Advances in Research on miR-21 and Breast Cancer_Journal of Biomedical Engineering

Authors：

ZHANGHe ^1,2 , ZHANGYulong ¹ ,  ZOULinglin ¹

1. West China School of Medicine, Sichuan University, Chengdu 610041, China;
2. Chinese Academy Of Medical Sciences & Peking Union Medical College, Beijing 100730, China;

Corresponding author：

ZOULinglin, Email: huaxi_zll@163.com

Keywords：

breast cancer; microRNA; miR-21

DOI：

10.7507/1001-5515.20150130

Video：

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Breast cancer is a malignant tumor from normal breast epithelial. In recent years, many literature reports sought to determine the expression of predicted target genes of microRNA and their potential function, pathways and networks, which are involved in the tumorigenesis, metastasis and prognosis of breast cancer. The miR-21 has recently been found to be highly expressed in solid tumors than normal tissue, and it has exposed some layers of gene expression regulation that becomes a hot topic of breast cancer. This paper briefly reviews advances in research on miR-21 in breast cancer.

Citation： ZHANGHe, ZHANGYulong, ZOULinglin. Advances in Research on miR-21 and Breast Cancer. Journal of Biomedical Engineering, 2015, 32(3): 712-716. doi: 10.7507/1001-5515.20150130 Copy

1.	JEMAL A, BRAY F, CENTER M M, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
2.	方琼英, 吴琼, 张秀玲, 等.乳腺癌的流行现状分析[J].中国社会医学杂志, 2012, 29(5):333-335.
3.	LEE C H, KUO W H, LIN C C, et al. MicroRNA-regulated protein-protein interaction networks and their functions in breast cancer[J]. Int J Mol Sci, 2013, 14(6):11560-11606.
4.	SAKURAI F, KATAYAMA K, MIZUGUCHI H. MicroRNA-regulated transgene expression systems for gene therapy and virotherapy[J]. Front Biosci (Landmark Ed), 2011, 16:2389-2401.
5.	WANG F, SUN G P, ZOU Y F, et al. MicroRNAs as promising biomarkers for gastric cancer[J]. Cancer Biomark, 2012, 11(6):259-267.
6.	BOERI M, PASTORINO U, SOZZI G, et al. Role of microRNAs in lung cancer:microRNA signatures in cancer prognosis[J]. Cancer J, 2012, 18(3):268-274.
7.	NAVARRO A, CLOT G, PRIETO M, et al. MicroRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics[J]. Clin Cancer Res, 2013, 19(12):3121-3129.
8.	GALASSO M, SANDHU S K, VOLINIA S. MicroRNA expression signatures in solid malignancies[J]. Cancer J, 2012, 18(3):238-243.
9.	FARAZI T A, HORLINGS H M, TEN HOEVE J J, et al. MicroRNA sequence and expression analysis in breast tumors by deep sequencing[J]. Cancer Res, 2011, 71(13):4443-4453.
10.	YAN L X, WU Q N, ZHANG Y, et al. Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth[J]. Breast Cancer Res, 2011, 13(1):R2.
11.	IYEVLEVA A G, KULIGINA E S H, MITIUSHKINA N V, et al. High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas[J]. Breast Cancer Res Treat, 2012, 131(3):1049-1059.
12.	LIAO S J, ZHOU Y H, YUAN Y, et al. Triggering of Toll-like receptor 4 on metastatic breast cancer cells promotesαvβ3-mediated adhesion and invasive migration[J]. Breast Cancer Res Treat, 2012, 133(3):853-863.
13.	TILGHMAN S L, BRATTON M R, SEGAR H C, et al. Endocrine disruptor regulation of microRNA expression in breast carcinoma cells[J]. PLoS One, 2012, 7(3):e32754.
