Design and Implementation of a Medical Nitric Oxide Flow Control Device_Journal of Biomedical Engineering

Authors：

1. Mechanical Engineering College, University of Shanghai for Science and Technology, Shanghai 200093, China;
2. School of Medical Instrumentation, Shanghai University of Medicine and Health Sciences 200093, China;

Corresponding author：

Keywords：

nitric oxide; flow control device; monitor system; pulmonary hypertension

DOI：

10.7507/1001-5515.20160125

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Medical nitric oxide (NO) flow control system plays an important role in lowering pulmonary hypertension. The design requirements, overall scheme, delivery system and hardware circuits of a medical NO flow control system were introduced in this paper. Particularly, we proposed the design of NO delivery system and hardware circuits in detail. To deliver nitric oxide of a variable concentration, the designed system needs to work with a ventilator. The system can adjust and monitor the inhaled nitric oxide concentrations and send out sound and light alarms when the inhaled nitric oxide concentrations are out of the set range. To validate reliability and efficacy, we measured specifications such as linearity, stability and response time of the proposed NO flow control system by continuously administering nitric oxide into inspiratory circuit to deliver nitric oxide of variable concentrations to a test lung. The experiments showed that these specifications can meet the desired requirements.

Citation： SUNChenglu, HUZhaoyan, CHENZhenglong, ZHAOBaigan. Design and Implementation of a Medical Nitric Oxide Flow Control Device. Journal of Biomedical Engineering, 2016, 33(4): 770-778. doi: 10.7507/1001-5515.20160125 Copy

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1. ARANDA M, PEARL R G. Inhaled nitric oxide and pulmonary vasoreactivity[J]. J Clin Monit Comput, 2000, 16(5/6):393-401.
2. ANTONIOU T, KOLETSIS E N, PROKAKIS C, et al. Hemodynamic effects of combination therapy with inhaled nitric oxide and iloprost in patients with pulmonary hypertension and right ventricular dysfunction after high-risk cardiac surgery[J]. J Cardiothorac Vasc Anesth, 2013, 27(3):459-466.
3. 孙波.呼吸机治疗低氧性呼吸衰竭吸入一氧化氮的作用[J].中国实用儿科杂志, 2010(2):110-114.
4. MILLER O I, CELERMAJER D S, DEANFIELD J E, et al. Guidelines for the safe administration of inhaled nitric oxide[J]. Arch Dis Child Fetal Neonatal Ed, 1994, 70(1):F47-F49.
5. 王江涛, 刘仲明.吸入一氧化氮输送与监测系统的研究[J].中国医学物理学杂志, 2006, 23(6):449-453.
6. WESSEL D L, ADATIA I, THOMPSON J E, et al. Delivery and monitoring of inhaled nitric oxide in patients with pulmonary hypertension[J]. Crit Care Med, 1994, 22(6):930-938.
7. CLARK R H, KUESER T J, WALKER M W, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn[J]. New England Journal of Medicine, 2000, 342(7):469-474.
8. 王玉红, 付春花.高频振荡通气联用一氧化氮吸入在新生儿气胸中的应用[J].实用儿科临床杂志, 2011, 26(6):433-435.
9. 葛斌.人体机能替代装置[M].北京:科学出版社, 2007:179-193.
10. 周光坰, 严宗毅, 许世雄, 等.流体力学上册[M].北京:高等教育出版社, 2001:149-157.
11. 刘光宗.流体力学原理与分析方法[M].北京:高等教育出版社, 1992:35-48.
12. 王福军.计算流体动力学分析-CFD软件原理与应用[M].北京:北京大学出版社, 2004:7-11.
13. Atmel Corporation. 8-bit Atmel Microcontroller with 16/32/64KB In-System Programmable Flash[DB/OL]. (2014-02)[2016-03-30]. http://www.atmel.com/devices/atmega1280.aspx.
14. 崔思思, 陈海燕, 胡育筑, 等.生物体内一氧化氮检测方法及评价[J].中国药学杂志, 2010(20):1524-1527.

Journal of Biomedical Engineering

Design and Implementation of a Medical Nitric Oxide Flow Control Device

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