Evaluating the Left Ventricular Diastolic Function of Diabetes Mellitus Patients Using Dual-gate Doppler_Journal of Biomedical Engineering

Authors：

LIUJiani , CHENLiping , ZHANGXiaoling , SHANGYanwen , WANGFang ,  TANGHong

Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

TANGHong, Email: hxyyth@gmail.com

Keywords：

diabetes mellitus; dual-gate Doppler; left ventricular diastolic function

DOI：

10.7507/1001-5515.20150030

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

To evaluate the value of left ventricular diastolic function in type 2 diabetes mellitus (DM) using dual-gate Doppler and relative factors, we included 50 non-obesity and hypertension-free DM patients into the controlled group in the study along with 48 age-and-gender-matched healthy volunteer subjects. The peak early diastolic velocity (E), peak later diastolic velocity (A), deceleration time (DT), anterior mitral annulus diastolic peak velocity (e'), isovolumic relaxation time (IVRT), E/A, E/e', Tei index and T_E-e' were measured with dual-gate Doppler. 20 subjects were randomly selected for repetitive analysis. Study showed statistical difference in E/A, DT, e', E/e', IVRT, Tei index and T_E-e' between the two groups (P < 0.05). Linear regression analysis showed positive correlation between T_E-e' and IVRT, course of DM patients and T_E-e'(Beta=0.295, P=0.020), and HbA_1C control level and T_E-e'(Beta=0.399, P=0.010). Repeated analysis showed good reproducibility for both within and between groups. Dual-gate Doppler has clinical value in evaluating left ventricular diastolic function in type 2 diabetes mellitus patients. The course of type 2 diabetes mellitus patients and HbA_1C control level were both closely related with left ventricular diastolic function.

Citation： LIUJiani, CHENLiping, ZHANGXiaoling, SHANGYanwen, WANGFang, TANGHong. Evaluating the Left Ventricular Diastolic Function of Diabetes Mellitus Patients Using Dual-gate Doppler. Journal of Biomedical Engineering, 2015, 32(1): 163-167. doi: 10.7507/1001-5515.20150030 Copy

1.	ZHOU G, LI X, HEIND W, et al. Metallothionein suppresses angiotensinⅡ-induced nicotinamide adeninedinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodelingin the diabetic heart[J]. J Am Coll Cardiol, 2008, 52(8): 667-669.
2.	BERGEROT C, ERNST R, RIETZSCHE L, et al. Diastolic dysfunction in patients with type 2 diabetes mellitus: is it really the first marker of diabetic 2011 cardiomyopathy[J]. J Am Soc Echocardiogr, 2011, 24(11): 1268-1275.
3.	CALDERISI M. Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography[J]. J Am Coll Cardiol, 2006, 48(8): 1548-1551.
4.	DI BONITO P, MOIO N, CAVUTO L, et al. Early detection of diabetic cardiomyopathy: usefulness of tissue Doppler imaging[J]. Diabet Med, 2005, 22(12): 1720-1725.
5.	POIRIER P, BOGATY P, MAROIS L, et al. Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes[J]. Diabetes Care, 2001, 24(1): 5-10.
6.	LI C, ZHANG J, ZHOU C, et al. Will simultaneous measurement of E/e' index facilitate the non-invasive assessment of left ventricular filling pressure in patients with non-valvular atrial fibrillation?[J]. European Journal of Echocardiography, 2010, 11: 296-301.
7.	KUSUNOSE K, YAMADA H, NISHIO S, et al. Clinical utility of single-beat E/e' obtained by simultaneous recording of flow and tissue Doppler velocities in atrial fibrillation with preserved systolic function[J]. JACC Cardiovasc Imaging, 2009, 2(10): 1147-1156.
8.	FROM A M, SCOTT C G, CHEN H H. The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study[J]. J Am Coll Cardiol, 2010, 55(4): 300-305.
9.	POULSEN M K, HENRIKSEN J E, DAHL J A, et al. Left ventricular diastolic function in type 2 diabetes mellitus prevalence and association with myocardial and vascular disease[J]. Circ Cardiovasc Imaging, 2010, 3(1): 24-31.
10.	FROM A M, SCOTT C G, CHEN H H. Changes in diastolic dysfunction in diabetes mellitus over time[J]. Am J Cardiol, 2009, 103(10): 1463-1466.
11.	GALDERISI M. Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography[J]. J Am Coll Cardiol, 2006, 48(8): 1548-1551.
12.	NAGUEH S F, APPLETON C P, GILLEBERT T C, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography[J]. J Am Soc Echocardiogr, 2009, 22(2): 107-133.
13.	DIWAN A, DIWAN A, MCCULLOCH M, et al. Doppler estimation of left ventricular filling pressures in patients with mitral valve disease[J]. Circulation, 2005, 111(24): 3281-3289.
14.	RIVAS-GOTZ C, KHOURY D S, MANOLIOS M, et al. Time interval between onset of mitral inflow and onset of early diastolic velocity by tissue Doppler: a novel index of left ventricular relaxation: experimental studies and clinical application[J]. J Am Coll Cardiol, 2003, 42(8): 1463-1470.
15.	CHOI J O, PARK S W, SHIN D H, et al. Preload dependency of the time interval between the onset of mitral inflow and the early diastolic annular motion: a hemodialysis-related preload reduction study[J]. Circ J, 2007, 71(5): 669-674.
16.	CHOI J O, PARK S W, SHIN D H, et al. Simultaneous Doppler tracing of the mitral inflow and annular motion provides a useful means of evaluating left ventricular diastolic function[J]. Clin Cardiol, 2008, 31(8): 360-367.
17.	杨跃进, 王红, 宋光远.糖尿病心肌病[J].中国糖尿病杂志, 2012, 20(10):794-796.
18.	DE SUTTER J, DE BACKER J, VAN DE VEIRE N, et al. Effects of age, gender, and left ventricular mass on septal mitral annulus velocity (E') and the ratio of transmitral early peak velocity to E' (E/E')[J]. Am J Cardiol, 2005, 95(8): 1020-1023.
19.	ALMUNTASER I, BROWN A, MURPHY R, et al. Comparison of echocardiographic measures of left ventricular diastolic function in early hypertension[J]. Am J Cardiol, 2007, 100(12): 1771-1775.
20.	DEE S G, GOTTDIENER J S, CHINALIM, et al. Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study[J]. Eur Heart J, 2008, 29(6): 741-747.

