Research Progress on Application of Gold Magnetic Nanocomposite in Biomedicine_Journal of Biomedical Engineering

Authors：

XUEYang ¹ , ZHAOLingyun ² , TANGJingtian ² ,  YAOCuiping ¹

1. The School of Life Science and Technology, Key Laboratory of Biomedical Information Engineering, Ministry of Education, Xi'an Jiaotong University, Xi'an 710049, China;
2. Department of Engineering Physics, Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Tsinghua University, Beijing 100084, China;

Corresponding author：

YAOCuiping, Email: zsycp@mail.xjtu.edu.cn

Keywords：

gold magnetic nanocomposite; superparamagnetic iron oxide nanoparticles; gold nanoparticles; biomedical application

DOI：

10.7507/1001-5515.20140085

Video：

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This paper provides a brief overview of the current research activities which focused on the bio-application of gold magnetic nanocomposite particles. By combining the magnetic characteristics of the iron oxide core with the unique features of nano-gold particles such as targeting by surface modification and optical properties, such composite nanoparticles have a wide range of applications in cancer hyperthermia, CT and MRI imaging, bio-separation, biosensors, gene diagnosis, drug targeting and many other biomedical fields.

Citation： XUEYang, ZHAOLingyun, TANGJingtian, YAOCuiping. Research Progress on Application of Gold Magnetic Nanocomposite in Biomedicine. Journal of Biomedical Engineering, 2014, 31(2): 462-466. doi: 10.7507/1001-5515.20140085 Copy

