Change of Volume and Mechanical Properties of Femoral Bone in Rabbits at Different Ages with Knee Osteoarthritis under Sand-therapy_Journal of Biomedical Engineering

Authors：

HUXiaoxin ¹ ,  JULAITI·Maitirouzi ¹ , HUANGShaojun ¹ , MUHETAER·Kelimu ¹ , DILINAER·Mahemuti ¹ , ZHANGChunguang ¹ , ABLIMIT·Mamat ¹ , ZHANGRui ² , ARXIDIN·Ablat ²

1. College of Mechanical Engineering;Xinjiang University;Urumqi 830047, China;
2. Imaging Center CT Room;The Sixth Affiliated Hospital;Xinjiang Medical University;Urumqi 830054;

Corresponding author：

JULAITI·Maitirouzi, Email: jurat@xju.edu.cn

Keywords：

osteoarthritis; MIMICS; scancellous bone and cortical bone; bone volume; biomechanic

DOI：

10.7507/1001-5515.20150184

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The present paper is aimed to study the effect of sand-therapy with Uyghur medicine on biomechanical properties and femoral bone volume of the femur of osteoarthritis (OA) rabbits at two different ages. In the experiments, we injected Papain through the joint space of right knees into the bodies of New Zealand rabbits (16 in the growing group, and 16 in the mature group), and established an OA model. The 16 rabbits in the mature group were divided randomly into 2 sub-groups: 8 in control group (no sand therapy), and 8 sand-therapy group. The 16 rabbits in the growing group were divided randomly into 2 groups as well: 8 in the control group (no sand therapy), and 8 in the sand-therapy group. We carried out CT scanning four times (1 day before, 13^th, 27^th and 41st days after the establishment of the model, respectively). After importing the CT data to MIMICS, the different volumes of each sclerotin were recorded and change of the percentage of each sclerotins in total femur bone volume were analyzed. Finally the rabbit femurs were given three-point bending test, the elastic load and the elastic deflection were obtained and the inertia of the section, the maximum bending stresses, the bending modulus of elasticity and the structural rigidity were calculated. The experimental results showed that ① Compared with 1 day before and 13^th day after establishment of model at maturity, the cancellous bone volume increased and cortical bone volume decreased (P<0.05), but compared with those in the control group, the cancellous bone volume of femurs decrease and cortical bone volume increased under sand-therapy (P<0.05). Compared with those in the control group, there were no significant changes in the deflection and cross-sectional moment of inertia in the sand-therapy group (P>0.05), but the maximum bending normal stress, maximum load, elastic modulus, and structural stiffness (P<0.05) in the sand therapy group were larger than those in the control group. The study showed that sand-therapy in Uyghur medicine has benign effect on bone volume of the OA rabbit femur in two ages and the mechanical properties of the OA rabbit femur at the two ages induced by sand-therapy in Uyghur medicine have been improved.

Citation： HUXiaoxin, JULAITI·Maitirouzi, HUANGShaojun, MUHETAER·Kelimu, DILINAER·Mahemuti, ZHANGChunguang, ABLIMIT·Mamat, ZHANGRui, ARXIDIN·Ablat. Change of Volume and Mechanical Properties of Femoral Bone in Rabbits at Different Ages with Knee Osteoarthritis under Sand-therapy. Journal of Biomedical Engineering, 2015, 32(5): 1038-1043. doi: 10.7507/1001-5515.20150184 Copy

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11.	RODAN G A. Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption[J]. J Bone Miner Res, 1991, 6(6):527-530.
12.	KANIS J A, MCCLOSKEY E V. Evaluation of the risk of hip fracture[J]. Bone, 1996, 18(Suppl):S127-S132.
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14.	FRANCESCO M. Microstrip-antenna design for hyperthermia treatment of superficial tumors[J]. IEEE Trans On Biomedical Eng, 1992, 39(6):580-588.
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1. GOLDING M B. Anticytokine therapy for osteoarthritis[J]. Expert Opin Boil Ther, 2001, 1(5):817-829.
2. 居来提·买提肉孜,孔春元,迪丽娜尔·马合木提.室内人工维医沙疗实验系统的建立[EB/OL]. (2008-5-11)[2014-07-26] http://www.paper.edu.cn.
3. MAJUMDAR S, BAY B K. Noninvasive assessment of trabecular bone architecture and the competence of bone[M]. Dordrecht:Kluwer Academic/Plenum Publishers:2001:63-83,95-97.
4. 刘保华.纵跳对悬吊大鼠骨密度、生物力学指标及股骨RUNX2MRNA表达的影响[D].上海:华东师范大学,2010.
5. 李伟,居来提·买提肉孜,迪丽娜·马合木提等.兔骨性关节炎模型股骨各骨质层体积与力学性能的关联性分析[J].吉林大学学报(医学版),2013,39(4):680-683.
6. 费王华.基于新鲜骨骼CT图像的有限元分析及实验验证[D].南京:南京理工大学,2008.
7. ODGAARD A. Three-dimensional of cancellous bone architecture[M]//COWIN SC. Bone mechanics bandbook. Boca Raton:CRC Press,2001:14-1-14-9.
8. 宫赫,张明,朱东等.62岁和69岁椎体松质骨表观弹性模量与骨量的关系[J].清华大学学报(自然科学版),2007,47(8):1393-1396.
9. 孔春元,迪丽娜尔·马合木提,卫荣.沙疗对关节炎兔股骨力学性能的影响及其有限元分析[J].中南大学学报(医学版),2009,34(1):8-12.
10. ANDERSON-MACENZIE J M, QUASNICHKA H L, STARR R L, et al. Fundamental subchondral bone changes in spontaneous knee osteoarthritis[J]. Biochem Cell Biol, 2005, 37(1):224-236.
11. RODAN G A. Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption[J]. J Bone Miner Res, 1991, 6(6):527-530.
12. KANIS J A, MCCLOSKEY E V. Evaluation of the risk of hip fracture[J]. Bone, 1996, 18(Suppl):S127-S132.
13. HOLZER G, SKRBENSKY G V, HOLZER L A, et a1. Hip fractures and the contribution of cortical versus trabecular bone to femoral neck strength[J]. J Bone Miner Res, 2009, 24(3):468-474.
14. FRANCESCO M. Microstrip-antenna design for hyperthermia treatment of superficial tumors[J]. IEEE Trans On Biomedical Eng, 1992, 39(6):580-588.
15. TUNER C H, AKHTER M P, HEANEY R P. The effect of fluoridated water on bone strength[J]. J Orthop Res, 1992, 10(4):581-587.

Journal of Biomedical Engineering

Change of Volume and Mechanical Properties of Femoral Bone in Rabbits at Different Ages with Knee Osteoarthritis under Sand-therapy

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