Research and Design of an Experimental Apparatus Based on the "Open Fireplace" in Xuanwei District_Journal of Biomedical Engineering

Authors：

YANGJiapeng ¹ ,  HUANGYunchao ¹ , ZIWenhua ² , BAIYunbao ³ , LIGuangjian ¹ , YELianhua ¹ , ZHOUYongchun ¹ , ZHAOGuangqiang ¹ , LEIYujie ¹ , CHENXiaobo ¹ , CHENYing ¹ , ZHANGYanjun ¹

1. Department of Thoracic Surgery 1 Ward, The Third Affiliated Hospital of Kunming Medical University' Yunnan Provincial Tumor Hospital,Yunnan Key Laboratory of Lung Cancer, Kunming 650118, China;
2. Yunnan Reascend Tobacco Technology Group Co., Ltd, Kunming 650000, China;
3. Yunnan Institute of Environmental Science, Kunming 650000, China;

Corresponding author：

HUANGYunchao, Email: huangych2001@aliyun.com

Keywords：

Xuanwei; indoor air pollution; experimental apparatus; lung injury

DOI：

10.7507/1001-5515.20160019

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Xuanwei district in Yunnan Province of China has pretty high incidence of lung cancer in China, even around the world. Studies have shown that there exists a close relationship between lung cancer and local indoor air pollution caused by Bituminous coal. Considering that the indoor air pollution in Xuanwei District is caused by "open fireplace", an indoor air pollution simulation system was designed, and an F344 rats lung damage model was established for this indoor air pollution fireplace. The model is based on indoor air pollution simulation system with signal multiplexer control and multichannel acquisition, and mining PID algorithm was used for polynomial fitting to each test point, and a relatively constant PM2.5 air pollution status was simulated. The results showed that the system could simulate a variety of states of air pollution, provide a new test method for evaluation of human injury caused by indoor air pollution and a new idea for the study of the incidence of lung cancer in Xuanwei district and other places.

Citation： YANGJiapeng, HUANGYunchao, ZIWenhua, BAIYunbao, LIGuangjian, YELianhua, ZHOUYongchun, ZHAOGuangqiang, LEIYujie, CHENXiaobo, CHENYing, ZHANGYanjun. Research and Design of an Experimental Apparatus Based on the "Open Fireplace" in Xuanwei District. Journal of Biomedical Engineering, 2016, 33(1): 101-107. doi: 10.7507/1001-5515.20160019 Copy

1.	赫捷, 陈万青.2011年中国肿瘤登记年报[M] .北京:军事医学科学出版社, 2012.
2.	MUMFORD J L, HE X Z, CHAPMAN R S, et al. Lung cancer and indoor air pollution in Xuan Wei. China[J] . Science, 1987, 235(4785):217-220.
3.	LAN Qing, HE Xingzhou, SHEN Min, et al. Variation in lung cancer risk by smoky coal subtype in Xuanwei, China[J] . Int J Cancer, 2008, 123(9): 2164-2169.
4.	顾庆平. 西藏室内多环芳烃污染特征及其致癌风险[D] . 上海:复旦大学, 2009.
5.	LAN Qing, CHAPMAN R S, SCHREINEMACHERS D M, et al. Household stove improvement and risk of lung cancer in Xuanwei, China[J] . J Natl Cancer Inst, 2002, 94(11): 826-835.
6.	MANTOVANI A. Cancer: inflammation by remote control[J] . Nature, 2005, 435(743): 752-753.
7.	VALAVANIDIS A, VLACHOGIANNI T, FIOTAKIS C. 8-hydroxy-2′ -deoxyguanosine (8-OhdG): A critical biomarker of oxidative stress and carcinogenesis[J] . J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2009, 27(2): 120-139.
8.	朱泽安, 陈志航. 基于Arduino的多场景PM25检测仪[J] . 电子技术与软件工程, 2015, (3):154.
9.	王述彦, 师宇, 冯忠绪. 基于模糊PID控制器的控制方法研究[J] . 机械科学与技术, 2011, 30(1):166-172.
10.	樊景森, 邵龙义, 王静, 等. 云南宣威燃煤室内可吸入颗粒物质量浓度变化特征[J] . 中国环境科学, 2012, 32(8):1379-1383.
11.	MONN C, BECKER S. Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM 2.5) and coarse particles (PM 10-2.5) in outdoor and indoor air[J] . Toxicol Appl Pharmacol, 1999, 155(3): 245-252.
12.	李光剑, 王霁阳, 黄云超, 等. 云南省宣威地区烟煤燃烧后的底灰对BEAS-2B细胞的体外毒性作用[J] . 广东医学, 2012, 33(19):2890-2893.
13.	DONALDSON K, LI X-y, MACNEE W. Ultrafine ( anometer) particle mediated lung injury[J] . J Aerosol Sci, 1998, 29(5-6): 553-560.
14.	PINKERTON K E, GREEN F H, SAIKI C, et al. Distribution of particulate matter and tissue remodeling in the human lung[J] . Environ Health Perspect, 2000, 108(11): 1063-1069.
15.	GONDA T A, TU Shuiping, WANG T C. Chronic inflammation, the tumor microenvironment and carcinogenesis[J] . Cell Cycle, 2009, 8(13): 2005-2013.
16.	BROWN D M, STONE V, FINDLAY P, et al. Increased inflammation and intracellular calcium caused by ultrafine carbon black is Independent of transition metals or other soluble components[J] . Occup Environ Med, 2000, 57(10): 685-691.
17.	BAAN R, STRAIF K, GROSSE Y, et al. Carcinogenicity of carbon black, titanium dioxide, and talc[J] . Lancet Oncol, 2006, 7(4): 295-296.
18.	GREENBLATT M S, BENNETT W P, HOLLSTEIN M, et al. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis[J] . Cancer Res, 1994, 54(18): 4855-4878.
19.	COUSSENS L M, WERB Z. Inflammation and cancer[J] . Nature, 2002, 420(6917): 860-867.

