Analysis of Abnormal Muscular Coupling During Rehabilitation after Stroke_Journal of Biomedical Engineering

Authors：

XIEPing ¹ , SONGYan ¹ , GUOZihui ¹ , CHENXiaoling ¹ , WUXiaoguang ¹ , SUYuping ² ,  DUYihao ¹

1. Institute of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China;
2. Department of Rehabilitation, Qinhuangdao People's Hospital, Qinhuangdao 066000, China;

Corresponding author：

DUYihao, Email: duyihao@126.com

Keywords：

surface electromyogram signal; intermuscular coherence; abnormal muscular coupling; rehabilitation assessment of movement

DOI：

10.7507/1001-5515.20160043

Video：

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For the questions of deeply researching abnormal neuromuscular coupling and better evaluating motor function of stroke patients with motor dysfunction, an effective intermuscular coherence analysis method and index are studied to explore the neuromuscular oscillation and the pathomechanism of motor dysfunction, based on which an assessment standard of muscle function is established. Firstly, the contrastive analysis about the intermuscular coherence of antagonistic muscle of affected and intact upper limbs of stroke patients was conducted. Secondly, a significant indicator of Fisher's Z-transformed coherence significant indicator was defined to quantitatively describe the coupling differences in certain functional frequency domain between surface electromyogram (sEMG) of affected and intact sides. Further more, the relationship between intermuscular coherence and motor task was studied. Through the analysis of intermuscular coherence during elbow flexion-extension of affected and intact sides, we found that the intermuscular coherence was associated with motor task and the stroke patients exhibited significantly lower beta-band intermuscular coherence in performing the task with their affected upper limbs. More conclusion can be drawn that beta-band intermuscular coherence has been found concerned with Fugle-Meyer scale, which indicates that beta-band intermuscular coherence could be an index assisting in evaluating motor function of patients.

Citation： XIEPing, SONGYan, GUOZihui, CHENXiaoling, WUXiaoguang, SUYuping, DUYihao. Analysis of Abnormal Muscular Coupling During Rehabilitation after Stroke. Journal of Biomedical Engineering, 2016, 33(2): 244-254. doi: 10.7507/1001-5515.20160043 Copy

