Preliminary Studies on the Hydrodynamic Behaviors and Mechanisms of Hepatic Vessel Perfusion Using Simple Vessel Models_Journal of Biomedical Engineering

Authors：

 LIUJun ^1,2 , FANYong ¹ , LIUYihe ^3,4

1. Mechanical Engineering College, Tianjin University of Technology, Tianjin 300384, China;
2. Tianjin Key Laboratory of the Design and Intelligent Control of the Advanced Mechanical System, Tianjin University of Technology, Tianjin 300384, China;
3. Department of Transplant Surgery, Tianjin First Central Hospital, Tianjin 300192, China;
4. Tianjin Key Laboratory of Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, China;

Corresponding author：

LIUJun, Email: liujunjpna@163.com

Keywords：

first-class vessel model; equations of turbulence liquid; perfusion; fluid-solid coupling calculation; mechanism study

DOI：

10.7507/1001-5515.20160045

Video：

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Abstract Full text Figures/Tables Video References Cited by

The hydrodynamic behavior of the perfusion process (cleaning) of the liver endovascular before the operation was studied to provide a theoretical guidance to the relative operations. A straight and a curved first-class vascular entity model with foreign matter and the control equations of turbulence liquid in vessel was established. With the physical parameters of a medical infusion liquid measured, an estimation method of perfusion parameters as an example, the perfusion velocity was proposed. The simulation was performed by changing technical parameters of the perfusion. Based on the control equations of turbulent liquid in vessel and the preliminarily calculated results using the vessel model, the results fitted the values of the real operation. The simulation results showed clearly the fluid dynamics behavior around the foreign matter, for example the swirling flow. The results also showed the distribution of velocity of the fluid and the wall pressure of the vessels. With the increasing velocity of the entrance perfusion, the pressure and the velocity field were increased in the two types of the vessel model. The negative wall pressure and recirculation region appeared and located in the foreign matter. Because of influence of the shape, the fluid dynamics behavior in the curved vessel model was more complicated than that in the straight vessel model. The swirling flow and the phenomenon of stagnation of the perfusion fluid were more likely to appear in the curved vessel than in the straight vessel. The most important conclusion of this paper is that the appropriate perfusion velocity can be esti-mated using the methods proposed in this paper.

Citation： LIUJun, FANYong, LIUYihe. Preliminary Studies on the Hydrodynamic Behaviors and Mechanisms of Hepatic Vessel Perfusion Using Simple Vessel Models. Journal of Biomedical Engineering, 2016, 33(2): 260-267. doi: 10.7507/1001-5515.20160045 Copy

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1. 刘向明, 林岚, 林家瑞.试论生物医学数学建模中的若干问题[J].生物医学工程与临床, 1998, 2(1):4-8.
2. 王振全, 张宇辉, 王希军.肝脏血流动力学的临床应用研究进展[J].华北国防医药, 2009, 21(1):80-81.
3. 朱玉云, 史小平, 伍炼.基于曲面拟合法的肝脏超声成像仿真数学建模[J].生物医学工程与临床, 2008, 12(6):443-445.
4. SINGAL A K, AHMAD M, SOLOWAY R D. Duplex Doppler ultrasound examination of the portal venous system:an emerging novel technique for the estimation of portal vein pressure[J]. Dig Dis Sci, 2010, 55(5):1230-1240.
5. 周洋, 杜联芳.实时超声造影在正常移植肝血流动力学研究中的应用[J].实用医学杂志, 2008, 24(14):2429-2430.
6. HE Yong, TERRY C M, NGUYEN C, et al. Serial analysis of lumen geometry and hemodynamics in human arteriovenous fistula for hemodialysis using magnetic resonance imaging and computational fluid dynamics[J]. J Biomech, 2013, 46(1):165-169.
7. BRIX L, RINGGAARD S, SØRENSEN T S, et al. Three-dimensional liver motion tracking using real-time two-dimensional MRI[J]. Med Phys, 2014, 41(4):042302(1-10).
8. KLINE T L, ZAMIR M, RITMAN E L. Relating function to branching geometry:a micro-CT study of the hepatic artery, portal vein, and biliary tree[J]. Cells Tissues Organs, 2011, 194(5):431-442.
9. 刘学静, 武乐斌, 柳澄, 等.多层螺旋CT肝门静脉成像及其临床应用价值[J].中国临床解剖学杂志, 2004, 22(5):478-480, 484.
10. 刘晶晶, 张智, 世碧波, 等.基于多尺度滤波的肝门静脉CT图像增强方法[J].中国图象图形学报, 2008, 13(11):2117-2122.
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13. DEBBAUT C, MONBALIU D, CASTELEYN C, et al. From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion[J]. IEEE Trans Biomed Eng, 2011, 58(1):25-35.
14. LI Z, KLEINSTREUER C. Fluid-structure interaction effects on sac-blood pressure and wall stress in a stented aneurysm[J]. J Bionic Eng, 2005, 127(4):662-671.
15. DI MARTINO E S, GUADAGNI G, FUMERO A, et al. Fluid-structure interaction within realistic three-dimensional models of the aneurysmatic aorta as a guidance to assess the risk of rupture of the aneurysm[J]. Med Eng Phys, 2001, 23(9):647-655.
16. 刘肖, 孙安强, 占帆, 等.动脉血流旋动原理在人造血管研制和血管移植术中的应用[J].医用生物力学, 2010, 25(5):334-337.
17. 王福军.计算流体动力学分析——CFD软件原理与应用[M].北京:清华大学出版, 2004:7-12.
18. 何凡, 李晓阳.血流与动脉壁的流固耦合研究[J].医用生物力学, 2008, 23(5):405-410.
19. 廖亚玲, 安薇, 高鸿慈.议羟乙基淀粉的摩尔质量及摩尔取代度[J].数理医药学杂志, 2011, 24(3):377-378.
20. 谢龙汉, 赵新宇, 张炯明.ANSYS CFX流体分析及仿真[M].北京:电子工业出版社, 2012.
21. 杨建国, 张兆营, 鞠晓丽, 等.工程流体动力学[M].北京:北京大学出版社, 2010:234-242.
22. 高立丹, 刘赵淼.狭窄动脉血管流固耦合数值模型的研究[C]//北京力学会第18届学术年会论文集.北京:2012, 2:13-14.

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Preliminary Studies on the Hydrodynamic Behaviors and Mechanisms of Hepatic Vessel Perfusion Using Simple Vessel Models

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