Diagnosis and treatment progress of lamellar hole-associated epiretinal proliferation_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhou Nan ,  Wei Wenbin

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Medical Artificial Intelligence Research and Verification Laboratory of Ministry of Industry and Information Technology, Beijing 100730, China;

Corresponding author：

Wei Wenbin, Email: tr_weiwenbin@163.com

Keywords：

Retinal perforations; Review; Epiretinal proliferation membrane

DOI：

10.3760/cma.j.issn.1005-1015.2019.06.023

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The current understanding of lamellar hole-associated epiretinal proliferation (LHEP) is based on OCT examination. This preretinal proliferation is seen at the edge of the lamina macular hole (LMH) as a meso-reflective substance under linear strong reflection, located between the internal limiting membranes and the nerve fiber layer. LHEP is often associated with LMH, but its histological origin, morphology and OCT characteristics are different from LMH, and its visual prognosis is worse. At present, the relationship between the occurrence of LHEP and clinical prognosis is still under study. This article reviews the pathology, morphology, clinical features, diagnosis and treatment of LHEP, in order to enhance clinical understanding of this disease.

Citation： Zhou Nan, Wei Wenbin. Diagnosis and treatment progress of lamellar hole-associated epiretinal proliferation. Chinese Journal of Ocular Fundus Diseases, 2019, 35(6): 618-620. doi: 10.3760/cma.j.issn.1005-1015.2019.06.023 Copy

1.	Michalewska Z, Michalewski J, Odrobina D, et al. Non-full-thickness macular holes reassessed with spectral domain optical coherence tomography[J]. Retina, 2012, 32(5): 922-929. DOI: 10.1097/IAE.0b013e318227.
2.	Schumann RG, Compera D, Schaumberger MM, et al. Epiretinal membrane characteristics correlate with photoreceptor layer defects in lamellar macular holes and macular pseudoholes[J]. Retina, 2015, 35(4): 727-735. DOI: 10.1097/IAE.0000000000000375.
3.	Govetto A, Dacquay Y, Farajzadeh M, et al. Lamellar macular hole: two distinct clinical entities?[J]. Am J Ophthalmol, 2016, 164: 99-109. DOI: 10.1016/j.ajo.2016.02.008.
4.	Compera D, Entchev E, Haritoglou C, et al. Lamellar hole-associated epiretinal proliferation in comparison to epiretinal membranes of macular pseudoholes[J]. Am J Ophthalmol, 2015, 160(2): 373-384. DOI: 10.1016/j.ajo.2015.05.010.
5.	Pang CE, Maberley DA, Freund KB, et al. Lamellar hole-associated epiretinal proliferation: a clinicopathologic correlation[J]. Retina, 2016, 36(7): 1408-1412. DOI: 10.1097/IAE.0000000000001069.
6.	Gass JD. Müller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis[J]. Arch Ophthalmol, 1999, 117(6): 821-823. DOI: 10.1001/archopht.117.6.821.
7.	Pang CE, Spaide RF, Freund KB. Epiretinal proliferation seen in association with lamellar macular holes:a distinct clinical entity[J]. Retina, 2014, 34(8): 1513-1523. DOI: 10.1097/IAE.0000000000000163.
8.	Parolini B, Schumann RG, Cereda MG, et al. Lamellar macular hole:a clinicopathologic correlation of surgically excised epiretinal membranes[J]. Invest Ophthalmol Vis Sci, 2011, 52(12): 9074-9083. DOI: 10.1167/iovs.11-8227.
9.	Compera D, Entchev E, Haritoglou C, et al. Correlative microscopy of lamellar hole-associated epiretinal proliferation[J]. J Ophthalmol, 2015, 2015: 450212. DOI: 10.1155/2015/450212.
10.	Hiscott PS, Grierson I, Trombetta CJ, et al. Retinal and epiretinal glia--an immunohistochemical study[J]. Br J Ophthalmol, 1984, 68(10): 698-707. DOI: 10.1136/bjo.68.10.698.
11.	Obana A, Sasano H, Okazaki S. Evidence of carotenoid in surgically removed lamellar hole-associated epiretinal proliferation[J]. Invest Ophthalmol Vis Sci, 2017, 58(12): 5157-5163. DOI: 10.1167/iovs.17-22347.
12.	dell'Omo R, Virgili G, Rizzo S, et al. Role of lamellar hole-associated epiretinal proliferation in lamellar macular holes[J]. Am J Ophthalmol, 2017, 175: 16-29. DOI: 10.1016/j.ajo.2016.11.007.
13.	Witkin AJ, Ko TH, Fujimoto JG, et al. Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study[J]. Ophthalmology, 2006, 113(3): 388-397. DOI: 10.1016/j.ophtha.2005.10.047.
14.	Ko J, Kim GA, Lee SC, et al. Surgical outcomes of lamellar macular holes with and without lamellar hole-associated epiretinalproliferation[J]. Acta Ophthalmol, 2017, 95(3): 221-226. DOI: 10.1111/aos.13245.
15.	Hirakawa M, Uemura A, Nakano T, et al. Pars plana vitrectomy with gas tamponade for lamellar macular holes[J]. Am J Ophthalmol, 2005, 140(6): 1154-1155. DOI: 10.1016/j.ajo.2005.07.022.
16.	Lai TT, Chen SN, Yang CM. Epiretinal proliferation in lamellar macular holes and full-thickness macular holes: clinical and surgical findings[J]. Graefe’s Arch Clin Exp Ophthalmol, 2016, 254(4): 629-638. DOI: 10.1007/s00417-015-3133-9.
17.	Compera D, Schumann RG, Cereda MG. Progression of lamellar hole-associated epiretinal proliferation and retinal changes during long-term follow-up[J]. Br J Ophthalmol, 2018, 102(1): 84-90. DOI: 10.1136/bjophthalmol-2016-310128.

