Research Progress on the Development and Regulation of Embryonic Hematopoietic Stem Cells_Journal of Biomedical Engineering

Authors：

MUWeiyun ,  YAOWeijuan

Hemorheology Center, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China;

Corresponding author：

YAOWeijuan, Email: weijuanyao@bjmu.edu.cn

Keywords：

hematopoietic stem cell; aorta-gonad-mesonephros; signaling pathway; microRNA; hemodynamics

DOI：

10.7507/1001-5515.20150202

Video：

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Abstract Full text Figures/Tables Video References Cited by

Hematopoietic stem cells (HSCs) are tissue specific stem cells that replenish all mature blood lineages during the lifetime of an individual. Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the formation of the adult blood system. Recently, people have learned a lot about the embryonic HSCs on their development and homing. During their differentiation, HSCs are regulated by the transcription factors, such as Runx1 and Notch signaling pathway, etc. MicroRNAs also regulate the self-renewal and differentiation of hematopoietic stem/progenitor cells on the post-transcriptional levels. Since the onset of circulation, the formation of HSCs and their differentiation into blood cells, especially red blood cells, are regulated by the hemodynamic forces. It would be of great significance if we could treat hematologic diseases with induced HSCs in vitro on the basis of fully understanding of hemotopoietic stem cell development. This review is focused on the advances in the research of HSCs' development and regulation.

Citation： MUWeiyun, YAOWeijuan. Research Progress on the Development and Regulation of Embryonic Hematopoietic Stem Cells. Journal of Biomedical Engineering, 2015, 32(5): 1141-1145. doi: 10.7507/1001-5515.20150202 Copy

1.	GORDON-KEYLOCK S, SOBIESIAK M, RYBTSOV S, et al. Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs[J]. Blood, 2013, 122(14):2338-2345.
2.	LI Z, LAN Y, HE W Y, et al. Mouse embryonic head as a site for hematopoietic stem cell development[J]. Cell Stem Cell, 2012, 11(5):663-675.
3.	NAKANO H, LIU X Q, ARSHI A, et al. Haemogenic endocardium contributes to transient definitive haematopoiesis[J]. Nat Commun, 2013, 4:1564.
4.	TANAKA Y, HAYASHI M, KUBOTA Y, et al. Early ontogenic origin of the hematopoietic stem cell lineage[J]. Proc Natl Acad Sci U S A, 2012, 109(12):4515-4520.
5.	LEE H J, LI N, EVANS S M, et al. Biomechanical force in blood development:extrinsic physical cues drive pro-hematopoietic signaling[J]. Differentiation, 2013, 86(3, SI):92-103.
6.	LEVANTINI E, LEE S, RADOMSKA H S, et al. RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element[J]. EMBO J, 2011, 30(19):4059-4070.
7.	TERRIENTE-FELIX A, LI J H, COLLINS S A, et al. Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme[J]. Development, 2013, 140(4):926-937.
8.	TANAKA Y, JOSHI A, WILSON N K, et al. The transcriptional programme controlled by Runx1 during early embryonic blood development[J]. Dev Biol, 2012, 366(2):404-419.
9.	CHEN M J, YOKOMIZO T, ZEIGLER B M, et al. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter[J]. Nature, 2009, 457(7231):887-891.
10.	RICHARD C, DREVON C, CANTO P Y, et al. Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis[J]. Dev Cell, 2013, 24(6):600-611.
11.	KNEZEVIC K, BEE T, WILSON N K, et al. A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis[J]. Mol Cell Biol, 2011, 31(14):2817-2826.
12.	BIGAS A, GUIU J, GAMA-NORTON L. Notch and Wnt signaling in the emergence of hematopoietic stem cells[J]. Blood Cells Mol Dis, 2013, 51(4):264-270.
13.	LARANJEIRO R, ALCOBIA I, NEVES H, et al. The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development[J]. PLoS One, 2012, 7(4):e34553.
14.	RUIZ H C, GUIU J, D'ALTRI T, et al. Hematopoietic stem cell development requires transient Wnt/β-catenin activity[J]. J Exp Med, 2012, 209(8):1457-1468.
15.	CLEMENTS W K, KIM A D, ONG K G, et al. A somatic Wnt16/Notch pathway specifies haematopoietic stem cells[J]. Nature, 2011, 474(7350):220-224.
16.	CLEMENTS W K, TRAVER D. Signalling pathways that control vertebrate haematopoietic stem cell specification[J]. Nat Rev Immunol, 2013, 13(5):336-348.
17.	FELLI N, FONTANA L, PELOSI E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation[J]. Proc Natl Acad Sci U S A, 2005, 102(50):18081-18086.
18.	GABBIANELLI M, TESTA U, MORSILLI O, et al. Mechanism of human Hb switching:a possible role of the kit receptor/miR 221-222 complex[J]. Haematologica, 2010, 95(8):1253-1260.
19.	HUANG X, GSCHWENG E, VAN HANDEL B, et al. Regulated expression of microRNAs-126/126^* inhibits erythropoiesis from human embryonic stem cells[J]. Blood, 2011, 117(7):2157-2165.
20.	ZHANG L, FLYGARE J, WONG P, et al. miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1[J]. Genes Dev, 2011, 25(2):119-124.
21.	MORRIS V A, ZHANG A, YANG T, et al. MicroRNA-150 expression induces myeloid differentiation of human acuteleukemia cells and normal hematopoietic progenitors[J]. PLoS One, 2013, 8(9):e75815.
22.	CULVER J C, DICKINSON M E. The effects of hemodynamic force on embryonic development.Microcirculation[J]. Microcirculation, 2010, 17(3):164-178.
23.	ADAMO L, NAVEIRAS O, WENZEL P L, et al. Biomechanical forces promote embryonic haematopoiesis[J]. Nature, 2009, 459(7250):U120-1131.
24.	NORTH T E, GOESSLING W, PEETERS M, et al. Hematopoietic stem cell development is dependent on blood flow[J]. Cell, 2009, 137(4):736-748.
25.	SONG J W, MUNN L L. Fluid forces control endothelial sprouting[J]. Proc Natl Acad Sci U S A, 2011, 108(37):15342-15347.
26.	WANG L, ZHANG P P, WEI Y L, et al. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos[J]. Blood, 2011, 118(15):4102-4110.
27.	WATSON O, NOVODVORSKY P, GRAY C, et al. Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling[J]. Cardiovasc Res, 2013, 100(2):252-261.

