Diagnostic performance of confocal scanning laser ophthalmoscope imaging and compared with color fundus camera in retinal pigment epithelial detachment of polypoidal choroidal vasculopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Huo Yanjiao , Yang Lihong , Guo Yan ,  Wei Wenbin

Beijing Ophthalmology & Visual Science Key Laboratory, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;

Corresponding author：

Wei Wenbin, Email: weiwenbintr@163.com

Keywords：

Choroid diseases; Retinal pigment epithelial detachment; Confocal scanning laser ophthalmoscope; Color fundus camera

DOI：

10.3760/cma.j.issn.1005-1015.2019.04.007

Video：

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Objective To observe confocal scanning laser ophthalmoscope (cSLO) based retinal imaging and color fundus camera in pigment epithelial detachment (PED) of polypoidal choroidal vasculopathy (PCV).Methods PED of 30 patients (32 eyes) were recruited from June 2016 to June 2017 in the Beijing Tongren Hospital who were detected in high-definition OCT (HD-OCT) and diagnosed as PCV by FFA and ICGA. There were 16 males (17 eyes) and 14 females (15 eyes); aged from 50-83 years, with the mean age of 66.59 years. The photographs of ocular fundus including color fundus camera, cSLO imaging, HD-OCT, FFA and ICGA were analyzed. Multimodal imaging results were regarded as gold standard. Sensitivity and specificity were calculated in serous and hemorrhagic PED diagnosis using color fundus camera and cSLO imaging. The positive number of PED was used to compare between two modes fundus imaging by using χ² test.Results Twenty serous PED eyes, 3 hemorrhagic PED eyes and 9 serous/hemorrhagic PED eyes were determined using multimodal imaging. The sensitivity and specificity of color fundus camera were 45% and 100% in detecting serous PED and 100% and 91% in detecting hemorrhagic PED. The sensitivity and specificity of cSLO imaging were 83% and 100% in detecting serous PED and 50% and 86% in detecting hemorrhagic PED. The positive number of serous PED in cSLO imaging was significantly higher than color fundus camera (χ²=7.752, P=0.011). The positive number of hemorrhagic PED in cSLO imaging shows no obvious difference compared with color fundus camera (χ²=1.164, P=0.419).Conclusion The sensitivity and positive number of detecting serous PED with PCV in cSLO fundus imaging were higher than the color fundus camera technology.

Citation： Huo Yanjiao, Yang Lihong, Guo Yan, Wei Wenbin. Diagnostic performance of confocal scanning laser ophthalmoscope imaging and compared with color fundus camera in retinal pigment epithelial detachment of polypoidal choroidal vasculopathy. Chinese Journal of Ocular Fundus Diseases, 2019, 35(4): 348-352. doi: 10.3760/cma.j.issn.1005-1015.2019.04.007 Copy

