Research progress of optical coherence tomography angiography in retinal vein occlusion_Chinese Journal of Ocular Fundus Diseases

Authors：

Chen Lulu ,  Chen Youxin

Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China;

Corresponding author：

Chen Youxin, Email: chenyouxinpumch@163.com

Keywords：

Retinal vein occlusion; Tomography, optical coherence; Review

DOI：

10.3760/cma.j.issn.1005-1015.2019.04.021

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Retinal vein occlusion (RVO) is a vascular disease characterized by intraretinal hemorrhage, edema and hard exudation, which is caused by increased retinal vein pressure. OCT angiography (OCTA) has been widely used in the diagnosis of retinal vascular diseases including RVO by virtue of non-invasive, high resolution and stratified display of superficial, deep retinal vessels and quantification of retinal vessel density and non-perfusion area size. OCTA can provide information of retinal microvascular structure and blood perfusion under the condition of disease, it also can be used to evaluate the effect of treatment and changes of retinal circulation during the course of disease follow-up. Although OCTA cannot replace fundus angiography completely, it has brought us more information about the pathogenesis, disease progression and prognostic factors of RVO. It is believed that with the progress of technology, OCTA will bring us a new chapter in the study of retinal vascular diseases including RVO.

Citation： Chen Lulu, Chen Youxin. Research progress of optical coherence tomography angiography in retinal vein occlusion. Chinese Journal of Ocular Fundus Diseases, 2019, 35(4): 399-402. doi: 10.3760/cma.j.issn.1005-1015.2019.04.021 Copy