1.	赵戎蓉,鲁芳.超顺磁氧化铁纳米粒子特性研究[J].中国医药生物技术,2012,7(3):221-223.
2.	LEUNG K C,XUAN S,ZHU X,et al.Gold and iron oxide hybrid nanocomposite materials[J].Chem Soc Rev,2012,41(5):1911-1928.
3.	马千里,董相廷,王进贤,等.纳米四氧化三铁的化学制备方法研究进展[J].化工进展,2012,31(3):562-573.
4.	崔亚丽,惠文利,苏婧,等.Fe₃O₄/Au纳米复合粒子及其光学性质[J].中国科学(B辑化学),2005,35(2):89-93.
5.	石延峰,周樨,钟鹭斌,等.Fe₃O₄@Au核壳纳米颗粒的制备及其形成机制探讨[J].东南大学学报(医学版),2011,30(1):6-10.
6.	WANG A J,LI Y F,LI Z H,et al.Amperometric glucose sensor based on enhanced catalytic reduction of oxygen using glucose oxidase adsorbed onto core-shell Fe₃O₄@silica@Au magnetic nanoparticles[J].Mater Sci Eng C,2012,32(6):1640-1647.
7.	HUI W,SHI F,YAN K,et al.Fe₃O₄/Au/Fe₃O₄ nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation[J].Nanoscale,2012,4(3):747-751.
8.	YEAP S P,TOH P Y,AHMAD A L,et al.Colloidal stability and magnetophoresis of gold-coated iron oxide nanorods in biological media[J].J Phys Chem C,2012,116(42):22561-22569.
9.	ZHAO L Y,TANG J T,FENG S S.Nanothermotherapy by high performance magnetic nanoparticles[J].Nanomedicine (Lond),2010,5(9):1305-1308.
10.	LI Y T,LIU J,ZHONG Y J,et al.Biocompatibility of Fe₃O₄@Au composite magnetic nanoparticles in vitro and in vivo[J].Int J Nanomedicine,2011,6:2805-2819.
11.	MOHAMMAD F,BALAJI G,WEBER A,et al.Influence of gold nanoshell on hyperthermia of superparamagnetic iron oxide nanoparticles[J].J Phys Chem C,2010,114(45):19194-19201.
12.	DONG W J,LI Y S,NIU D C,et al.Facile synthesis of monodisperse superparamagnetic Fe₃O₄ core@hybrid@Au shell nanocomposite for bimodal imaging and photothermal therapy[J].Adv Mater,2011,23(45):5392-5397.
13.	REN J F,SHEN S,PANG Z Q,et al.Facile synthesis of superparamagnetic Fe₃O₄@Au nanoparticles for photothermal destruction of cancer cells[J].Chem Commun (Camb),2011,47(42):11692-11694.
14.	ATKINSON R L,ZHANG M,DIAGARADJANE P,et al.Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy[J].Sci Transl Med,2010,2(55):55ra79.
15.	KIRUI D K,REY D A,BATT C A.Gold hybrid nanoparticles for targeted phototherapy and cancer imaging[J].Nanotechnology,2010,21(10):105105-105114.
16.	NARAYANAN S,SATHY B N,MONY U,et al.Biocompatible magnetite/gold nanohybrid contrast agents via green chemistry for MRI and CT bioimaging[J].ACS Appl Mater Interfaces,2012,4(1):251-260.
17.	UMUT E,PINEIDER F,AROSIO P,et al.Magnetic,optical and relaxometric properties of organically coated gold-magnetite (Au-Fe₃O₄) hybrid nanoparticles for potential use in biomedical applications[J].J Magn Magn Mater,2012,324(15):2373-2379.
18.	SMOLENSKY E D,NEARY M C,ZHOU Y,et al.Fe₃O₄@organic@Au:core-shell nanocomposites with high saturation magnetisation as magnetoplasmonic MRI contrast agents[J].Chem Commun (Camb),2011,47(7):2149-2151.
19.	CUI Y R,HONG C,ZHOU Y L,et al.Synthesis of orientedly bioconjugated core/shell Fe₃O₄@Au magnetic nanoparticles for cell separation[J].Talanta,2011,85(3):1246-1252.
20.	PARK H Y,SCHADT M J,WANG L Y,et al.Fabrication of magnetic core@shell Fe oxide@Au nanoparticles for interfacial bioactivity and Bio-separation[J].Langmuir,2007,23(17):9050-9056.
21.	王健,王丽英,孙颖,等.核壳型Fe₃O₄/Au粒子的制备及其在表面等离子体子共振传感器中的应用[J].化学学报,2010,68(3):263-268.
22.	HILL H D,VEGA R A,MIRKIN C A.Nonenzymatic detection of bacterial genomic DNA using the bio bar code assay[J].Anal Chem,2007,79(23):9218-9223.
23.	刘松婷,尹惠琼,贾茗娴,等.生物条形码检测技术及其研究进展[J].生物技术通讯,2010,21(4):597-600.
24.	ZHAO M,ZHANG X Q,WANG S,et al.A simple method for purification of genomic DNA from whole blood using Fe₃O₄/Au composite particles as a carrier[J].J Med Coll PLA,2009,24(4):239-243.
25.	CHATTERJEE S,BANDYOPADHYAY A,SARKAR K.Effect of iron oxide and gold nanoparticles on bacterial growth leading towards biological application[J].J Nanobiotechnology,2011,9:34-40.
26.	TALEKAR M,KENDALL J,DENNY W,et al.Targeting of nanoparticles in cancer:drug delivery and diagnostics[J].Anticancer Drugs,2011,22(10):949-962.

