Curative Effects of Pulsed Electromagnetic Fields on Postmenopausal Osteoporosis_Journal of Biomedical Engineering

Authors：

LIUHuifang ¹ , LIUYing ² , YANGLin ¹ , WANGChunyan ³ , WUYuanchao ¹ ,  HEChengqi ¹

1. Department of Rehabilitation, West China Hospital, Sichuan University;Rehabilitation Medicine, Sichuan Province Key Lab, Chengdu 610041, China;
2. Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China;
3. Department of Rehabilitation, General Hospital of Tianjin Medical University, Tianjin 300052, China;

Corresponding author：

HEChengqi, Email: chengqi.he3477@gmail.com

Keywords：

osteoporosis; postmenopausal; pulsed electromagnetic field; bisphosphonates; bone mineral density; pain

DOI：

10.7507/1001-5515.20140010

Video：

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Abstract Full text Figures/Tables Video References Cited by

We investigated the effects and optimal treatment frequency of pulsed electromagnetic fields (PEMFs) on postmenopausal osteoporosis (PMO). A comparison was performed with the cyclical alendronate and a course of PEMFs in the treatment for postmenopausal osteoporosis on bone mineral density (BMD), pain intensity and balance function. There was no significant difference between the two groups on mean percentage changes from baseline of BMD within 24 weeks after random treatments (P≥0.05). However, at the ends of 48 weeks and 72 weeks, the BMD of the PEMFs group were significantly lower than that of the alendronate group (P<0.05). No significant difference was detected between the two groups with regard to treatment effects on Visual Analogue Scale score, the Timed Up & Go Test and Berg Balance Scale score. Compared with cyclical alendronate, a course of PEMFs was as effective as alendronate in treating PMO for at least 24weeks. So its optimal treatment frequency for PMO may be one course per six months.

Citation： LIUHuifang, LIUYing, YANGLin, WANGChunyan, WUYuanchao, HEChengqi. Curative Effects of Pulsed Electromagnetic Fields on Postmenopausal Osteoporosis. Journal of Biomedical Engineering, 2014, 31(1): 48-52. doi: 10.7507/1001-5515.20140010 Copy

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5.	谢小波,崔红岩,庞丽云,等.脉冲电磁场用于治疗骨质疏松性疼痛的疗效评估及分析[J].国际生物医学工程杂志,2011,34(2):107-110.
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8.	GIORDANO N, BATTISTI E, GERACI S, et al. Effect of electromagnetic fields on bone mineral density and biochemical markers of bone turnover in osteoporosis:a single-blind, randomized pilot study[J]. Curr Ther Res, 2001, 62(3):187-193.
9.	余雷,罗二平,申广浩,等.低强度脉冲电磁场治疗骨质疏松的作用[J].中国临床康复,2003,7(12):1801-1802.
10.	肖登,杨霖,雷中杰,等.不同治疗时间脉冲电磁场对去卵巢大鼠股骨生物力学性能的影响[J].四川大学学报(医学版),2010,41(2):296-298,311.
11.	NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy[J]. JAMA, 2001, 285(6):785-795.
12.	管玉涛,蔡莲莲,丁红香,等.不同方案联合用药治疗围绝经期及绝经后期骨质疏松症的疗效观察[J].中华妇产科杂志,2010,45(8):571-574.
13.	YASUDA L. Fundamental aspects of fracture treatment[J]. J Kyoto Med Soc, 1953, 4:395-406.
14.	BASSETT C A, PILLA A A, PAWLUK R J. A non-operative salvage of surgically-resistant pseudarthroses and non-unions by pulsing electromagnetic fields.a preliminary report[J]. Clin Orthop Relat Res, 1977(124):128-143.
15.	BASSETT C A. Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMFs)[J]. Crit Rev Biomed Eng, 1989, 17(5):451-529.
16.	CLEOPHAS T J, ZWINDERMAN A H, VAN OUWERKERK B. Clinical research:a novel approach to the analysis of repeated measures[J]. Am J Ther,2012, 19(1):E1-E7.
17.	SHUPAK N M, HENSEL J M, CROSS-MELLOR S K, et al. Analgesic and behavioral effects of a 100 microt specific pulsed extremely low frequency magnetic field on control and morphine treated CF-1 mice[J]. Neurosci Lett, 2004, 354(1):30-33.

1. National Osteoporosis Foundation. Learn about osteoporosis:bone health basics:get the facts[EB/OL].(2012-12-20)[2012-12-22]. http://www.nof.org/learn/basics.
2. RACHNER T D, KHOSLA S, HOFBAUER L C. Osteoporosis:now and the future[J]. Lancet, 2011, 377(9773):1276-1287.
3. BILEZIKIAN J P. Efficacy of bisphosphonates in reducing fracture risk in postmenopausal osteoporosis[J]. Am J Med, 2009, 122(2 Suppl):S14-S21.
4. KOTHAWALA P, BADAMGARAV E, RYU S, et al. Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis[J]. Mayo Clin Proc, 2007, 82(12):1493-1501.
5. 谢小波,崔红岩,庞丽云,等.脉冲电磁场用于治疗骨质疏松性疼痛的疗效评估及分析[J].国际生物医学工程杂志,2011,34(2):107-110.
6. LI J K,LIN J C,LIU H C,et al.Cytokine release from osteoblasts in response to different intensities of pulsed electromagnetic field stimulation[J]. Electromagn Biol Med, 2007, 26(3):153-165.
7. 杨霖,雷中杰,何成奇.低频脉冲电磁场治疗骨质疏松症的临床观察[J].中国骨质疏松杂志,2006,12(6):592-593,560.
8. GIORDANO N, BATTISTI E, GERACI S, et al. Effect of electromagnetic fields on bone mineral density and biochemical markers of bone turnover in osteoporosis:a single-blind, randomized pilot study[J]. Curr Ther Res, 2001, 62(3):187-193.
9. 余雷,罗二平,申广浩,等.低强度脉冲电磁场治疗骨质疏松的作用[J].中国临床康复,2003,7(12):1801-1802.
10. 肖登,杨霖,雷中杰,等.不同治疗时间脉冲电磁场对去卵巢大鼠股骨生物力学性能的影响[J].四川大学学报(医学版),2010,41(2):296-298,311.
11. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy[J]. JAMA, 2001, 285(6):785-795.
12. 管玉涛,蔡莲莲,丁红香,等.不同方案联合用药治疗围绝经期及绝经后期骨质疏松症的疗效观察[J].中华妇产科杂志,2010,45(8):571-574.
13. YASUDA L. Fundamental aspects of fracture treatment[J]. J Kyoto Med Soc, 1953, 4:395-406.
14. BASSETT C A, PILLA A A, PAWLUK R J. A non-operative salvage of surgically-resistant pseudarthroses and non-unions by pulsing electromagnetic fields.a preliminary report[J]. Clin Orthop Relat Res, 1977(124):128-143.
15. BASSETT C A. Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMFs)[J]. Crit Rev Biomed Eng, 1989, 17(5):451-529.
16. CLEOPHAS T J, ZWINDERMAN A H, VAN OUWERKERK B. Clinical research:a novel approach to the analysis of repeated measures[J]. Am J Ther,2012, 19(1):E1-E7.
17. SHUPAK N M, HENSEL J M, CROSS-MELLOR S K, et al. Analgesic and behavioral effects of a 100 microt specific pulsed extremely low frequency magnetic field on control and morphine treated CF-1 mice[J]. Neurosci Lett, 2004, 354(1):30-33.

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