Effect of Stimulating Pulse Width on the Threshold of Electrically Evoked Compound Action Potential_Journal of Biomedical Engineering

Authors：

 YUZhongde ¹ , XIAOLing ¹ , LIPing ¹ , MENGLi ¹ , ZIRui ² , FEIXingbo ²

1. Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190, China;
2. RZC Co. Ltd, Beijing 100085, China;

Corresponding author：

YUZhongde, Email: moguyunyu@hotmail.com

Keywords：

stimulating pulse width; electrically evoked compound action potential; threshold

DOI：

10.7507/1001-5515.20140255

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This paper discusses the relationship between stimulating pulse width and the threshold of electrically evoked compound action potential (ECAP). Firstly, the rheobase and chronaxy from strength-duration curve of nerve fiber was computed using the shepherd's experiment results. Secondly, based on the relationship between ECAP and the action potential of nerve fiber, a mathematical expression to describe the relationship between stimulating pulse width and ECAP threshold was proposed. Thirdly, the parameters were obtained and the feasibility was proved to the expression with the results of experiment using guinea pigs. Research result showed that with ECAP compared to the action potential of nerve fiber, their threshold function relationship with stimulating pulse width was similar, and rheobase from the former was an order smaller in the magnitude than the latter, but the chronaxy was close to each other. These findings may provide meaningful guidance to clinical ECAP measurement and studying speech processing strategies of cochlear implant.

Citation： YUZhongde, XIAOLing, LIPing, MENGLi, ZIRui, FEIXingbo. Effect of Stimulating Pulse Width on the Threshold of Electrically Evoked Compound Action Potential. Journal of Biomedical Engineering, 2014, 31(6): 1187-1190. doi: 10.7507/1001-5515.20140255 Copy

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2.	SHERPHERD R K, ERIC JAVEL E. Electrically stimulation of the auditory nerve:Ⅱ. Effect of stimulus wave shape on single fiber response properties[J]. Hear Res, 1999, 130(1-2):171-188.
3.	MILLER C A, ABBAS P J, RUBBINSTEIN J T, et al. Electrically evoked compound action potential of guinea pig and cat:responsed to monopolar, monophasic stimulation[J]. Hear Res, 1998, 119(1-2):142-154.
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6.	SRINIVASAN A G, LANDSBERGER D M, SHANNON R V. Current focusing sharpens local peaks of excitation in cochlear implant stimulation[J]. Hear Res, 2010, 270(1):89-100.
7.	PFINGST B E, BOWLING S A, COLESA D J, et al. Cochlear infrastructure for electrical hearing[J]. Hear Res, 2011, 281(1):65-73.
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10.	UNDURRAGA J A, CARLYON R P, MACHEREY O, et al. Spread of excitation varies for different electrical pulse shapes and stimulation modes in cochlear implants[J]. Hear Res, 2012, 290(1):21-36.
11.	WESTEN A A, DEKKER D M T, BRIAIRE J J, et al. Stimulus level effects on neural excitation and eCAP amplitude[J]. Hear Res, 2011, 280(1):166-176.

1. VAN DEN HONERT C, STYPULKOWSKI P H. Physiological properties of the electrically stimulated auditory nerves. Ⅱ. Single fiber recordings[J]. Hear Res, 1984, 14(3):225-243.
2. SHERPHERD R K, ERIC JAVEL E. Electrically stimulation of the auditory nerve:Ⅱ. Effect of stimulus wave shape on single fiber response properties[J]. Hear Res, 1999, 130(1-2):171-188.
3. MILLER C A, ABBAS P J, RUBBINSTEIN J T, et al. Electrically evoked compound action potential of guinea pig and cat:responsed to monopolar, monophasic stimulation[J]. Hear Res, 1998, 119(1-2):142-154.
4. LAPICQUE L. Definition experimentalede l'excitabilite[J]. C R Acad Sci, 1909, 67(2):280-283.
5. GEDDES L A, BOURLAND J D. The strength duration curve[J]. IEEE Trans Biomed Eng, 1985, 32(6):458-459.
6. SRINIVASAN A G, LANDSBERGER D M, SHANNON R V. Current focusing sharpens local peaks of excitation in cochlear implant stimulation[J]. Hear Res, 2010, 270(1):89-100.
7. PFINGST B E, BOWLING S A, COLESA D J, et al. Cochlear infrastructure for electrical hearing[J]. Hear Res, 2011, 281(1):65-73.
8. FRIJINS J H M, MOOIJ M, TEN KATE J H. A quantitative approach to modeling mammalian myelinated nerve fibers for electrical prosthesis design[J]. IEEE Trans Biomed Eng, 1994, 41(6):556-566.
9. BROWN C J, ABBAS P J. Electrically evoke whole-nerve action potentials:parametric data from the cat[J]. J Acoustic Soc Am, 1990, 88(5):2205-2210.
10. UNDURRAGA J A, CARLYON R P, MACHEREY O, et al. Spread of excitation varies for different electrical pulse shapes and stimulation modes in cochlear implants[J]. Hear Res, 2012, 290(1):21-36.
11. WESTEN A A, DEKKER D M T, BRIAIRE J J, et al. Stimulus level effects on neural excitation and eCAP amplitude[J]. Hear Res, 2011, 280(1):166-176.

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