The comparison of optic disc parameters and the thickness of circumpapillary retinal nerve fiber layer between acute Vogt-Koyanagi-Harada syndrome and acute central serous chorioretinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

Pang Yanhua , Nie Lijiao , Tan Zhi , Zhou Fengyan , Yuan Xuehui , Lyu Qiurong ,  Zhao Guiling

Department of Ophthalmology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China;

Corresponding author：

Zhao Guiling, Email: zhaoguiling@qq.com

Keywords：

Uveomeningoencephalitic syndrome; Central serous chorioretinopathy; Optic disk; Nerve fibers; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2019.04.011

Video：

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Objective To compare the differences of optic nerve head (ONH) parameters and the thickness of circumpapillary retinal nerve fiber layer (CP-RNFL) between acute Vogt-Koyanagi-Harada syndrome (VKH) and acute central serous chorioretinopathy (CSC) patients.Methods Retrospective clinical case control analysis. This study included 38 eyes of 20 acute VKH patients (VKH group) and 37 eyes of 37 acute CSC patients (CSC group). Seventy five eyes of 57 normal healthy subjects, matching patients with age and gender, were collected as control group. The disc RPE angle, the thickness of average CP-RNFL, the nasal, superior, temporal and inferior quadrant CP-RNFL thickness, and ONH parameters including optic disc area, cup area, rim area, C/D area ratio, linear CD ratio (CDR), vertical CDR were measured by 3D-OCT. Analysis of variance was performed for comparison among three groups. Minimum significant difference t test was performed for comparison between two groups.Results The differences of ONH parameters between VKH group and CSC group: 29 eyes of VKH group appeared retinal detachment next to disc, only 12 eyes appeared in CSC group. Twenty one eyes of VKH group appeared optic disc hyperemia while none in CSC group. The three groups’ disc RPE angles were (138.62±11.96)°, (154.09±5.85)° and (153.41±5.77)°. VKH group were significantly smaller than CSC group (t=－2.05, P=0.00) and control group (t=－1.68, P=0.00), while there was no significant difference between CSC group and control group (t=－1.88, P=0.72). The optic cup area and rim area were significantly bigger in VKH group than in CSC group (t=4.61, 2.71; P=0.00, 0.01), and the thickness of mean CP-RNFL, all quadrants of CP-RNFL were significantly thicker in VKH group than in CSC group (t=6.25, 4.40, 3.53, 5.48, 2.69; P=0.00, 0.00, 0.00, 0.00, 0.01).Conclusion Compared with the acute CSC, VKH patients are likely to appear retinal detachment next to disc, their disc RPE angles are smaller, their optic cup area and rim area are bigger, and their CP-RNFL thickness are thicker.

Citation： Pang Yanhua, Nie Lijiao, Tan Zhi, Zhou Fengyan, Yuan Xuehui, Lyu Qiurong, Zhao Guiling. The comparison of optic disc parameters and the thickness of circumpapillary retinal nerve fiber layer between acute Vogt-Koyanagi-Harada syndrome and acute central serous chorioretinopathy. Chinese Journal of Ocular Fundus Diseases, 2019, 35(4): 369-373. doi: 10.3760/cma.j.issn.1005-1015.2019.04.011 Copy

