A Detection Method of Liver Iron Overload Based on Static Field Magnetization Principle_Journal of Biomedical Engineering

Authors：

ZHANGZiyi ^1,2 ,  LIUPeiguo ² , ZHANGLiang ^1,2 , DINGLiang ² , LINXiaohong ²

1. College of Science, National University of Defense Technology, Changsha 410073, China;
2. College of Electronic Science and Engineering, National University of Defense Technology, Changsha 410073, China;

Corresponding author：

LIUPeiguo, Email: peiguo_Liu@hotmail.com

Keywords：

liver iron overload; magnetic susceptibility; coil system; static field magnetization

DOI：

10.7507/1001-5515.20140006

Video：

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Magnetic induction method aims at the noninvasive detection of liver iron overload by measuring the hepatic magnetic susceptibility. To solve the difficulty that eddy current effects interfere with the measurement of magnetic susceptibility, we proposed an improved coil system based on the static field magnetization principle in this study. We used a direct current excitation to eliminate the eddy current effect, and a rotary receiver coil to get the induced voltage. The magnetic field for a cylindrical object due to the magnetization effect was calculated and the relative change of maximum induced voltage was derived. The correlation between magnetic susceptibility of object and maximum magnetic flux, maximum induced voltage and relative change of maximum induced voltage of the receiver coil were obtained by simulation experiments, and the results were compared with those of the theory calculation. The contrast shows that the simulation results fit the theory results well, which proves our method can eliminate the eddy current effect effectively.

Citation： ZHANGZiyi, LIUPeiguo, ZHANGLiang, DINGLiang, LINXiaohong. A Detection Method of Liver Iron Overload Based on Static Field Magnetization Principle. Journal of Biomedical Engineering, 2014, 31(1): 29-34. doi: 10.7507/1001-5515.20140006 Copy

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2.	BRITTENHAM G M, BADMAN D G. Noninvasive measurement of iron:report of an NIDDK workshop[J]. Blood, 2003, 101(1):15-19.
3.	BAUMAN J H, HARRIS J W. Estimation of hepatic iron stores by in vivo measurement of magnetic susceptibility[J]. J Lab Clin Med, 1967, 70(2):246-257.
4.	BAUMAN J H, HOFFMAN R W. Magnetic susceptibility meter for in vivo estimation of hepatic iron stores[J]. IEEE Trans Biomed Eng, 1967, 14(4):239-243.
5.	CASAAS R, SCHARFETTER H, ALTES A, et al. Magnetic induction system for noninvasive measurement of susceptibility and conductivity of biological tissues[C]//Proc 11th Conf on Electrical Bio-Impedance, Oslo, Norway, June 2001:623-626.
6.	SCHARFETTER H, CASAAS R, ROSELL J. Biological tissue characterization by magnetic induction spectroscopy (MIS):requirements and limitations[J]. IEEE Trans Biomed Eng, 2003, 50(7):870-880.
7.	CASAAS R, SCHARFETTER H, ALTES A, et al. Measurement of liver iron overload by magnetic induction using a planar gradiometer:preliminary human results[J]. Physiol Meas, 2004, 25(1):315-323.
8.	PAULSON D N, FAGALY R L, TOUSSAINT R M. Biomagnetic susceptibility with SQUID instrumentation[J]. IEEE Trans Magn, 1991, 27(2):3249-3252.
9.	ANDRÄW, NOWAK H. Magnetism in medicine-a handbook[M]. 2nd ed. Berlin:Wiley-VCH, 2007:535.
10.	GABRIEL S, LAU R W, GABRIEL C. The dielectric properties of biological tissues:III. Parametric models for the dielectric spectrum of tissues[J]. Phys Med Biol, 1996, 41(11):2271-2293.
11.	GRIFFITHS H, STEWART W R, GOUGH W. Magnetic induction tomography-a measuring system for biological[J]. Ann NY Acad Sci, 1999, 873(1):335-345.
12.	惠小强, 陈文学. 有限长通电螺线管空间的磁场分布[J]. 物理与工程, 2004, 14(2):22-25.
13.	吴万春, 李缉熙, 冯亚伯等. 电磁场理论[M]. 北京:电子工业出版社, 1985:53-73.
14.	ROSELL J, CASAÑAS R, SCHARFETTER H. Sensitivity maps and requirements for magnetic induction tomography using a planar gradiometer[J]. Physiol Meas, 2001, 22(1):121-130.

1. SCHANDER A, CAPPELLINI M D, GOODNOUGH L T. Iron overload and toxicity:the hidden risk of multiple blood transfusions[J]. Vox Sang, 2009, 97(3):185-197.
2. BRITTENHAM G M, BADMAN D G. Noninvasive measurement of iron:report of an NIDDK workshop[J]. Blood, 2003, 101(1):15-19.
3. BAUMAN J H, HARRIS J W. Estimation of hepatic iron stores by in vivo measurement of magnetic susceptibility[J]. J Lab Clin Med, 1967, 70(2):246-257.
4. BAUMAN J H, HOFFMAN R W. Magnetic susceptibility meter for in vivo estimation of hepatic iron stores[J]. IEEE Trans Biomed Eng, 1967, 14(4):239-243.
5. CASAAS R, SCHARFETTER H, ALTES A, et al. Magnetic induction system for noninvasive measurement of susceptibility and conductivity of biological tissues[C]//Proc 11th Conf on Electrical Bio-Impedance, Oslo, Norway, June 2001:623-626.
6. SCHARFETTER H, CASAAS R, ROSELL J. Biological tissue characterization by magnetic induction spectroscopy (MIS):requirements and limitations[J]. IEEE Trans Biomed Eng, 2003, 50(7):870-880.
7. CASAAS R, SCHARFETTER H, ALTES A, et al. Measurement of liver iron overload by magnetic induction using a planar gradiometer:preliminary human results[J]. Physiol Meas, 2004, 25(1):315-323.
8. PAULSON D N, FAGALY R L, TOUSSAINT R M. Biomagnetic susceptibility with SQUID instrumentation[J]. IEEE Trans Magn, 1991, 27(2):3249-3252.
9. ANDRÄW, NOWAK H. Magnetism in medicine-a handbook[M]. 2nd ed. Berlin:Wiley-VCH, 2007:535.
10. GABRIEL S, LAU R W, GABRIEL C. The dielectric properties of biological tissues:III. Parametric models for the dielectric spectrum of tissues[J]. Phys Med Biol, 1996, 41(11):2271-2293.
11. GRIFFITHS H, STEWART W R, GOUGH W. Magnetic induction tomography-a measuring system for biological[J]. Ann NY Acad Sci, 1999, 873(1):335-345.
12. 惠小强, 陈文学. 有限长通电螺线管空间的磁场分布[J]. 物理与工程, 2004, 14(2):22-25.
13. 吴万春, 李缉熙, 冯亚伯等. 电磁场理论[M]. 北京:电子工业出版社, 1985:53-73.
14. ROSELL J, CASAÑAS R, SCHARFETTER H. Sensitivity maps and requirements for magnetic induction tomography using a planar gradiometer[J]. Physiol Meas, 2001, 22(1):121-130.

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