The clinical applications of adaptive optics scanning laser ophthalmoscope_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhang Jianping ,  Zhang Meixia

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, China;

Corresponding author：

Zhang Meixia, Email: meixiazhang@foxmail.com

Keywords：

Microscopy, confocal; Review; Adaptive optics

DOI：

10.3760/cma.j.issn.1005-1015.2019.06.025

Video：

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Adaptive optics (AO) is a technique to improve the performance of optical systems by reducing the influence of optical aberrations. Combined with scanning laser ophthalmoscope (AOSLO), the aberration of human refractive system can be corrected. Thus, the resolution and quality of imaging can be greatly improved to the cellular level in vivo retina (such as photoreceptor, nerve fibers, vascular parietal cell), therefore the earlier changes of the diseases can be detected. At the same time, microstructure changes of retinal can also be observed during the follow-up of the disease. Due to inherent technical defects of AOSLO, its wide application in clinical practice is limited. With the continuous progress of AO technology and the further improvement of related software functions, the function of the system will become more stronger and will play a more and more important role in scientific research and clinic.

Citation： Zhang Jianping, Zhang Meixia. The clinical applications of adaptive optics scanning laser ophthalmoscope. Chinese Journal of Ocular Fundus Diseases, 2019, 35(6): 625-627. doi: 10.3760/cma.j.issn.1005-1015.2019.06.025 Copy

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2.	Babcock HW. The possibility of compensating astronomical seeing[J]. Publ Astron Soc Pac, 1953, 65(386): 229-236.
3.	Roorda A. Applications of adaptive optics scanning laser ophthalmoscopy[J]. Optom Vis Sci, 2010, 87(4): 260-268. DOI: 10.1097/OPX.0b013e3181d39479.
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5.	Zhang B, Li N, Kang J, et al. Adaptive optics scanning laser ophthalmoscopy in fundus imaging, a review and update[J]. Int J Ophthalmol, 2017, 10(11): 1751-1758. DOI: 10.18240/ijo.2017.11.18.
6.	Mujat M, Ferguson RD, Iftimia N, et al. Compact adaptive optics line scanning ophthalmoscope[J]. Opt Express, 2009, 17(12): 10242-10258. DOI: 10.1364/oe.17.010242.
7.	Boretsky A, Khan F, Burnett G, et al. In vivo imaging of photoreceptor disruption associated with age-related macular degeneration: a pilot study[J]. Lasers Surg Med, 2012, 44(8): 603-610. DOI: 10.1002/lsm.22070.
8.	Sheehy CK, Tiruveedhula P, Sabesan R, et al. Active eye-tracking for an adaptive optics scanning laser ophthalmoscope[J]. Biomed Opt Express, 2015, 6(7): 2412-2423. DOI: 10.1364/BOE.6.002412.
