Research on the Mechanical Properties of Bone Scaffold Reinforced by Magnesium Alloy/Bioceramics Composite with Stereolithography Double Channels_Journal of Biomedical Engineering

Authors：

LIChanghai ,  LIANQin , ZHUANGPei , WANGJunzhong , LIDichen

State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, China;

Corresponding author：

LIANQin, Email: lqiamt@mail.xjtu.edu.cn

Keywords：

stereolithography; magnesium alloy; bioceramics; double channels; mechanical properties

DOI：

10.7507/1001-5515.20150014

Video：

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Focusing on the poor mechanical strength of porous bioceramics bone scaffold, and taking into account of the good mechanical properties of biodegradable magnesium alloy, we proposed a novel method to fabricate magnesium alloy/bioceramics composite bone scaffold with stereolithography double channels. Firstly, a scaffold structure without mutually connected double channels was designed. Then, an optimized bioceramics scaffold was fabricated according to stereolithography and gel-casing. Molten AZ31 magnesium alloy was perfused into the secondary channel of scaffold by low-pressure casting, and magnesium alloy/bioceramics composite bone scaffold was obtained when magnesium alloy was solidified. The compression test showed that the strength of bioceramics scaffold with only one channel and without magnesium alloy was (9.76±0.64) MPa, while the strength of magnesium alloy/bioceramics composite scaffold with double channels was (17.25±0.88) MPa. It can be concluded that the magnesium alloy/bioceramics composite is obviously able to improve the scaffold strength.

Citation： LIChanghai, LIANQin, ZHUANGPei, WANGJunzhong, LIDichen. Research on the Mechanical Properties of Bone Scaffold Reinforced by Magnesium Alloy/Bioceramics Composite with Stereolithography Double Channels. Journal of Biomedical Engineering, 2015, 32(1): 77-81. doi: 10.7507/1001-5515.20150014 Copy

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1. WU S C, HSU H C, HSU S K, et al. Preparation and characterization of four different compositions of Calcium phosphate scaffolds for bone tissue engineering[J]. Mater Character, 2011, 62(5): 526-534.
2. ESHRAGHI S, DAS S. Micromechanical finite-element modeling and experimental characterization of the compressive mechanical properties of polycaprolactone-hydroxyapatite composite scaffolds prepared by selective laser sintering for bone tissue engineering[J]. Acta Biomater, 2012, 8 (8): 3138-3143.
3. MARTÍNEZ-VÁZQUEZ F J, PERERA F H, MIRANDA P, et al. Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration[J]. Acta Biomater, 2010, 6(11): 4361-4368.
4. AMIRKHANI S, BAGHERI R, YAZDI A Z. Effect of pore geometry and loading direction on deformation mechanism of rapid prototyped scaffolds[J]. Acta Materialia, 2012, 60: 2778-2789.
5. OGOSE A, HOTTA T, HATANO H, et al. Histological examination of beta-tricalcium phosphate graft in human femur[J]. J Biomed Mater Res, 2002, 63(5): 601-604.
6. RAMAY H R, ZHANG M. Biphasic Calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering[J]. Biomaterials, 2004, 25(21): 5171-5180.
7. PERERA F H, MARTÍNEZ-VÁZQUEZ F J, MIRANDA P, et al. Clarifying the effect of sintering conditions on the microstructure and mechanical properties ofβ-tricalcium phosphate[J]. Ceram Int, 2010, 36(6): 1929-1935.
8. LIN K L, CHANG J, LU J X, et al. Properties ofβ-Ca3(PO4)2 bioceramics prepared using nano-size powders[J]. Ceram Int, 2007, 33(6): 979-985.
9. WANG Q, TAN L L, XU W L, et al. Dynamic behaviors of a Ca-P coated AZ31B Magnesium alloy during in vitro and in vivo degradations[J]. Mater Sci Eng: B, 2011, 176(20): 1718-1726.
10. WANG H, SHI Z M. In vitro biodegradation behavior of Magnesium and Magnesium alloy[J]. J Biomed Mater Res B Appl Biomater, 2011, 98B(2): 203-209.
11. ZHU Y Y, WU G M, ZHANG Y H, et al. Growth and characterization of Mg(OH)2 film on Magnesium alloy AZ31[J]. Appl Surf Sci, 2011, 257(14): 6129-6137.
12. WITTE F, KAESE V, HAFERKAMP H, et al. In vivo corrosion of four Magnesium alloys and the associated bone response[J]. Biomater, 2005, 26(17): 3557-3563.
13. LI X, BIAN W, LI D, et al. Fabrication of porous beta-tricalcium phosphate with microchannel and customized geometry based on gel-casting and rapid prototyping[J]. Proc Inst Mech Eng H, 2011, 225(3): 315-323.

Journal of Biomedical Engineering

Research on the Mechanical Properties of Bone Scaffold Reinforced by Magnesium Alloy/Bioceramics Composite with Stereolithography Double Channels

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