1. GORDON-KEYLOCK S, SOBIESIAK M, RYBTSOV S, et al. Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs[J]. Blood, 2013, 122(14):2338-2345.
2. LI Z, LAN Y, HE W Y, et al. Mouse embryonic head as a site for hematopoietic stem cell development[J]. Cell Stem Cell, 2012, 11(5):663-675.
3. NAKANO H, LIU X Q, ARSHI A, et al. Haemogenic endocardium contributes to transient definitive haematopoiesis[J]. Nat Commun, 2013, 4:1564.
4. TANAKA Y, HAYASHI M, KUBOTA Y, et al. Early ontogenic origin of the hematopoietic stem cell lineage[J]. Proc Natl Acad Sci U S A, 2012, 109(12):4515-4520.
5. LEE H J, LI N, EVANS S M, et al. Biomechanical force in blood development:extrinsic physical cues drive pro-hematopoietic signaling[J]. Differentiation, 2013, 86(3, SI):92-103.
6. LEVANTINI E, LEE S, RADOMSKA H S, et al. RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element[J]. EMBO J, 2011, 30(19):4059-4070.
7. TERRIENTE-FELIX A, LI J H, COLLINS S A, et al. Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme[J]. Development, 2013, 140(4):926-937.
8. TANAKA Y, JOSHI A, WILSON N K, et al. The transcriptional programme controlled by Runx1 during early embryonic blood development[J]. Dev Biol, 2012, 366(2):404-419.
9. CHEN M J, YOKOMIZO T, ZEIGLER B M, et al. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter[J]. Nature, 2009, 457(7231):887-891.
10. RICHARD C, DREVON C, CANTO P Y, et al. Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis[J]. Dev Cell, 2013, 24(6):600-611.
11. KNEZEVIC K, BEE T, WILSON N K, et al. A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis[J]. Mol Cell Biol, 2011, 31(14):2817-2826.
12. BIGAS A, GUIU J, GAMA-NORTON L. Notch and Wnt signaling in the emergence of hematopoietic stem cells[J]. Blood Cells Mol Dis, 2013, 51(4):264-270.
13. LARANJEIRO R, ALCOBIA I, NEVES H, et al. The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development[J]. PLoS One, 2012, 7(4):e34553.
14. RUIZ H C, GUIU J, D'ALTRI T, et al. Hematopoietic stem cell development requires transient Wnt/β-catenin activity[J]. J Exp Med, 2012, 209(8):1457-1468.
15. CLEMENTS W K, KIM A D, ONG K G, et al. A somatic Wnt16/Notch pathway specifies haematopoietic stem cells[J]. Nature, 2011, 474(7350):220-224.
16. CLEMENTS W K, TRAVER D. Signalling pathways that control vertebrate haematopoietic stem cell specification[J]. Nat Rev Immunol, 2013, 13(5):336-348.
17. FELLI N, FONTANA L, PELOSI E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation[J]. Proc Natl Acad Sci U S A, 2005, 102(50):18081-18086.
18. GABBIANELLI M, TESTA U, MORSILLI O, et al. Mechanism of human Hb switching:a possible role of the kit receptor/miR 221-222 complex[J]. Haematologica, 2010, 95(8):1253-1260.
19. HUANG X, GSCHWENG E, VAN HANDEL B, et al. Regulated expression of microRNAs-126/126^* inhibits erythropoiesis from human embryonic stem cells[J]. Blood, 2011, 117(7):2157-2165.
20. ZHANG L, FLYGARE J, WONG P, et al. miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1[J]. Genes Dev, 2011, 25(2):119-124.
21. MORRIS V A, ZHANG A, YANG T, et al. MicroRNA-150 expression induces myeloid differentiation of human acuteleukemia cells and normal hematopoietic progenitors[J]. PLoS One, 2013, 8(9):e75815.
22. CULVER J C, DICKINSON M E. The effects of hemodynamic force on embryonic development.Microcirculation[J]. Microcirculation, 2010, 17(3):164-178.
23. ADAMO L, NAVEIRAS O, WENZEL P L, et al. Biomechanical forces promote embryonic haematopoiesis[J]. Nature, 2009, 459(7250):U120-1131.
24. NORTH T E, GOESSLING W, PEETERS M, et al. Hematopoietic stem cell development is dependent on blood flow[J]. Cell, 2009, 137(4):736-748.
25. SONG J W, MUNN L L. Fluid forces control endothelial sprouting[J]. Proc Natl Acad Sci U S A, 2011, 108(37):15342-15347.
26. WANG L, ZHANG P P, WEI Y L, et al. A blood flow-dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos[J]. Blood, 2011, 118(15):4102-4110.
27. WATSON O, NOVODVORSKY P, GRAY C, et al. Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling[J]. Cardiovasc Res, 2013, 100(2):252-261.

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