Finite Element Analysis of Temperature Field of Retina by Electrical Stimulation with Microelectrode Array_Journal of Biomedical Engineering

Authors：

WANGWei ,  QIAOQingli , GAOWeiping , WUJun

School of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China;

Corresponding author：

QIAOQingli, Email: qlqiao@gmail.com

Keywords：

microelectrode array; retina; electric stimulation; temperature field; finite elements method

DOI：

10.7507/1001-5515.20140238

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Abstract Full text Figures/Tables Video References Cited by

We studied the influence of electrode array parameters on temperature distribution to the retina during the use of retinal prosthesis in order to avoid thermal damage to retina caused by long-term electrical stimulation. Based on real epiretinal prosthesis, a three-dimensional model of electrical stimulation for retina with 4×4 microelectrode array had been established using the finite element software (COMSOL Multiphysics). The steady-state temperature field of electrical stimulation of the retina was calculated, and the effects of the electrode parameters such as the distance between the electrode contacts, the materials and area of the electrode contact on temperature field were considered. The maximum increase in the retina steady temperature was about 0.004℃ with practical stimulation current. When the distance between the electrode contacts was changed from 130 μm to 520 μm, the temperature was reduced by about 0.006℃. When the contact radius was doubled from 130 μm to 260 μm, the temperature decrease was about 0.005℃. It was shown that there were little temperature changes in the retina with a 4×4 epiretinal microelectrode array, reflecting the safety of electrical stimulation. It was also shown that the maximum temperature in the retina decreased with increasing the distance between the electrode contacts, as well as increasing the area of electrode contact. However, the change of the maximum temperature was very small when the distance became larger than the diameter of electrode contact. There was no significant difference in the effects of temperature increase among the different electrode materials. Rational selection of the distance between the electrode contacts and their area in electrode design can reduce the temperature rise induced by electrical stimulation.

Citation： WANGWei, QIAOQingli, GAOWeiping, WUJun. Finite Element Analysis of Temperature Field of Retina by Electrical Stimulation with Microelectrode Array. Journal of Biomedical Engineering, 2014, 31(6): 1255-1259,1271. doi: 10.7507/1001-5515.20140238 Copy

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1. FERNANDES R B, DINIZ B, RIBEIRO R, et al. Artificial vision through neuronal stimulation[J]. Neurosci Lett, 2012, 519(2):122-128.
2. 石萍,邱意弘,朱贻盛,等.人工视觉假体研究综述(Ⅰ)——视网膜假体研究现状[J].生物医学工程学杂志,2008,25(3):734-737.
3. LAZZI G. Thermal effects of bioimplants[J]. IEEE Eng Med Biol Mag, 2005, 24(5):75-81.
4. GURNEY P W V. Is our ‘inverted’ retina really ‘bad design?’[J]. Technical Journal-in-depth Journal of Creation,1999,13(1):37-44.
5. VOS J J. A theory of retinal burns[J]. Bull Math Biophys, 1962, 24(2):115-128.
6. 颜威利,徐桂芝.生物医学电磁场数值分析[M].北京:机械工业出版社,2006:18-20.
7. ELWASSIF M M, KONG Q, VAZQUEZ M, et al. Bio-heat transfer model of deep brain stimulation induced temperature changes[J]. Conf Proc IEEE Eng Med Biol Soc, 2006, 1:3580-3583.
8. DATTA A, ELWASSIF M, BIKSON M. Bio-heat transfer model of transcranial DC stimulation:comparison of conventional pad versus ring electrode[C]//31th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,Minneapolis:2009:670-673.
9. 郭红伟,乔清理,罗芳.螺旋袖套电极胞外刺激视神经的电场有限元分析[J].生物医学工程学杂志,2012,29(5):820-824.
10. 邢玉梅.基于Parylene的柔性微电极研制及应用基础研究[D].上海:上海交通大学,2009.
11. YANAI D, WEILAND J D, MAHADEVAPPA M, et al. Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa[J]. American journal of ophthalmology, 2007, 143(5):820-827.
12. KASI H, HASENKAMP W, COSENDAI G, et al. Simulation of epiretinal prostheses-evaluation of geometrical factors affecting stimulation thresholds[J]. J Neuroeng Rehabil, 2011, 8:44.
13. DE BALTHASAR C, PATEL S, ROY A, et al. Factors affecting perceptual thresholds in epiretinal prostheses[J]. Invest Ophthalmol Vis Sci, 2008, 49(6):2303-2314.
14. 侯文生,章毅,郑小林,等.基于有限元法的硬脑膜外视皮层电刺激仿真研究[J].中国生物医学工程学报,2010,29(4):557-563.

Journal of Biomedical Engineering

Finite Element Analysis of Temperature Field of Retina by Electrical Stimulation with Microelectrode Array

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