The value of color Doppler ultrasound in the detection of macular diseases in age-related cataract patients_Chinese Journal of Ocular Fundus Diseases

Authors：

Shen Lin ,  Yang Wenli , Li Dongjun , Wang Ziyang , Chen Wei , Zhao Qi , Li Yifeng , Cui Rui , Xian Junfang

Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;

Corresponding author：

Yang Wenli, Email: yangwl_tr@163.com

Keywords：

Ultrasonography, doppler, color; Macular degeneration; Cataract

DOI：

10.3760/cma.j.issn.1005-1015.2020.01.008

Video：

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Objective To observe the application value with color Doppler flow imaging (CDFI) in the detection of macular diseases in senile cataract.Methods A cross-sectional descriptive study. From December 1 to December 30, 2017, 720 senile cataract patients (1380 eyes) diagnosed in Beijing Tongren Eye Center were included in this study. There were 330 males (629 eyes) and 390 females (751 eyes), with the mean age of 70.35±19.05 years. There were 716 right eyes and 664 left eyes, with the visual acuity 0.05-0.8. The fundus of all the patients can be observed. All patients were examined by OCT using Cirrus HD-Model 5000 produced by German Carl Zeiss company and CDFI using MyLab90 color Doppler ultrasound system produced by ESAOTE S.P.A. Comparing the detection rate of macular lesions between the two methods by using χ² test. Using statistical methods to evaluate diagnostic tests, a crosstabulation was made to compare the consistency of frequency-domain OCT and CDFI in the diagnosis of macular lesions. Logistic regression analysis of correlation between detection of CDFI macular lesions and central foveal thickness (CFT), average thickness (AT), with or without macular anterior membrane, retinal folds, retinal cystoid edema, hard exudation, macular hole or lamellar macular hole, superficial detachment of neuroepithelium, detachment of pigment epithelium, vitreous macular traction.Results Two hundreds and thirty-nine eyes (17.3%) showed macular disease by OCT, and 161 eyes (11.7%) showed the abnormal echo in the macular region by CDFI. The detection rate of the macular disease between two methods were statistically significant (χ²=851.661, P＜0.001), however, the consistency was well (κ=0.766, P=0.000). Logistic analysis showed that the detection rate of macular lesions was related to retinal folds, cysts in retina and CFT (r=1.396, 1.041, 0.12; P＜0.01).Conclusion CDFI can effectively detect macular lesions that affect the visual prognosis of senile cataract patients.

Citation： Shen Lin, Yang Wenli, Li Dongjun, Wang Ziyang, Chen Wei, Zhao Qi, Li Yifeng, Cui Rui, Xian Junfang. The value of color Doppler ultrasound in the detection of macular diseases in age-related cataract patients. Chinese Journal of Ocular Fundus Diseases, 2020, 36(1): 33-37. doi: 10.3760/cma.j.issn.1005-1015.2020.01.008 Copy