9.	Mo S, Krawitz B, Efstathiadis E, et al. Imaging foveal microvasculature: optical coherence tomography angiography versus adaptive optics scanning light ophthalmoscope fluorescein angiography[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 130-140. DOI: 10.1167/iovs.15-18932.
10.	Chui TY, Gast TJ, Burns SA. Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy[J]. Invest Ophthalmol Vis Sci, 2013, 54(10): 7115-7124. DOI: 10.1167/iovs.13-13027.
11.	Chen M, Cooper RF, Han GK, et al. Multimodal automatic montaging of adaptive optics retinal images[J]. Biomed Opt Express, 2016, 7(12): 4899-4918. DOI: 10.1364/BOE.7.004899.
12.	Thaung J, Knutsson P, Popovic Z, et al. Dual-conjugate adaptive optics for wide-field high-resolution retinal imaging[J]. Opt Express, 2009, 17(6): 4454-4467. DOI: 10.1364/oe.17.004454.
13.	刘瑞雪, 郑贤良, 夏明亮, 等. 视标引导的自适应光学眼底成像视场精确定位[J]. 红外与激光工程, 2015, 44(6): 1794-1799. DOI: 10.3969/j.issn.1007-2276.2015.06.021.Liu RX, Zheng XL, Xia ML, et al. Accurate fixation of adaptive optics fundus imaging field of view based on visual target guidance[J]. Infrared and Laser Engineering, 2015, 44(6): 1794-1799. DOI: 10.3969/j.issn.1007-2276.2015.06.021.
14.	Luo T, Gast TJ, Vermeer TJ, et al. Retinal vascular branching in healthy and diabetic subjects[J]. Invest Ophthalmol Vis Sci, 2017, 58(5): 2685-2694. DOI: 10.1167/iovs.17-21653.
15.	Lammer J, Prager SG, Cheney MC, et al. Cone photoreceptor irregularity on adaptive optics scanning laser ophthalmoscopy correlates with severity of diabetic retinopathy and macular edema[J]. Invest Ophthalmol Vis Sci, 2016, 57(15): 6624-6632. DOI: 10.1167/iovs.16-19537.
16.	Arichika S, Uji A, Murakami T, et al. Retinal hemorheologic characterization of early-stage diabetic retinopathy using adaptive optics scanning laser ophthalmoscopy[J]. Invest Ophthalmol Vis Sci, 2014, 55(12): 8513-8522. DOI: 10.1167/iovs.14-15121.
17.	Birnbach CD, Jarvelainen M, Possin DE, et al. Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus[J]. Ophthalmology, 1994, 101(7): 1211-1219. DOI: 10.1016/s0161-6420(13)31725-4.
18.	Talcott KE, Ratnam K, Sundquist SM, et al. Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment[J]. Invest Ophthalmol Vis Sci, 2011, 52(5): 2219-2226. DOI: 10.1167/iovs.10-6479.
19.	Park SP, Lee W, Bae EJ, et al. Early structural anomalies observed by high-resolution imaging in two related cases of autosomal-dominant retinitis pigmentosa[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(5): 469-473. DOI: 10.3928/23258160-20140908-01.
20.	Nakatake S, Murakami Y, Funatsu J, et al. Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(6): 1169-1181. DOI: 10.1007/s00417-019-04307-0.
21.	Steinmetz RL, Garner A, Maguire JI, et al. Histopathology of incipient fundus flavimaculatus[J]. Ophthalmology, 1991, 98(6): 953-956. DOI: 10.1016/s0161-6420(91)32197-3.
22.	Chen Y, Ratnam K, Sundquist SM, et al. Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease[J]. Invest Ophthalmol Vis Sci, 2011, 52(6): 3281-3292. DOI: 10.1167/iovs.10-6538.

