• Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China;
Wu Qiang, Email: qiang.wu@shsmu.edu.cn
Export PDF Favorites Scan Get Citation

ObejctiveTo investigate the consistency and reproducibility of macular perfusion parameters in early diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA).MethodsA prospective cross-sectional observational study. Forty-six patients (46 eyes) diagnosed with mild nonproliferative DR were included in this study. There were 24 males and 22 females, with the mean age of 59.16±10.32 years. Two macular scan sizes of 3 mm×3 mm and 6 mm×6 mm were performed by the same operator, and the same test was performed by another operator. The superficial retinal layer (SRL) and deep retinal layer (DRL) in the foveal avascular zone (FAZ) and vessel density (VD) were quantified. The consistency of the two scan sizes and the reproducibility of the same scan size were also evaluated. The consistency was determined by the intraclass correlation coefficient (ICC). If the intraclass correlation coefficient (ICC)>0.80, consistency was good; if 0.4≤ICC<0.8, consistency was general; if ICC<0.40, consistency was poor.ResultsIn the 3 mm×3 mm and 6 mm×6 mm scanning sizes, the mean results of the two examiners were calculated. The FAZ of SRL were 0.39±0.13 mm2 and 0.42±0.15 mm2, FAZ of DRL were 0.74±0.22 mm2 and 0.89±0.23 mm2. The VD of SRL were (32.23±2.86)% and (31.91±3.01)%, VD of DRL were (43.73±4.64)% and (45.12±5.49)%. The consistency analysis showed that the ICC of SRL-FAZ and DRL-FAZ were 0.920 and 0.812, respectively; the ICC of VD were 0.833 and 0.830, respectively. The consistency was good. The reproducibility analysis of different examiners in the same scan size was better in the consistency of SRL FAZ and VD.ConclusionOCTA in two scanning sizes to measure FAZ and VD of early DR has good consistency and reproducibility.

Citation: Wang Xiangning, Zhao Jiawei, Li Shuting, Du Xinhua, Wu Qiang. The consistency and reproducibility of macular perfusion parameters in early diabetic retinopathy using optical coherence tomography angiography. Chinese Journal of Ocular Fundus Diseases, 2018, 34(4): 323-327. doi: 10.3760/cma.j.issn.1005-1015.2018.04.003 Copy

  • Previous Article

    The shortcoming and developing perspective of optical coherence tomography angiography in clinical diagnosis and treatment of ocular fundus diseases
  • Next Article

    The macular capillary morphology in diabetic patients by optical coherence tomography angiography