1.	钟世镇. 眼科临床解剖学[M]. 济南: 山东科学技术出版社, 2009: 45.Zhong SZ. Ophthalmology clinical anatomy[M]. Jinan: Shandong Science and Technology Press, 2009: 45.
2.	王进达, 张景尚, 李婧, 等. 高度近视合并白内障患者白内障超声乳化联合IOL植入术后的视力预后及其影响因素[J]. 中华眼视光学及视觉科学杂志, 2014, 16(11): 679-681. DOI: 10.3760/cma.j.issn.1674-845X.2014.11.010.Wang JD, Zhang JS, Li J, et al. Visual outcomes and related factors in cataract patients with high myopia after phacoemulsification and intraocular lenes implantation[J]. Chin J Ophthalmol Vis Sci, 2014, 16(11): 679-681. DOI: 10.3760/cma.j.issn.1674-845X.2014.11.010.
3.	王凯, 鲍永珍, 侯宪如, 等. 大量集中白内障手术术后早期视力状况及相关因素分析[J]. 中国实用眼科杂志, 2010, 28(7): 794-796. DOI: 10.3760/cma.j.issn.1006-4443.2010.07.035.Wang K, Bao YZ, Hou XR, et al. Analysis of correlation factors concerning early visual acuity of high volume cataract surgery[J]. Chin J Pract Ophthalmol, 2010, 28(7): 794-796. DOI: 10.3760/cma.j.issn.1006-4443.2010.07.035.
4.	Dimitrova G, Kato S. Color Doppler imaging of retinal diseases[J]. Surv Ophthalmol, 2010, 55(3): 193-214. DOI: 10.1016/j.survophthal.2009.06.010.
5.	Philippakis E, Legrand M, El Sanharawi M, et al. Measurement of full-thickness macular hole size using en face optical coherence tomography[J]. Eye (Lond), 2018, 32(3): 590-596. DOI: 10.1038/eye.2017.254.
6.	杨文利, 魏文斌, 王景昭. 年龄相关性黄斑变性的彩色多普勒超声影像特征[J]. 中华眼科杂志, 2005, 41(1): 300-304. DOI: 10.3760/j.issn.0412-4081.2005.04.004.Yang WL, Wei WB, Wang JZ. Analysis of changes of color Doppler flow imaging in age-related macular degeneration[J]. Chin J Ophthalmol, 2005, 41(1): 300-304. DOI: 10.3760/j.issn.0412-4081.2005.04.004.
7.	Hassenstein A, Scholz F, Inboffen W, et al. Clinical relevance of a new digital integration method (DIM)for the precise integration of OCT and fluorescein angiography(FLA)[J]. Klin Monatsbl Augenheilkd, 2009, 226(2): 90-96. DOI: 10.1055/s-2008-1027872.
8.	Murakami T, Nishijima K, Sakamoto A, et al. Association of pathomorphology, photore ceptor statusand retinal thickness visual acuity in diabefic retinopathyf[J]. Am J Ophthalmol, 2011, 151(2): 310-317. DOI: 10.1016/j.ajo.2010.08.022.
9.	葛坚. 眼科学[M]. 北京, 人民卫生出版社, 2005: 512.Ge J. Ophthalmology[M]. Beijing: People's Medical Publishing House, 2005: 512.
10.	王建伟, 接传红, 陶永健, 等. 糖尿病黄斑水肿患眼黄斑区视功能与黄斑中心凹视网膜厚度的相关性分析[J]. 中华眼底病杂志, 2017, 33(3): 267-270. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.011.Wang JW, Jie CH, Tao YJ, er al. Correlation of macular visual function and macular central retinal thickness in diabetic macular edema eyes[J]. Chin J Ocul Fundus Dis, 2017, 33(3): 267-270. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.011.
11.	谢娟, 成霄黎, 李西玲, 等. 黄斑水肿的光相干断层扫描分析[J]. 中华眼底病杂志, 2004, 20(3): 152-155. DOI: 10.3760/j.issn.1005-1015.2004.03.007.Xie J, Cheng XL, Li XL, et al. Optical coherence tomography in macular edema[J]. Chin J Ocul Fundus Dis, 2004, 20(3): 152-155. DOI: 10.3760/j.issn.1005-1015.2004.03.007.
12.	米兰, 黄时洲, 肖辉, 等. 特发性视网膜前膜患者黄斑区视网膜厚度及显微结构改变与视力的关系[J]. 中华实验眼科杂志, 2013, 31(5): 461-464. DOI: 10.3760/cma.j.issn.2095-0160.2013.05.011.Mi L, Huang SZ, Xiao H, et al. Relationship of the change of macular thickness and microstructure with visual acuity in eye with idiopathic epiretinal membrane[J]. Chin J Exp Ophthalmol, 2013, 31(5): 461-464. DOI: 10.3760/cma.j.issn.2095-0160.2013.05.011.
