Study on Real-time Monitoring and Assessment of Near-infrared in the Dehydration Treatment of Traumatic Brain Injury_Journal of Biomedical Engineering

Authors：

JIAYumei ,  QIANZhiyu , LIWeitao , XIEJieru

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China;

Corresponding author：

QIANZhiyu, Email: zhiyu@nuaa.edu.cn

Keywords：

brain edema; near infrared spectroscopy; reduced scattering coefficient; intracranial pressure; mannitol

DOI：

10.7507/1001-5515.20140162

Video：

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Abstract Full text Figures/Tables Video References Cited by

We used near-infrared spectroscopy technology to monitor and assess the treatment effect of dehydrating agent in injured rat brain in real time style. We employed the brain edema model in rats resulting from Feeney's freefall damage, then treated with different doses of mannitol, and collected reduced scattering coefficient (μ'_s) and intracranial pressure (ICP) values after the injury and during the treatment. The results showed that brain edema happened 1 h after the injury in rats' brain tissue, peaked around 72 h after injury, and then began to decrease gradually. The reduced scattering coefficient and ICP values of the treatment group injected with mannitol all decreased after administration. Compared with the effect of low-dose mannitol treatment, that of high-dose mannitol treatment was much better. The duration of the plateau was longer and most experiments results declined significantly. From this we conclude that the reduced scattering coefficient and ICP are consistent with the trend changes, and the reduced scattering coefficient could be used as an indicator for monitoring cerebral edema.

Citation： JIAYumei, QIANZhiyu, LIWeitao, XIEJieru. Study on Real-time Monitoring and Assessment of Near-infrared in the Dehydration Treatment of Traumatic Brain Injury. Journal of Biomedical Engineering, 2014, 31(4): 861-864,874. doi: 10.7507/1001-5515.20140162 Copy

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3.	ADEVA M M, SOUTO G, DONAPETRY C, et al. Brain edema in diseases of different etiology:common pathophysiology[J]. Neurochem Int, 2012, 61(2): 166-174.
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7.	肖志辉,刘波.MRI和CT诊断脑水肿的比较研究[J].江西医药,2009,44(8):822-823.
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9.	钱志余,顾月清,刘汉莉.实时在位测定大鼠脑组织优化散射系数(μ'_s)的技术研究[J].中国医学物理学杂志,2005,22(2):463-465.
10.	何亮,杨天明,钱志余.近红外光谱技术实时监测创伤性脑水肿的可行性研究[J].东南大学学报:医学版,2011,30(5):703-706.
11.	TANAKA Y, MARUMO T, SHIBUTA H, et al. Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke[J]. Brain Res Bull, 2009, 78(4-5): 158-163.
12.	FEENEY D M, BOYESON M G, LINN R T, et al. Responses to cortical injury: methodology and local effects of contusions in the rat[J]. Brain Res, 1981, 211(1): 67-77.
13.	ROOKER S, DE VISSCHER G, VAN DEUREN B, et al. Comparison of intracranial pressure measured in the cerebral cortex and the cerebellum of the rat[J]. J Neurosci Methods, 2002, 119(1): 83-88.
14.	VERLOOY J, SELOSSE P, VAN REEMPTS J, et al. Fiberoptic intracranial pressure monitoring in rats[J]. J Neurosci Methods, 1990, 31(1): 1-6.
15.	SAMDANI A F, TAMARAGO R J, LONG D M. Brain edema:a review of current ideas[J]. Neurosurg Quarterly, 1999, 9(2): 120-137.
16.	WAI F C, SCOTT A P, ASHLEY J W. A review of the optical properties of biological tissues[J]. IEEE J Quant Elec, 1990, 26(12): 2166-2185.
17.	RABINSTEIN A A. Treatment of cerebral edema[J]. Neurologist, 2006, 12(2): 59-73.

1. TURKOGLU O F, EROGLU H, OKUTAN O, et al. A comparative study of treatment for brain edema: magnesium sulphate versus dexamethasone sodium phosphate[J]. J Clin Neurosci, 2008, 15(1): 60-65.
2. HEUZE I, ROBERT B, PETIT J Y, et al. Role of Gd-DOTA in the evaluation and imaging of experimental blood-brain barrier disruption in brain edemas and their improvement after anti-inflammatory drugs treatment[J]. Pharmacol Res, 1993, 27(1): 89-95.
3. ADEVA M M, SOUTO G, DONAPETRY C, et al. Brain edema in diseases of different etiology:common pathophysiology[J]. Neurochem Int, 2012, 61(2): 166-174.
4. 徐如祥.创伤性脑水肿研究进展[J].中国现代神经疾病杂志,2004,4(3):141-145.
5. 贾宏彬,朱四海,周志强,等.高渗盐水复合液对兔颅脑损伤后颅内压及脑水肿的实验研究[J].医学研究生学报,2009,22(4):359-362.
6. MOUSSA W M. Predictive value of brain edema in preoperative computerized tomography scanning on the recurrence of meningioma[J]. Alexandria Journal of Medicine, 2012, 48(4): 373-379.
7. 肖志辉,刘波.MRI和CT诊断脑水肿的比较研究[J].江西医药,2009,44(8):822-823.
8. 谢捷如,钱志余,何亮,等.基于微创光学参数(优化散射系数)测试的创伤性脑水肿甘露醇疗效评估研究[J].光谱学与光谱分析,2009,29(12):3254-3258.
9. 钱志余,顾月清,刘汉莉.实时在位测定大鼠脑组织优化散射系数(μ'_s)的技术研究[J].中国医学物理学杂志,2005,22(2):463-465.
10. 何亮,杨天明,钱志余.近红外光谱技术实时监测创伤性脑水肿的可行性研究[J].东南大学学报:医学版,2011,30(5):703-706.
11. TANAKA Y, MARUMO T, SHIBUTA H, et al. Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke[J]. Brain Res Bull, 2009, 78(4-5): 158-163.
12. FEENEY D M, BOYESON M G, LINN R T, et al. Responses to cortical injury: methodology and local effects of contusions in the rat[J]. Brain Res, 1981, 211(1): 67-77.
13. ROOKER S, DE VISSCHER G, VAN DEUREN B, et al. Comparison of intracranial pressure measured in the cerebral cortex and the cerebellum of the rat[J]. J Neurosci Methods, 2002, 119(1): 83-88.
14. VERLOOY J, SELOSSE P, VAN REEMPTS J, et al. Fiberoptic intracranial pressure monitoring in rats[J]. J Neurosci Methods, 1990, 31(1): 1-6.
15. SAMDANI A F, TAMARAGO R J, LONG D M. Brain edema:a review of current ideas[J]. Neurosurg Quarterly, 1999, 9(2): 120-137.
16. WAI F C, SCOTT A P, ASHLEY J W. A review of the optical properties of biological tissues[J]. IEEE J Quant Elec, 1990, 26(12): 2166-2185.
17. RABINSTEIN A A. Treatment of cerebral edema[J]. Neurologist, 2006, 12(2): 59-73.

Journal of Biomedical Engineering

Study on Real-time Monitoring and Assessment of Near-infrared in the Dehydration Treatment of Traumatic Brain Injury

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