1. ZHOU G, LI X, HEIND W, et al. Metallothionein suppresses angiotensinⅡ-induced nicotinamide adeninedinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodelingin the diabetic heart[J]. J Am Coll Cardiol, 2008, 52(8): 667-669.
2. BERGEROT C, ERNST R, RIETZSCHE L, et al. Diastolic dysfunction in patients with type 2 diabetes mellitus: is it really the first marker of diabetic 2011 cardiomyopathy[J]. J Am Soc Echocardiogr, 2011, 24(11): 1268-1275.
3. CALDERISI M. Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography[J]. J Am Coll Cardiol, 2006, 48(8): 1548-1551.
4. DI BONITO P, MOIO N, CAVUTO L, et al. Early detection of diabetic cardiomyopathy: usefulness of tissue Doppler imaging[J]. Diabet Med, 2005, 22(12): 1720-1725.
5. POIRIER P, BOGATY P, MAROIS L, et al. Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes[J]. Diabetes Care, 2001, 24(1): 5-10.
6. LI C, ZHANG J, ZHOU C, et al. Will simultaneous measurement of E/e' index facilitate the non-invasive assessment of left ventricular filling pressure in patients with non-valvular atrial fibrillation?[J]. European Journal of Echocardiography, 2010, 11: 296-301.
7. KUSUNOSE K, YAMADA H, NISHIO S, et al. Clinical utility of single-beat E/e' obtained by simultaneous recording of flow and tissue Doppler velocities in atrial fibrillation with preserved systolic function[J]. JACC Cardiovasc Imaging, 2009, 2(10): 1147-1156.
8. FROM A M, SCOTT C G, CHEN H H. The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study[J]. J Am Coll Cardiol, 2010, 55(4): 300-305.
9. POULSEN M K, HENRIKSEN J E, DAHL J A, et al. Left ventricular diastolic function in type 2 diabetes mellitus prevalence and association with myocardial and vascular disease[J]. Circ Cardiovasc Imaging, 2010, 3(1): 24-31.
10. FROM A M, SCOTT C G, CHEN H H. Changes in diastolic dysfunction in diabetes mellitus over time[J]. Am J Cardiol, 2009, 103(10): 1463-1466.
11. GALDERISI M. Diastolic dysfunction and diabetic cardiomyopathy: evaluation by Doppler echocardiography[J]. J Am Coll Cardiol, 2006, 48(8): 1548-1551.
12. NAGUEH S F, APPLETON C P, GILLEBERT T C, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography[J]. J Am Soc Echocardiogr, 2009, 22(2): 107-133.
13. DIWAN A, DIWAN A, MCCULLOCH M, et al. Doppler estimation of left ventricular filling pressures in patients with mitral valve disease[J]. Circulation, 2005, 111(24): 3281-3289.
14. RIVAS-GOTZ C, KHOURY D S, MANOLIOS M, et al. Time interval between onset of mitral inflow and onset of early diastolic velocity by tissue Doppler: a novel index of left ventricular relaxation: experimental studies and clinical application[J]. J Am Coll Cardiol, 2003, 42(8): 1463-1470.
15. CHOI J O, PARK S W, SHIN D H, et al. Preload dependency of the time interval between the onset of mitral inflow and the early diastolic annular motion: a hemodialysis-related preload reduction study[J]. Circ J, 2007, 71(5): 669-674.
16. CHOI J O, PARK S W, SHIN D H, et al. Simultaneous Doppler tracing of the mitral inflow and annular motion provides a useful means of evaluating left ventricular diastolic function[J]. Clin Cardiol, 2008, 31(8): 360-367.
17. 杨跃进, 王红, 宋光远.糖尿病心肌病[J].中国糖尿病杂志, 2012, 20(10):794-796.
18. DE SUTTER J, DE BACKER J, VAN DE VEIRE N, et al. Effects of age, gender, and left ventricular mass on septal mitral annulus velocity (E') and the ratio of transmitral early peak velocity to E' (E/E')[J]. Am J Cardiol, 2005, 95(8): 1020-1023.
19. ALMUNTASER I, BROWN A, MURPHY R, et al. Comparison of echocardiographic measures of left ventricular diastolic function in early hypertension[J]. Am J Cardiol, 2007, 100(12): 1771-1775.
20. DEE S G, GOTTDIENER J S, CHINALIM, et al. Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study[J]. Eur Heart J, 2008, 29(6): 741-747.

Journal of Biomedical Engineering

Evaluating the Left Ventricular Diastolic Function of Diabetes Mellitus Patients Using Dual-gate Doppler

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content