13.	张惠蓉, 王欣, 鹿新荣, 等. 视网膜静脉阻塞致黄斑水肿患者相干光断层扫描和视力预后观察[J]. 中华眼科杂志, 2005, 41(10): 910-916. DOI: 10.3760/j.issn.0412-4081.2005.10.011.Zhang HR, Wang X, Lu XR, et al. Measurement of macular edema in retinal vein occlusion using optical coherence tomography and its visual prognosis[J]. Chin J Ophthalmol, 2005, 41(10): 910-916. DOI: 10.3760/j.issn.0412-4081.2005.10.011.
14.	Suh MH, Seo JM, Park KH, et al. Associations between macular findings by optical coherence tomography and visual outcomes after epiretinal membrane removal[J]. Am J Ophthalmol, 2009, 147(3): 473-480. DOI: 10.1016/j.ajo.2008.09.020.
15.	杨晓璐, 邹海东, 许迅, 等. 不同类型糖尿病黄斑水肿患者视网膜敏感度和视力与黄斑厚度相关性分析[J]. 中华眼科杂志, 2013, 49(12): 1081-1089. DOI: 10.3760/cma.j.issn.0412-4081.2013.12.006.Yang XL, Zou HD, Xu X, et al. Correlation of retinal sensitivity, visual acuity and central macular thickness in different types of diabetic macular edema[J]. Chin J Ophthalmol, 2013, 49(12): 1081-1089. DOI: 10.3760/cma.j.issn.0412-4081.2013.12.006.
16.	Wang MZ, Feng K, Lu Y, et al. Predictors of short-term outcomes related to central subfield foveal thickness after intravitreal bevacizumab for macular edema due to central retinal vein occlusion[J]. Int J Ophthalmol, 2016, 9(1): 86-92. DOI: 10.18240/ijo.2016.01.15.
17.	Willmann G, Nepomuceno AB, Messias K, et al. Foveal thickness reduction after anti-vascular endothelial growth factor treatment in chronic diabetic macular edema[J]. Int J Ophthalmol, 2017, 10(5): 760-764. DOI: 10.18240/ijo.2017.05.17.
18.	俞茄, 姜春晖, 徐格致, 等. 特发性黄斑前膜的频域光相干断层扫描特征以及与视力的相互关系[J]. 中华眼底病杂志, 2009, 25(3): 179-181. DOI: 10.3760/cma.j.issn.1005-1015.2009.03.006.Yu J, Jiang CH, Xu GZ, et al. Characteristics of idiopathic epiretinal membrane by new Fourier-domain optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2009, 25(3): 179-181. DOI: 10.3760/cma.j.issn.1005-1015.2009.03.006.
19.	Holland SM, Dodwell DG, Krimmel DA, et al. Retrospective analyses of optical coherence tomography in recurrent macular edema following intravitreal therapy in patients with retinal vein occlusion[J]. BMC Ophthalmol, 2015, 15(9): 117.
20.	李玮, 杜新华, 李淑婷, 等. 糖尿病黄斑水肿光相干断层扫描分型与糖尿病视网膜病变分期及全身因素的相关性分析[J]. 中华眼底病杂志, 2017, 33(3): 262-266. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.010.Li W, Du XH, Li ST, et al. Optical coherence tomography distribution patterns of diabetic macular edema and its correlations with diabetic retinopathy stages and systemic factors[J]. Chin J Ocul Fundus Dis, 2017, 33(3): 262-266. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.010.
21.	Ting TD, Oh M, Cox TA, et al. Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration[J]. Arch Ophthalmol, 2002, 120(6): 731-737. DOI: 10.1001/archopht.120.6.731.
22.	冯雪峰, 丁爱华, 王欣, 等. B型超声和频域光相干断层扫描在玻璃体后脱离临床诊断中的作用[J]. 中华眼底病杂志, 2013, 29(5): 470-473. DOI: 10.3760/cma.j.issn.1005-1015.2013.05.006.Feng XF, Ding AH,Wang X, et al. Diagnosis of posterior vitreous detachment with B-mode ultrasonography and optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2013, 29(5): 470-473. DOI: 10.3760/cma.j.issn.1005-1015.2013.05.006.

