Effect of Stellate Ganglion Block on Bilateral Regional Cerebral Oxygen Saturation and Postoperative Cognitive Function_Journal of Biomedical Engineering

Authors：

ZHANGYuan ^1,2,3 , QIANYanning ² , BAOHongguang ³ , SHIHongwei ³ ,  ZHOUJianwei ¹

1. Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China;
2. (Department of Anesthesiology, The first Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China);
3. (Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China;

Corresponding author：

ZHOUJianwei, Email: jwzhou@njmu.edu.cn

Keywords：

stellate ganglion block; regional cerebral oxygen saturation; cognitive dysfunction

DOI：

10.7507/1001-5515.20160024

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The present study was to examine the effect of stellate ganglion block (SGB) on bilateral regional cerebral oxygen saturation (rSO2) and postoperative cognitive function. Eighty patients undergoing selective coronary artery bypass graft with cardiopulmonary bypass (CPB) were randomly and equally divided into two groups. The patients in group S were given right SGB with ropivacaine, while the patients in group C were injected with normal saline. We compared the bilateral rSO2 after SGB. Minimum Mental State Examination (MMSE), Visual Verbal Learning Test (VVLT), and Digital Span Test (DST) were applied to observe the effect on cognitive function. We found that the incidence of postoperative cognitive dysfunction (POCD) 7 days after surgery in group S was lower than that in group C. The level of blocked side rSO2 of S group were significantly higher before CPB time of rewarming than that before SGB (P＜0.05), much higher than corresponding non-blocked side rSO2 before CPB (P＜0.05), and much higher than rSO2 level in group C before CPB and after CPB(P＜0.05). The non-blocked side rSO2 in group S before anesthesia were much lower than basic levels and those in group C (P＜0.05). It could be concluded from the above results that there was significant increase in the blocked-side rSO2 compared to the non-blocked side and there was significant decrease in the incidence of POCD compared to the control group after SGB.

Citation： ZHANGYuan, QIANYanning, BAOHongguang, SHIHongwei, ZHOUJianwei. Effect of Stellate Ganglion Block on Bilateral Regional Cerebral Oxygen Saturation and Postoperative Cognitive Function. Journal of Biomedical Engineering, 2016, 33(1): 132-135. doi: 10.7507/1001-5515.20160024 Copy

1.	张媛，程浩，徐晨婕，等．超声引导星状神经节阻滞对老年患者术中脑氧代谢及术后认知功能的影响[J]．生物医学工程学杂志， 2014, 31（5）： 1107-1110.
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4.	PARK H M, KIM T W, CHOI H G, et al. The change in regional cerebral oxygen saturation after stellate ganglion block[J]. Korean J Pain, 2010, 23(2): 142-146.
5.	BALLARD C, JONES E, GAUGE N, et al. Optimised anaesthesia to reduce postoperative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial[J]. PLoS One, 2012, 7(6): e37410.
6.	LIPOV E G, NAVAIE M, BROWN P R. Stellate ganglion block improves refractory post-traumatic stress disorder and associated memory dysfunction: a case report and systematic literature review[J]. Mil Med, 2013, 178(2): e260-e264.
7.	HARILALL Y, ADAM J K, BICCARD B M, et al. The effect of optimising cerebral tissue oxygen saturation on markers of neurological injury during coronary artery bypass graft surgery[J]. Heart Lung Circ, 2014, 23(1): 68-74.
8.	PARK C S, KWAK J G, LEE C, et al. Near-infrared spectroscopy as a possible device for continuous monitoring of arterial carbon dioxide tension during cardiac surgery[J]. Perfusion, 2011, 26(6): 524-528.
9.	KIM E M, YOON K B, LEE J H, et al. The effect of oxygen administration on regional cerebral oxygen saturation after stellate ganglion block on the non-blocked side[J]. Pain Physician, 2013, 16(2): 117-124.
10.	ZULUETA J L, VIDA V L, PERISINOTTO E, et al. Role of intraoperative regional oxygen saturation using near infrared spectroscopy in the prediction of low output syndrome after pediatric heart surgery[J]. J Card Surg, 2013, 28(4): 446-452.

1. 张媛，程浩，徐晨婕，等．超声引导星状神经节阻滞对老年患者术中脑氧代谢及术后认知功能的影响[J]．生物医学工程学杂志， 2014, 31（5）： 1107-1110.
2. KADOIY, SAITO S, FUJITA N, et al. Effects of Balloon-Induced pulsatile perfusion on postoperative short- and long-term cognitive dysfunction in diabetic patients with impaired cerebrovascular carbon dioxide reactivity[J]. J Cardiothorac Vasc Anesth, 2013, 27(2): 238-244.
3. OTOMO S, MAEKAWA K, GOTO T, et al. Pre-existing cerebral infarcts as a risk factor for delirium after coronary artery bypass graft surgery[J]. Interact Cardiovasc Thorac Surg, 2013, 17(5): 799-804.
4. PARK H M, KIM T W, CHOI H G, et al. The change in regional cerebral oxygen saturation after stellate ganglion block[J]. Korean J Pain, 2010, 23(2): 142-146.
5. BALLARD C, JONES E, GAUGE N, et al. Optimised anaesthesia to reduce postoperative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial[J]. PLoS One, 2012, 7(6): e37410.
6. LIPOV E G, NAVAIE M, BROWN P R. Stellate ganglion block improves refractory post-traumatic stress disorder and associated memory dysfunction: a case report and systematic literature review[J]. Mil Med, 2013, 178(2): e260-e264.
7. HARILALL Y, ADAM J K, BICCARD B M, et al. The effect of optimising cerebral tissue oxygen saturation on markers of neurological injury during coronary artery bypass graft surgery[J]. Heart Lung Circ, 2014, 23(1): 68-74.
8. PARK C S, KWAK J G, LEE C, et al. Near-infrared spectroscopy as a possible device for continuous monitoring of arterial carbon dioxide tension during cardiac surgery[J]. Perfusion, 2011, 26(6): 524-528.
9. KIM E M, YOON K B, LEE J H, et al. The effect of oxygen administration on regional cerebral oxygen saturation after stellate ganglion block on the non-blocked side[J]. Pain Physician, 2013, 16(2): 117-124.
10. ZULUETA J L, VIDA V L, PERISINOTTO E, et al. Role of intraoperative regional oxygen saturation using near infrared spectroscopy in the prediction of low output syndrome after pediatric heart surgery[J]. J Card Surg, 2013, 28(4): 446-452.

Journal of Biomedical Engineering

Effect of Stellate Ganglion Block on Bilateral Regional Cerebral Oxygen Saturation and Postoperative Cognitive Function

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