Numerical Study on the Performance Effect of the Ratio of Long Axis to Short Axis of Upright Polypropylene Infusion Bag_Journal of Biomedical Engineering

Authors：

DENGKe ¹ , GUOWeipeng ¹ , ZHUShuiwen ² , TANGZhixiong ¹ ,  ANGWentao ¹

1. Laboratory of Biomechanical Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, China;
2. Staff Room of Mechanics, Southwest University of Science and Technology, Mianyang 621000, China;

Corresponding author：

ANGWentao, Email: scubme@aliyun.com

Keywords：

intravenous infusion; upright polypropylene infusion bag; ratio of long axis to short axis; emptying rate; steadiness coefficient

DOI：

10.7507/1001-5515.20140114

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The study aims to investigate the effect of the ratio of long axis to short axis (RLS) of upright polypropylene infusion bag on discharging process and to search the best RLS. Aiming at five different RLS (1.5:1, 2:1, 3:1, 4:1 and 5:1, respectively) with the volume of 100 mL, 250 mL and 500 mL, respectively, based on finite element method, analyzing the variation of stress distribution, emptying rate, drugging space and steadiness coefficient, etc. For the bags of the same volume, emptying rate increased with increasing of RLS, but the steadiness coefficient decreased with increasing of RLS. The specific increasing amplitude of emptying rate and decreasing range of steadiness coefficient were as follows: 20% and 49% for 100mL infusion bag, 9% and 51% for 250 mL infusion bag, and 11% and 46% for 500 mL infusion bag, respectibvely, when RLS increased from 1.5:1 to 5:1. Comparatively speaking, the increasing amplitude of the emptying rate is remarkably less than the decreasing range of the steadiness coefficient. By comprehensive consideration of both emptying rate and steadiness coefficient, lower RLS is recommended for upright polypropylene infusion bag.

Citation： DENGKe, GUOWeipeng, ZHUShuiwen, TANGZhixiong, ANGWentao. Numerical Study on the Performance Effect of the Ratio of Long Axis to Short Axis of Upright Polypropylene Infusion Bag. Journal of Biomedical Engineering, 2014, 31(3): 606-611. doi: 10.7507/1001-5515.20140114 Copy

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1. QUINTINI G, BARBERA V, IANNITTO E, et al. Continuous intravenous infusion of dipyridamole as adjunctive therapy in the treatment of thrombotic thrombocytopenic purpura[J]. Transfus Apher Sci, 2003, 29(2):141-145.
2. DITTRICH S, GERMANAKIS J, DÄHNERT I, et al. Randomised trial on the influenceof continuous magnesium infusionon arrhythmias following cardiopulmonarybypass surgery for congenital heart disease[J]. Intensive Care Med, 2003, 29(7):1141-1144.
3. THABET F, BOURGEOIS J, GUY B, et al. Continuous insulin infusion in hyperglycaemic very-low-birth-weight infants receiving parenteral nutrition[J]. Clin Nutr, 2003, 22(6):545-547.
4. 王建东,陈友岱,董芸,等.静脉注射6%羟乙基淀粉130/0.4和呋噻米治疗急性胰腺炎[J].生物医学工程学杂志,2010,27(5):1138-1141,1145.
5. GIULIANI J. A severe delayed infusion reaction induced by trastuzumab:a life-threatening condition[J]. Med Oncol, 2012, 29(5):3597-3598.
6. THIESEN J, KRÄMER I. Physico-chemical stability of docetaxel premix solution and docetaxelinfusion solutions in PVC bags and polyolefine containers[J]. Pharm World Sci, 1999, 21(3):137-141.
7. CAI Qiang, BARRIE M, OLEJEME H, et al. A pilot study of efficacy and safety of continuous intravenousinfusion of pantoprazole in the treatment of severe erosiveesophagitis[J]. Dig Dis Sci, 2008, 53(6):1500-1505.
8. 徐丽娟,刘全校,许文才,等.PVC输液袋的安全性研究[J].包装工程,2010,31(19):113-116,127.
9. CHANG J Y, XIAO N J, ZHU Min, et al. Leachables from saline-containing IV Bags can alter therapeutic protein properties[J]. Pharm Res, 2010, 27(11):2402-2413.
10. 马瑞申,陈洁.PVC输血袋增塑剂的"耐萃取性"测定[J].生物医学工程学杂志,1993,10(1):98-99.
11. 任晓明,钟秀,杨鸣春,等.国产直立式聚丙烯输液袋临床实用性考察[J].中国药师,2011,14(3):437-438.
12. HOLMES C J, ALLWOOD M C. The assessment of air-inlet filters for intravenous infusions in glass bottles[J]. Int J Pharm, 1978, 1(3):133-139.
13. VAN DOOREN A A. PVC as pharmaceutical packaging material[J]. Pharmaceutisch Weekblad, 1991, 13(3):109-118.

Journal of Biomedical Engineering

Numerical Study on the Performance Effect of the Ratio of Long Axis to Short Axis of Upright Polypropylene Infusion Bag

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