Research on Residual Aberrations Correction with Adaptive Optics Technique in Patients Undergoing Orthokeratology_Journal of Biomedical Engineering

Authors：

GONGRui ¹ , YANGBi ¹ ,  LIULongqian ¹ , DAIYun ² , ZHANGYudong ² , ZHAOHaoxin ²

1. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China;
2. Institute of Optics and Electronics, Chinese Academy of Science, Chengdu 610209, China;

Corresponding author：

LIULongqian, Email: bq15651@hotmail.com

Keywords：

orthokeratology; residual aberrations; contrast sensitivity; adaptive optics

DOI：

10.7507/1001-5515.20160089

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We conducted this study to explore the influence of the ocular residual aberrations changes on contrast sensitivity (CS) function in eyes undergoing orthokeratology using adaptive optics technique. Nineteen subjects' nineteen eyes were included in this study. The subjects were between 12 and 20 years (14.27±2.23 years) of age. An adaptive optics (AO) system was adopted to measure and compensate the residual aberrations through a 4-mm artificial pupil, and at the same time the contrast sensitivities were measured at five spatial frequencies (2,4,8,16, and 32 cycles per degree).The CS measurements with and without AO correction were completed. The sequence of the measurements with and without AO correction was randomly arranged without informing the observers. A two-interval forced-choice procedure was used for the CS measurements. The paired t-test was used to compare the contrast sensitivity with and without AO correction at each spatial frequency. The results revealed that the AO system decreased the mean total root mean square (RMS) from 0.356 μm to 0.160 μm(t=10.517, P＜0.001), and the mean total higher-order RMS from 0.246 μm to 0.095 μm(t=10.113, P＜0.001). The difference in log contrast sensitivity with and without AO correction was significant only at 8 cpd (t=-2.51, P=0.02). Thereby we concluded that correcting the ocular residual aberrations using adaptive optics technique could improve the contrast sensitivity function at intermediate spatial frequency in patients undergoing orthokeratology.

Citation： GONGRui, YANGBi, LIULongqian, DAIYun, ZHANGYudong, ZHAOHaoxin. Research on Residual Aberrations Correction with Adaptive Optics Technique in Patients Undergoing Orthokeratology. Journal of Biomedical Engineering, 2016, 33(3): 533-537. doi: 10.7507/1001-5515.20160089 Copy

1.	JESSEN G N. Orthofocus techniques[J]. Contacto. 1962, 6(7):200-204.
2.	MIKA R, MORGAN B, CRON M, et al. Safety and efficacy of overnight orthokeratology in myopic children[J]. Optometry, 2007, 78(5):225-231.
3.	CHO P, CHEUNG S W. Retardation of myopia in Orthokeratology (ROMIO) study:a 2-year randomized clinical trial[J]. Invest Ophthalmol Vis Sci, 2012, 53(11):7077-7085.
4.	KAKITA T, HIRAOKA T, OSHIKA T. Influence of overnight orthokeratology on axial elongation in childhood myopia[J]. Invest Ophthalmol Vis Sci, 2011, 52(5):2170-2174.
5.	CHARM J, CHO P. High myopia-partial reduction ortho-k:a 2-year randomized study[J]. Optom Vis Sci, 2013, 90(6):530-539.
6.	LIAN Yan, SHEN Meixiao, HUANG Shenghai, et al. Corneal reshaping and wavefront aberrations during overnight orthokeratology[J]. Eye Contact Lens, 2014, 40(3):161-168.
7.	HIRAOKA T, OKAMOTO C, ISHII Y, et al. Time course of changes in ocular higher-order aberrations and contrast sensitivity after overnight orthokeratology[J]. Invest Ophthalmol Vis Sci, 2008, 49(10):4314-4320.
8.	STILLITANO I, SCHOR P, LIPENER C, et al. Long-term follow-up of orthokeratology corneal reshaping using wavefront aberrometry and contrast sensitivity[J]. Eye Contact Lens, 2008, 34(3):140-145.
9.	HIRAOKA T, OKAMOTO C, ISHII Y, et al. Contrast sensitivity function and ocular higher-order aberrations following overnight orthokeratology[J]. Invest Ophthalmol Vis Sci, 2007, 48(2):550-556.
10.	LI S, XIONG Y, LI J, et al. Effects of monochromatic aberration on visual acuity using adaptive optics[J]. Optom Vis Sci, 2009, 86(7):868-874.
11.	YANG Bi, LIANG Bo, LIU Longqian, et al. Contrast sensitivity function after correcting residual wavefront aberrations during RGP lens wear[J]. Optom Vis Sci, 2014, 91(10):1271-1277.
12.	ZHOU J, ZHANG Y, DAI Y, et al. The eye limits the brain's learning potential[J]. Sci Rep, 2012, 2:364.
13.	THIBOS L N, APPLEGATE R A, SCHWIEGERLING J, et al. Standards taskforce members. Standards for reporting the optical aberrations of eyes[M]//LAKSHMINARAYANAN V. OSA technical digest series:Vision science and its applications:trends in optics and photonics. Washington, DC:Optical Society of America, 2000, 35:232Y44.
14.	BERNTSEN D A, BARR J T, MITCHELL G L. The effect of overnight contact lens corneal reshaping on higher-order aberrations and best-corrected visual acuity[J]. Optom Vis Sci, 2005, 82(6):490-497.
15.	ROCHA K M, VABRE L, HARMS F, et al. Effects of Zernike wavefront aberrations on visual acuity measured using electromagnetic adaptive optics technology[J]. J Refract Surg, 2007, 23(9):953-959.
16.	ELLIOTT S L, CHOI S S, DOBLE N, et al. Role of high-order aberrations in senescent changes in spatial vision[J]. J Vis, 2009, 9(2):24.1-2416.
17.	HOFER H, ARTAL P, SINGER B, et al. Dynamics of the eye's wave aberration[J]. J Opt Soc Am A, 2001, 18(3):497-506.
18.	HIRAOKA T, KAKITA T, OKAMOTO F, et al. Influence of ocular wavefront aberrations on axial length elongation in myopic children treated with overnight orthokeratology[J]. Ophthalmology, 2015, 122(1):93-100.