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1. Yannuzzi LA, Ciardella A, Spaide RF, et al. The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy[J]. Arch Ophthalmol, 1997, 115(4): 478-485. DOI: 10.1001/archopht.1997.01100150480005.
2. Kawali A, Pichi F, Avadhani K, et al. Multimodal imaging of the normal eye[J]. Ocul Immunol Inflamm, 2017, 25(5): 721-731. DOI: 10.1080/09273948.2017.1375531.
3. Coscas G, Yamashiro K, Coscas F, et al. Comparison of exudative age-related macular degeneration subtypes in Japanese and French patients: multicenter diagnosis with multimodal imaging[J]. Am J Ophthalmol, 2014, 158(2): 309-318. DOI: 10.1016/j.ajo.2014.05.004.
4. 霍妍佼, 郭彦, 杨丽红, 等. 共聚焦激光扫描检眼镜眼底成像与传统眼底彩色照相对老年人黄斑前膜检出结果比较[J]. 中华眼底病杂志, 2016, 32(6): 615-618. DOI: 10.3760/cma.j.issn.1005-1015.2016.06.012.Huo YJ, Guo Y, Yang LH, et al. Comparison of the screening efficiency of epiretinal membrane using confocal scanning laser ophthalmoscope imaging and color fundus camera in elderly people[J]. Chin J Ocul Fundus Dis, 2016, 32(6): 615-618. DOI: 10.3760/cma.j.issn.1005-1015.2016.06.012.
5. 霍妍佼, 杨丽红, 崔蕊, 等. 共焦激光扫描检眼镜与眼底彩色照相对视网膜和脉络膜病变的检出比较[J]. 中华眼底病杂志, 2016, 32(3): 270-274. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.010.Huo YJ, Yang LH, Cui R, et al. Comparison of confocal scanning laser ophthalmoscope and color fundus camera to assess retinal and choroidal disease using[J]. Chin J Ocul Fundus Dis, 2016, 32(3): 270-274. DOI: 10.3760/cma.j.issn.1005-1015.2016.03.010.
6. 霍妍佼, 杨丽红, 魏文斌. 黄斑前膜患者激光视网膜成像特点分析[J]. 中华眼科杂志, 2016, 52(11): 836-839. DOI: 10.3760/cma.j.issn.0412-4081.2016.11.007.Huo YJ, Yang LH, Wei WB, et al. Diagnostic performance of laser retinal imaging in the epiretinal membrane[J]. Chin J Ophthalmol, 2016, 52(11): 836-839. DOI: 10.3760/cma.j.issn.0412-4081.2016.11.007.
7. 霍妍佼, 杨丽红, 魏文斌. 激光扫描共焦检眼镜对黄斑囊样水肿成像的定量分析[J]. 中华实验眼科杂志, 2017, 35(1): 53-57. DOI: 10.3760/cma.j.issn.2095-0160.2017.01.011.Huo YJ, Yang LH, Wei WB. Imaging performance and quantitative analysis of confocal scanning laser ophthalmoscope for systoid macular edema[J]. Chin J Exp Ophthalmol, 2017, 35(1): 53-57. DOI: 10.3760/cma.j.issn.2095-0160.2017.01.011.
8. 陈有信. 特发性息肉样脉络膜血管病变[M]//魏文斌, 陈积中. 眼底病鉴别诊断学. 北京: 人民卫生出版社, 2012: 304-316.Chen YX. Idiopathic polypoidal choroidal vasculoathy[M]//Wei WB, Chen JZ. Differential diagnosis of fundus diseases. Beijing: People’s Medical Publishing House, 2012: 304-316.
9. 魏文斌, 杨丽红. 同仁荧光素眼底血管造影手册[M].北京: 人民卫生出版社, 2014:4-6.Wei WB,Yang LH. The Tongren manual of fluorescein fundus angiography [M]. Beijing: People’s Medical Publishing House, 2014:4-6.
10. Tan AC, Fleckenstein M, Schmitz-Valckenberg S, et al. Clinical application of multicolor imaging technology[J]. Ophthalmologica, 2016, 236(1): 8-18. DOI: 10.1159/000446857.
11. 吴文娟, 李东, 王国祥, 等. 血液在可见光及近红外范围内随温度变化的动态吸收特性[J]. 化工学报, 2013, 64(4): 1157-1206. DOI: 10.3969/j.issn.0438-1157.2013.04.004.Wu WJ, Li D, Wang GX, et al. Dynamic optical absorption characteristic of human blood in visible- and near-infrared light with variable temperature[J]. CIESC Journal, 2013, 64(4): 1157-1206. DOI: 10.3969/j.issn.0438-1157.2013.04.004.
12. 文峰, 吴德正, 李海涛, 等. 息肉状脉络膜血管病变的眼底特征分析[J]. 中华眼底病杂志, 2003, 19(5): 269-272. DOI: 10.3760/j.issn:1005-1015.2003.05.001.Wen F, Wu DZ, Li HT, et al. Characteristics of the ocular fundus of Chinese patients with polypoidal choroidal vasculopathy[J]. Chin J Ocul Fundus Dis, 2003, 19(5): 269-272. DOI: 10.3760/j.issn:1005-1015.2003.05.001.

Chinese Journal of Ocular Fundus Diseases

Diagnostic performance of confocal scanning laser ophthalmoscope imaging and compared with color fundus camera in retinal pigment epithelial detachment of polypoidal choroidal vasculopathy

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