1. 赫捷, 陈万青.2011年中国肿瘤登记年报[M] .北京:军事医学科学出版社, 2012.
2. MUMFORD J L, HE X Z, CHAPMAN R S, et al. Lung cancer and indoor air pollution in Xuan Wei. China[J] . Science, 1987, 235(4785):217-220.
3. LAN Qing, HE Xingzhou, SHEN Min, et al. Variation in lung cancer risk by smoky coal subtype in Xuanwei, China[J] . Int J Cancer, 2008, 123(9): 2164-2169.
4. 顾庆平. 西藏室内多环芳烃污染特征及其致癌风险[D] . 上海:复旦大学, 2009.
5. LAN Qing, CHAPMAN R S, SCHREINEMACHERS D M, et al. Household stove improvement and risk of lung cancer in Xuanwei, China[J] . J Natl Cancer Inst, 2002, 94(11): 826-835.
6. MANTOVANI A. Cancer: inflammation by remote control[J] . Nature, 2005, 435(743): 752-753.
7. VALAVANIDIS A, VLACHOGIANNI T, FIOTAKIS C. 8-hydroxy-2′ -deoxyguanosine (8-OhdG): A critical biomarker of oxidative stress and carcinogenesis[J] . J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2009, 27(2): 120-139.
8. 朱泽安, 陈志航. 基于Arduino的多场景PM25检测仪[J] . 电子技术与软件工程, 2015, (3):154.
9. 王述彦, 师宇, 冯忠绪. 基于模糊PID控制器的控制方法研究[J] . 机械科学与技术, 2011, 30(1):166-172.
10. 樊景森, 邵龙义, 王静, 等. 云南宣威燃煤室内可吸入颗粒物质量浓度变化特征[J] . 中国环境科学, 2012, 32(8):1379-1383.
11. MONN C, BECKER S. Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM 2.5) and coarse particles (PM 10-2.5) in outdoor and indoor air[J] . Toxicol Appl Pharmacol, 1999, 155(3): 245-252.
12. 李光剑, 王霁阳, 黄云超, 等. 云南省宣威地区烟煤燃烧后的底灰对BEAS-2B细胞的体外毒性作用[J] . 广东医学, 2012, 33(19):2890-2893.
13. DONALDSON K, LI X-y, MACNEE W. Ultrafine ( anometer) particle mediated lung injury[J] . J Aerosol Sci, 1998, 29(5-6): 553-560.
14. PINKERTON K E, GREEN F H, SAIKI C, et al. Distribution of particulate matter and tissue remodeling in the human lung[J] . Environ Health Perspect, 2000, 108(11): 1063-1069.
15. GONDA T A, TU Shuiping, WANG T C. Chronic inflammation, the tumor microenvironment and carcinogenesis[J] . Cell Cycle, 2009, 8(13): 2005-2013.
16. BROWN D M, STONE V, FINDLAY P, et al. Increased inflammation and intracellular calcium caused by ultrafine carbon black is Independent of transition metals or other soluble components[J] . Occup Environ Med, 2000, 57(10): 685-691.
17. BAAN R, STRAIF K, GROSSE Y, et al. Carcinogenicity of carbon black, titanium dioxide, and talc[J] . Lancet Oncol, 2006, 7(4): 295-296.
18. GREENBLATT M S, BENNETT W P, HOLLSTEIN M, et al. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis[J] . Cancer Res, 1994, 54(18): 4855-4878.
19. COUSSENS L M, WERB Z. Inflammation and cancer[J] . Nature, 2002, 420(6917): 860-867.

Journal of Biomedical Engineering

Research and Design of an Experimental Apparatus Based on the "Open Fireplace" in Xuanwei District

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content