1. 钟世镇. 眼科临床解剖学[M]. 济南: 山东科学技术出版社, 2009: 45.Zhong SZ. Ophthalmology clinical anatomy[M]. Jinan: Shandong Science and Technology Press, 2009: 45.
2. 王进达, 张景尚, 李婧, 等. 高度近视合并白内障患者白内障超声乳化联合IOL植入术后的视力预后及其影响因素[J]. 中华眼视光学及视觉科学杂志, 2014, 16(11): 679-681. DOI: 10.3760/cma.j.issn.1674-845X.2014.11.010.Wang JD, Zhang JS, Li J, et al. Visual outcomes and related factors in cataract patients with high myopia after phacoemulsification and intraocular lenes implantation[J]. Chin J Ophthalmol Vis Sci, 2014, 16(11): 679-681. DOI: 10.3760/cma.j.issn.1674-845X.2014.11.010.
3. 王凯, 鲍永珍, 侯宪如, 等. 大量集中白内障手术术后早期视力状况及相关因素分析[J]. 中国实用眼科杂志, 2010, 28(7): 794-796. DOI: 10.3760/cma.j.issn.1006-4443.2010.07.035.Wang K, Bao YZ, Hou XR, et al. Analysis of correlation factors concerning early visual acuity of high volume cataract surgery[J]. Chin J Pract Ophthalmol, 2010, 28(7): 794-796. DOI: 10.3760/cma.j.issn.1006-4443.2010.07.035.
4. Dimitrova G, Kato S. Color Doppler imaging of retinal diseases[J]. Surv Ophthalmol, 2010, 55(3): 193-214. DOI: 10.1016/j.survophthal.2009.06.010.
5. Philippakis E, Legrand M, El Sanharawi M, et al. Measurement of full-thickness macular hole size using en face optical coherence tomography[J]. Eye (Lond), 2018, 32(3): 590-596. DOI: 10.1038/eye.2017.254.
6. 杨文利, 魏文斌, 王景昭. 年龄相关性黄斑变性的彩色多普勒超声影像特征[J]. 中华眼科杂志, 2005, 41(1): 300-304. DOI: 10.3760/j.issn.0412-4081.2005.04.004.Yang WL, Wei WB, Wang JZ. Analysis of changes of color Doppler flow imaging in age-related macular degeneration[J]. Chin J Ophthalmol, 2005, 41(1): 300-304. DOI: 10.3760/j.issn.0412-4081.2005.04.004.
7. Hassenstein A, Scholz F, Inboffen W, et al. Clinical relevance of a new digital integration method (DIM)for the precise integration of OCT and fluorescein angiography(FLA)[J]. Klin Monatsbl Augenheilkd, 2009, 226(2): 90-96. DOI: 10.1055/s-2008-1027872.
8. Murakami T, Nishijima K, Sakamoto A, et al. Association of pathomorphology, photore ceptor statusand retinal thickness visual acuity in diabefic retinopathyf[J]. Am J Ophthalmol, 2011, 151(2): 310-317. DOI: 10.1016/j.ajo.2010.08.022.
9. 葛坚. 眼科学[M]. 北京, 人民卫生出版社, 2005: 512.Ge J. Ophthalmology[M]. Beijing: People's Medical Publishing House, 2005: 512.
10. 王建伟, 接传红, 陶永健, 等. 糖尿病黄斑水肿患眼黄斑区视功能与黄斑中心凹视网膜厚度的相关性分析[J]. 中华眼底病杂志, 2017, 33(3): 267-270. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.011.Wang JW, Jie CH, Tao YJ, er al. Correlation of macular visual function and macular central retinal thickness in diabetic macular edema eyes[J]. Chin J Ocul Fundus Dis, 2017, 33(3): 267-270. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.011.
11. 谢娟, 成霄黎, 李西玲, 等. 黄斑水肿的光相干断层扫描分析[J]. 中华眼底病杂志, 2004, 20(3): 152-155. DOI: 10.3760/j.issn.1005-1015.2004.03.007.Xie J, Cheng XL, Li XL, et al. Optical coherence tomography in macular edema[J]. Chin J Ocul Fundus Dis, 2004, 20(3): 152-155. DOI: 10.3760/j.issn.1005-1015.2004.03.007.
12. 米兰, 黄时洲, 肖辉, 等. 特发性视网膜前膜患者黄斑区视网膜厚度及显微结构改变与视力的关系[J]. 中华实验眼科杂志, 2013, 31(5): 461-464. DOI: 10.3760/cma.j.issn.2095-0160.2013.05.011.Mi L, Huang SZ, Xiao H, et al. Relationship of the change of macular thickness and microstructure with visual acuity in eye with idiopathic epiretinal membrane[J]. Chin J Exp Ophthalmol, 2013, 31(5): 461-464. DOI: 10.3760/cma.j.issn.2095-0160.2013.05.011.