1. Michalewska Z, Michalewski J, Odrobina D, et al. Non-full-thickness macular holes reassessed with spectral domain optical coherence tomography[J]. Retina, 2012, 32(5): 922-929. DOI: 10.1097/IAE.0b013e318227.
2. Schumann RG, Compera D, Schaumberger MM, et al. Epiretinal membrane characteristics correlate with photoreceptor layer defects in lamellar macular holes and macular pseudoholes[J]. Retina, 2015, 35(4): 727-735. DOI: 10.1097/IAE.0000000000000375.
3. Govetto A, Dacquay Y, Farajzadeh M, et al. Lamellar macular hole: two distinct clinical entities?[J]. Am J Ophthalmol, 2016, 164: 99-109. DOI: 10.1016/j.ajo.2016.02.008.
4. Compera D, Entchev E, Haritoglou C, et al. Lamellar hole-associated epiretinal proliferation in comparison to epiretinal membranes of macular pseudoholes[J]. Am J Ophthalmol, 2015, 160(2): 373-384. DOI: 10.1016/j.ajo.2015.05.010.
5. Pang CE, Maberley DA, Freund KB, et al. Lamellar hole-associated epiretinal proliferation: a clinicopathologic correlation[J]. Retina, 2016, 36(7): 1408-1412. DOI: 10.1097/IAE.0000000000001069.
6. Gass JD. Müller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis[J]. Arch Ophthalmol, 1999, 117(6): 821-823. DOI: 10.1001/archopht.117.6.821.
7. Pang CE, Spaide RF, Freund KB. Epiretinal proliferation seen in association with lamellar macular holes:a distinct clinical entity[J]. Retina, 2014, 34(8): 1513-1523. DOI: 10.1097/IAE.0000000000000163.
8. Parolini B, Schumann RG, Cereda MG, et al. Lamellar macular hole:a clinicopathologic correlation of surgically excised epiretinal membranes[J]. Invest Ophthalmol Vis Sci, 2011, 52(12): 9074-9083. DOI: 10.1167/iovs.11-8227.
9. Compera D, Entchev E, Haritoglou C, et al. Correlative microscopy of lamellar hole-associated epiretinal proliferation[J]. J Ophthalmol, 2015, 2015: 450212. DOI: 10.1155/2015/450212.
10. Hiscott PS, Grierson I, Trombetta CJ, et al. Retinal and epiretinal glia--an immunohistochemical study[J]. Br J Ophthalmol, 1984, 68(10): 698-707. DOI: 10.1136/bjo.68.10.698.
11. Obana A, Sasano H, Okazaki S. Evidence of carotenoid in surgically removed lamellar hole-associated epiretinal proliferation[J]. Invest Ophthalmol Vis Sci, 2017, 58(12): 5157-5163. DOI: 10.1167/iovs.17-22347.
12. dell'Omo R, Virgili G, Rizzo S, et al. Role of lamellar hole-associated epiretinal proliferation in lamellar macular holes[J]. Am J Ophthalmol, 2017, 175: 16-29. DOI: 10.1016/j.ajo.2016.11.007.
13. Witkin AJ, Ko TH, Fujimoto JG, et al. Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study[J]. Ophthalmology, 2006, 113(3): 388-397. DOI: 10.1016/j.ophtha.2005.10.047.
14. Ko J, Kim GA, Lee SC, et al. Surgical outcomes of lamellar macular holes with and without lamellar hole-associated epiretinalproliferation[J]. Acta Ophthalmol, 2017, 95(3): 221-226. DOI: 10.1111/aos.13245.
15. Hirakawa M, Uemura A, Nakano T, et al. Pars plana vitrectomy with gas tamponade for lamellar macular holes[J]. Am J Ophthalmol, 2005, 140(6): 1154-1155. DOI: 10.1016/j.ajo.2005.07.022.
16. Lai TT, Chen SN, Yang CM. Epiretinal proliferation in lamellar macular holes and full-thickness macular holes: clinical and surgical findings[J]. Graefe’s Arch Clin Exp Ophthalmol, 2016, 254(4): 629-638. DOI: 10.1007/s00417-015-3133-9.
17. Compera D, Schumann RG, Cereda MG. Progression of lamellar hole-associated epiretinal proliferation and retinal changes during long-term follow-up[J]. Br J Ophthalmol, 2018, 102(1): 84-90. DOI: 10.1136/bjophthalmol-2016-310128.

Chinese Journal of Ocular Fundus Diseases

Diagnosis and treatment progress of lamellar hole-associated epiretinal proliferation

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content