1. JESSEN G N. Orthofocus techniques[J]. Contacto. 1962, 6(7):200-204.
2. MIKA R, MORGAN B, CRON M, et al. Safety and efficacy of overnight orthokeratology in myopic children[J]. Optometry, 2007, 78(5):225-231.
3. CHO P, CHEUNG S W. Retardation of myopia in Orthokeratology (ROMIO) study:a 2-year randomized clinical trial[J]. Invest Ophthalmol Vis Sci, 2012, 53(11):7077-7085.
4. KAKITA T, HIRAOKA T, OSHIKA T. Influence of overnight orthokeratology on axial elongation in childhood myopia[J]. Invest Ophthalmol Vis Sci, 2011, 52(5):2170-2174.
5. CHARM J, CHO P. High myopia-partial reduction ortho-k:a 2-year randomized study[J]. Optom Vis Sci, 2013, 90(6):530-539.
6. LIAN Yan, SHEN Meixiao, HUANG Shenghai, et al. Corneal reshaping and wavefront aberrations during overnight orthokeratology[J]. Eye Contact Lens, 2014, 40(3):161-168.
7. HIRAOKA T, OKAMOTO C, ISHII Y, et al. Time course of changes in ocular higher-order aberrations and contrast sensitivity after overnight orthokeratology[J]. Invest Ophthalmol Vis Sci, 2008, 49(10):4314-4320.
8. STILLITANO I, SCHOR P, LIPENER C, et al. Long-term follow-up of orthokeratology corneal reshaping using wavefront aberrometry and contrast sensitivity[J]. Eye Contact Lens, 2008, 34(3):140-145.
9. HIRAOKA T, OKAMOTO C, ISHII Y, et al. Contrast sensitivity function and ocular higher-order aberrations following overnight orthokeratology[J]. Invest Ophthalmol Vis Sci, 2007, 48(2):550-556.
10. LI S, XIONG Y, LI J, et al. Effects of monochromatic aberration on visual acuity using adaptive optics[J]. Optom Vis Sci, 2009, 86(7):868-874.
11. YANG Bi, LIANG Bo, LIU Longqian, et al. Contrast sensitivity function after correcting residual wavefront aberrations during RGP lens wear[J]. Optom Vis Sci, 2014, 91(10):1271-1277.
12. ZHOU J, ZHANG Y, DAI Y, et al. The eye limits the brain's learning potential[J]. Sci Rep, 2012, 2:364.
13. THIBOS L N, APPLEGATE R A, SCHWIEGERLING J, et al. Standards taskforce members. Standards for reporting the optical aberrations of eyes[M]//LAKSHMINARAYANAN V. OSA technical digest series:Vision science and its applications:trends in optics and photonics. Washington, DC:Optical Society of America, 2000, 35:232Y44.
14. BERNTSEN D A, BARR J T, MITCHELL G L. The effect of overnight contact lens corneal reshaping on higher-order aberrations and best-corrected visual acuity[J]. Optom Vis Sci, 2005, 82(6):490-497.
15. ROCHA K M, VABRE L, HARMS F, et al. Effects of Zernike wavefront aberrations on visual acuity measured using electromagnetic adaptive optics technology[J]. J Refract Surg, 2007, 23(9):953-959.
16. ELLIOTT S L, CHOI S S, DOBLE N, et al. Role of high-order aberrations in senescent changes in spatial vision[J]. J Vis, 2009, 9(2):24.1-2416.
17. HOFER H, ARTAL P, SINGER B, et al. Dynamics of the eye's wave aberration[J]. J Opt Soc Am A, 2001, 18(3):497-506.
18. HIRAOKA T, KAKITA T, OKAMOTO F, et al. Influence of ocular wavefront aberrations on axial length elongation in myopic children treated with overnight orthokeratology[J]. Ophthalmology, 2015, 122(1):93-100.

Journal of Biomedical Engineering

Research on Residual Aberrations Correction with Adaptive Optics Technique in Patients Undergoing Orthokeratology

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