13. 张惠蓉, 王欣, 鹿新荣, 等. 视网膜静脉阻塞致黄斑水肿患者相干光断层扫描和视力预后观察[J]. 中华眼科杂志, 2005, 41(10): 910-916. DOI: 10.3760/j.issn.0412-4081.2005.10.011.Zhang HR, Wang X, Lu XR, et al. Measurement of macular edema in retinal vein occlusion using optical coherence tomography and its visual prognosis[J]. Chin J Ophthalmol, 2005, 41(10): 910-916. DOI: 10.3760/j.issn.0412-4081.2005.10.011.
14. Suh MH, Seo JM, Park KH, et al. Associations between macular findings by optical coherence tomography and visual outcomes after epiretinal membrane removal[J]. Am J Ophthalmol, 2009, 147(3): 473-480. DOI: 10.1016/j.ajo.2008.09.020.
15. 杨晓璐, 邹海东, 许迅, 等. 不同类型糖尿病黄斑水肿患者视网膜敏感度和视力与黄斑厚度相关性分析[J]. 中华眼科杂志, 2013, 49(12): 1081-1089. DOI: 10.3760/cma.j.issn.0412-4081.2013.12.006.Yang XL, Zou HD, Xu X, et al. Correlation of retinal sensitivity, visual acuity and central macular thickness in different types of diabetic macular edema[J]. Chin J Ophthalmol, 2013, 49(12): 1081-1089. DOI: 10.3760/cma.j.issn.0412-4081.2013.12.006.
16. Wang MZ, Feng K, Lu Y, et al. Predictors of short-term outcomes related to central subfield foveal thickness after intravitreal bevacizumab for macular edema due to central retinal vein occlusion[J]. Int J Ophthalmol, 2016, 9(1): 86-92. DOI: 10.18240/ijo.2016.01.15.
17. Willmann G, Nepomuceno AB, Messias K, et al. Foveal thickness reduction after anti-vascular endothelial growth factor treatment in chronic diabetic macular edema[J]. Int J Ophthalmol, 2017, 10(5): 760-764. DOI: 10.18240/ijo.2017.05.17.
18. 俞茄, 姜春晖, 徐格致, 等. 特发性黄斑前膜的频域光相干断层扫描特征以及与视力的相互关系[J]. 中华眼底病杂志, 2009, 25(3): 179-181. DOI: 10.3760/cma.j.issn.1005-1015.2009.03.006.Yu J, Jiang CH, Xu GZ, et al. Characteristics of idiopathic epiretinal membrane by new Fourier-domain optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2009, 25(3): 179-181. DOI: 10.3760/cma.j.issn.1005-1015.2009.03.006.
19. Holland SM, Dodwell DG, Krimmel DA, et al. Retrospective analyses of optical coherence tomography in recurrent macular edema following intravitreal therapy in patients with retinal vein occlusion[J]. BMC Ophthalmol, 2015, 15(9): 117.
20. 李玮, 杜新华, 李淑婷, 等. 糖尿病黄斑水肿光相干断层扫描分型与糖尿病视网膜病变分期及全身因素的相关性分析[J]. 中华眼底病杂志, 2017, 33(3): 262-266. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.010.Li W, Du XH, Li ST, et al. Optical coherence tomography distribution patterns of diabetic macular edema and its correlations with diabetic retinopathy stages and systemic factors[J]. Chin J Ocul Fundus Dis, 2017, 33(3): 262-266. DOI: 10.3760/cma.j.issn.1005-1015.2017.03.010.
21. Ting TD, Oh M, Cox TA, et al. Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration[J]. Arch Ophthalmol, 2002, 120(6): 731-737. DOI: 10.1001/archopht.120.6.731.
22. 冯雪峰, 丁爱华, 王欣, 等. B型超声和频域光相干断层扫描在玻璃体后脱离临床诊断中的作用[J]. 中华眼底病杂志, 2013, 29(5): 470-473. DOI: 10.3760/cma.j.issn.1005-1015.2013.05.006.Feng XF, Ding AH,Wang X, et al. Diagnosis of posterior vitreous detachment with B-mode ultrasonography and optical coherence tomography[J]. Chin J Ocul Fundus Dis, 2013, 29(5): 470-473. DOI: 10.3760/cma.j.issn.1005-1015.2013.05.006.

Chinese Journal of Ocular Fundus Diseases

The value of color Doppler ultrasound in the detection of macular diseases in age-related cataract patients

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