Research on Amplitude of Low-frequency Fluctuation in Patients with Major Depression Based on Resting-state Functional Magnetic Resonance Imaging_Journal of Biomedical Engineering

Authors：

QIUHaitang ¹ , LIUHaixia ¹ , HEQian ² , MENGHuaqing ¹ , FUYixiao ¹ , DULian ¹ , QIUTian ¹ ,  LUOQinghua ¹

1. Department of Mental Health, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;
重庆医科大学附属第一医院放射科, 重庆 400016;

Corresponding author：

LUOQinghua, Email: qiu_nease@163.com

Keywords：

major depressive disorder; resting-state functional magnetic resonance imaging; amplitude of low-frequency fluctuation

DOI：

10.7507/1001-5515.20140019

Video：

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We investigated the baseline brain activity level in patients with major depressive disorder (MDD) by amplitude of low-frequency fluctuation (ALFF) based on resting-state functional MRI (fMRI). We examined 13 patients in the MDD group and 14 healthy volunteers in the control group by resting-state fMRI on GE Signa 3.0T. We calculated and compared the ALFF values of the two groups. In the MDD group, ALFF values in the right medial prefrontal were higher than those in control group, with statistically significant differences (P<0.001). ALFF values in the left parietal in the MDD group were lower than those in control group with statistically significant differences (P<0.001). This resting-state fMRI study suggested that the alteration brain activity in the right medial prefrontal and left parietal ALFF contributed to the understanding of the pathophysiological mechanism of MDD patients.

Citation： QIUHaitang, LIUHaixia, HEQian, MENGHuaqing, FUYixiao, DULian, QIUTian, LUOQinghua. Research on Amplitude of Low-frequency Fluctuation in Patients with Major Depression Based on Resting-state Functional Magnetic Resonance Imaging. Journal of Biomedical Engineering, 2014, 31(1): 97-102. doi: 10.7507/1001-5515.20140019 Copy