14.	TERAO M, FRATELLI M, KUROSAKI M, et al. Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells:biological correlates and molecular targets[J]. J Biol Chem, 2011, 286(5):4027-4042.
15.	ZHU S, SI M L, WU H, et al. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)[J]. J Biol Chem, 2007, 282(19):14328-14336.
16.	LEUPOLD J H, YANG H S, COLBURN N H, et al. Asangani I, post S, allgayer H.tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor(u-PAR) gene expression via sp-transcription factors[J]. Oncogene, 2007, 26(31):4550-4562.
17.	ZHU S, WU H, WU F, et al. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis[J]. Cell Res, 2008, 18(3):350-359.
18.	BERARDI R, MORGESE F, ONOFRI A, et al. Role of maspin in cancer[J]. Clin Transl Med, 2013, 2(1):8.
19.	WANG Z X, LU B B, WANG H, et al. MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN[J]. Arch Med Res, 2011, 42(4):281-290.
20.	PEREZ E A, DUECK A C, MCCULLOUGH A E, et al. Impact of PTEN protein expression on benefit from adjuvant trastuzumab in early-stage human epidermal growth factor receptor 2-positive breast cancer in the North Central Cancer Treatment Group N9831 trial[J]. J Clin Oncol, 2013, 31(17):2115-2122.
21.	GABRIELY G, WURDINGER T, KESARI S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators[J]. Dig Dis Sci, 2008, 28(17):5369-5380.
22.	HONG K J, HSU M C, HOU M F, et al. The tumor suppressor RECK interferes with HER-2/Neu dimerization and attenuates its oncogenic signaling[J]. FEBS Lett, 2011, 585(4):591-595.
23.	SONG B, WANG C, LIU J, et al. MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression[J]. J Exp Clin Cancer Res, 2010, 29:29.
24.	CONNOLLY E C, VAN DOORSLAER K, ROGLER L E, et al. Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB[J]. Mol Cancer Res, 2010, 8(5):691-700.
25.	KAZEROUNIAN S, GERALD D, HUANG M, et al. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis[J]. Cancer Res, 2013, 73(1):50-61.
26.	SELCUKLU S D, DONOGHUE M T, KERIN M J, et al. Regulatory interplay between miR-21, JAG1 and 17beta-estradiol(E2)in breast cancer cells[J]. Biochem Biophys Res Commun, 2012, 423(2):234-239.
27.	IZRAILIT J, BERMAN H K, DATTI A, et al. High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβpathways as fundamental Notch regulators in breast cancer[J]. Proc Natl Acad Sci U S A, 2013, 110(5):1714-1719.
28.	YANG Y, CHAERKADY R, BEER M A, et al. Identification of miR-21 targets in breast cancer cells using a quantitative proteomic approach[J]. Proteomics, 2009, 9(5):1374-1384.
29.	GONG C, YAO Y, WANG Y, et al. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer[J]. J Biol Chem, 2011, 286(21):19127-19137.
30.	ANASTASOV N, HÖFIG I, VASCONCELLOS I G, et al. Radiation resistance due to high expression of miR-21 and G2, M checkpoint arrest in breast cancer cells[J]. Radiat Oncol, 2012, 7:206.
31.	YAN L X, HUANG X F, SHAO Q, et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis[J]. RNA, 2008, 14(11):2348-2360.
32.	LEE J A, LEE H Y, LEE E S, et al. Prognostic implications of MicroRNA-21 overexpression in invasive ductal carcinomas of the breast[J]. J Breast Cancer, 2011, 14(4):269-275.

