Experimental Research on Detection of Breast Carcinoma and Adjacent Tissues Based on Open-ended Coaxial Probe Tumor Sensor with Radio Frequencies_Journal of Biomedical Engineering

Authors：

CHENMiaoliang ¹ , CHENJianguo ² , WEIShanshan ² , FUFangxiang ² , XUCailing ² , FENGXiaochuang ² , DUANJingjing ² ,  LIZhou ¹ , XINXuegang ³ , HANShuai ¹ , WANGWeiwei ¹ , DUANSong ³ , DENGGuanhua ³

1. Zhujiang Hospital of Southern Medical University, Department of General Surgery, Guangzhou 510515, China;
2. Southern Medical University, Second Clinical Medical College, Guangzhou 510515, China;
3. Southern Medical University, School of Biomedical Engineering, Guangzhou 510515, China;

Corresponding author：

LIZhou, Email: leezhou888@126.com

Keywords：

open-ended coaxial line; breast invasive ductal carcinoma; conductivity; permittivity

DOI：

10.7507/1001-5515.20160154

Video：

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This study aimed to verify whether the open-ended coaxial line tumor sensor with radio frequency was effective or not in detecting the differences in permittivity and conductivity between the breast malignant tissues and adjacent tissues. Sixteen breast infiltrating ductal carcinoma samples were freshly obtained from the department of general surgery in Zhujiang Hospital. The permittivity and conductivity of cancerous nidus points of breast samples, 3 cm adjacent tissue points and 5 cm adjacent tissue points were detected respectively by the open-ended coaxial line tumor sensor with radio frequency noninvasively in conjunction with vector network analyzer at the frequency ranging from 42.85~500 MHz. All the detected points were marked. After finishing the detection, we conducted postoperative pathological examinations on all the marked points. According to the statistics, there were statistically significant differences between the breast cancerous tissues and the 3 cm adjacent tissues for the dielectric properties (P < 0.01). There were statistically significant differences between the breast cancerous tissues and the 5 cm adjacent tissues for the dielectric properties (P < 0.01). There was no statistically significant difference in the dielectric properties between the 3 cm adjacent tissues and 5 cm adjacent tissues (P > 0.05). Both the 3 cm adjacent tissues and 5 cm adjacent tissues were found no breast cancer cell infiltration. The results indicated that the open-ended coaxial line tumor sensor at radio frequency could be effective in detecting the differences in permittivity and conductivity between breast cancerous tissues and adjacent tissues and, therefore, it may have a potential prospect in making a final diagnosis to confirm whether the detected breast tissue is malignant or not.

Citation： CHEN Miaoliang, CHEN Jianguo, WEI Shanshan, FU Fangxiang, XU Cailing, FENG Xiaochuang, DUAN Jingjing, LI Zhou, XIN Xuegang, HAN Shuai, WANG Weiwei, DUAN Song, DENG Guanhua. Experimental Research on Detection of Breast Carcinoma and Adjacent Tissues Based on Open-ended Coaxial Probe Tumor Sensor with Radio Frequencies. Journal of Biomedical Engineering, 2016, 33(5): 958-962. doi: 10.7507/1001-5515.20160154 Copy

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1. SIEGEL R, NAISHADHAM D, JEMAL A. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1):10-29.
2. TORRE L A, BRAY F, SIEGEL R L, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2):87-108.
3. CHEN Wanqing, ZHENG Rongshou, ZENG Hongmei, et al. Annual report on status of cancer in China, 2011[J]. Chin J Cancer Res, 2015, 27(1):2-12.
4. CHEN Wanqing, ZHENG Rongshou, ZENG Hongmei, et al. Annual report on status of cancer in China, 2011[J]. Chin J Cancer Res, 2015, 27(1):2-12.
5. PRESAZZI A, DI GIULIO G, CALLIADA F. Breast hamartoma:ultrasound, elastosonographic, and mammographic features. Mini pictorial essay[J]. J Ultrasound, 2015, 18(4):373-377.
6. VENKATESH S S, LEVENBACK B J, SULTAN L R, et al. Going beyond a first reader:A machine learning methodology for optimizing cost and performance in breast ultrasound diagnosis[J]. Ultrasound Med Biol, 2015, 41(12):3148-3162.
7. ROGANOVIC D, DJILAS D, VUJNOVIC S, et al. Breast MRI, digital mammography and breast tomosynthesis:Comparison of three methods for early detection of breast cancer[J]. Bosn J Basic Med Sci, 2015, 15(4):64-68.
8. FU F, XIN S X, CHEN W. Temperature-and frequency-dependent dielectric properties of biological tissues within the temperature and frequency ranges typically used for magnetic resonance imaging-guided focused ultrasound surgery[J]. International Journal of Hyperthermia, 2014, 30(1):56-65.
9. BOBOWSKI J S, JOHNSON T. Permittivity measurements of biological samples by an open-ended coaxial line[J]. Progress In Electromagnetics Research B, 2012, 40(40):159-183.
10. ZHANG L, SHI X, YOU F, et al. Improved circuit model of open-ended coaxial probe for measurement of the biological tissue dielectric properties between megahertz and gigahertz[J]. Physiol Meas, 2013, 34(10):N83-N96.
11. ZHANG L, LIU P, DONG X, et al. A method for in vivo detection of abnormal subepidermal tissues based on dielectric properties[J]. Biomed Mater Eng, 2014, 24(6):3455-3462.
12. LAZEBNIK M, MCCARTNEY L, POPOVIC D, et al. A large-scale study of the ultrawideband microwave dielectric properties of normal breast tissue obtained from reduction surgeries[J]. Phys Med Biol, 2007, 52(10):2637-2656.
13. LAZEBNIK M, POPOVIC D, MCCARTNEY L, et al. A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries[J]. Phys Med Biol, 2007, 52(20):6093-6115.
14. SASAKI K, SEGAWA H, MIZUNO M, et al. Development of the complex permittivity measurement system for high-loss biological samples using the free space method in quasi-millimeter and millimeter wave bands[J]. Phys Med Biol, 2013, 58(5):1625-1633.
15. BANERJEE P, BISWAS S K, GHOSH G. Dielectric properties of EVA rubber composites at microwave frequencies theory, instrumentation and measurements[J]. J Microw Power Electromagn Energy, 2011, 45(1):24-29.
16. CHEN Z, SCHWING M, KARLOVŠEK J, et al. Broadband dielectric measurement methods for soft geomaterials:coaxial transmission line cell and open-ended coaxial probe[J]. International Journal of Engineering and Technology, 2014, 6(5):373-380.
17. ZHADOBOV M, AUGUSTINE R, SAULEAU R, et al. Complex permittivity of representative biological solutions in the 2-67 GHz range[J]. Bioelectromagnetics, 2012, 33(4):346-355.
18. GABRIEL C, GABRIEL S, CORTHOUT E. The dielectric properties of biological tissues:Ⅰ. Literature survey[J]. Phys Med Biol, 1996, 41(11):2231-2249.
19. GABRIEL S, LAU R W, GABRIEL C. The dielectric properties of biological tissues:Ⅱ. Measurements in the frequency range 10 Hz to 20 GHz[J]. Phys Med Biol, 1996, 41(11):2251-2269.

Journal of Biomedical Engineering

Experimental Research on Detection of Breast Carcinoma and Adjacent Tissues Based on Open-ended Coaxial Probe Tumor Sensor with Radio Frequencies

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