1.	GARRETT A, KELLY R, GOMEZ R, et al. Aberrant brain activation during a working memory task in psychotic major depression[J]. Am J Psychiatry, 2011, 168(2):173-182.
2.	GUO W B, SUN X L, LIU L, et al. Disrupted regional homogeneity in treatment-resistant depression:a resting-state fMRI study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2011, 35(5):1297-1302.
3.	WU C W, CHEN C L, LIU P Y, et al. Empirical evaluations of slice-timing, smoothing, and normalization effects in seed-based, resting-state functional magnetic resonance imaging analyses[J]. Brain Connect, 2011, 1(5):401-410.
4.	LIU C H, MA X, WU X, et al. Resting-state abnormal baseline brain activity in unipolar and bipolar depression[J]. Neurosci Lett, 2012, 516(2):202-206.
5.	LI Z, KADIVAR A, PLUTA J, et al. Test-retest stability analysis of resting brain activity revealed by blood oxygen level-dependent functional MRI[J]. J Magn Reson Imaging, 2012, 36(2):344-354.
6.	刘虎,范国光,徐克,等.低频振幅fMRI评价精神分裂症患者静息状态下脑功能活动[J].中国医学影像技术,2010,26(9):1659-1662.
7.	龙玉,刘波,雒晓东,等.静息态fMRI在帕金森病基线脑活动变化中的初步研究[J].临床放射学杂志,2009,28(8):1069-1072.
8.	KIM S G, OGAWA S. Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals[J]. J Cereb Blood Flow Metab. 2012, 32(7):1188-1206.
9.	ZANG Y F, HE Y, ZHU C Z, et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI[J]. Brain Dev, 2007, 29(2):83-91.
10.	ZOU Q H, ZHU C Z, YANG Y H, et al. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI:Fractional ALFF. JNeurosci Methods, 2008, 172(1):137-141.
11.	钟婧捷,陈思翰,欧阳琴,等.初发颞叶癫痫患者的静息态功能磁共振ReHo研究[J].生物医学工程学杂志,2012,29(2):229-232.
12.	HAYASHI T. Functional connectivity analysis of the brain network using resting-state FMRI[J]. Brain Nerve, 2011, 63(12):1307-1318.
13.	DI SIMPLICIO M, NORBURY R, HARMER C J. Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression[J]. Mol Psychiatry, 2012, 17(5):503-510.
14.	DICHTER G S, FELDER J N, SMOSKI M J. The effects of brief behavioral activation therapy for depression on cognitive control in affective contexts:an fMRI investigation[J]. J Affect Disord, 2010, 126(1-2):236-244.
15.	董国珍,杨志,王培培,等.利用独立成分分析技术和静息fMRI数据对脑功能区进行定位[J].中国医学影像技术,2008,24(11):1829-1832.
16.	秦玲娣,周滟,许建荣.磁共振成像技术在评价抑郁症疗效方面的研究进展[J].医学影像学杂志,2009,19(11):1485-1488.
17.	LEYMAN L, DE RAEDT R, VANDERHASSELT M A, et al. Effects of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex on the attentional processing of emotional information in major depression:a pilot study[J]. Psychiatry Res, 2011, 185(1-2):102-107.
18.	SHELINE Y I, PRICE J L, YAN Z, et al. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus[J]. Proc Natl Acad Sci U S A, 2010, 107(24):11020-11025.
19.	GOTLIB I H, HAMILTON J P, COONEY R E, et al. Neural processing of reward and loss in girls at risk for major depression[J]. Arch Gen Psychiatry, 2010, 67(4):380-387.
20.	PRICE J L, DREVETS W C. Neurocircuitry of mood disorders[J]. Neuropsychopharmacology, 2010, 35(1):192-216.
21.	YAO Z, WANG L, LU Q, et al. Regional homogeneity in depression and its relationship with separate depressive symptom clusters:a resting-state fMRI study[J]. J Affect Disord, 2009, 115(3):430-438.
22.	HAMILTON J P, CHEN G, THOMASON M E, et al. Investigating neural primacy in major depressive disorder:multivariate granger causality analysis of resting-state fMRI time-series data[J]. Mol Psychiatry, 2011, 16(7):763-772.
23.	YUAN Y, ZHANG Z, BAI F, et al. Abnormal neural activity in the patients with remitted geriatric depression:a resting-state functional magnetic resonance imaging study[J]. J Affect Disord, 2008, 111(2-3):145-152.
24.	YOSHIMURA S, OKAMOTO Y, ONODA K, et al. Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity[J]. J Affect Disord, 2010, 122(1-2):76-85.
25.	KENDLER K S, MYERS J. The genetic and environmental relationship between major depression and the five-factor model of personality[J]. Psychol Med, 2010, 40(5):801-806.
26.	SEIDEL E M, SATTERTHWAITE T D, EICKHOFF S B, et al. Neural correlates of depressive realism--an fMRI study on causal attribution in depression[J]. J Affect Disord, 2012, 138(3):268-276.
27.	RAICHLE M E, MACLEOD A M, SNYDER A Z, et al. A default mode of brain function[J]. Proc Natl Acad Sci U S a, 2001, 98(2):676-682.
28.	WU Q Z, LI D M, KUANG W H, et al. Abnormal regional spontaneous neural activity in treatment-refractory depression revealed by resting-state fMRI[J]. Hum Brain Mapp, 2011, 32(8):1290-1299.
29.	EUGÈNE F, JOORMANN J, COONEY R E, et al. Neural correlates of inhibitory deficits in depression[J]. Psychiatry Res, 2010, 181(1):30-35.
30.	GUO W B, LIU F, XUE Z M, et al. Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression:a resting-state fMRI study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 37(1):153-160.