1.	Hayreh SS, Zimmerman MB. Fundus changes in central retinal vein occlusion[J]. Retina, 2015, 35(1): 29-42. DOI: 10.1097/IAE.0000000000000256.
2.	Hayreh SS, Zimmerman MB. Fundus changes in branch retinal vein occlusion[J]. Retina, 2015, 35(5): 1016-1027. DOI: 10.1097/IAE.0000000000000418.
3.	Ha SO, Kim DY, Sohn CH, et al. Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature[J]. Intern Emerg Med, 2014, 9(3): 325-330. DOI: 10.1007/s11739-013-1019-6.
4.	Fang PP, Lindner M, Steinberg JS, et al. Clinical applications of OCT angiography[J]. Ophthalmologe, 2016, 113(1): 14-22. DOI: 10.1007/s00347-015-0192-6.
5.	Suzuki N, Hirano Y, Yoshida M, et al. Microvascular abnormalities on optical coherence tomography angiography in macular edema associated with branch retinal vein occlusion[J]. Am J Ophthalmol, 2016, 161: 126-132. DOI: 10.1016/j.ajo.2015.09.038.
6.	Chung CY, Tang HHY, Li SH, et al. Differential microvascular assessment of retinal vein occlusion with coherence tomography angiography and fluorescein angiography: a blinded comparative study[J]. Int Ophthalmol, 2018, 38(3): 1119-1128. DOI: 10.1007/s10792-017-0570-y.
7.	Nobre Cardoso J, Keane PA, Sim DA, et al. Systematic evaluation of optical coherence tomography angiography in retinal vein occlusion[J]. Am J Ophthalmol, 2016, 163: 93-107. DOI: 10.1016/j.ajo.2015.11.025.
8.	Adhi M, Filho MA, Louzada RN, et al. Retinal capillary network and foveal avascular zone in eyes with vein occlusion and fellow eyes analyzed with optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 486-494. DOI: 10.1167/iovs.15-18907.
9.	Wons J, Pfau M, Wirth MA, et al. Optical coherence tomography angiography of the foveal avascular zone in retinal vein occlusion[J]. Ophthalmologica, 2016, 235(4): 195-202. DOI: 10.1159/000445482.
10.	Coscas F, Glacet-Bernard A, Miere A, et al. Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa[J]. Am J Ophthalmol, 2016, 161: 160-171. DOI: 10.1016/j.ajo.2015.10.008.
11.	Freund KB, Sarraf D, Leong BCS, et al. Association of optical coherence tomography angiography of collaterals in retinal vein occlusion with major venous outflow through the deep vascular complex[J]. JAMA Ophthalmol, 2018, 136(11): 1262-1270. DOI: 10.1001/jamaophthalmol.2018.3586.
12.	Koulisis N, Kim AY, Chu Z, et al. Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography [J/OL]. PLoS One, 2017, 12(4): 0176404[2017-04-24]. http://dx.plos.org/10.1371/journal.pone.0176404. DOI: 10.1371/journal.pone.0176404.
13.	Tsuboi K, Ishida Y, Kamei M. Gap in capillary perfusion on optical coherence tomography angiography associated with persistent macular edema in branch retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2017, 58(4): 2038-2043. DOI: 10.1167/iovs.17-21447.
14.	Kakihara S, Hirano T, Iesato Y, et al. Extended field imaging using swept-source optical coherence tomography angiography in retinal vein occlusion[J]. Jpn J Ophthalmol, 2018, 62(3): 274-279. DOI: 10.1007/s10384-018-0590-9.
15.	Casselholmde Salles M, Kvanta A, Amren U, et al. Optical coherence tomography angiography in central retinal vein occlusion: correlation beween the foveal avascular zone and visual acuity[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 242-246. DOI: 10.1167/iovs.15-18819.
16.	Samara WA, Shahlaee A, Sridhar J, et al. Quantitative optical coherence tomography angiography features and visual function in eyes with branch retinal vein occlusion[J]. Am J Ophthalmol, 2016, 166: 76-83. DOI: 10.1016/j.ajo.2016.03.033.
17.	Seknazi D, Coscas F, Sellam A, et al. Optical coherence tomography angiography in retinal vein occlusion: correlations between macular vascular density, visual acuity, and peripheral nonperfusion area on fluorescein angiography[J]. Retina, 2018, 38(8): 1562-1570. DOI: 10.1097/IAE.0000000000001737.
