Effect of Respiratory Movement on Cone Beam Computed Tomography Images_Journal of Biomedical Engineering

Authors：

GUOChang ¹ , ZHONGRenming ² , LIGuangjun ² , JIChuanxian ² , LIChengqiang ¹ , QUANHong ¹ ,  BAISen ²

1. School of Physics Science and Technology, Wuhan University, Wuhan 430072, China;
2. Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

BAISen, Email: baisen@scu.edu.cn

Keywords：

eone beam computed tomography; respiratory movement; internal target; image guided radiation therapy

DOI：

10.7507/1001-5515.20140059

Video：

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To investigate the impact of respiratory movement to determine the target volume on cone beam CT (CBCT) for lung tumor,we used CIRS dynamic thorax phantom (Model-CIRS008) to simulate the sinusoidal motion of lung tumor. With a constant amplitude, the ratio of the time of near-end-expiratory and near-end- inspiratory (E/I) changed when it was scanned with CBCT. We analyzed the contrast changes of target by extracting the CT value of each pixel on the center line of the target movement direction. The targets were contoured with region growing method and compared with the motion volume generated by the tumor trajectory method. The result showed that the contrast of near-end-expiratory increased and the contrast of near-end-inspiratory decreased with increasing E/I. The contoured volume generated by region growing method decreased with increasing E/I. When E/I=4, the amplitude A=1 cm, diameter of 1 cm and 3 cm target volumes were reduced by 48.2% and 22.7%.The study showed that CBCT was not suitable to be used to accurately determine the range of lung tumor movement. The internal target volume (ITV) may be underestimated in CBCT images.

Citation： GUOChang, ZHONGRenming, LIGuangjun, JIChuanxian, LIChengqiang, QUANHong, BAISen. Effect of Respiratory Movement on Cone Beam Computed Tomography Images. Journal of Biomedical Engineering, 2014, 31(2): 314-318. doi: 10.7507/1001-5515.20140059 Copy

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1. MASI L,CASAMASSIMA F,MENICHELLI C,et al.On-line image guidance for frameless stereotactic radiotherapy of lung malignancies by cone beam CT:comparison between target localization and alignment on bony anatomy[J].Acta Oncol,2008,47(7):1422-1431.
2. FELDKAMP L A,DAVIS L C,KRESS J W.Practical cone-beam algorithm[J].J Opt Soc Am A Opt Image Sci Vis,1984,1(6):612-619.
3. WANG Z,WU Q J,MARKS L B,et al.Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions[J].Int J Radiat Oncol Biol Phys,2007,69(5):1618-1624.
4. International Commission on Radiation Units and Measurements (ICRU).Report 62:Prescribing,recording and reporting photon beam therapy (supplement to ICRU report 50)[R].Bethesda:ICRU Publications,1999.
5. RUAN D,FESSLER J A,BALTER J M,et al.Real-time profiling of respiratory motion:baseline drift,frequency variation and fundamental pattern change[J].Phys Med Biol,2009,54(15):4777-4792.
6. LUJAN A E,LARSEN E W,BALTER J M,et al.A method for incorporating organ motion due to breathing into 3D dose calculations[J].Med Phys,1999,26(5):715-720.
7. 汪隽琦,徐志勇,胡伟刚,等.千伏级锥形束CT图像质量和稳定性及三维影像体积重建精度研究[J].中华放射肿瘤学杂志,2012,21(2):176-180.
8. SWEENEY R A,SEUBERT B,STARK S,et al.Accuracy and inter-observer variability of 3D versus 4D cone-beam CT based image-guidance in SBRT for lung tumors[J/OL].Radiat Oncol,2012,7:81(2012-06-08)[2012-12-21].http://www.ro-journal.com/content/pdf/1748-717X-7-81.pdf.
9. VERGALASOVA I,MAURER J,YIN F F.Potential underestimation of the internal target volume (ITV) from free-breathing CBCT[J].Med Phys,2011,38(8):4689-4699.
10. SONKE J J,ZIJP L,REMEIJER P,et al.Respiratory correlated cone beam CT[J].Med Phys,2006,32(4):1176-1186.
11. SONKE J J,ROSSI M,WOLTHAUS J,et al.Frameless stereotactic body radiotherapy for lung cancer using four-dimensional cone beam CT guidance[J].Int J Radiat Oncol Biol Phys,2009,74(2):567-574.
12. WANG X,ZHONG R M,BAI S,et al.Lung tumor reproducibility with active breath control (ABC) in image-guided radiotherapy based on cone-beam computed tomography with two registration methods[J].Radiother Oncol,2011,99(2):148-154.

Journal of Biomedical Engineering

Effect of Respiratory Movement on Cone Beam Computed Tomography Images

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