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2.	CONWAY B A, HALLIDAY D M, SHAHANI U, et al. Common frequency components identified from correlations between magnetic recordings of cortical activity and the electromyogram in man[J]. J Physiol, 1995, 483(1):35-69.
3.	GROSSE P, CASSIDY M J, BROWN P. EEG-EMG, MEG-EMG and EMG-EMG frequency analysis:physiological principles and clinical applications[J]. Clinical Neurophysiol, 2002, 113(10):1523-1531.
4.	PATINO L, OMLOR W, CHAKAROV V, et al. Absence of gamma-range corticomuscular coherence during dynamic force in a deafferented patient[J]. J Neurophysiol, 2008, 99(4):1906-1916.
5.	KILNER J M, BAKER S N, SALENIUS S, et al. Task-dependent modulation of 15-30 Hz coherence between rectified EMGs from human hand and forearm muscles[J]. J Physiol, 1999, 516(2):559-570.
6.	BROWN P, FARMER S F, HALLIDAY D M, et al. Coherent cortical and muscle discharge in cortical myoclonus[J]. Brain, 1999, 122(Pt 3):461-472.
7.	FARMER S F, BREMNER F D, HALLIDAY D M, et al. The frequency content of common synaptic inputs to motoneurones studied during voluntary isometric contraction in man[J]. J Physiol, 1993, 470(1):127-155.
8.	GROSSE P, GUERRINI R, PARMEGGIANI L, et al. Abnormal corticomuscular and intermuscular coupling in high-frequency rhythmic myoclonus[J]. Brain, 2003, 126(2):326-342.
9.	BAKER S N, OLIVIER E, LEMON R N. Coherent oscillations in monkey motor cortex and hand muscle EMG show task-dependent modulation[J]. J Physiol, 1997, 501(Pt 1):225-241.
10.	NORTON J A, GORASSINI M A. Changes in cortically related intermuscular coherence accompanying improvements in locomotor skills in incomplete spinal cord injury[J]. J Neurophysiol, 2006, 95(4):2580-2589.
11.	NASHNER L M. Fixed patterns of rapid postural responses among leg muscles during stance[J]. Experimental Brain Research, 1977, 30(1):13-24.
12.	GROSSE P, EDWARDS M, TIJSSEN M A, et al. Patterns of EMG-EMG coherence in limb dystonia[J]. Mov Disord, 2004, 19(7):758-769.
13.	FISHER K M, ZAAIMI B, WILLIAMS T L, et al. Beta-band intermuscular coherence:a novel biomarker of upper motor neuron dysfunction in motor neuron disease[J]. Brain, 2012, 135(9):2849-2864.
14.	KISIEL-SAJEWICZ K, FANG Y, HROVAT K, et al. Weakening of synergist muscle coupling during reaching movement in stroke patients[J]. Neurorehabil Neural Repair, 2011, 25(4):359-368.
15.	GROSSE P, EDWAEDS M, TIJSSEN M J, et al. Patterns of EMG-EMG coherence in limb dystonia[J]. Movement Disorders, 2004, 19(7):758-769.
16.	MYERS L J, LOWERY M, O'MALLEY M, et al. Rectification and non-linear pre-processing of EMG signals for cortico-muscular analysis[J]. J Neurosci Methods, 2003, 124(2):157-165.
17.	LEE S W, LANDERS K, HARRIS-LOVE M L. Activation and intermuscular coherence of distal arm muscles during proximal muscle contraction[J]. Experimental Brain Research, 2014, 232(3):739-752.
18.	ROSENBERG J R, AMJAD A M, BREEZE P, et al. The fourier approach to the identification of functional coupling between neuronal spike trains[J]. Prog Biophys Mol Biol, 1989, 53(1):1-31.
19.	HALLIDAY D M, ROSENBERG J R, AMJAD A M, et al. A framework for the analysis of mixed time series/point process data-theory and application to the study of physiological tremor, single motor unit discharges and electromyograms[J]. Prog Biophys Mol Biol, 1995, 64(2):237-278.
20.	HANSEN N L, CONWAY B A, HALLIDAY D M, et al. Reduction of common synaptic drive to ankle dorsiflexor motoneurons during walking in patients with spinal cord lesion[J]. J Neurophysiol, 2005, 94(2):934-942.
21.	FARMER S F, SWASH M, INGRAM D A, et al. Changes in motor unit synchronization following central nervous lesions in man[J]. J Physiol, 1993, 463(1):83-105.
22.	NORTON J A, WOOD D E, MARSDEN J F, et al. Spinally generated electromyographic oscillations and spasms in a low-thoracic complete paraplegic[J]. Movement Disorders, 2003, 18(1):101-106.
23.	DEWALD J A, POPE P S, GIVEN J D, et al. Abnormal muscle coactivation patterns during isometric torque generation at the elbow and shoulder in hemiparetic subjects[J]. Brain, 1995, 118(2):495-510.
24.	WAGNER J M, DROMERICK A W, SAHRMANN S A, et al. Upper extremity muscle activation during recovery of reaching in subjects with post-stroke hemiparesis[J]. Clin Neurophysiol, 2007, 118(1):164-176.
25.	BOONSTRA T W. The potential of corticomuscular and intermuscular coherence for research on human motor control[J]. Front Hum Neurosci, 2013, 7(5):855.
26.	STEPP C E, OYUNERDENE N, MATSUOKA Y. Kinesthetic motor imagery modulates intermuscular coherence[J]. IEEE Trans Neural Systems Rehabilita Eng, 2011, 19(6):638-643.

