Efficacy of Wound Dressing with Microspheres Containing Levofloxacin on Burns Treatment_Journal of Biomedical Engineering

Authors：

GAOPing ¹ ,  WANGXiaohui ¹ , HUANGShujie ² , WANGYing ¹ , GUANJing ² , LIYimin ¹ , TAOZunwei ¹

1. Institute of Medical Sciences, Tianjin 300020, China;
2. Research of Medical Equipment Institute of Military Medical Science Academy of the PLA, Tianjin 300161, China;

Corresponding author：

WANGXiaohui, Email: vwangtxh@126.com

Keywords：

chitosan; ofloxacin; delayed-action; burns; skin irritation; hydroxyproline

DOI：

10.7507/1001-5515.20140151

Video：

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This research was aimed to find the skin irritation and burns treatment effect of wound dressing with microspheres containing levofloxacin. We used reference GB/T16886.10-2005 to evaluate the dressing skin irritation. We prepared rabbit models divided into three groups. The control group was rapped with Vaseline gauze bandage, while the positive control group was rapped with the wounds of nano-silver paste bandage. The experimental sample group was rapped with wound dressing with microspheres containing levofloxacin. We measured the wound without healing area and the hydroxyproline content at the ends of 3 d, 6 d, 9 d, 14 d, 21 d, 28 d. and meanwhile performed histopathological examination. The experimental results showed that the dressing primary irritation index was 0. The nonhealing wound area of theexperimental sample group and positive control group at the ends of 6 d, 9 d, 14 d, 21 d were less than that of the control group (P<0.05). The nonhealing wound area of the experimental sample group at the ends of 9 d and 14 d was significantly lower than that of the positive control group (P<0.05). The hydroxyproline content of the experimental sample group at the ends of 6 d, 9 d and 14 d was significantly higher than that of the positive control group and blank control group (P<0.05). The pathology observed of the experimental sample group at 21 d were the earliest appendages. The wound dressing with microspheres containing levofloxacin has minimal skin irritation, effectively promote wound healing of burn.

Citation： GAOPing, WANGXiaohui, HUANGShujie, WANGYing, GUANJing, LIYimin, TAOZunwei. Efficacy of Wound Dressing with Microspheres Containing Levofloxacin on Burns Treatment. Journal of Biomedical Engineering, 2014, 31(4): 806-810. doi: 10.7507/1001-5515.20140151 Copy

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1. TAMURA H, FURUIKE T, NAIR S V, et al. Biomedical applications of chitin hydrogel membranes and scaffolds[J]. Carbohydr Polym, 2011, 84(2): 820-824.
2. SHALUMON K T, ANULEKHA K H, GIRISH C M, et al. Single step electrospinning of chitosan/poly(caprolactone)nanofibers using formic acid/acetone solvent mixture[J]. Carbohydr Polym, 2010, 80(2): 413-419.
3. ASHISH D, JITHIN M C, SREEJA V, et al. Novel carboxymethyl chitin nanoparticles for Cancer drug delivery applications[J]. Carbohydr Polym, 2010, 79(4): 1073-1079.
4. VAVRIKOVA E, MANDIKOVA J, TREJTNAR F, et al. Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs[J]. Carbohydr Polym, 2011, 83(10): 1901-1907.
5. 黄姝杰,关静,李志宏,等.一种左氧氟沙星缓释微球和长效缓释创伤敷料及制备方法:CN102302458A[P].2012-01-04.
6. 郁佳,徐翔,徐慧敏.左氧氟沙星所致223例不良反应报告分析[J].中国药业,2011,20(1):65-66.
7. KIMURA S, TODA H, SHIMABUKURO Y, et al. Topical chemotherapy in human periodontitis using a new controlled-release insert containing ofloxacin. I. Microbiological observation[J]. J Periodontal Res, 1991, 26(1): 33-41.
8. PAUL W, SHARMA C P. Chitosan and alginate wound dressings:a short review[J]. Trends Biomater Artif Organs, 2004, 18(1): 18-23.
9. 薛明,胡建华.连柏软膏促进烧烫伤愈合作用的实验研究[J].上海中医药杂志,2011,12( 12):88-90.

Journal of Biomedical Engineering

Efficacy of Wound Dressing with Microspheres Containing Levofloxacin on Burns Treatment

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