18.	Wakabayashi T, Sato T, Hara-Ueno C, et al. Retinal microvasculature and visual acuity in eyes with branch retinal vein occlusion: imaging analysis by optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2017, 58(4): 2087-2094. DOI: 10.1167/iovs.16-21208.
19.	Balaratnasingam C, Inoue M, Ahn S, et al. Visual acuity is correlated with the area of the foveal avascular zone in diabetic retinopathy and retinal vein occlusion[J]. Ophthalmology, 2016, 123(11): 2352-2367. DOI: 10.1016/j.ophtha.2016.07.008.
20.	Manabe S, Osaka R, Nakano Y, et al. Association between parafoveal capillary nonperfusion and macular function in eyes with branch retinal vein occlusion[J]. Retina, 2017, 37(9): 1731-1737. DOI: 10.1097/iae.0000000000001417.
21.	Ghashut R, Muraoka Y, Ooto S, et al. Evaluation of macular ischemia in eyes with retinal vein occlusion: an optical coherence tomography angiography study[J]. Retina, 2018, 38(8): 1571-1580. DOI: 10.1097/IAE.0000000000001749.
22.	Kadomoto S, Muraoka Y, Ooto S, et al. Evaluation of macular ischemia in eyes with branch vein occlusion: an optical coherence tomography angiography study[J]. Retina, 2018, 38(2): 272-282. DOI: 10.1097/IAE.0000000000001541.
23.	Yeh S, Kim SJ, Ho AC, et al. Therapies for macular edema associated with central retinal vein occlusion: a report by the American Academy of Ophthalmology[J]. Ophthalmology, 2015, 122(4): 769-778. DOI: 10.1016/j.ophtha.2014.10.013.
24.	Glacet-Bernard A, Sellam A, Coscas F, et al. Optical coherence tomography angiography in retinal vein occlusion treated with dexamethasone implant: a new test for follow-up evaluation[J]. Eur J Ophthalmol, 2016, 26(5): 460-468. DOI: 10.5301/ejo.5000829.
25.	Mastropasqua R, Toto L, Di Antonio L, et al. Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions [J/OL]. Sci Rep, 2017, 7: 40763[2017-01-18]. http://dx.doi.org/10.1038/srep40763. DOI: 10.1038/srep40763.
26.	Lee EK, Han JM, Hyon JY, et al. Changes in choroidal thickness after intravitreal dexamethasone implant injection in retinal vein occlusion[J]. Br J Ophthalmol, 2015, 99(11): 1543-1549. DOI: 10.1136/bjophthalmol-2014-306417.
27.	Kim KH, Lee DH, Lee JJ, et al. Regional choroidal thickness changes in branch retinal vein occlusion with macular edema[J]. Ophthalmologica, 2015, 234(2): 109-118. DOI: 10.1159/000437276.
28.	Ghasemi Falavarjani K, Iafe NA, Hubschman JP, et al. Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-VEGF therapy in eyes with diabetic macular edema and retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2017, 58(1): 30-34. DOI: 10.1167/iovs.16-20579.
29.	Suzuki N, Hirano Y, Tomiyasu T, et al. Retinal hemodynamics seen on optical coherence tomography angiography before and after treatment of retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2016, 57(13): 5681-5687. DOI: 10.1167/iovs-16-20648.
30.	Winegarner A, Wakabayashi T, Hara-Ueno C, et al. Retinal microvasculature and visual acuity after intravitreal Aflibercept in eyes with central retinal vein occlusion: an optical coherence tomography angiography study[J]. Retina, 2018, 38(10): 2067-2072. DOI: 10.1097/IAE.0000000000001828.
31.	Ghasemi Falavarjani K, Al-Sheikh M, Akil H, et al. Image artefacts in swept-source optical coherence tomography angiography[J]. Br J Ophthalmol, 2017, 101(5): 564-568. DOI: 10.1136/bjophthalmol-2016-309104.
32.	Cole ED, Moult EM, Dang S, et al. The definition, rationale, and effects of thresholding in OCT angiography[J]. Ophthalmol Retina, 2017, 1(5): 435-447. DOI: 10.1016/j.oret.2017.01.019.
33.	Spaide RF, Fujimoto JG, Waheed NK, et al. Optical coherence tomography angiography[J]. Prog Retin Eye Res, 2018, 64: 1-55. DOI: 10.1016/j.preteyeres.2017.11.003.
34.	Chung CY, Li KKW. Optical coherence tomography angiography wide-field montage in branch retinal vein occlusion before and after anti-vascular endothelial-derived growth factor injection[J]. Int Ophthalmol, 2018, 38(3): 1305-1307. DOI: 10.1007/s10792-017-0568-5.

