Imaging analysis of jaw defects reparation with antigen-extracted porcine cancellous bone_Journal of Biomedical Engineering

Authors：

CHEN Xufeng ¹ , LU Lihong ¹ , FENG Zhiqiang ¹ , YIN Zhongda ² ,  LAI Renfa ¹

1. The Medical Centre of Stomatology, The 1st Affiliated Hospital of Jinan University, Guangzhou 510630, P.R.China;
2. Department of Stomatology, Dongguan People’s Hospital, Dongguan, Guangdong 523059, P.R.China;

Corresponding author：

LAI Renfa, Email: prof.dr.lai@163.com

Keywords：

antigen-extracted porcine cancellous bone; jaw defects; computed tomography; cone beam computed tomography; single-photon emission computed tomography; image fusion

DOI：

10.7507/1001-5515.201511047

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At present, most of the bone xenograft for clinical application comes from bovine. In recent years, many studies have been done on the clinical application of porcine xenograft bone. The goal of this study was to evaluate the effect of canine mandibular defects reparation with antigen-extracted porcine cancellous bone by imaging examination. Four dogs’ bilateral mandibular defects were created, with one side repaired with autologous bone (set as control group) while the other side repaired with antigen-extracted porcine cancellous bone (set as experimental group). Titanium plates and titanium screws were used for fixation. Cone beam computed tomography (CBCT), computed tomography (CT), single-photon emission computed tomography (SPECT) were undertaken at week 12 and 24 postoperatively, and SPECT and CT images were fused. The results demonstrated that the remodeling of antigen-extracted porcine cancellous bone was slower than that of autologous bone, but it can still be used as scaffold for jaw defects. The results in this study provide a new choice for materials required for clinical reparation of jaw defects.

Citation： CHEN Xufeng, LU Lihong, FENG Zhiqiang, YIN Zhongda, LAI Renfa. Imaging analysis of jaw defects reparation with antigen-extracted porcine cancellous bone. Journal of Biomedical Engineering, 2017, 34(6): 883-888. doi: 10.7507/1001-5515.201511047 Copy

1.	王呈, 曾炳芳. 骨移植替代材料在创伤骨科的应用. 国际骨科学杂志, 2012, 33(1): 37-38.
2.	Long Bi, Dan Li, Jian Liu, et al. Evaluation of a novel reconstituted bone xenograft using processed bovine cancellous bone in combination with purified bovine bone morphogenetic protein. Xenotransplantation, 2012, 19(2): 122-132.
3.	Salgado A J, Figueiredo J E, Coutinho O P, et al. Biological response to pre-mineralized starch based scaffolds for bone tissue engineering. J Mater Sci Mater Med, 2005, 16(3): 267-275.
4.	Saito A, Saito E, Handa R, et al. Influence of residual bone on recombinant human bone morphogenetic protein-2-induced periodontal regeneration in experimental periodontitis in dogs. J Periodontol, 2009, 80(6): 961-968.
5.	王小志, 何惠宇, 杨楠, 等. 基因转染骨髓间充质干细胞复合同种异体骨修复绵羊极限骨缺损. 中国组织工程研究, 2013, 17(47): 8141-8148.
6.	Li Zejian, Lu Chunting, Feng Zhiqiang, et al. Antigen-extracted xenogeneic cancellous bone graft with recombinant human bone morphogenetic protein-2 enhances bone regeneration in repair of mandibular defect in rabbits. Kaohsiung J Med Sci, 2015, 31(1): 18-25.
7.	Athanasiou V T, Papachristou D J, Panagopoulos A, et al. Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: an experimental study in rabbits. Med Sci Monit, 2010, 16(1): BR24-BR31.
8.	Accorsi-Mendonça T, Conz M B, Barros T C, et al. Physicochemical characterization of two deproteinized bovine xenografts. Braz Oral Res, 2008, 22(1): 5-10.
9.	施新猷. 现代医学实验动物学. 北京: 人民军医出版社, 2000: 136.
10.	Delloye C, Cnockaert N, Cornu O. Bone substitutes in 2003: an overview. Acta Orthop Belg, 2003, 69(1): 1-8.
11.	雷荣昌, 翦新春. 松质骨支架的制备及结构特征观察. 生物医学工程与临床, 2006, 10(3): 128-130.
12.	Zabel-du Bois A, Nill S, Ulrich S, et al. Dosimetric integration of daily mega-voltage cone-beam CT for image-guided intensity-modulated radiotherapy. Strahlenther Onkol, 2012, 188(2): 120-126.
13.	李泽键, 赖仁发, 黄荣. CBCT 在骨岛定位及指导牙种植体植入中的应用研究. 重庆医学, 2013, 42(22): 2644-2646.
14.	孙涛, 韩善清, 汪家旺. PET/CT 成像原理、优势及临床应用. 中国医学物理学杂志, 2010, 27(1): 1581-1582, 1587.
15.	Zhao Zhen, Li Lin, Li Fanglan, et al. Single photon emission computed tomography/spiral computed tomography fusion imaging for the diagnosis of bone metastasis in atients with known cancer. Skeletal Radiol, 2010, 39(2): 147-153.
16.	王嘉兴, 汤伟军, 张锦明, 等. SPECT 与 CT 3D 图像异机融合的实验研究. 中国医学计算机成像杂志, 2010, 16(1): 42-45.
17.	Weber W A, Grosu A L, Czernin J. Technology insight: advances in molecular imaging and an appraisal of PET/CT scanning. Nat Clin Pract Oncol, 2008, 5(3): 160-170.
18.	朱明, 李戈, 杨桂星, 等. CT 骨重建与 SPECT 异机融合显像在骨转移瘤诊断的应用价值. 中国冶金工业医学杂志, 2012, 29(4): 386-388.
19.	Jansen E J, Sladek R E, Bahar H, et al. Hydrophobicity as a design criterion for polymer scaffolds in bone tissue engineering. Biomaterials, 2005, 26(21): 4423-4431.