1. JEMAL A, BRAY F, CENTER M M, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
2. 方琼英, 吴琼, 张秀玲, 等.乳腺癌的流行现状分析[J].中国社会医学杂志, 2012, 29(5):333-335.
3. LEE C H, KUO W H, LIN C C, et al. MicroRNA-regulated protein-protein interaction networks and their functions in breast cancer[J]. Int J Mol Sci, 2013, 14(6):11560-11606.
4. SAKURAI F, KATAYAMA K, MIZUGUCHI H. MicroRNA-regulated transgene expression systems for gene therapy and virotherapy[J]. Front Biosci (Landmark Ed), 2011, 16:2389-2401.
5. WANG F, SUN G P, ZOU Y F, et al. MicroRNAs as promising biomarkers for gastric cancer[J]. Cancer Biomark, 2012, 11(6):259-267.
6. BOERI M, PASTORINO U, SOZZI G, et al. Role of microRNAs in lung cancer:microRNA signatures in cancer prognosis[J]. Cancer J, 2012, 18(3):268-274.
7. NAVARRO A, CLOT G, PRIETO M, et al. MicroRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics[J]. Clin Cancer Res, 2013, 19(12):3121-3129.
8. GALASSO M, SANDHU S K, VOLINIA S. MicroRNA expression signatures in solid malignancies[J]. Cancer J, 2012, 18(3):238-243.
9. FARAZI T A, HORLINGS H M, TEN HOEVE J J, et al. MicroRNA sequence and expression analysis in breast tumors by deep sequencing[J]. Cancer Res, 2011, 71(13):4443-4453.
10. YAN L X, WU Q N, ZHANG Y, et al. Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth[J]. Breast Cancer Res, 2011, 13(1):R2.
11. IYEVLEVA A G, KULIGINA E S H, MITIUSHKINA N V, et al. High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas[J]. Breast Cancer Res Treat, 2012, 131(3):1049-1059.
12. LIAO S J, ZHOU Y H, YUAN Y, et al. Triggering of Toll-like receptor 4 on metastatic breast cancer cells promotesαvβ3-mediated adhesion and invasive migration[J]. Breast Cancer Res Treat, 2012, 133(3):853-863.
13. TILGHMAN S L, BRATTON M R, SEGAR H C, et al. Endocrine disruptor regulation of microRNA expression in breast carcinoma cells[J]. PLoS One, 2012, 7(3):e32754.
14. TERAO M, FRATELLI M, KUROSAKI M, et al. Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells:biological correlates and molecular targets[J]. J Biol Chem, 2011, 286(5):4027-4042.
15. ZHU S, SI M L, WU H, et al. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)[J]. J Biol Chem, 2007, 282(19):14328-14336.
16. LEUPOLD J H, YANG H S, COLBURN N H, et al. Asangani I, post S, allgayer H.tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor(u-PAR) gene expression via sp-transcription factors[J]. Oncogene, 2007, 26(31):4550-4562.
17. ZHU S, WU H, WU F, et al. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis[J]. Cell Res, 2008, 18(3):350-359.
18. BERARDI R, MORGESE F, ONOFRI A, et al. Role of maspin in cancer[J]. Clin Transl Med, 2013, 2(1):8.
19. WANG Z X, LU B B, WANG H, et al. MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN[J]. Arch Med Res, 2011, 42(4):281-290.
20. PEREZ E A, DUECK A C, MCCULLOUGH A E, et al. Impact of PTEN protein expression on benefit from adjuvant trastuzumab in early-stage human epidermal growth factor receptor 2-positive breast cancer in the North Central Cancer Treatment Group N9831 trial[J]. J Clin Oncol, 2013, 31(17):2115-2122.
21. GABRIELY G, WURDINGER T, KESARI S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators[J]. Dig Dis Sci, 2008, 28(17):5369-5380.
22. HONG K J, HSU M C, HOU M F, et al. The tumor suppressor RECK interferes with HER-2/Neu dimerization and attenuates its oncogenic signaling[J]. FEBS Lett, 2011, 585(4):591-595.
23. SONG B, WANG C, LIU J, et al. MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression[J]. J Exp Clin Cancer Res, 2010, 29:29.
24. CONNOLLY E C, VAN DOORSLAER K, ROGLER L E, et al. Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB[J]. Mol Cancer Res, 2010, 8(5):691-700.
25. KAZEROUNIAN S, GERALD D, HUANG M, et al. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis[J]. Cancer Res, 2013, 73(1):50-61.
26. SELCUKLU S D, DONOGHUE M T, KERIN M J, et al. Regulatory interplay between miR-21, JAG1 and 17beta-estradiol(E2)in breast cancer cells[J]. Biochem Biophys Res Commun, 2012, 423(2):234-239.
27. IZRAILIT J, BERMAN H K, DATTI A, et al. High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβpathways as fundamental Notch regulators in breast cancer[J]. Proc Natl Acad Sci U S A, 2013, 110(5):1714-1719.
28. YANG Y, CHAERKADY R, BEER M A, et al. Identification of miR-21 targets in breast cancer cells using a quantitative proteomic approach[J]. Proteomics, 2009, 9(5):1374-1384.
29. GONG C, YAO Y, WANG Y, et al. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer[J]. J Biol Chem, 2011, 286(21):19127-19137.
30. ANASTASOV N, HÖFIG I, VASCONCELLOS I G, et al. Radiation resistance due to high expression of miR-21 and G2, M checkpoint arrest in breast cancer cells[J]. Radiat Oncol, 2012, 7:206.
31. YAN L X, HUANG X F, SHAO Q, et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis[J]. RNA, 2008, 14(11):2348-2360.
32. LEE J A, LEE H Y, LEE E S, et al. Prognostic implications of MicroRNA-21 overexpression in invasive ductal carcinomas of the breast[J]. J Breast Cancer, 2011, 14(4):269-275.

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