1. Mainster MA, Timberlake GT, Webb RH. Scaning laser ophthalmoscopy: clinical applications[J]. Ophthalmology, 1982, 89: 852-857. DOI: 10.1016/s0161-6420(82)34714-4.
2. Babcock HW. The possibility of compensating astronomical seeing[J]. Publ Astron Soc Pac, 1953, 65(386): 229-236.
3. Roorda A. Applications of adaptive optics scanning laser ophthalmoscopy[J]. Optom Vis Sci, 2010, 87(4): 260-268. DOI: 10.1097/OPX.0b013e3181d39479.
4. Liang J, Williams DR, Miller DT. Supernormal vision and highresolution retinal imaging through adaptive optics[J]. J Opt Soc Am A Opt Image Sci Vis, 1997, 14(11): 2884-2892. DOI: 10.1364/josaa.14.002884.
5. Zhang B, Li N, Kang J, et al. Adaptive optics scanning laser ophthalmoscopy in fundus imaging, a review and update[J]. Int J Ophthalmol, 2017, 10(11): 1751-1758. DOI: 10.18240/ijo.2017.11.18.
6. Mujat M, Ferguson RD, Iftimia N, et al. Compact adaptive optics line scanning ophthalmoscope[J]. Opt Express, 2009, 17(12): 10242-10258. DOI: 10.1364/oe.17.010242.
7. Boretsky A, Khan F, Burnett G, et al. In vivo imaging of photoreceptor disruption associated with age-related macular degeneration: a pilot study[J]. Lasers Surg Med, 2012, 44(8): 603-610. DOI: 10.1002/lsm.22070.
8. Sheehy CK, Tiruveedhula P, Sabesan R, et al. Active eye-tracking for an adaptive optics scanning laser ophthalmoscope[J]. Biomed Opt Express, 2015, 6(7): 2412-2423. DOI: 10.1364/BOE.6.002412.
9. Mo S, Krawitz B, Efstathiadis E, et al. Imaging foveal microvasculature: optical coherence tomography angiography versus adaptive optics scanning light ophthalmoscope fluorescein angiography[J]. Invest Ophthalmol Vis Sci, 2016, 57(9): 130-140. DOI: 10.1167/iovs.15-18932.
10. Chui TY, Gast TJ, Burns SA. Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy[J]. Invest Ophthalmol Vis Sci, 2013, 54(10): 7115-7124. DOI: 10.1167/iovs.13-13027.
11. Chen M, Cooper RF, Han GK, et al. Multimodal automatic montaging of adaptive optics retinal images[J]. Biomed Opt Express, 2016, 7(12): 4899-4918. DOI: 10.1364/BOE.7.004899.
12. Thaung J, Knutsson P, Popovic Z, et al. Dual-conjugate adaptive optics for wide-field high-resolution retinal imaging[J]. Opt Express, 2009, 17(6): 4454-4467. DOI: 10.1364/oe.17.004454.
13. 刘瑞雪, 郑贤良, 夏明亮, 等. 视标引导的自适应光学眼底成像视场精确定位[J]. 红外与激光工程, 2015, 44(6): 1794-1799. DOI: 10.3969/j.issn.1007-2276.2015.06.021.Liu RX, Zheng XL, Xia ML, et al. Accurate fixation of adaptive optics fundus imaging field of view based on visual target guidance[J]. Infrared and Laser Engineering, 2015, 44(6): 1794-1799. DOI: 10.3969/j.issn.1007-2276.2015.06.021.
14. Luo T, Gast TJ, Vermeer TJ, et al. Retinal vascular branching in healthy and diabetic subjects[J]. Invest Ophthalmol Vis Sci, 2017, 58(5): 2685-2694. DOI: 10.1167/iovs.17-21653.
15. Lammer J, Prager SG, Cheney MC, et al. Cone photoreceptor irregularity on adaptive optics scanning laser ophthalmoscopy correlates with severity of diabetic retinopathy and macular edema[J]. Invest Ophthalmol Vis Sci, 2016, 57(15): 6624-6632. DOI: 10.1167/iovs.16-19537.
16. Arichika S, Uji A, Murakami T, et al. Retinal hemorheologic characterization of early-stage diabetic retinopathy using adaptive optics scanning laser ophthalmoscopy[J]. Invest Ophthalmol Vis Sci, 2014, 55(12): 8513-8522. DOI: 10.1167/iovs.14-15121.
17. Birnbach CD, Jarvelainen M, Possin DE, et al. Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus[J]. Ophthalmology, 1994, 101(7): 1211-1219. DOI: 10.1016/s0161-6420(13)31725-4.
18. Talcott KE, Ratnam K, Sundquist SM, et al. Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment[J]. Invest Ophthalmol Vis Sci, 2011, 52(5): 2219-2226. DOI: 10.1167/iovs.10-6479.
19. Park SP, Lee W, Bae EJ, et al. Early structural anomalies observed by high-resolution imaging in two related cases of autosomal-dominant retinitis pigmentosa[J]. Ophthalmic Surg Lasers Imaging Retina, 2014, 45(5): 469-473. DOI: 10.3928/23258160-20140908-01.
20. Nakatake S, Murakami Y, Funatsu J, et al. Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(6): 1169-1181. DOI: 10.1007/s00417-019-04307-0.
21. Steinmetz RL, Garner A, Maguire JI, et al. Histopathology of incipient fundus flavimaculatus[J]. Ophthalmology, 1991, 98(6): 953-956. DOI: 10.1016/s0161-6420(91)32197-3.
22. Chen Y, Ratnam K, Sundquist SM, et al. Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease[J]. Invest Ophthalmol Vis Sci, 2011, 52(6): 3281-3292. DOI: 10.1167/iovs.10-6538.

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