: 10.3760/cma.j.issn.1005-1015.2017.04.007.
22. Ho TC, Ho A, Chen MS. Vitrectomy with a modified temporal inverted limiting membrane flap to reconstruct the foveolar architecture for macular hole retinal detachment in highly myopic eyes[J]. Acta Ophthalmol, 2018, 96(1): 46-53.DOI: 10.1111/aos.13514.
23. Michalewska Z, Michalewski J, Adelman RA, et al. Inverted internal limiting membrane flap technique for large macular holes[J]. Ophthalmology, 2010, 117(10): 2018-2025. DOI: 10.1016/j.ophtha.2010.02.011.
24. Shin MK, Park KH, Park SW, et al.Perfluoro-n-octane-assisted single-layered inverted internal limiting membrane flap technique for macular hole surgery[J]. Retina, 2014, 34(9): 1905-1910. DOI: 10.1097/IAE.0000000000000339.
25. Kuriyama S, Hayashi H, Jingami Y, et al.Efficacy of inverted internal limiting membrane flap technique for the treatment of macular hole in high myopia[J]. Am J Ophthalmol, 2013, 156 (1): 125-131.DOI: 10.1016/j.ajo.2013.02.014.
26. Michalewska Z, Michalewski J, Dulczewska-Cichecka K, et al.Inverted internal limiting membrane flap technique for surgical repair of myopic macular holes[J]. Retina, 2014, 34(4): 664-669.DOI: 10.1097/IAE.0000000000000042.
27. Oleñik A, Rios J, Mateo C. Inverted internal limiting membrane flap technique for macular holes in high myopia with axial length≥30 mm[J]. Retina, 2016, 36(9): 1688-1693. DOI: 10.1097/IAE.0000000000001010.
28. Chen SN, Yang CM. Inverted internal limiting membrane insertion for macular hole-associated retinal detachment in high myopia[J]. Am J Ophthalmol, 2016, 162: 99-106. DOI: 10.1016/j.ajo.2015.11.013.
29. Baba R, Wakabayashi Y, Umazume K, et al. Efficacy of the inverted internal limiting membrane flap technique with vitrectomy for retinal detachment associated with myopic macular holes[J]. Retina, 2017, 37(3): 466-471.DOI: 10.1097/IAE.0000000000001211.
30. Lai CC, Chen YP, Wang NK, et al. Vitrectomy with internal limiting membrane repositioning and autologous blood for macular hole retinal detachment in highly myopic eyes[J]. Ophthalmology, 2015, 122(9): 1889-1898.DOI: 10.1016/j.ophtha.2015.05.040.

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Chinese Journal of Ocular Fundus Diseases

Inverted internal limiting membrane flap technique for macular hole retinal detachment of high myopia

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