1. Hayreh SS, Zimmerman MB. Fundus changes in central retinal vein occlusion[J]. Retina, 2015, 35(1): 29-42. DOI: 10.1097/IAE.0000000000000256.
2. Hayreh SS, Zimmerman MB. Fundus changes in branch retinal vein occlusion[J]. Retina, 2015, 35(5): 1016-1027. DOI: 10.1097/IAE.0000000000000418.
3. Ha SO, Kim DY, Sohn CH, et al. Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature[J]. Intern Emerg Med, 2014, 9(3): 325-330. DOI: 10.1007/s11739-013-1019-6.
4. Fang PP, Lindner M, Steinberg JS, et al. Clinical applications of OCT angiography[J]. Ophthalmologe, 2016, 113(1): 14-22. DOI: 10.1007/s00347-015-0192-6.
5. Suzuki N, Hirano Y, Yoshida M, et al. Microvascular abnormalities on optical coherence tomography angiography in macular edema associated with branch retinal vein occlusion[J]. Am J Ophthalmol, 2016, 161: 126-132. DOI: 10.1016/j.ajo.2015.09.038.
6. Chung CY, Tang HHY, Li SH, et al. Differential microvascular assessment of retinal vein occlusion with coherence tomography angiography and fluorescein angiography: a blinded comparative study[J]. Int Ophthalmol, 2018, 38(3): 1119-1128. DOI: 10.1007/s10792-017-0570-y.
7. Nobre Cardoso J, Keane PA, Sim DA, et al. Systematic evaluation of optical coherence tomography angiography in retinal vein occlusion[J]. Am J Ophthalmol, 2016, 163: 93-107. DOI: 10.1016/j.ajo.2015.11.025.
8. Adhi M, Filho MA, Louzada RN, et al. Retinal capillary network and foveal avascular zone in eyes with vein occlusion and fellow eyes analyzed with optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 486-494. DOI: 10.1167/iovs.15-18907.
9. Wons J, Pfau M, Wirth MA, et al. Optical coherence tomography angiography of the foveal avascular zone in retinal vein occlusion[J]. Ophthalmologica, 2016, 235(4): 195-202. DOI: 10.1159/000445482.
10. Coscas F, Glacet-Bernard A, Miere A, et al. Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa[J]. Am J Ophthalmol, 2016, 161: 160-171. DOI: 10.1016/j.ajo.2015.10.008.
11. Freund KB, Sarraf D, Leong BCS, et al. Association of optical coherence tomography angiography of collaterals in retinal vein occlusion with major venous outflow through the deep vascular complex[J]. JAMA Ophthalmol, 2018, 136(11): 1262-1270. DOI: 10.1001/jamaophthalmol.2018.3586.
12. Koulisis N, Kim AY, Chu Z, et al. Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography [J/OL]. PLoS One, 2017, 12(4): 0176404[2017-04-24]. http://dx.plos.org/10.1371/journal.pone.0176404. DOI: 10.1371/journal.pone.0176404.
13. Tsuboi K, Ishida Y, Kamei M. Gap in capillary perfusion on optical coherence tomography angiography associated with persistent macular edema in branch retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2017, 58(4): 2038-2043. DOI: 10.1167/iovs.17-21447.
14. Kakihara S, Hirano T, Iesato Y, et al. Extended field imaging using swept-source optical coherence tomography angiography in retinal vein occlusion[J]. Jpn J Ophthalmol, 2018, 62(3): 274-279. DOI: 10.1007/s10384-018-0590-9.
15. Casselholmde Salles M, Kvanta A, Amren U, et al. Optical coherence tomography angiography in central retinal vein occlusion: correlation beween the foveal avascular zone and visual acuity[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 242-246. DOI: 10.1167/iovs.15-18819.
16. Samara WA, Shahlaee A, Sridhar J, et al. Quantitative optical coherence tomography angiography features and visual function in eyes with branch retinal vein occlusion[J]. Am J Ophthalmol, 2016, 166: 76-83. DOI: 10.1016/j.ajo.2016.03.033.
17. Seknazi D, Coscas F, Sellam A, et al. Optical coherence tomography angiography in retinal vein occlusion: correlations between macular vascular density, visual acuity, and peripheral nonperfusion area on fluorescein angiography[J]. Retina, 2018, 38(8): 1562-1570. DOI: 10.1097/IAE.0000000000001737.
18. Wakabayashi T, Sato T, Hara-Ueno C, et al. Retinal microvasculature and visual acuity in eyes with branch retinal vein occlusion: imaging analysis by optical coherence tomography angiography[J]. Invest Ophthalmol Vis Sci, 2017, 58(4): 2087-2094. DOI: 10.1167/iovs.16-21208.
