Study of the Effect of Cholecystokinin-Induced Acute Pancreatitis on the Free-Running Rhythm of Mouse_Journal of Biomedical Engineering

Authors：

LIYonghong ¹ , YANGXiaoping ¹ , GUOPanpan ¹ ,  LIUYanyou ² , YANHongli ¹ , LIShuaizhen ¹ , GUANJunwen ³

1. Department of Electronic Engineering, Chengdu University of Information Technology, Key Laboratory of Biological Effect of Physical Field and Instrument of Sichuan provincial Department of Education, Chengdu 610225, China;
2. Key Laboratory of Chronobiology, Ministry of Health of Sichuan University, Chengdu 610041, China;
3. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIUYanyou, Email: 264790802@qq.com

Keywords：

cholecystokinin; acute pancreatitis; circadian rhythm; free-running

DOI：

10.7507/1001-5515.20160021

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The present paper reports the effect of pancreatitis induced by cholecystokinin (CCK) on free-running rhythm of locomotor activity of the ICR mice, and analyzes the interaction of inflammatory diseases and acute pancreatitis with circadian rhythm system. In the study, the mice were modeled under different phases of acute pancreatitis in DD status (Double Dark，constant dark condition). By comparing of the inflammatory status and the indicators of rhythm before and after modeling of the running wheel activity group and the rest group, it was observed that the rest group showed more possibility of inflammation than the activity group did in ICR mice model of acute pancreatitis. In the rest phase model, the extension of the period is particularly longer. The results presented indicated that CCK-induced acute pancreatitis impacted free activity rhythm of ICR mice. Also in a free running model under different phase, the inflammation severity was proved significantly different. This study provides possible clues for the research of the pathogenesis of acute pancreatitis severe tendency.

Citation： LIYonghong, YANGXiaoping, GUOPanpan, LIUYanyou, YANHongli, LIShuaizhen, GUANJunwen. Study of the Effect of Cholecystokinin-Induced Acute Pancreatitis on the Free-Running Rhythm of Mouse. Journal of Biomedical Engineering, 2016, 33(1): 115-119. doi: 10.7507/1001-5515.20160021 Copy

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12.	DOLATABADI L K, REISI P. Acute effect of cholecystokinin on short-term synaptic plasticity in the rat hippocampus[J]. Res Pharm Sci, 2015, 9(5): 331-336.
13.	BODE B, TANEJA R, ROSSNER M J, et al. Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice[J]. Chronobiol Int, 2011, 28(9): 737-750.
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1. CUTOLO M, SULLI A, PINCUS T. Circadian use of glucocorticoids in rheumatoid arthritis[J]. Neuroimmunomodulation, 2015, 22(1-2): 33-39.
2. SADKI A, BENTIVOGLIO M, KRISTENSSON K, et al. Suppressors, receptors and effects of cytokines on the aging mouse biological clock[J]. Neurobiol Aging, 2007, 28(2): 296-305.
3. CAVADINI G, PETRZILKA S, KOHLER P, et al. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription[J]. Proc Natl Acad Sci U S A, 2007, 104(31): 12843-12848.
4. JAWOREK J, KONTUREK S J, TOMASZEWSKA R, et al. The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat[J]. J Pineal Res, 2004, 37(3): 161-170.
5. PANEK J, KUSNIERZ-CABALA B, DOLECKI M, et al. Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis[J]. Pol Przegl Chir, 2012, 84(5): 230-237.
6. FOITZIK T, HOTZ H G, EIBL G, et al. Experimental models of acute pancreatitis: are they suitable for evaluating therapy?[J]. Int J Colorectal Dis, 2000, 15(3): 127-135.
7. KURODA H, FUKUSHIMA M, NAKAI M, et al. Daily wheel running activity modifies the period of free-running rhythm in rats via intergeniculate leaflet[J]. Physiol Behav, 1997, 61(5): 633-637.
8. AN H J, LEE J H, LEE H J, et al. Electroacupuncture protects against CCK-induced acute pancreatitis in rats[J]. Neuroimmunomodulation, 2007, 14(2): 112-118.
9. REDDY R C, HAO Y, LEE S H, et al. Pioglitazone reverses insulin resistance and impaired CCK-stimulated pancreatic secretion in eNOS(-/-) mice: therapy for exocrine pancreatic disorders?[J]. Am J Physiol Gastrointest Liver Physiol, 2007, 293(1): G112-G120.
10. LETOHA T, SOMLAI C, TAKACS T, et al. A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis[J]. World J Gastroenterol， 2005， 11(7): 990-999.
11. YANG Yuting, CHENG Shuting, LI Yonghong, et al. The influence of L-arginine on circadian rhythm and circadian period genes[J]. Biological Rhythm Research, 2013, 44(4): 511-518.
12. DOLATABADI L K, REISI P. Acute effect of cholecystokinin on short-term synaptic plasticity in the rat hippocampus[J]. Res Pharm Sci, 2015, 9(5): 331-336.
13. BODE B, TANEJA R, ROSSNER M J, et al. Advanced light-entrained activity onsets and restored free-running suprachiasmatic nucleus circadian rhythms in per2/dec mutant mice[J]. Chronobiol Int, 2011, 28(9): 737-750.
14. MUHLBAUER E, WOLGAST S, FINCKH U, et al. Indication of circadian oscillations in the rat pancreas[J]. Febs Lett, 2004, 564(1-2): 91-96.

Journal of Biomedical Engineering

Study of the Effect of Cholecystokinin-Induced Acute Pancreatitis on the Free-Running Rhythm of Mouse

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