1. GARRETT A, KELLY R, GOMEZ R, et al. Aberrant brain activation during a working memory task in psychotic major depression[J]. Am J Psychiatry, 2011, 168(2):173-182.
2. GUO W B, SUN X L, LIU L, et al. Disrupted regional homogeneity in treatment-resistant depression:a resting-state fMRI study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2011, 35(5):1297-1302.
3. WU C W, CHEN C L, LIU P Y, et al. Empirical evaluations of slice-timing, smoothing, and normalization effects in seed-based, resting-state functional magnetic resonance imaging analyses[J]. Brain Connect, 2011, 1(5):401-410.
4. LIU C H, MA X, WU X, et al. Resting-state abnormal baseline brain activity in unipolar and bipolar depression[J]. Neurosci Lett, 2012, 516(2):202-206.
5. LI Z, KADIVAR A, PLUTA J, et al. Test-retest stability analysis of resting brain activity revealed by blood oxygen level-dependent functional MRI[J]. J Magn Reson Imaging, 2012, 36(2):344-354.
6. 刘虎,范国光,徐克,等.低频振幅fMRI评价精神分裂症患者静息状态下脑功能活动[J].中国医学影像技术,2010,26(9):1659-1662.
7. 龙玉,刘波,雒晓东,等.静息态fMRI在帕金森病基线脑活动变化中的初步研究[J].临床放射学杂志,2009,28(8):1069-1072.
8. KIM S G, OGAWA S. Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals[J]. J Cereb Blood Flow Metab. 2012, 32(7):1188-1206.
9. ZANG Y F, HE Y, ZHU C Z, et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI[J]. Brain Dev, 2007, 29(2):83-91.
10. ZOU Q H, ZHU C Z, YANG Y H, et al. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI:Fractional ALFF. JNeurosci Methods, 2008, 172(1):137-141.
11. 钟婧捷,陈思翰,欧阳琴,等.初发颞叶癫痫患者的静息态功能磁共振ReHo研究[J].生物医学工程学杂志,2012,29(2):229-232.
12. HAYASHI T. Functional connectivity analysis of the brain network using resting-state FMRI[J]. Brain Nerve, 2011, 63(12):1307-1318.
13. DI SIMPLICIO M, NORBURY R, HARMER C J. Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression[J]. Mol Psychiatry, 2012, 17(5):503-510.
14. DICHTER G S, FELDER J N, SMOSKI M J. The effects of brief behavioral activation therapy for depression on cognitive control in affective contexts:an fMRI investigation[J]. J Affect Disord, 2010, 126(1-2):236-244.
15. 董国珍,杨志,王培培,等.利用独立成分分析技术和静息fMRI数据对脑功能区进行定位[J].中国医学影像技术,2008,24(11):1829-1832.
16. 秦玲娣,周滟,许建荣.磁共振成像技术在评价抑郁症疗效方面的研究进展[J].医学影像学杂志,2009,19(11):1485-1488.
17. LEYMAN L, DE RAEDT R, VANDERHASSELT M A, et al. Effects of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex on the attentional processing of emotional information in major depression:a pilot study[J]. Psychiatry Res, 2011, 185(1-2):102-107.
18. SHELINE Y I, PRICE J L, YAN Z, et al. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus[J]. Proc Natl Acad Sci U S A, 2010, 107(24):11020-11025.
19. GOTLIB I H, HAMILTON J P, COONEY R E, et al. Neural processing of reward and loss in girls at risk for major depression[J]. Arch Gen Psychiatry, 2010, 67(4):380-387.
20. PRICE J L, DREVETS W C. Neurocircuitry of mood disorders[J]. Neuropsychopharmacology, 2010, 35(1):192-216.
21. YAO Z, WANG L, LU Q, et al. Regional homogeneity in depression and its relationship with separate depressive symptom clusters:a resting-state fMRI study[J]. J Affect Disord, 2009, 115(3):430-438.
22. HAMILTON J P, CHEN G, THOMASON M E, et al. Investigating neural primacy in major depressive disorder:multivariate granger causality analysis of resting-state fMRI time-series data[J]. Mol Psychiatry, 2011, 16(7):763-772.
23. YUAN Y, ZHANG Z, BAI F, et al. Abnormal neural activity in the patients with remitted geriatric depression:a resting-state functional magnetic resonance imaging study[J]. J Affect Disord, 2008, 111(2-3):145-152.
24. YOSHIMURA S, OKAMOTO Y, ONODA K, et al. Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity[J]. J Affect Disord, 2010, 122(1-2):76-85.
25. KENDLER K S, MYERS J. The genetic and environmental relationship between major depression and the five-factor model of personality[J]. Psychol Med, 2010, 40(5):801-806.
26. SEIDEL E M, SATTERTHWAITE T D, EICKHOFF S B, et al. Neural correlates of depressive realism--an fMRI study on causal attribution in depression[J]. J Affect Disord, 2012, 138(3):268-276.
27. RAICHLE M E, MACLEOD A M, SNYDER A Z, et al. A default mode of brain function[J]. Proc Natl Acad Sci U S a, 2001, 98(2):676-682.
28. WU Q Z, LI D M, KUANG W H, et al. Abnormal regional spontaneous neural activity in treatment-refractory depression revealed by resting-state fMRI[J]. Hum Brain Mapp, 2011, 32(8):1290-1299.
29. EUGÈNE F, JOORMANN J, COONEY R E, et al. Neural correlates of inhibitory deficits in depression[J]. Psychiatry Res, 2010, 181(1):30-35.
30. GUO W B, LIU F, XUE Z M, et al. Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression:a resting-state fMRI study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 37(1):153-160.

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