1. BAKER S N. Oscillatory interactions between sensorimotor cortex and the periphery[J]. Curr Opin Neurobiol, 2007, 17(6):649-655.
2. CONWAY B A, HALLIDAY D M, SHAHANI U, et al. Common frequency components identified from correlations between magnetic recordings of cortical activity and the electromyogram in man[J]. J Physiol, 1995, 483(1):35-69.
3. GROSSE P, CASSIDY M J, BROWN P. EEG-EMG, MEG-EMG and EMG-EMG frequency analysis:physiological principles and clinical applications[J]. Clinical Neurophysiol, 2002, 113(10):1523-1531.
4. PATINO L, OMLOR W, CHAKAROV V, et al. Absence of gamma-range corticomuscular coherence during dynamic force in a deafferented patient[J]. J Neurophysiol, 2008, 99(4):1906-1916.
5. KILNER J M, BAKER S N, SALENIUS S, et al. Task-dependent modulation of 15-30 Hz coherence between rectified EMGs from human hand and forearm muscles[J]. J Physiol, 1999, 516(2):559-570.
6. BROWN P, FARMER S F, HALLIDAY D M, et al. Coherent cortical and muscle discharge in cortical myoclonus[J]. Brain, 1999, 122(Pt 3):461-472.
7. FARMER S F, BREMNER F D, HALLIDAY D M, et al. The frequency content of common synaptic inputs to motoneurones studied during voluntary isometric contraction in man[J]. J Physiol, 1993, 470(1):127-155.
8. GROSSE P, GUERRINI R, PARMEGGIANI L, et al. Abnormal corticomuscular and intermuscular coupling in high-frequency rhythmic myoclonus[J]. Brain, 2003, 126(2):326-342.
9. BAKER S N, OLIVIER E, LEMON R N. Coherent oscillations in monkey motor cortex and hand muscle EMG show task-dependent modulation[J]. J Physiol, 1997, 501(Pt 1):225-241.
10. NORTON J A, GORASSINI M A. Changes in cortically related intermuscular coherence accompanying improvements in locomotor skills in incomplete spinal cord injury[J]. J Neurophysiol, 2006, 95(4):2580-2589.
11. NASHNER L M. Fixed patterns of rapid postural responses among leg muscles during stance[J]. Experimental Brain Research, 1977, 30(1):13-24.
12. GROSSE P, EDWARDS M, TIJSSEN M A, et al. Patterns of EMG-EMG coherence in limb dystonia[J]. Mov Disord, 2004, 19(7):758-769.
13. FISHER K M, ZAAIMI B, WILLIAMS T L, et al. Beta-band intermuscular coherence:a novel biomarker of upper motor neuron dysfunction in motor neuron disease[J]. Brain, 2012, 135(9):2849-2864.
14. KISIEL-SAJEWICZ K, FANG Y, HROVAT K, et al. Weakening of synergist muscle coupling during reaching movement in stroke patients[J]. Neurorehabil Neural Repair, 2011, 25(4):359-368.
15. GROSSE P, EDWAEDS M, TIJSSEN M J, et al. Patterns of EMG-EMG coherence in limb dystonia[J]. Movement Disorders, 2004, 19(7):758-769.
16. MYERS L J, LOWERY M, O'MALLEY M, et al. Rectification and non-linear pre-processing of EMG signals for cortico-muscular analysis[J]. J Neurosci Methods, 2003, 124(2):157-165.
17. LEE S W, LANDERS K, HARRIS-LOVE M L. Activation and intermuscular coherence of distal arm muscles during proximal muscle contraction[J]. Experimental Brain Research, 2014, 232(3):739-752.
18. ROSENBERG J R, AMJAD A M, BREEZE P, et al. The fourier approach to the identification of functional coupling between neuronal spike trains[J]. Prog Biophys Mol Biol, 1989, 53(1):1-31.
19. HALLIDAY D M, ROSENBERG J R, AMJAD A M, et al. A framework for the analysis of mixed time series/point process data-theory and application to the study of physiological tremor, single motor unit discharges and electromyograms[J]. Prog Biophys Mol Biol, 1995, 64(2):237-278.
20. HANSEN N L, CONWAY B A, HALLIDAY D M, et al. Reduction of common synaptic drive to ankle dorsiflexor motoneurons during walking in patients with spinal cord lesion[J]. J Neurophysiol, 2005, 94(2):934-942.
21. FARMER S F, SWASH M, INGRAM D A, et al. Changes in motor unit synchronization following central nervous lesions in man[J]. J Physiol, 1993, 463(1):83-105.
22. NORTON J A, WOOD D E, MARSDEN J F, et al. Spinally generated electromyographic oscillations and spasms in a low-thoracic complete paraplegic[J]. Movement Disorders, 2003, 18(1):101-106.
23. DEWALD J A, POPE P S, GIVEN J D, et al. Abnormal muscle coactivation patterns during isometric torque generation at the elbow and shoulder in hemiparetic subjects[J]. Brain, 1995, 118(2):495-510.
24. WAGNER J M, DROMERICK A W, SAHRMANN S A, et al. Upper extremity muscle activation during recovery of reaching in subjects with post-stroke hemiparesis[J]. Clin Neurophysiol, 2007, 118(1):164-176.
25. BOONSTRA T W. The potential of corticomuscular and intermuscular coherence for research on human motor control[J]. Front Hum Neurosci, 2013, 7(5):855.
26. STEPP C E, OYUNERDENE N, MATSUOKA Y. Kinesthetic motor imagery modulates intermuscular coherence[J]. IEEE Trans Neural Systems Rehabilita Eng, 2011, 19(6):638-643.

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