Quantitative analysis of visual field loss after 577 nm krypton pan-retinal photocoagulation for diabetic retinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

 Wu Chunrong , Yan Hongxin , Guo Huiling , Xia Liping , Liu Liang , Qu Liyan

Department of Ophthalmology, No. 306 Hospital of PLA, Beijing 100101, China;

Corresponding author：

Wu Chunrong, Email: chun130@foxmail.com

Keywords：

Diabetic retinopathy/therapy; Laser coagulation/adverse effects; Visual fields

DOI：

10.3760/cma.j.issn.1005-1015.2019.01.014

Video：

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Objective To observe the visual field loss after 577 nm krypton pan-retinal photocoagulation (PRP) in the treatment of diabetic retinopathy (DR). Methods A prospective clinical studies. Forty-six eyes of 26 patients with proliferative DR (PDR) and severe non-proliferative DR (NPDR) diagnosed by clinical examination from No. 306 Hospital of PLA during January 2014 and December 2015 were included in this study. Among them, 21 eyes of NPDR and 20 eyes of PDR; 13 eyes with diabetic macular edema (DME) (DME group) and 28 eyes without DME (non-DME group). All eyes underwent best corrected visual acuity (BCVA), fundus color photography, fundus fluorescein angiography (FFA) and optical coherence tomography (SD-OCT) examinations. The visual field index (VFI) and visual field mean defect (MD) values were recorded by Humphrey-7401 automatic visual field examination (center 30° visual field). The BCVA of DR eyes was 0.81±0.28; the VFI and MD values were (89.8±8.4)% and −7.5±3.85 dB, respectively. The BCVA of the eyes in the without DME group and DME group were 0.92±0.20 and 0.57±0.27, the VFI were (90.86±7.86)% and (87.46±9.41)%, the MD values were −6.86±3.43 and 8.87±4.48 dB. PRP was performed on eyes using 577 nm krypton laser. The changes of VFI, MD and BCVA were observed at 1, 3, and 6 months after treatment. Results Compared with before treatment, the VFI of DR eyes decreased by 12.0%, 12.3% and 14.8% (t=7.423, 4.549, 4.79; P＜0.001); the MD values were increased by −4.55, −4.75, 6.07 dB (t=−8.221, −5.313, −5.383; P＜0.001) at 1, 3 and 6 months after treatment, the differences were statistically significant. There was no difference on VFI (t=1.090, −0.486; P＞0.05) and MD value (t=−0.560, −0.337; P＞0.05) at different time points after treatment. Compared with before treatment, the BCVA was significantly decreased in DR eyes at 1 month after treatment, the difference was statistically significant (t=2.871, P＜0.05). Before and after treatment, the BCVA of the DME group was lower than that of the non-DME group, the difference were statistically significant (t=4.560, 2.848, 3.608, 5.694; P＜0.001); but there was no differences on the VFI (t=1.209, 0.449, 0.922, 0.271; P＞0.05) and MD values (t=1.582, 0.776, 0.927, 1.098; P＞0.05) between the two groups. Conclusion The range of 30° visual field loss is about 12%-14.8% after 577 nm krypton laser PRP for DR. VFI and MD can quantitatively analyze the and extent of visual field loss after PRP treatment.

Citation： Wu Chunrong, Yan Hongxin, Guo Huiling, Xia Liping, Liu Liang, Qu Liyan. Quantitative analysis of visual field loss after 577 nm krypton pan-retinal photocoagulation for diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2019, 35(1): 65-69. doi: 10.3760/cma.j.issn.1005-1015.2019.01.014 Copy

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7.	The Early Treatment Diabetic Retinopathy Study Research Group. Techniques for scatter and local photocoagulation treatment of diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report no.3[J]. Int Ophthalmol Clin, 1987, 27(4): 254-264. DOI: 10.1097/00004397-198702740-00005.
8.	张茉莉, 田蓓, 魏文斌. 577 nm激光多点与单点扫描模式全视网膜激光光凝治疗非增生期糖尿病视网膜病变疗效比较[J]. 中华眼底病杂志, 2015, 31(1): 36-40. DOI: 10.3760/cma.j.issn.1005-1015.2015.01.010.Zhang ML, Tian B, Wei WB. Comparison of the efficacy of multi-point or single-point mode of 577 nm laser in the treatment of diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2015, 31(1): 36-40. DOI: 10.3760/cma.j.issn.1005-1015.2015.01.010.
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11.	姚慧萍, 丁慰祖, 刘嫣, 等. 视野与糖尿病视网膜病变相关性的研究[J]. 临床眼科杂志, 2012, 20(3): 235-237. DOI: 10.3969/j.issn.1006-8422.2012.03.015.Yao HP, Ding WZ, Liu Y , et al. Research of relationship between visual field and diabetic retinopathy[J]. J Clin Ophthalmol, 2012, 20(3): 235-237. DOI: 10.3969/j.issn.1006-8422.2012.03.015.