1. 王呈, 曾炳芳. 骨移植替代材料在创伤骨科的应用. 国际骨科学杂志, 2012, 33(1): 37-38.
2. Long Bi, Dan Li, Jian Liu, et al. Evaluation of a novel reconstituted bone xenograft using processed bovine cancellous bone in combination with purified bovine bone morphogenetic protein. Xenotransplantation, 2012, 19(2): 122-132.
3. Salgado A J, Figueiredo J E, Coutinho O P, et al. Biological response to pre-mineralized starch based scaffolds for bone tissue engineering. J Mater Sci Mater Med, 2005, 16(3): 267-275.
4. Saito A, Saito E, Handa R, et al. Influence of residual bone on recombinant human bone morphogenetic protein-2-induced periodontal regeneration in experimental periodontitis in dogs. J Periodontol, 2009, 80(6): 961-968.
5. 王小志, 何惠宇, 杨楠, 等. 基因转染骨髓间充质干细胞复合同种异体骨修复绵羊极限骨缺损. 中国组织工程研究, 2013, 17(47): 8141-8148.
6. Li Zejian, Lu Chunting, Feng Zhiqiang, et al. Antigen-extracted xenogeneic cancellous bone graft with recombinant human bone morphogenetic protein-2 enhances bone regeneration in repair of mandibular defect in rabbits. Kaohsiung J Med Sci, 2015, 31(1): 18-25.
7. Athanasiou V T, Papachristou D J, Panagopoulos A, et al. Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: an experimental study in rabbits. Med Sci Monit, 2010, 16(1): BR24-BR31.
8. Accorsi-Mendonça T, Conz M B, Barros T C, et al. Physicochemical characterization of two deproteinized bovine xenografts. Braz Oral Res, 2008, 22(1): 5-10.
9. 施新猷. 现代医学实验动物学. 北京: 人民军医出版社, 2000: 136.
10. Delloye C, Cnockaert N, Cornu O. Bone substitutes in 2003: an overview. Acta Orthop Belg, 2003, 69(1): 1-8.
11. 雷荣昌, 翦新春. 松质骨支架的制备及结构特征观察. 生物医学工程与临床, 2006, 10(3): 128-130.
12. Zabel-du Bois A, Nill S, Ulrich S, et al. Dosimetric integration of daily mega-voltage cone-beam CT for image-guided intensity-modulated radiotherapy. Strahlenther Onkol, 2012, 188(2): 120-126.
13. 李泽键, 赖仁发, 黄荣. CBCT 在骨岛定位及指导牙种植体植入中的应用研究. 重庆医学, 2013, 42(22): 2644-2646.
14. 孙涛, 韩善清, 汪家旺. PET/CT 成像原理、优势及临床应用. 中国医学物理学杂志, 2010, 27(1): 1581-1582, 1587.
15. Zhao Zhen, Li Lin, Li Fanglan, et al. Single photon emission computed tomography/spiral computed tomography fusion imaging for the diagnosis of bone metastasis in atients with known cancer. Skeletal Radiol, 2010, 39(2): 147-153.
16. 王嘉兴, 汤伟军, 张锦明, 等. SPECT 与 CT 3D 图像异机融合的实验研究. 中国医学计算机成像杂志, 2010, 16(1): 42-45.
17. Weber W A, Grosu A L, Czernin J. Technology insight: advances in molecular imaging and an appraisal of PET/CT scanning. Nat Clin Pract Oncol, 2008, 5(3): 160-170.
18. 朱明, 李戈, 杨桂星, 等. CT 骨重建与 SPECT 异机融合显像在骨转移瘤诊断的应用价值. 中国冶金工业医学杂志, 2012, 29(4): 386-388.
19. Jansen E J, Sladek R E, Bahar H, et al. Hydrophobicity as a design criterion for polymer scaffolds in bone tissue engineering. Biomaterials, 2005, 26(21): 4423-4431.

Journal of Biomedical Engineering

Imaging analysis of jaw defects reparation with antigen-extracted porcine cancellous bone

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