1. 赵戎蓉,鲁芳.超顺磁氧化铁纳米粒子特性研究[J].中国医药生物技术,2012,7(3):221-223.
2. LEUNG K C,XUAN S,ZHU X,et al.Gold and iron oxide hybrid nanocomposite materials[J].Chem Soc Rev,2012,41(5):1911-1928.
3. 马千里,董相廷,王进贤,等.纳米四氧化三铁的化学制备方法研究进展[J].化工进展,2012,31(3):562-573.
4. 崔亚丽,惠文利,苏婧,等.Fe₃O₄/Au纳米复合粒子及其光学性质[J].中国科学(B辑化学),2005,35(2):89-93.
5. 石延峰,周樨,钟鹭斌,等.Fe₃O₄@Au核壳纳米颗粒的制备及其形成机制探讨[J].东南大学学报(医学版),2011,30(1):6-10.
6. WANG A J,LI Y F,LI Z H,et al.Amperometric glucose sensor based on enhanced catalytic reduction of oxygen using glucose oxidase adsorbed onto core-shell Fe₃O₄@silica@Au magnetic nanoparticles[J].Mater Sci Eng C,2012,32(6):1640-1647.
7. HUI W,SHI F,YAN K,et al.Fe₃O₄/Au/Fe₃O₄ nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation[J].Nanoscale,2012,4(3):747-751.
8. YEAP S P,TOH P Y,AHMAD A L,et al.Colloidal stability and magnetophoresis of gold-coated iron oxide nanorods in biological media[J].J Phys Chem C,2012,116(42):22561-22569.
9. ZHAO L Y,TANG J T,FENG S S.Nanothermotherapy by high performance magnetic nanoparticles[J].Nanomedicine (Lond),2010,5(9):1305-1308.
10. LI Y T,LIU J,ZHONG Y J,et al.Biocompatibility of Fe₃O₄@Au composite magnetic nanoparticles in vitro and in vivo[J].Int J Nanomedicine,2011,6:2805-2819.
11. MOHAMMAD F,BALAJI G,WEBER A,et al.Influence of gold nanoshell on hyperthermia of superparamagnetic iron oxide nanoparticles[J].J Phys Chem C,2010,114(45):19194-19201.
12. DONG W J,LI Y S,NIU D C,et al.Facile synthesis of monodisperse superparamagnetic Fe₃O₄ core@hybrid@Au shell nanocomposite for bimodal imaging and photothermal therapy[J].Adv Mater,2011,23(45):5392-5397.
13. REN J F,SHEN S,PANG Z Q,et al.Facile synthesis of superparamagnetic Fe₃O₄@Au nanoparticles for photothermal destruction of cancer cells[J].Chem Commun (Camb),2011,47(42):11692-11694.
14. ATKINSON R L,ZHANG M,DIAGARADJANE P,et al.Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy[J].Sci Transl Med,2010,2(55):55ra79.
15. KIRUI D K,REY D A,BATT C A.Gold hybrid nanoparticles for targeted phototherapy and cancer imaging[J].Nanotechnology,2010,21(10):105105-105114.
16. NARAYANAN S,SATHY B N,MONY U,et al.Biocompatible magnetite/gold nanohybrid contrast agents via green chemistry for MRI and CT bioimaging[J].ACS Appl Mater Interfaces,2012,4(1):251-260.
17. UMUT E,PINEIDER F,AROSIO P,et al.Magnetic,optical and relaxometric properties of organically coated gold-magnetite (Au-Fe₃O₄) hybrid nanoparticles for potential use in biomedical applications[J].J Magn Magn Mater,2012,324(15):2373-2379.
18. SMOLENSKY E D,NEARY M C,ZHOU Y,et al.Fe₃O₄@organic@Au:core-shell nanocomposites with high saturation magnetisation as magnetoplasmonic MRI contrast agents[J].Chem Commun (Camb),2011,47(7):2149-2151.
19. CUI Y R,HONG C,ZHOU Y L,et al.Synthesis of orientedly bioconjugated core/shell Fe₃O₄@Au magnetic nanoparticles for cell separation[J].Talanta,2011,85(3):1246-1252.
20. PARK H Y,SCHADT M J,WANG L Y,et al.Fabrication of magnetic core@shell Fe oxide@Au nanoparticles for interfacial bioactivity and Bio-separation[J].Langmuir,2007,23(17):9050-9056.
21. 王健,王丽英,孙颖,等.核壳型Fe₃O₄/Au粒子的制备及其在表面等离子体子共振传感器中的应用[J].化学学报,2010,68(3):263-268.
22. HILL H D,VEGA R A,MIRKIN C A.Nonenzymatic detection of bacterial genomic DNA using the bio bar code assay[J].Anal Chem,2007,79(23):9218-9223.
23. 刘松婷,尹惠琼,贾茗娴,等.生物条形码检测技术及其研究进展[J].生物技术通讯,2010,21(4):597-600.
24. ZHAO M,ZHANG X Q,WANG S,et al.A simple method for purification of genomic DNA from whole blood using Fe₃O₄/Au composite particles as a carrier[J].J Med Coll PLA,2009,24(4):239-243.
25. CHATTERJEE S,BANDYOPADHYAY A,SARKAR K.Effect of iron oxide and gold nanoparticles on bacterial growth leading towards biological application[J].J Nanobiotechnology,2011,9:34-40.
26. TALEKAR M,KENDALL J,DENNY W,et al.Targeting of nanoparticles in cancer:drug delivery and diagnostics[J].Anticancer Drugs,2011,22(10):949-962.

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