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2.	Nicolò M, Rosa R, Musetti D, et al. Choroidal vascular flow area in central serous chorioretinopathy using swept-source optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2017, 58(4): 2002-2010. DOI: 10.1167/iovs.17-21417.
3.	Shin WB, Kim MK, Lee CS, et al. Comparison of the clinical manifestationsbetween acute Vogt-Koyanagi-Harada disease and acute bilateral central serous chorioretinopathy[J]. J Ophthalmol, 2015, 29(6): 389-395. DOI: 10.3341/kjo.2015.29.6.389.
4.	Lin D, Chen W, Zhang G, et al. Comparison of the optical coherence tomographic characters between acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy[J]. BMC Ophthalmol, 2014, 14: 87. DOI: 10.1186/1471-2415-14-87.
5.	Lodhi SA, Reddy JL, Peram V. Clinical spectrum and management options in Vogt-Koyanagi-Harada disease[J]. Clin Ophthalmol, 2017, 11: 1399-1406. DOI: 10.2147/OPTH.S134977.
6.	Sakata VM, da Silva FT, Hirata CE, et al. Diagnosis and classification of Vogt-Koyanagi-Harada disease[J]. Autoimmun Rev, 2014, 13(4-5): 550-555. DOI: 10.1016/j.autrev.2014.01.023.
7.	庞燕华, 谭志, 王秀琴, 等. Vogt-Koyanagi-Harada综合征与视神经炎患眼视盘水肿形态结构参数的三维光相干断层扫描观察[J]. 中华眼底病杂志, 2017, 33(5): 476-480. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.009.Pang YH, Tan Z, Wang XQ, et al. The changes in optic disc parameters of Vogt-Koyanagi-Harada syndrome and optic neuritis with optic disc edema using three-dimensional optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 476-480. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.009.
8.	Herbort CP Jr, Abu El Asrar AM, Yamamoto JH, et al. Reappraisal of the management of Vogt-Koyanagi-Harada disease: sunset glow fundus is no more a fatality[J]. Int Ophthalmol, 2017, 37(6): 1383-1395. DOI: 10.1007/s10792-016-0395-0.
9.	Lavezzo MM, Sakata VM, Morita C, et al. Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes[J]. Orphanet J Rare Dis, 2016, 11: 29. DOI: 10.1186/s13023-016-0412-4.
10.	Chan SY, Wang Q, Wei WB, et al. Optical coherence tomographic angiography in central serous chorioretinopathy[J]. Retina, 2016, 36(11): 2051-2058. DOI: 10.1097/IAE.0000000000001064.
11.	Ferrara D, Mohler KJ, Waheed N, et al. En face enhanced-depth swept-source optical coherence tomography features of chronic central serous chorioretinopathy[J]. Ophthalmology, 2014, 121(3): 719-726. DOI: 10.1016/j.ophtha.2013.10.014.
12.	Lee WJ1, Lee JW, Park SH, et al. En face choroidal vascular feature imaging in acute andchronic central serous chorioretinopathy using swept source optical coherence tomography[J]. Br J Ophthalmol, 2017, 101(5): 580-586. DOI: 10.1136/bjophthalmol-2016-308428.
13.	裴锦云, 郑曰忠. Vogt-小柳-原田病诊治分析[J]. 中国实用眼科杂志, 2015, 33(9): 1013-1017. DOI: 10.3760/cma.j.issn.1006-4443.2015.09.015.Pei JY, Zheng YZ. Analysis of the diagnosis and treatment of Vogt-Koyanagi-Harada disease[J]. Chin J Pract Ophthalmol, 2015, 33(9): 1013-1017. DOI: 10.3760/cma.j.issn.1006-4443.2015.09.015.
14.	Nakao K, Abematsu N, Mizushima Y, et al. Optic disc swelling in Vogt-Koyanagi-Harada disease[J]. Invest Ophthalmol Vis Sci, 2012, 53(4): 1917-1922. DOI: 10.1167/iovs.11-8984.
15.	郭娅玲, 何剑峰. 伏格特-小柳-原田病的病理学特点[J]. 眼科研究, 2009, 27(9): 830-832. DOI: 10.3760/cma.j.issn.2095-0160.2009.09.022.Guo YL, He JF. Pathology features of Vogt-Koyanagi-Harada disease[J]. Chin Ophthal Res, 2009, 27(9): 830-832. DOI: 10.3760/cma.j.issn.2095-0160.2009.09.022.
16.	Nicholson B, Noble J, Forooghian F, et al. Central serous chorioretinopathy: update on pathophysiology and treatment[J]. Surv Ophthalmol, 2013, 58(2): 103-126. DOI: 10.1016/j.survophthal.2012.07.004.

