Quantitative Evaluation of Regularity of Finger Tapping Movement for Patients with Parkinson's disease_Journal of Biomedical Engineering

Authors：

LIUYao ^1,2 , WANGXun ³ , XUShengqiang ^1,2 , CHENGNan ^1,3 , TANGZheng ¹ , SUNYining ¹ ,  YANGXianjun ¹

1. Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, China;
2. Department of Automation, University of Science and Technology of China, Hefei 230026, China;
3. Hospital Affiliated to Institute of Neurology, Anhui University of Traditional Chinese Medicine, Hefei 230061, China;

Corresponding author：

YANGXianjun, Email: xjyang@iim.ac.cn

Keywords：

finger tapping test; Parkinson's disease; regularity; quantitative evaluation; approximate entropy; sample entropy

DOI：

10.7507/1001-5515.20160157

Video：

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Finger tapping test is a common testing item for patients with Parkinson's disease (PD) in clinical neurology. It mainly evaluates the fine motor function of patient's hand in three aspects:amplitude, speed and regularity of the movement. This paper focused on the quantitative assessment of regularity of finger tapping movement for PD patients. The movement signals of thumb and index finger were recorded by using inertial sensor unit in the process of tapping test. Two nonlinear dynamic indexes, approximate entropy (ApEn) and sample entropy (SampEn), were calculated, and then the values were statistically analyzed. The experimental results indicated that both indexes had significant differences between patient group and control group. Moreover, the indexes had relatively high correlation with the scores of corresponding unified Parkinson's disease rating scale (UPDRS) item rated by clinical clinician, which illustrated that these two indexes could reflect the injury level of the repetitive finger movement. So, as a reliable method, it can be provided to the clinical evaluation of hand movement function for PD patients.

Citation： LIU Yao, WANG Xun, XU Shengqiang, CHENG Nan, TANG Zheng, SUN Yining, YANG Xianjun. Quantitative Evaluation of Regularity of Finger Tapping Movement for Patients with Parkinson's disease. Journal of Biomedical Engineering, 2016, 33(5): 979-984. doi: 10.7507/1001-5515.20160157 Copy

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1. 陈佳妮.帕金森病概述[J].生物学教学, 2010, 35(8):2-4.
2. JANKOVIC J. Parkinson's disease:clinical features and diagnosis[J]. J Neurol Neurosurg Psychiatry, 2008, 79(4):368-376.
3. GOETZ G, POEWE W, RASCOL O, et al. The unified parkinson's disease rating scale(UPDRS):status and recommendations[J]. Movement Disorders, 2003, 18(7):738-750.
4. OKUNO R, YOKOE M, AKAZAWA K, et al. Finger taps movement acceleration measurement system for quantitative diagnosis of Parkinson's disease[C]//Proceedings of the 28th IEEE EMBS Annual International Conference.New York City, USA, 2006.
5. KIM J W, LEE J H, KWON Y, et al. Quantification of bradykinesia during clinical finger taps using a gyrosensor in patients with Parkinson's disease[J]. Med Biol Eng Comput, 2011, 49(3):365-371.
6. STAMATAKIS J, AMBROISE J, CRÉMERS J, et al. Finger tapping clinimetric score prediction in Parkinson's disease using low-cost accelerometers[J]. Comput Intell Neurosci, 2013:717853.
7. PINCUS S M. Approximate entropy as a measure of system complexity[J]. Proc Natl Acad Sci U S A, 1991, 88(6):2297-2301.
8. RICHMAN J S, MOORMAN J R. Physiological time-series analysis using approximate entropy and sample entropy[J]. Am J Physiol Heart Circ Physiol, 2000, 278(6):H2039-H2049.
9. YENTES J M, HUNT N, SCHMID K K, et al. The appropriate use of approximate entropy and sample entropy with short data sets[J]. Ann Biomed Eng, 2013, 41(2):349-365.
10. PINCUS S M, GOLDBERGER A L. Physiological time-series analysis:what does regularity quantify?[J]. Am J Physiol, 1994, 266(4 Pt 2):H1643-H1656.
11. 贾俊平, 何晓群, 金勇进.统计学[M].第5版.北京:中国人民大学出版社, 2012:1-332.
12. 张文彤, 邝春伟.SPSS统计分析基础教程[M].第2版.北京:高等教育出版社, 2011:1-415.
13. AGOSTINO R, CURRÀ A, GIOVANNELLI M, et al. Impairment of individual finger movements in Parkinson's disease[J]. Mov Disord, 2003, 18(5):560-565.

Journal of Biomedical Engineering

Quantitative Evaluation of Regularity of Finger Tapping Movement for Patients with Parkinson's disease

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