Organogenesis Using Three-dimensional Culture Technology_Journal of Biomedical Engineering

Authors：

DUXiao , LIJun , ZHOUXiaonan , WUYanshuang ,  LEILei

Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China;

Corresponding author：

LEILei, Email: leiys2002@yahoo.com

Keywords：

three-dimensional culture; organ regeneration; decellularize

DOI：

10.7507/1001-5515.20160065

Video：

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A critical shortage of donor organs raises a question of needs for alternative organ sources for regenerative medicine. Over the last decade, three-dimensional (3D) culture has become a new approach for organ regeneration. The 3D culture takes significant advantages of cells spatial relationships between multiple cellular types and surrounding matrices of dynamic cellular interactions, which plays a key role in structural self-formation of complex organ buds. Here we present major classic cases of 3D culture organ regeneration to show how it works, and then we try to find the way of future organ regeneration.

Citation： DUXiao, LIJun, ZHOUXiaonan, WUYanshuang, LEILei. Organogenesis Using Three-dimensional Culture Technology. Journal of Biomedical Engineering, 2016, 33(2): 382-387. doi: 10.7507/1001-5515.20160065 Copy

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28.	MAQUART F X, MONBOISSE J C. Extracellular matrix and wound healing[J]. Pathol Biol (Paris), 2014, 62(2):91-95.
29.	曲晓丽, 王敏, 贺健康, 等.共培养的大块组织工程肝构建及体内植入研究[J].中国修复重建外科杂志, 2014, 28(3):325-330.
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1. SASAI Y. Next-generation regenerative medicine:organogenesis from stem cells in 3D culture[J]. Cell Stem Cell, 2013, 12(5):520-530.
2. GIBBS D M, BLACK C R, DAWSON J I, et al. A review of hydrogel use in fracture healing and bone regeneration[J]. J Tissue Eng Regen Med, 2014:DOI:10.1002/term.1968.
3. KHAN A A, VISHWAKARMA S K, BARDIA A, et al. Repopulation of decellularized whole organ scaffold using stem cells:an emerging technology for the development of neo-organ[J]. J Artif Organs, 2014, 17(4):291-300.
4. FAULK D M, JOHNSON S A, ZHANG Li, et al. Role of the extracellular matrix in whole organ engineering[J]. J Cell Physiol, 2014, 229(8):984-989.
5. 董教明, 莫秀梅, 李雨, 等.天然组织去细胞技术的研究进展[J].生物医学工程学杂志, 2012, 29(5):1008-1013.
6. SABETKISH S, KAJBAFZADEH A M, SABETKISH N, et al. Whole-organ tissue engineering:Decellularization and recellularization of three-dimensional matrix liver scaffolds[J]. J Biomed Mater Res A, 2015, 103(4):1498-1508.
7. SULLIVAN D C, MIRMALEK-SANI S H, DEEGAN D B, et al. Decellularization methods of porcine kidneys for whole organ engineering using a high-throughput system[J]. Biomaterials, 2012, 33(31):7756-7764.
8. O'NEILL J D, ANFANG R, ANANDAPPA A, et al. Decellularization of human and porcine lung tissues for pulmonary tissue engineering[J]. Ann Thorac Surg, 2013, 96(3):1046-1055; discussion 1055-1056.
9. YU Y L, SHAO Y K, DING Y Q, et al. Decellularized kidney scaffold-mediated renal regeneration[J]. Biomaterials, 2014, 35(25):6822-6828.
10. OTT H C, MATTHIESEN T S, GOH S K, et al. Perfusion-decellularized matrix:using nature's platform to engineer a bioartificial heart[J]. Nat Med, 2008, 14(2):213-221.
11. LU T Y, LIN B, KIM J, et al. Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells[J]. Nat Commun, 2013, 4:2307.
12. PETERSEN T H, CALLE E A, ZHAO Liping, et al. Tissue-engineered lungs for in vivo implantation[J]. Science, 2010, 329(5991):538-541.
13. OTT H C, CLIPPINGER B, CONRAD C, et al. Regeneration and orthotopic transplantation of a bioartificial lung[J]. Nat Med, 2010, 16(8):927-933.
14. BADYLAK S F, TAYLOR D, UYGUN K. Whole-organ tissue engineering:decellularization and recellularization of three-dimensional matrix scaffolds[J]. Annu Rev Biomed Eng, 2011, 13:27-53.
15. BELL R M, MOCANU M M, YELLON D M. Retrograde heart perfusion:the Langendorff technique of isolated heart perfusion[J]. J Mol Cell Cardiol, 2011, 50(6):940-950.
16. XU L, GUTBROD S R, BONIFAS A P, et al.3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium[J]. Nat Commun, 2014, 5:3329.
17. TAKAHASHI K, TANABE K, OHNUKI M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J]. Cell, 2007, 131(5):861-872.
18. LANCASTER M A, RENNER M, MARTIN C A, et al. Cerebral organoids model human brain development and microcephaly[J]. Nature, 2013, 501(7467):373-379.
19. KOEHLER K R, MIKOSZ A M, MOLOSH A I, et al. Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture[J]. Nature, 2013, 500(7461):217-221.
20. SUGA H, KADOSHIMA T, MINAGUCHI M, et al. Self-formation of functional adenohypophysis in three-dimensional culture[J]. Nature, 2011, 480(7375):57-U215.
21. NAKANO T, ANDO S, TAKATA N, et al. Self-Formation of optic cups and storable stratified neural retina from human ESCs[J]. Cell Stem Cell, 2012, 10(6):771-785.
22. TAKEBE T, KOIKE N, SEKINE K, et al. Engineering of human hepatic tissue with functional vascular networks[J]. Organogenesis, 2014, 10(2):260-267.
23. MCCRACKEN K W, CATA E M, CRAWFORD C M, et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids[J]. Nature, 2014, 516(7531):400-404.
24. WATSON C L, MAHE M M, MUNERA J, et al. An in vivo model of human small intestine using pluripotent stem cells[J]. Nat Med, 2014, 20(11):1310-1314.
25. VERHULSEL M, VIGNES M, DESCROIX S, et al. A review of microfabrication and hydrogel engineering for micro-organs on chips[J]. Biomaterials, 2014, 35(6):1816-1832.
26. RUEDINGER F, LAVRENTIEVA A, BLUME C, et al. Hydrogels for 3D mammalian cell culture:a starting guide for laboratory practice[J]. Appl Microbiol Biotechnol, 2015, 99(2):623-636.
27. VATS K, BENOIT D S. Dynamic manipulation of hydrogels to control cell behavior:a review[J]. Tissue Eng Part B Rev, 2013, 19(6):455-469.
28. MAQUART F X, MONBOISSE J C. Extracellular matrix and wound healing[J]. Pathol Biol (Paris), 2014, 62(2):91-95.
29. 曲晓丽, 王敏, 贺健康, 等.共培养的大块组织工程肝构建及体内植入研究[J].中国修复重建外科杂志, 2014, 28(3):325-330.
30. PATI F, JANG J, HA D H, et al. Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink[J]. Nat Commun, 2014, 5:3935.
31. EL-SHERBINY I M, YACOUB M H. Hydrogel scaffolds for tissue engineering:Progress and challenges[J]. Glob Cardiol Sci Pract, 2013(3):316-342.
32. DING Jianqiang, YANNAM G R, ROY-CHOWDHURY N A, et al. Spontaneous hepatic repopulation in transgenic mice expressing mutant human alpha 1-antitrypsin by wild-type donor hepatocytes[J]. J Clin Invest, 2011, 121(5):1930-1934.

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Organogenesis Using Three-dimensional Culture Technology

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