1. Hedayatfar A, Hosseini SM, Karimi N, et al. The spectrum of Vogt-Koyanagi-Harada disease in Iran[J]. Int Ophthalmol, 2017, 4(3): 1-7. DOI: 10.1007/s10792-017-0478-6.
2. Nicolò M, Rosa R, Musetti D, et al. Choroidal vascular flow area in central serous chorioretinopathy using swept-source optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2017, 58(4): 2002-2010. DOI: 10.1167/iovs.17-21417.
3. Shin WB, Kim MK, Lee CS, et al. Comparison of the clinical manifestationsbetween acute Vogt-Koyanagi-Harada disease and acute bilateral central serous chorioretinopathy[J]. J Ophthalmol, 2015, 29(6): 389-395. DOI: 10.3341/kjo.2015.29.6.389.
4. Lin D, Chen W, Zhang G, et al. Comparison of the optical coherence tomographic characters between acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy[J]. BMC Ophthalmol, 2014, 14: 87. DOI: 10.1186/1471-2415-14-87.
5. Lodhi SA, Reddy JL, Peram V. Clinical spectrum and management options in Vogt-Koyanagi-Harada disease[J]. Clin Ophthalmol, 2017, 11: 1399-1406. DOI: 10.2147/OPTH.S134977.
6. Sakata VM, da Silva FT, Hirata CE, et al. Diagnosis and classification of Vogt-Koyanagi-Harada disease[J]. Autoimmun Rev, 2014, 13(4-5): 550-555. DOI: 10.1016/j.autrev.2014.01.023.
7. 庞燕华, 谭志, 王秀琴, 等. Vogt-Koyanagi-Harada综合征与视神经炎患眼视盘水肿形态结构参数的三维光相干断层扫描观察[J]. 中华眼底病杂志, 2017, 33(5): 476-480. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.009.Pang YH, Tan Z, Wang XQ, et al. The changes in optic disc parameters of Vogt-Koyanagi-Harada syndrome and optic neuritis with optic disc edema using three-dimensional optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2017, 33(5): 476-480. DOI: 10.3760/cma.j.issn.1005-1015.2017.05.009.
8. Herbort CP Jr, Abu El Asrar AM, Yamamoto JH, et al. Reappraisal of the management of Vogt-Koyanagi-Harada disease: sunset glow fundus is no more a fatality[J]. Int Ophthalmol, 2017, 37(6): 1383-1395. DOI: 10.1007/s10792-016-0395-0.
9. Lavezzo MM, Sakata VM, Morita C, et al. Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes[J]. Orphanet J Rare Dis, 2016, 11: 29. DOI: 10.1186/s13023-016-0412-4.
10. Chan SY, Wang Q, Wei WB, et al. Optical coherence tomographic angiography in central serous chorioretinopathy[J]. Retina, 2016, 36(11): 2051-2058. DOI: 10.1097/IAE.0000000000001064.
11. Ferrara D, Mohler KJ, Waheed N, et al. En face enhanced-depth swept-source optical coherence tomography features of chronic central serous chorioretinopathy[J]. Ophthalmology, 2014, 121(3): 719-726. DOI: 10.1016/j.ophtha.2013.10.014.
12. Lee WJ1, Lee JW, Park SH, et al. En face choroidal vascular feature imaging in acute andchronic central serous chorioretinopathy using swept source optical coherence tomography[J]. Br J Ophthalmol, 2017, 101(5): 580-586. DOI: 10.1136/bjophthalmol-2016-308428.
13. 裴锦云, 郑曰忠. Vogt-小柳-原田病诊治分析[J]. 中国实用眼科杂志, 2015, 33(9): 1013-1017. DOI: 10.3760/cma.j.issn.1006-4443.2015.09.015.Pei JY, Zheng YZ. Analysis of the diagnosis and treatment of Vogt-Koyanagi-Harada disease[J]. Chin J Pract Ophthalmol, 2015, 33(9): 1013-1017. DOI: 10.3760/cma.j.issn.1006-4443.2015.09.015.
14. Nakao K, Abematsu N, Mizushima Y, et al. Optic disc swelling in Vogt-Koyanagi-Harada disease[J]. Invest Ophthalmol Vis Sci, 2012, 53(4): 1917-1922. DOI: 10.1167/iovs.11-8984.
15. 郭娅玲, 何剑峰. 伏格特-小柳-原田病的病理学特点[J]. 眼科研究, 2009, 27(9): 830-832. DOI: 10.3760/cma.j.issn.2095-0160.2009.09.022.Guo YL, He JF. Pathology features of Vogt-Koyanagi-Harada disease[J]. Chin Ophthal Res, 2009, 27(9): 830-832. DOI: 10.3760/cma.j.issn.2095-0160.2009.09.022.
16. Nicholson B, Noble J, Forooghian F, et al. Central serous chorioretinopathy: update on pathophysiology and treatment[J]. Surv Ophthalmol, 2013, 58(2): 103-126. DOI: 10.1016/j.survophthal.2012.07.004.

Chinese Journal of Ocular Fundus Diseases

The comparison of optic disc parameters and the thickness of circumpapillary retinal nerve fiber layer between acute Vogt-Koyanagi-Harada syndrome and acute central serous chorioretinopathy

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