Analysis and Computational Fluid Dynamics Simulation of Hemodynamic Influences Caused by Splenic Vein Thrombosis_Journal of Biomedical Engineering

Authors：

 ZHOUHongyu , GONGPeiyun , DUXuesen , WANGMeng

College of Power Engineering, Chongqing University, Chongqing 400044, China;

Corresponding author：

ZHOUHongyu, Email: cquzhy@cqu.edu.cn

Keywords：

splenic vein thrombosis; portal venous system; hemodynamics; color Doppler ultrasound; computational fluid dynamics

DOI：

10.7507/1001-5515.20150008

Video：

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This paper aims to analyze the impact of splenic vein thrombosis (SVT) on the hemodynamic parameters in hepatic portal vein system. Based on computed tomography (CT) images of a patient with portal hypertension and commercial software MIMICS, the patient's portal venous system model was reconstructed. Color Doppler ultrasound method was used to measure the blood flow velocity in portal vein system and then the blood flow velocities were used as the inlet boundary conditions of simulation. By using the computational fluid dynamics (CFD) method, we simulated the changes of hemodynamic parameters in portal venous system with and without splenic vein thrombosis and analyzed the influence of physiological processes. The simulation results reproduced the blood flow process in portal venous system and the results showed that the splenic vein thrombosis caused serious impacts on hemodynamics. When blood flowed through the thrombosis, blood pressure reduced, flow velocity and wall shear stress increased. Flow resistance increased, blood flow velocity slowed down, the pressure gradient and wall shear stress distribution were more uniform in portal vein. The blood supply to liver decreased. Splenic vein thrombosis led to the possibility of forming new thrombosis in portal vein and surroundings.

Citation： ZHOUHongyu, GONGPeiyun, DUXuesen, WANGMeng. Analysis and Computational Fluid Dynamics Simulation of Hemodynamic Influences Caused by Splenic Vein Thrombosis. Journal of Biomedical Engineering, 2015, 32(1): 43-47. doi: 10.7507/1001-5515.20150008 Copy

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8.	SVENSSON J, GARDHAGEN R, HEIBERG E, et al. Feasibility of patient specific aortic blood flow CFD simulation[J]. Med Image Comput Comput Assist Interv, 2006, 9(Pt 1): 257-263.
9.	RANI H P, TONY W H, CHANG T M, et al. Numerical investigation of non-newtonian microcirculatory blood flow in hepatic lobule[J]. J Biomech, 2006, 39(3): 551-563.
10.	WINSLOW E R, BRUNT L M, DREBIN J A, et al. Portal vein thrombosis after splenectomy[J]. Am J Surg, 2002, 184(6): 631-635.
11.	HO H, BARTLETT A, HUNTER P. Non-newtonian blood flow analysis for the portal vein based on a CT image[J]. Computational and Clinical Applications Lecture Notes in Computer Science, 2012, 7601: 283-291.
12.	IKEDA M, SEKIMOTO M, TAKIGUCHI S, et al. Total splenic vein thrombosis after laparoscopic splenectomy: a possible candidate for treatment[J]. Ame J Surg, 2007, 193(1): 21-25.
13.	WANG L, LIU G J, CHEN Y X, et al. Combined use of D-dimer and P-selectin for the diagnosis of splenic or portal vein thrombosis following splenectomy[J]. Thromb Res, 2010, 125(5): e206-e209.

1. TRAN T, POLYHRONOPOULOS G, SEGUIN C, et al. Recommended timing for surveillance ultrasonography to diagnose portal splenic vein thrombosis after laparoscopic splenectomy[J]. Surg Endosc, 2010, 24(7): 1670-1678.
2. WEBER S M, RIKKERS L F. Splenic vein thrombosis and gastrointestinal bleeding in chronic pancreatitis[J]. World J Surg, 2003, 27(11): 1271-1274.
3. IKEDA M, SEKIMOTO M, TAKIGUCHI S, et al. High incidence of thrombosis of the portal venous system after laparoscopic splenectomy: a prospective study with contrast-enhanced CT scan[J]. Ann Surg, 2005, 241(2): 208-216.
4. CITO S, MAZZEO M D, BADIMON L. A review of macroscopic thrombus modeling methods[J]. Thromb Res, 2013, 131(2): 116-124.
5. 张忠涛.循证医学时代对门静脉高压症外科治疗的思考[J].中华肝胆外科杂志, 2008, 14(2):77-78.
6. KAGAWA S, UNO F, GOCHI A, et al. Portal/splenic vein thrombosis following splenectomy in gastric cancer surgery[J]. Asian J Surg, 2010, 33(4): 208-211.
7. HO C M, LIN R K, TSAI S F, et al. Simulation of portal hemodynamic changes in a donor after right hepatectomy[J]. J Biomech Eng, 2010, 132(4): 041002.
8. SVENSSON J, GARDHAGEN R, HEIBERG E, et al. Feasibility of patient specific aortic blood flow CFD simulation[J]. Med Image Comput Comput Assist Interv, 2006, 9(Pt 1): 257-263.
9. RANI H P, TONY W H, CHANG T M, et al. Numerical investigation of non-newtonian microcirculatory blood flow in hepatic lobule[J]. J Biomech, 2006, 39(3): 551-563.
10. WINSLOW E R, BRUNT L M, DREBIN J A, et al. Portal vein thrombosis after splenectomy[J]. Am J Surg, 2002, 184(6): 631-635.
11. HO H, BARTLETT A, HUNTER P. Non-newtonian blood flow analysis for the portal vein based on a CT image[J]. Computational and Clinical Applications Lecture Notes in Computer Science, 2012, 7601: 283-291.
12. IKEDA M, SEKIMOTO M, TAKIGUCHI S, et al. Total splenic vein thrombosis after laparoscopic splenectomy: a possible candidate for treatment[J]. Ame J Surg, 2007, 193(1): 21-25.
13. WANG L, LIU G J, CHEN Y X, et al. Combined use of D-dimer and P-selectin for the diagnosis of splenic or portal vein thrombosis following splenectomy[J]. Thromb Res, 2010, 125(5): e206-e209.

Journal of Biomedical Engineering

Analysis and Computational Fluid Dynamics Simulation of Hemodynamic Influences Caused by Splenic Vein Thrombosis

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