19. Balaratnasingam C, Inoue M, Ahn S, et al. Visual acuity is correlated with the area of the foveal avascular zone in diabetic retinopathy and retinal vein occlusion[J]. Ophthalmology, 2016, 123(11): 2352-2367. DOI: 10.1016/j.ophtha.2016.07.008.
20. Manabe S, Osaka R, Nakano Y, et al. Association between parafoveal capillary nonperfusion and macular function in eyes with branch retinal vein occlusion[J]. Retina, 2017, 37(9): 1731-1737. DOI: 10.1097/iae.0000000000001417.
21. Ghashut R, Muraoka Y, Ooto S, et al. Evaluation of macular ischemia in eyes with retinal vein occlusion: an optical coherence tomography angiography study[J]. Retina, 2018, 38(8): 1571-1580. DOI: 10.1097/IAE.0000000000001749.
22. Kadomoto S, Muraoka Y, Ooto S, et al. Evaluation of macular ischemia in eyes with branch vein occlusion: an optical coherence tomography angiography study[J]. Retina, 2018, 38(2): 272-282. DOI: 10.1097/IAE.0000000000001541.
23. Yeh S, Kim SJ, Ho AC, et al. Therapies for macular edema associated with central retinal vein occlusion: a report by the American Academy of Ophthalmology[J]. Ophthalmology, 2015, 122(4): 769-778. DOI: 10.1016/j.ophtha.2014.10.013.
24. Glacet-Bernard A, Sellam A, Coscas F, et al. Optical coherence tomography angiography in retinal vein occlusion treated with dexamethasone implant: a new test for follow-up evaluation[J]. Eur J Ophthalmol, 2016, 26(5): 460-468. DOI: 10.5301/ejo.5000829.
25. Mastropasqua R, Toto L, Di Antonio L, et al. Optical coherence tomography angiography microvascular findings in macular edema due to central and branch retinal vein occlusions [J/OL]. Sci Rep, 2017, 7: 40763[2017-01-18]. http://dx.doi.org/10.1038/srep40763. DOI: 10.1038/srep40763.
26. Lee EK, Han JM, Hyon JY, et al. Changes in choroidal thickness after intravitreal dexamethasone implant injection in retinal vein occlusion[J]. Br J Ophthalmol, 2015, 99(11): 1543-1549. DOI: 10.1136/bjophthalmol-2014-306417.
27. Kim KH, Lee DH, Lee JJ, et al. Regional choroidal thickness changes in branch retinal vein occlusion with macular edema[J]. Ophthalmologica, 2015, 234(2): 109-118. DOI: 10.1159/000437276.
28. Ghasemi Falavarjani K, Iafe NA, Hubschman JP, et al. Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-VEGF therapy in eyes with diabetic macular edema and retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2017, 58(1): 30-34. DOI: 10.1167/iovs.16-20579.
29. Suzuki N, Hirano Y, Tomiyasu T, et al. Retinal hemodynamics seen on optical coherence tomography angiography before and after treatment of retinal vein occlusion[J]. Invest Ophthalmol Vis Sci, 2016, 57(13): 5681-5687. DOI: 10.1167/iovs-16-20648.
30. Winegarner A, Wakabayashi T, Hara-Ueno C, et al. Retinal microvasculature and visual acuity after intravitreal Aflibercept in eyes with central retinal vein occlusion: an optical coherence tomography angiography study[J]. Retina, 2018, 38(10): 2067-2072. DOI: 10.1097/IAE.0000000000001828.
31. Ghasemi Falavarjani K, Al-Sheikh M, Akil H, et al. Image artefacts in swept-source optical coherence tomography angiography[J]. Br J Ophthalmol, 2017, 101(5): 564-568. DOI: 10.1136/bjophthalmol-2016-309104.
32. Cole ED, Moult EM, Dang S, et al. The definition, rationale, and effects of thresholding in OCT angiography[J]. Ophthalmol Retina, 2017, 1(5): 435-447. DOI: 10.1016/j.oret.2017.01.019.
33. Spaide RF, Fujimoto JG, Waheed NK, et al. Optical coherence tomography angiography[J]. Prog Retin Eye Res, 2018, 64: 1-55. DOI: 10.1016/j.preteyeres.2017.11.003.
34. Chung CY, Li KKW. Optical coherence tomography angiography wide-field montage in branch retinal vein occlusion before and after anti-vascular endothelial-derived growth factor injection[J]. Int Ophthalmol, 2018, 38(3): 1305-1307. DOI: 10.1007/s10792-017-0568-5.

Previous Article
儿童Wiskott-Aldrich综合征合并巨细胞病毒性视网膜炎一例
Next Article
The status in the application of optical coherence tomography angiography in noninfectious uveitis

Chinese Journal of Ocular Fundus Diseases

Research progress of optical coherence tomography angiography in retinal vein occlusion

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content