1. 李欢, 罗向霞. 糖尿病视网膜病变激光光凝治疗对视野影响的研究进展[J]. 中国中医眼科杂志, 2015, 25(3): 217-219.Li H, Luo XX. Research on impact of vision with laser photocoagulation treatment for diabetic retinopathy[J]. Journal of Traditional Chinese Ophthalmology, 2015, 25(3): 217-219.
2. 钟颖, 梁永强, 袁红枝, 等. 激光治疗不同分期糖尿病视网膜病变的疗效观察[J]. 临床和实验医学杂志, 2014, 13(14): 1157-1159. DOI: 10.3969/cma.j.issn.1671-4695.2014.14.012.Zhong Y, Liang YQ, Yuan HZ, et al. Effects of laser photocoagulation in treating diabetic retinopathy[J]. Journal of Clinical and Experimental Medicine, 2014, 13(14): 1157-1159. DOI: 10.3969/cma.j.issn.1671-4695.2014.14.012.
3. 钱彤, 黎晓新, 姜燕荣, 等. 糖尿病视网膜病变激光术后视野的改变[J]. 中国实用眼科杂志, 2000, 18(6): 358-360. DOI: 10.3760/cma.j.issn.1006-4443.2000.06.014.Qian T, Li XX, Jiang YR, et al. The automated perimetic changes following retinal photocoagulation in diabetic retinopathy[J]. Chin J Pract Ophthalmol, 2000, 18(6): 358-360. DOI: 10.3760/cma.j.issn.1006-4443.2000.06.014.
4. 袁慧敏, 李摇锐, 岳章显. 532激光视网膜光凝治疗糖尿病视网膜病变后的视野改变[J]. 国际眼科杂志, 2012, 12(7): 1408. DOI: 10.3969/j.issn.1672-5123.2012.07.63.Yuan HM, Li YR, Yue ZX. Visual field changes after 532 laser photocoagulation for diabetic retinopathy[J]. Int Eye Sci, 2012, 12(7): 1408. DOI: 10.3969/j.issn.1672-5123.2012.07.63.
5. 中华医学会眼科学分会眼底病学组. 我国糖尿病视网膜病变临床诊疗指南(2014年)[J]. 中华眼科杂志, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.Chinese Ocular Fundus Diseases Society, Chinese Ophthalmological Society, Chinese Medical Association. Guidelines for clinical diagnosis and treatment of diabetic retinopathy in China[J]. Chin J Ophthalmol, 2014, 50(11): 851-865. DOI: 10.3760/cma.j.issn.0412-4081.2014.11.014.
6. Early Treatment Diabetic Retinopthy Study Research Group. Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopthy Study report number 1[J]. Arch Ophthalmol, 1985, 103(12): 1796-1806. DOI: 10.1001/archopht.1985.01050120030015.
7. The Early Treatment Diabetic Retinopathy Study Research Group. Techniques for scatter and local photocoagulation treatment of diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report no.3[J]. Int Ophthalmol Clin, 1987, 27(4): 254-264. DOI: 10.1097/00004397-198702740-00005.
8. 张茉莉, 田蓓, 魏文斌. 577 nm激光多点与单点扫描模式全视网膜激光光凝治疗非增生期糖尿病视网膜病变疗效比较[J]. 中华眼底病杂志, 2015, 31(1): 36-40. DOI: 10.3760/cma.j.issn.1005-1015.2015.01.010.Zhang ML, Tian B, Wei WB. Comparison of the efficacy of multi-point or single-point mode of 577 nm laser in the treatment of diabetic retinopathy[J]. Chin J Ocul Fundus Dis, 2015, 31(1): 36-40. DOI: 10.3760/cma.j.issn.1005-1015.2015.01.010.
9. Yang HS, Kim JG, Cha JB, et al. Quantitative analysis of neural tissues around the optic disc after panretinal photocoagulation in patients with diabetic retinopathy[J/OL]. PLoS One, 2017, 12(10): e0186229[2017-10-17]. https://doi.org/10.1371/journal.pone.0186229. DOI: 10.1371/journal.pone.0186229.
10. 李凤春, 刘彰. 糖尿病视网膜病变患者的视野变化分析[J]. 临床荟萃, 2012, 27(9): 780-781.Li FC, Liu Z. Analysis of visual field changes in patients with diabetic retinopathy[J]. Clinical Focus, 2012, 27(9): 780-781.
11. 姚慧萍, 丁慰祖, 刘嫣, 等. 视野与糖尿病视网膜病变相关性的研究[J]. 临床眼科杂志, 2012, 20(3): 235-237. DOI: 10.3969/j.issn.1006-8422.2012.03.015.Yao HP, Ding WZ, Liu Y , et al. Research of relationship between visual field and diabetic retinopathy[J]. J Clin Ophthalmol, 2012, 20(3): 235-237. DOI: 10.3969/j.issn.1006-8422.2012.03.015.

Chinese Journal of Ocular Fundus Diseases

Quantitative analysis of visual field loss after 577 nm krypton pan-retinal photocoagulation for diabetic retinopathy

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